Neuronal localization of CD38 antigen in the human brain
Abstract
CD38 is a lymphocyte differentiation antigen which is involved in the cyclic ADP-ribose-mediated second messenger system. We provide immunochemical and immunohistochemical evidence for the expression of CD38 in the adult human brain. We used six polyclonal antibodies against synthetic CD38 polypeptides, in addition to four monoclonal antibodies already available. Brain CD38 was detectable by Western blotting after immunoaffinity purification of the brain extracts. Immunoperoxidase staining localized CD38 immunoreactivity to the perikarya and dendrites of many neurons, such as the cerebellar Purkinje cells, implying that CD38 is involved in the signal transduction within the central nervous system neurons.
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CD38 is expressed in brain, and CD38 knockout mice show significant protection against ischemic brain damage.
“Despite CD38 being a lymphocyte differentiation antigen, it is also expressed in the brain (Mizuguchi et al., 1995), and CD38 knockout mice show significant protection against ischemic brain damage (Long et al., 2017).”
From NAD+ in Brain Aging and Neurodegenerative Disorders (2019) · cites this paper as Mizuguchi et al., 1995
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Reinherz, E. L., Kung, P. C., Goldstein, G., Levey, R. H., & Schlossman, S. F. (1980) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.77.3.1588 · Cited by 1,629 · see citing works
Formation and Hydrolysis of Cyclic ADP-Ribose Catalyzed by Lymphocyte Antigen CD38
Howard, M., Grimaldi, J. C., Bazán, J. F., Lund, F. E., Santos‐Argumedo, L., Parkhouse, R. M. E., Walseth, T. F., & Lee, H. C. (1993) · Science · doi:10.1126/science.8235624 · Cited by 737 · see citing works
Human CD38: a glycoprotein in search of a function
Malavasi, F., Funaro, A., Roggero, S., Horenstein, A. L., Calosso, L., & Mehta, K. (1994) · Immunology Today · doi:10.1016/0167-5699(94)90148-1 · Cited by 344 · see citing works
Jackson, D. G., & Bell, J. I. (1990) · The Journal of Immunology · doi:10.4049/jimmunol.144.7.2811 · Cited by 343 · see citing works
Berridge, M. J. (1993) · Nature · doi:10.1038/365388a0 · Cited by 343 · see citing works
Biochemical studies of the human thymocyte cell-surface antigens T6, T9 and T10
Terhorst, C., Agthoven, A. V., LeClair, K. P., Snow, P. M., Reinherz, E. L., & Schlossman, S. F. (1981) · Cell · doi:10.1016/0092-8674(81)90441-4 · Cited by 286 · see citing works
Zocchi, E., Franco, L., Guida, L., Benatti, U., Bargellesi, A., Malavasi, F., Lee, H. C., & Deflora, A. (1993) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1993.2416 · Cited by 278 · see citing works
Takasawa, S., Tohgo, A., Noguchi, N., Koguma, T., Nata, K., Sugimoto, T., Yonekura, H., & Okamoto, H. (1993) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)74275-6 · Cited by 273 · see citing works
Cyclic ADP-Ribose: a New Way to Control Calcium
Galione, A. (1993) · Science · doi:10.1126/science.8380506 · Cited by 255 · see citing works
Funaro, A., Spagnoli, G. C., Ausiello, C. M., Alessio, M., Roggero, S., Delia, D., Zaccolo, M., & Malavasi, F. (1990) · The Journal of Immunology · doi:10.4049/jimmunol.145.8.2390 · Cited by 207 · see citing works
