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Cited by 139Circadian rhythm and melatoninDementia and Cognitive Impairment ResearchSleep and Work-Related Fatigue

The DOI matches its Crossref record; 29 of the 29 references it cites were found in a registry or an index.

Daily rhythm of serum melatonin in patients with dementia of the degenerate type

Uchida, Katsuhisa, Okamoto, Norio, Ohara, Kenshiro, Morita, Yukitomo·1996·Brain Research
DOI 10.1016/0006-8993(96)00086-8
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Abstract

The daily rhythm in serum melatonin levels was measured in patients with dementia of the degenerate type (Alzheimer's disease, Pick's disease and senile dementia of the Alzheimer type) by radioimmunoassay. Thirteen patients (age: 69.0 +/- 8.0 years, mean +/- S.D.) were studied. All patients were hospitalized at the time of the study and had a history of sleep-wake disturbances, nocturnal wandering and/or delirium. We also studied 13 age-matched healthy control subjects (control group 1), ten young adults (control group 2), and nine hospitalized patients without dementia (control group 3). Two subjects in the control groups showed no measurable changes in melatonin level throughout the day, while the other 30 control subjects exhibited a clear daily rhythm with the peak concentration occurring during the night. On the other hand, four out of the 13 patients with dementia did not show any melatonin rhythm. Two of the demented patients who did not exhibit melatonin rhythm displayed clinical symptoms of rhythm disorders. One out of the nine patients with melatonin rhythm presented with clinical symptoms, such as delirium and sleep-wake disturbance. Our results suggest that the probability of absent melatonin rhythm is higher in demented patients compared with subjects without dementia. However, a lack of melatonin rhythm is not always associated with symptomatic rhythm disorders. Since the melatonin rhythm reflects that of the suprachiasmatic nucleus, it follows that the SCN function of the patients having a history of rhythm disorders was not always severely damaged.

Overview

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Crossref · 10.1016/0006-8993(96)00086-8

Cites

29 of 29 references verified0 citation errors · 0 not checkable

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Citations

Cites

Research works printed but not linked: 2

  1. Moore, 1978, The innervation of the mammalian pineal gland, Vol. 4, 1
  2. Moore, 1992, The organization of the human circadian timing system, Vol. 93, 101

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Metadata

Authors
Uchida, K., Okamoto, N., Ohara, K., & Morita, Y.
Affiliations
Hamamatsu University (JP)
Venue
Brain Research
Publisher
Elsevier BV
Published
1996-04
Volume
717
Issue
1-2
Pages
154-159
ISSN
0006-8993 (ISSN-L)
DOI
10.1016/0006-8993(96)00086-8
OpenAlex
W2036215613
Cited by
138
References
29
Citations by year
2026: 1 · 2025: 2 · 2024: 1 · 2023: 4 · 2022: 3 · 2021: 9 · 2020: 8 · 2019: 4 · 2018: 6 · 2017: 4 · 2016: 7 · 2014: 5 · 2013: 6 · 2012: 9
FWCI
1.93
Type
journal article
Language
en
Open access
closed
Licence
Locations
  • Brain Research (publishedVersion)
  • PubMed (publishedVersion)
Funders
Ministry of Education, Culture, Sports, Science and Technology (05455011)
Topics
  • Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
  • Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
  • Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and Work-Related Fatigue
Keywords
serum melatonin, circadian rhythm, dementia, Alzheimer's disease, Pick's disease, senile dementia of the Alzheimer type, suprachiasmatic nucleus, sleep-wake disturbances, nocturnal wandering, delirium, circadian rhythm disorders
MeSH terms
Aged, Aged, 80 and over, Alzheimer Disease, Circadian Rhythm, Dementia, Female, Humans, Male, Melatonin, Middle Aged, Radioimmunoassay, Sleep Wake Disorders

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