Cited by 97Calcium signaling and nucleotide metabolismNeuroscience and Neuropharmacology ResearchProtein Kinase Regulation and GTPase Signaling

Neuronal localization of CD38 antigen in the human brain

Mizuguchi, Masashi, Otsuka, Naruhito, Sato, Maroto, Ishii, Yoshifumi, Kon, Shin-ichiro, Yamada, Mitsunori, Nishina, Hiroshi, Katada, Toshiaki +1 more·1995·Brain Research

Abstract

CD38 is a lymphocyte differentiation antigen which is involved in the cyclic ADP-ribose-mediated second messenger system. We provide immunochemical and immunohistochemical evidence for the expression of CD38 in the adult human brain. We used six polyclonal antibodies against synthetic CD38 polypeptides, in addition to four monoclonal antibodies already available. Brain CD38 was detectable by Western blotting after immunoaffinity purification of the brain extracts. Immunoperoxidase staining localized CD38 immunoreactivity to the perikarya and dendrites of many neurons, such as the cerebellar Purkinje cells, implying that CD38 is involved in the signal transduction within the central nervous system neurons.

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Crossref · 10.1016/0006-8993(95)00885-t

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  • CD38 is expressed in brain, and CD38 knockout mice show significant protection against ischemic brain damage.

    “Despite CD38 being a lymphocyte differentiation antigen, it is also expressed in the brain (Mizuguchi et al., 1995), and CD38 knockout mice show significant protection against ischemic brain damage (Long et al., 2017).”

    From NAD+ in Brain Aging and Neurodegenerative Disorders (2019) · cites this paper as Mizuguchi et al., 1995

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Authors
Mizuguchi, M., Otsuka, N., Sato, M., Ishii, Y., Kon, S.-I., Yamada, M., Nishina, H., Katada, T., & Ikeda, K.
Affiliations
  • Tokyo Institute of Psychiatry (JP)
  • Sapporo Medical University (JP)
  • Brain Research Institute, Niigata University (JP)
  • Tokyo Institute of Technology (JP)
Corresponding author
Mizuguchi, Masashi
Venue
Brain Research
Publisher
Elsevier BV
Published
1995-10
Volume
697
Issue
1-2
Pages
235-240
ISSN
0006-8993 (ISSN-L)
OpenAlex
W2051606662
Cited by
97
References
20
Citations by year
2026: 1 · 2025: 1 · 2024: 4 · 2023: 2 · 2022: 9 · 2021: 5 · 2020: 4 · 2019: 3 · 2018: 1 · 2016: 1 · 2015: 2 · 2014: 5 · 2013: 5 · 2012: 1
FWCI
2.14
Type
journal article
Language
en
Open access
closed
Locations
  • Brain Research (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • Ministry of Health, Labour and Welfare
  • Ministry of Education, Culture, Sports, Science and Technology (6A-2)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Physiology › Calcium signaling and nucleotide metabolism
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Protein Kinase Regulation and GTPase Signaling
Keywords
CD38, human brain, neuronal expression, Purkinje cells, cerebellum, cyclic ADP-ribose, second messenger signaling, signal transduction, dendrites, perikarya, monoclonal antibodies, polyclonal antibodies
MeSH terms
Adolescent, Adult, Aged, Antigens, Differentiation, Brain, Humans, Immunoenzyme Techniques, Membrane Glycoproteins, Middle Aged, Neurons, N-Glycosyl Hydrolases, Purkinje Cells, Tissue Distribution, Blotting, Western, Antigens, CD, ADP-ribosyl Cyclase, ADP-ribosyl Cyclase 1

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