Kontani, K., Nishina, H., Ohoka, Y., Takahashi, K., & Katada, T. (1993) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)85279-1 · Cited by 127 · see citing works
Self-citationAlessio, M., Roggero, S., Funaro, A., Monte, L. B. D., Peruzzi, L., Geuna, M., & Malavasi, F. (1990) · The Journal of Immunology · doi:10.4049/jimmunol.145.3.878 · Cited by 127 · see citing works
CD38: A multi-lineage cell activation molecule with a split personality
Malavasi, F., Funaro, A., Alessio, M., Monte, L. B. D., Ausiello, C. M., Dianzani, U., Lanza, F. B., Magrini, E., Momo, M., & Roggero, S. (1992) · International Journal of Clinical & Laboratory Research · doi:10.1007/bf02591400 · Cited by 126 · see citing works
Funaro, A., Monte, L. B. D., Dianzani, U., Forni, M., & Malavasi, F. (1993) · European Journal of Immunology · doi:10.1002/eji.1830231005 · Cited by 113 · see citing works
Koguma, T., Takasawa, S., Tohgo, A., Karasawa, T., Furuya, Y., Yonekura, H., & Okamoto, H. (1994) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/0167-4889(94)90087-6 · Cited by 108 · see citing works
Discontinuous expression of a membrane antigen (HB‐7) during B lymphocyte differentiation
Tedder, T. F., Clement, L. T., & Cooper, M. D. (1984) · Tissue Antigens · doi:10.1111/j.1399-0039.1984.tb02118.x · Cited by 62 · see citing works
Immunohistochemical localization of ryanodine receptors in mouse central nervous system
Nakanishi, S., Kuwajima, G., & Mikoshiba, K. (1992) · Neuroscience Research · doi:10.1016/0168-0102(92)90026-9 · Cited by 45 · see citing works
A Cloned Rat CD38-Homologous Protein and Its Expression in Pancreatic Islets
Li, Q., Yamada, Y., Yasuda, K., Ihara, Y., Okamoto, Y., Kaisaki, P. J., Watanabe, R., Ikeda, H., Tsuda, K., & Seino, Y. (1994) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1994.1974 · Cited by 21 · see citing works
Expression of Bcl-2 protein in murine neural cells in culture
Mizuguchi, M., Ikeda, K., Asada, M., Mizutani, S., & Kamoshita, S. (1994) · Brain Research · doi:10.1016/0006-8993(94)91064-2 · Cited by 19 · see citing works
Self-citationIshii, Y., Kon, S., Takei, T., Fujimoto, J., & Kikuchi, K. (1983) · PubMed Central · Cited by 19 · see citing works
Self-citation
Flagged first, then by citations
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Sorted by citations
Evolution and function of the ADP ribosyl cyclase/CD38 gene family in physiology and pathology
Malavasi, F., Deaglio, S., Funaro, A., Ferrero, E., Horenstein, A. L., Ortolan, E., Vaisitti, T., & Aydin, S. (2008) · Physiological Reviews · doi:10.1152/physrev.00035.2007 · Cited by 862 · see citing works
NAD+ in Brain Aging and Neurodegenerative Disorders
Lautrup, S., Sinclair, D. A., Mattson, M. P., & Fang, E. F. (2019) · Cell Metabolism · doi:10.1016/j.cmet.2019.09.001 · Cited by 790 · see citing works
Young, W., Steele, T. A., Bray, R. A., Hudson, J. A., Floyd, J. A., Hawkins, K. C., Thomas, K. S. C., Austin, T., Edwards, C., Cuzzourt, J., et al. (2001) · The Anatomical Record · doi:10.1002/ar.1128 · Cited by 545 · see citing works
CD38 expression as an important prognostic factor in B-cell chronic lymphocytic leukemia
Ibrahim, S., Keating, M. J., Do, K.-A., O'Brien, S. M., Huh, Y. O., Jilani, I. B., Lerner, S. A., Kantarjian, H. M., & Albitar, M. X. (2001) · Blood · doi:10.1182/blood.v98.1.181 · Cited by 451 · see citing works
Physiological functions of cyclic ADP-ribose and NAADP as calcium messengers
Lee, H. C. (2001) · Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev.pharmtox.41.1.317 · Cited by 433 · see citing works
Human CD38, a cell‐surface protein with multiple functions
Mehta, K., Umar, S., & Malavasi, F. (1996) · The FASEB Journal · doi:10.1096/fasebj.10.12.8903511 · Cited by 294 · see citing works
Human CD38: a (r)evolutionary story of enzymes and receptors
Deaglio, S., Mehta, K., & Malavasi, F. (2001) · Leukemia Research · doi:10.1016/s0145-2126(00)00093-x · Cited by 285 · see citing works
Cockayne, D. A., Muchamuel, T., Grimaldi, J. C., Muller‐Steffner, H., Randall, T. D., Lund, F. E., Murray, R., Schuber, F. J., & Howard, M. (1998) · Blood · doi:10.1182/blood.v92.4.1324 · Cited by 219 · see citing works
Dagar, G., Gupta, A., Masoodi, T., Nisar, S., Merhi, M., Hashem, S., Chauhan, R., Dagar, M., Mirza, S., Bagga, P., et al. (2023) · Journal of Translational Medicine · doi:10.1186/s12967-023-04292-3 · Cited by 218 · see citing works
CD38 in Neurodegeneration and Neuroinflammation
Guerreiro, S., Privat, A.-L., Bressac, L., & Toulorge, D. (2020) · Cells · doi:10.3390/cells9020471 · Cited by 143 · see citing works
Verderio, C., Bruzzone, S., Zocchi, E., Fedele, E., Schenk, U., FLORA, A. D., & Matteoli, M. (2001) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2001.00455.x · Cited by 128 · see citing works
Zocchi, E., Daga, A., Usai, C., Franco, L., Guida, L., Bruzzone, S., Costa, A., Marchetti, C., & FLORA, A. D. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.14.8017 · Cited by 122 · see citing works
Shubinsky, G., & Schlesinger, M. (1997) · Immunity · doi:10.1016/s1074-7613(00)80353-2 · Cited by 119 · see citing works
Alzheimer's disease pathology is attenuated in a <scp>CD</scp>38‐deficient mouse model
Blacher, E., Dadali, T., Bespalko, A., Haupenthal, V. J., Grimm, M. O. W., Hartmann, T., Lund, F. E., Stein, R., & Levy, A. (2015) · Annals of Neurology · doi:10.1002/ana.24425 · Cited by 117 · see citing works
CD38 is functionally dependent on the TCR/CD3 complex in human T cells
Morra, M., Zubiaur, M., Terhorst, C., Sancho, J., & Malavasi, F. (1998) · The FASEB Journal · doi:10.1096/fasebj.12.7.581 · Cited by 113 · see citing works
Ultrastructural localization of CD38 immunoreactivity in rat brain
Yamada, M., Mizuguchi, M., Otsuka, N., Ikeda, K., & Takahashi, H. (1997) · Brain Research · doi:10.1016/s0006-8993(97)00117-0 · Cited by 111 · see citing works
Self-citationHuman CD38 is an authentic NAD(P)+ glycohydrolase
Berthelier, V., Tixier, J. M., Muller‐Steffner, H., Schuber, F. J., & Déterre, P. (1998) · Biochemical Journal · doi:10.1042/bj3301383 · Cited by 109 · see citing works
Decreased cADPR and increased NAD+ in the Cd38−/− mouse
Young, G. S., Choleris, E., Lund, F. E., & Kirkland, J. B. (2006) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2006.05.100 · Cited by 94 · see citing works
High expression of nicotinamide N-methyltransferase in patients with idiopathic Parkinson's disease
Parsons, R. B., Smith, S. W., Waring, R. H., Williams, A. C., & Ramsden, D. B. (2003) · Neuroscience Letters · doi:10.1016/s0304-3940(03)00218-0 · Cited by 91 · see citing works
The CD38 glycohydrolase and the NAD sink: implications for pathological conditions
Zeidler, J. D., Hogan, K. A., Agorrody, G., Peclat, T., Kashyap, S., Kanamori, K. S., Gomez, L. S., Mazdeh, D. Z., Warner, G. M., Thompson, K. L., et al. (2022) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00451.2021 · Cited by 90 · see citing works
Neuron-Glia Interactions as Therapeutic Targets in Neurodegeneration
Salmina, A. B. (2009) · Journal of Alzheimer s Disease · doi:10.3233/jad-2009-0988 · Cited by 86 · see citing works
Cyclic ADP-ribose as a universal calcium signal molecule in the nervous system
Higashida, H., Salmina, A. B., Olovyannikova, R. Y., Hashii, M., Yokoyama, S., Koizumi, K., Jin, D., Liu, H.-X., Lopatina, O. L., Amina, S., et al. (2007) · Neurochemistry International · doi:10.1016/j.neuint.2007.06.023 · Cited by 84 · see citing works
The CD38/cyclic ADP-ribose system: A topological paradox
FLORA, A. D., Guida, L., Franco, L., & Zocchi, E. (1997) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/s1357-2725(97)00062-9 · Cited by 82 · see citing works
The metamorphosis of a molecule: from soluble enzyme to the leukocyte receptor CD38
Ferrero, E., & Malavasi, F. (1999) · Journal of Leukocyte Biology · doi:10.1002/jlb.65.2.151 · Cited by 79 · see citing works
CD38 at the junction between prognostic marker and therapeutic target
Deaglio, S., Aydin, S., Vaisitti, T., Bergui, L., & Malavasi, F. (2008) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2008.02.005 · Cited by 74 · see citing works
Ceni, C., Muller‐Steffner, H., Lund, F. E., Pochon, N., Schweitzer, A., WAARD, M. M. D., Schuber, F. J., Villaz, M., & Moutin, M. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m301196200 · Cited by 69 · see citing works
CD38-dependent ADP-ribosyl cyclase activity in developing and adult mouse brain
Ceni, C., Pochon, N., Brun, V., Muller‐Steffner, H., Andrieux, A., Grünwald, D., Schuber, F. J., WAARD, M. M. D., Lund, F. E., Villaz, M., et al. (2003) · Biochemical Journal · doi:10.1042/bj20020604 · Cited by 66 · see citing works
The Roles of Oxytocin and CD38 in Social or Parental Behaviors
Lopatina, O. L., Ивановна, И. А., Salmina, A. B., & Higashida, H. (2013) · Frontiers in Neuroscience · doi:10.3389/fnins.2012.00182 · Cited by 64 · see citing works
The balance between NAD+ biosynthesis and consumption in ageing
Strømland, Ø., Diab, J., Ferrario, E., Sverkeli, L. J., & Ziegler, M. (2021) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2021.111569 · Cited by 63 · see citing works
Higashida, H., Hashii, M., Yokoyama, S., Hoshi, N., Chen, X.-L., Egorova, A., Noda, M., & Zhang, J.-S. (2001) · Pharmacology & Therapeutics · doi:10.1016/s0163-7258(01)00142-5 · Cited by 61 · see citing works
The role of oxytocin and vasopressin in emotional and social behaviors
Bachner‐Melman, R., & Ebstein, R. P. (2014) · Handbook of clinical neurology · doi:10.1016/b978-0-444-59602-4.00004-6 · Cited by 62 · see citing works
CD38, CD157, and RAGE as Molecular Determinants for Social Behavior
Higashida, H., Hashii, M., Tanaka, Y., Matsukawa, S., Higuchi, Y., Gabata, R., Tsubomoto, M., Seishima, N., Teramachi, M., Kamijima, T., et al. (2019) · Cells · doi:10.3390/cells9010062 · Cited by 58 · see citing works
Antonelli, A., Tuomilehto, J., Nannipieri, M., Fallahi, P., Nesti, C., Okamoto, H., Groop, L., & Ferrannini, E. (2002) · Diabetologia · doi:10.1007/s00125-002-0886-6 · Cited by 55 · see citing works
Owens, K., Park, J. H., Schuh, R. A., & Kristián, T. (2013) · Translational Stroke Research · doi:10.1007/s12975-013-0278-x · Cited by 53 · see citing works
Neuroprotection in Glaucoma: NAD+/NADH Redox State as a Potential Biomarker and Therapeutic Target
Petriti, B., Williams, P. A., Lascaratos, G., Chau, K., & Garway‐Heath, D. F. (2021) · Cells · doi:10.3390/cells10061402 · Cited by 50 · see citing works
Cyclic ADP‐ribose as a potential second messenger for neuronal Ca2+ signaling
Higashida, H., Hashii, M., Yokoyama, S., Hoshi, N., Asai, K., & Kato, T. (2001) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2001.00082.x · Cited by 50 · see citing works
Anti-CD38 autoimmunity in patients with chronic autoimmune thyroiditis or Graves' disease
Antonelli, A., Fallahi, P., Nesti, C., Pupilli, C., Marchetti, P., Takasawa, S., Okamoto, H., & Ferrannini, E. (2001) · Clinical & Experimental Immunology · doi:10.1046/j.1365-2249.2001.01683.x · Cited by 49 · see citing works
Zhou, X., Rasche, L., Kortüm, K. M., Danhof, S., Hudecek, M., & Einsele, H. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.620312 · Cited by 47 · see citing works
Characterization and localization of CD38 in the vertebrate eye
Khoo, K. M., & Chang, C. F. (1999) · Brain Research · doi:10.1016/s0006-8993(98)01347-x · Cited by 47 · see citing works
The Making of a Leukocyte Receptor: Origin, Genes and Regulation of Human CD38 and Related Molecules
Ferrero, E., Saccucci, F., & Malavasi, F. (2000) · KARGER eBooks · doi:10.1159/000058763 · Cited by 46 · see citing works
CD38 through the life of a murine B lymphocyte
Vences‐Catalán, F., & Santos‐Argumedo, L. (2011) · IUBMB Life · doi:10.1002/iub.549 · Cited by 38 · see citing works
CD38 Facilitates Recovery from Traumatic Brain Injury
Levy, A., Bercovich-Kinori, A., Alexandrovich, A. G., Tsenter, J., Trembovler, V., Lund, F. E., Shohami, E., Stein, R., & Mayo, L. (2009) · Journal of Neurotrauma · doi:10.1089/neu.2008.0746 · Cited by 38 · see citing works
Salmina, A. B., Lopatina, O., Ekimova, M. V., Mikhutkina, S. V., & Higashida, H. (2010) · Journal of Neuroendocrinology · doi:10.1111/j.1365-2826.2010.01970.x · Cited by 36 · see citing works
Neurodegeneration and inflammation crosstalk: Therapeutic targets and perspectives
Mohamed, W. M. Y., Kumar, J., Alghamdi, B. S. A., Wadan, A.-H. S., & Yamashita, T. (2022) · IBRO Neuroscience Reports · doi:10.1016/j.ibneur.2022.12.003 · Cited by 38 · see citing works
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Zuo, W., Liu, N., Zeng, Y., Liu, Y., Li, B., Wu, K., Xiao, Y., & Liu, Q. (2020) · Cardiovascular Drugs and Therapy · doi:10.1007/s10557-020-07007-8 · Cited by 34 · see citing works
Bispecific Antibodies: A New Era of Treatment for Multiple Myeloma
Zhou, X., Einsele, H., & Danhof, S. (2020) · Journal of Clinical Medicine · doi:10.3390/jcm9072166 · Cited by 33 · see citing works
CD38 autoimmunity: Recent advances and relevance to human diabetes
Antonelli, A., & Ferrannini, E. (2004) · Journal of Endocrinological Investigation · doi:10.1007/bf03347507 · Cited by 32 · see citing works
Are retinoids potential therapeutic agents in disorders of social cognition including autism?
Ebstein, R. P., Mankuta, D., Yirmiya, N., & Malavasi, F. (2011) · FEBS Letters · doi:10.1016/j.febslet.2011.05.004 · Cited by 31 · see citing works
Calcium signaling by cyclic ADP-ribose and NAADP
Lee, H. C. (1998) · Cell Biochemistry and Biophysics · doi:10.1007/bf02738306 · Cited by 30 · see citing works
Cellular and Mitochondrial NAD Homeostasis in Health and Disease
Waddell, J., Khatoon, R., & Kristián, T. (2023) · Cells · doi:10.3390/cells12091329 · Cited by 30 · see citing works
Membrane‐Bound Form of ADP‐Ribosyl Cyclase in Rat Cortical Astrocytes in Culture
Hotta, T., Asai, K., Fujita, K., Kato, T., & Higashida, H. (2000) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2000.740669.x · Cited by 29 · see citing works
CARs and other T cell therapies for MM: The clinical experience
Danhof, S., Hudecek, M., & Smith, E. L. (2018) · Best Practice & Research Clinical Haematology · doi:10.1016/j.beha.2018.03.002 · Cited by 27 · see citing works
Pawlikowska, L., Cottrell, S. E., Harms, M. B., Li, Y., & Rosenberg, P. A. (1996) · Journal of Neuroscience · doi:10.1523/jneurosci.16-17-05372.1996 · Cited by 25 · see citing works
Young, G. S., & Kirkland, J. B. (2008) · Nutrition Research Reviews · doi:10.1017/s0954422408945182 · Cited by 20 · see citing works
Human Cerebral Cortex Proteome of Fragile X-Associated Tremor/Ataxia Syndrome
Holm, K. N., Herren, A. W., Taylor, S. L., Randol, J. L., Kim, K., Espinal, G. M., Martínez‐Cerdeño, V., Pessah, I. N., Hagerman, R. J., & Hagerman, P. J. (2021) · Frontiers in Molecular Biosciences · doi:10.3389/fmolb.2020.600840 · Cited by 17 · see citing works
Retinoid-Mediated Signaling Pathways in CD38 Antigen Expression in Myeloid Leukemia Cells
Mehta, K., & Cheema, S. K. (1999) · Leukemia & lymphoma/Leukemia and lymphoma · doi:10.3109/10428199909058401 · Cited by 17 · see citing works
A Bright Horizon: Immunotherapy for Pediatric T-Cell Malignancies
Newman, H. M., & Teachey, D. T. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23158600 · Cited by 12 · see citing works
Kareem, S. S., Viswanathan, N., Sahebjam, S., Tran, N., Gatewood, T. S., Tobon, K. A., Baz, R., Piña, Y., Shain, K. H., & Mokhtari, S. (2022) · OncoTargets and Therapy · doi:10.2147/ott.s365657 · Cited by 12 · see citing works
CD38 as a multifaceted immunotherapeutic target in CLL
Paulus, A., Malavasi, F., & Chanan-Khan, A. A. (2022) · Leukemia & lymphoma/Leukemia and lymphoma · doi:10.1080/10428194.2022.2090551 · Cited by 13 · see citing works
Neurophysiological functions and pharmacological tools of acidic and non-acidic Ca2+ stores
Martucci, L. L., & Cancela, J. (2022) · Cell Calcium · doi:10.1016/j.ceca.2022.102582 · Cited by 11 · see citing works
Hannawi, Y., Ewees, M. G., Moore, J. T., & Zweier, J. L. (2022) · Frontiers in Pharmacology · doi:10.3389/fphar.2022.881708 · Cited by 11 · see citing works
Altered CD38 expression in thioacetamide‐induced rat model of liver cirrhosis
Gan, B. H., Ng, G. L., Bay, B., & Chang, C. F. (2005) · Liver International · doi:10.1111/j.1478-3231.2005.01173.x · Cited by 10 · see citing works
Fluorometric studies of ligand-induced conformational changes of CD38
Lacapère, J.-J., Boulla, G., Lund, F. E., Primack, J., Oppenheimer, N. J., Schuber, F. J., & Déterre, P. (2003) · Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics · doi:10.1016/j.bbapap.2003.07.002 · Cited by 9 · see citing works
Expression of CD38 in Human Neuroblastoma Sh-SY5Y Cells
Orciani, M., Trubiani, O., Cavaletti, G., Guarnieri, S., Salvolini, E., Tredici, G., & Primio, R. D. (2008) · International Journal of Immunopathology and Pharmacology · doi:10.1177/039463200802100111 · Cited by 8 · see citing works
Mustafa, N. B., Azaman, M. I. B., Ng, G. G. K., & Chng, W. J. (2022) · Biomolecules · doi:10.3390/biom12091261 · Cited by 7 · see citing works
Salmina, A. B., Сергеевна, О. О., Malinovskaya, N. A., Таранушенко, Т. Е., Morgun, A. V., Mantorova, N. S., & Михуткина, С. В. (2008) · Neurochemical Journal · doi:10.1134/s1819712408030136 · Cited by 6 · see citing works
Enzymic and Signal Transduction Properties of CD38/NADase and PC-1/Phosphodiesterase
Katada, T., Kontani, K., Wada, T., Hosoda, N., Hoshino, S.-I., & Nishina, H. (2000) · KARGER eBooks · doi:10.1159/000058762 · Cited by 6 · see citing works
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Gordon, M. L., Christen, E., Keehlisen, L., Gong, M. N., Lam, F., Giliberto, L., Gomar, J. J., & Koppel, J. L. (2024) · Journal of Alzheimer s Disease Reports · doi:10.3233/adr-240089 · Cited by 6 · see citing works
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Zhang, W., Zheng, H., Pang, Y., Wang, Y., & Zhang, X. (2025) · Molecular Neurobiology · doi:10.1007/s12035-025-05243-3 · Cited by 4 · see citing works
Masuda, W., & Jimi, E. (2011) · Archives of Biochemistry and Biophysics · doi:10.1016/j.abb.2011.07.006 · Cited by 4 · see citing works
CD38 Facilitates Recovery from Traumatic Brain Injury
Levy, A., Bercovich-Kinori, A., Alexandrovich, A. G., Tsenter, J., Trembovler, V., Lund, F. E., Shohami, E., Stein, R., & Mayo, L. (2009) · Journal of Neurotrauma · doi:10.1089/neu.2008-0746 · Cited by 3 · see citing works
Mellatyar, H., Sattari, S., Asl, A. N., & Akbarzadeh, A. (2024) · BioNanoScience · doi:10.1007/s12668-024-01389-x · Cited by 3 · see citing works
Schnitzler, S. U., Kopitz, J., & Plaschke, K. (2016) · Neurological Research · doi:10.1080/01616412.2016.1242452 · Cited by 3 · see citing works
Malinovskaya, N. A., Prokopenko, S. V., Komleva, Y. K., Panina, Y. A., Пожиленкова, Е. А., Владимирович, Р. Р., & Salmina, A. B. (2014) · Siberian medical review · doi:10.20333/25000136-2014-5-5-15 · Cited by 2 · see citing works
Revolutionizing cancer treatment: an in-depth exploration of CAR-T cell therapies
Kandav, G., & Chandel, A. (2024) · Medical Oncology · doi:10.1007/s12032-024-02491-6 · Cited by 1 · see citing works
Oxytocin and vasopressin in human sociality and social psychopathologies
Ebstein, R. P., Shalev, I., Israel, S., Uzefovsky, F., Avinun, R., Knafo‐Noam, A., Yirmiya, N., & Mankuta, D. (2013) · Cambridge University Press eBooks · doi:10.1017/cbo9781139017855.023 · Cited by 1 · see citing works
Impaired NAD+ Metabolism in Neuronal Dysfunction in Critical Conditions
Салмина, А., Fursov, A. A., Михуткина, С. В., Shakhmayeva, S. V., & Mantorova, N. S. (2008) · General Reanimatology · doi:10.15360/1813-9779-2008-1-80 · Cited by 1 · see citing works
Han, M., Kwark, O.-S., Jang, K. Y., Lee, D., Oh, B.-C., An, N., & Kim, U. (1999) · Cancer Letters · doi:10.1016/s0304-3835(99)00267-0 · Cited by 1 · see citing works
Choleris, E., Pfaff, D. W., & Kavaliers, M. (2013) · Cambridge University Press eBooks · doi:10.1017/cbo9781139017855.021 · Cited by 1 · see citing works
The role of CD38 expression on NAD levels and cell physiology in a leukaemia model
Al-Abady, Z. N. (2013) · PEARL (University of Plymouth) · doi:10.13140/rg.2.2.34066.66249
Kidney ADP-Ribosyl Cyclase Inhibitors as a Therapeutic Tool for Diabetic Nephropathy
Kim, U. (2012) · InTech eBooks · doi:10.5772/35627
Astrocyte CD38: Links to Neuroinflammation in HAND
Banerjee, S., & Ghorpade, A. (2011) · InTech eBooks · doi:10.5772/22856
Untersuchungen zu ADP-Ribosylcyclasen in humanen immunkompetenten Zellen
Schweitzer, K. (2002)
Identification and characterization of novel ADP-ribosyl cyclase family members
Hirte, R. M. (2011) · University of Minnesota Digital Conservancy (University of Minnesota)
Young, H. Y., Ya, T., Ahawkins, K., Nthomas, K., Yaustin, T., Sedwards, C., Ycuzzourt, J., & Yduenzl, M. (2001)
EXPRESSION OF CD38 AND СХ43 IN THE MIDBRAIN CELLS AT EXPERIMENTAL PARKINSON'S DISEASE
Malinovskaya, N. A., Salmina, A. B., Prokopenko, S. V., Komleva, Y. K., Морозова, Г. А., Panina, Y. A., & Gasymly, E. D. (2014) · Siberian medical review · doi:10.20333/25000136-2014-6-20-25
Análise da tetramerização da proteína CD38 por meio de docking molecular
dos Santos, J. C. (2019) · Digital Library of Theses and Dissertations (Universidade de São Paulo) · doi:10.11606/d.95.2019.tde-25062020-130911
Barclay, A. N., Brown, M. H., Law, S. K. A., McKnight, A. J., Tomlinson, M. G., & van der Merwe, P. A. (1997) · Elsevier eBooks · doi:10.1016/b978-012078185-0/50472-8
Mangelberger-Eberl, D., Cosenza, M. E., Härtle, S., Luetjens, C. M., Welsh, B. T., Steidl, S., Flesher, D., & Chinn, L. W. (2024) · International Journal of Toxicology · doi:10.1177/10915818241289526
Royer, J. (2021) · theses.fr (ABES) · doi:10.70675/9561320dz3197z4755zbb24zf51613d38d02
New regulators in oxytocin and vasopressin release : role of the endolysosomal two-pore channels
Martucci, L. L. (2021) · theses.fr (ABES) · doi:10.70675/027d1ae2zd2ebz4677za019ze6ccd94cafe9
Harvey, J. R. M., Wight, T. H., Roberts, M., Mulligan, V. J., Barker, D. F., Sherlock, C., Ossola, B., Hewer, R., Xu, X., Page, K. J., et al. (2026) · Frontiers in Pharmacology · doi:10.3389/fphar.2026.1927552
Enzymatic Regulation of Opioid Antinociception and Tolerance
Hull, L. C. (2009) · VCU Scholars Compass (Virginia Commonwealth University) · doi:10.25772/0wyq-jx38
- Authors
- Mizuguchi, M., Otsuka, N., Sato, M., Ishii, Y., Kon, S.-I., Yamada, M., Nishina, H., Katada, T., & Ikeda, K.
- Affiliations
- Tokyo Institute of Psychiatry (JP)
- Sapporo Medical University (JP)
- Brain Research Institute, Niigata University (JP)
- Tokyo Institute of Technology (JP)
- Corresponding author
- Mizuguchi, Masashi
- Venue
- Brain Research
- Publisher
- Elsevier BV
- Published
- 1995-10
- Volume
- 697
- Issue
- 1-2
- Pages
- 235-240
- ISSN
- 0006-8993 (ISSN-L)
- OpenAlex
- W2051606662
- Cited by
- 97
- References
- 20
- Citations by year
- 2026: 1 · 2025: 1 · 2024: 4 · 2023: 2 · 2022: 9 · 2021: 5 · 2020: 4 · 2019: 3 · 2018: 1 · 2016: 1 · 2015: 2 · 2014: 5 · 2013: 5 · 2012: 1
- FWCI
- 2.14
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Brain Research (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Ministry of Health, Labour and Welfare
- Ministry of Education, Culture, Sports, Science and Technology (6A-2)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Physiology › Calcium signaling and nucleotide metabolism
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Protein Kinase Regulation and GTPase Signaling
- Keywords
- CD38, human brain, neuronal expression, Purkinje cells, cerebellum, cyclic ADP-ribose, second messenger signaling, signal transduction, dendrites, perikarya, monoclonal antibodies, polyclonal antibodies
- MeSH terms
- Adolescent, Adult, Aged, Antigens, Differentiation, Brain, Humans, Immunoenzyme Techniques, Membrane Glycoproteins, Middle Aged, Neurons, N-Glycosyl Hydrolases, Purkinje Cells, Tissue Distribution, Blotting, Western, Antigens, CD, ADP-ribosyl Cyclase, ADP-ribosyl Cyclase 1
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