Melatonin—A pleiotropic, orchestrating regulator molecule

Phototransduction by retinal ganglion cells that set the circadian clock

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Functional Brown Adipose Tissue in Healthy Adults

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Hypothalamic regulation of sleep and circadian rhythms

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The mammalian circadian timing system: organization and coordination of central and peripheral clocks

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Pineal Melatonin: Cell Biology of Its Synthesis and of Its Physiological Interactions*

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Mitochondria, oxidative stress and cell death

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ISOLATION OF MELATONIN, THE PINEAL GLAND FACTOR THAT LIGHTENS MELANOCYTES 1

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Melatonin : a potent, endogenous hydroxyl radical scavenger

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One molecule, many derivatives: A never-ending interaction of melatonin with reactive oxygen and nitrogen species?

Tan, D., Manchester, L. C., Terron, M. P., Flores, L. J., & Reiter, R. J. (2007) · Journal of Pineal Research · doi:10.1111/j.1600-079x.2006.00407.x · Cited by 1,601 · see citing works

The NAD+-dependent deacetylase SIRT1 modulates CLOCK-mediated chromatin remodeling and circadian control

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A role for the mitochondrial deacetylase Sirt3 in regulating energy homeostasis

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The Circadian Gene Period2 Plays an Important Role in Tumor Suppression and DNA Damage Response In Vivo

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Impaired Balance of Mitochondrial Fission and Fusion in Alzheimer's Disease

Wang, X., Su, B., Lee, H.-G., Li, X., Perry, G., Smith, M. A., & Zhu, X. (2009) · Journal of Neuroscience · doi:10.1523/jneurosci.1357-09.2009 · Cited by 1,224 · see citing works

Mammalian Sir2 homolog SIRT3 regulates global mitochondrial lysine acetylation

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Circadian Control of the NAD ⁺ Salvage Pathway by CLOCK-SIRT1

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Cloning and characterization of a mammalian melatonin receptor that mediates reproductive and circadian responses

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The melatonin rhythm: both a clock and a calendar

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Sleep spindles: an overview

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Molecular characterization of a second melatonin receptor expressed in human retina and brain: the Mel1b melatonin receptor.

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Melatonin: Nature’s most versatile biological signal?

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Oxidative damage in the central nervous system: protection by melatonin

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Amyloid-β overproduction causes abnormal mitochondrial dynamics via differential modulation of mitochondrial fission/fusion proteins

Wang, X., Su, B., Siedlak, S. L., Moreira, P. I., Fujioka, H., Wang, Y., Casadesus, G., & Zhu, X. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0804871105 · Cited by 835 · see citing works

Functional MT1 and MT2 Melatonin Receptors in Mammals

Dubocovich, M. L., & Markowska, M. (2005) · Endocrine · doi:10.1385/endo:27:2:101 · Cited by 816 · see citing works

Effect of Bright Light and Melatonin on Cognitive and Noncognitive Function in Elderly Residents of Group Care Facilities: A Randomized Controlled Trial

Riemersma-van der Lek, R. F. (2008) · JAMA · doi:10.1001/jama.299.22.2642 · Cited by 803 · see citing works

Physiological effects of melatonin: Role of melatonin receptors and signal transduction pathways

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Oxidative chemistry of nitric oxide: the roles of superoxide, peroxynitrite, and carbon dioxide

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Common variant in MTNR1B associated with increased risk of type 2 diabetes and impaired early insulin secretion

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A Length Polymorphism in the Circadian Clock Gene Per3 is Linked to Delayed Sleep Phase Syndrome and Extreme Diurnal Preference

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Molecular Dissection of Two Distinct Actions of Melatonin on the Suprachiasmatic Circadian Clock

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Superoxide flashes in single mitochondria

Wang, W., Fang, H., Groom, L., Cheng, A., Zhang, W., Liu, J., Wang, X., Li, K., Han, P., Zheng, M., et al. (2008) · Cell · doi:10.1016/j.cell.2008.06.017 · Cited by 715 · see citing works

Melatonin Shifts Human Orcadian Rhythms According to a Phase-Response Curve

Lewy, A. J., Ahmed, S., Jackson, J. M. L., & Sack, R. L. (1992) · Chronobiology International · doi:10.3109/07420529209064550 · Cited by 693 · see citing works

Antioxidative Protection by Melatonin: Multiplicity of Mechanisms from Radical Detoxification to Radical Avoidance

Hardeland, R. (2005) · Endocrine · doi:10.1385/endo:27:2:119 · Cited by 670 · see citing works

A Review of the Multiple Actions of Melatonin on the Immune System

Carrillo‐Vico, A., Guerrero, J. M., Lardone, P. J., & Reiter, R. J. (2005) · Endocrine · doi:10.1385/endo:27:2:189 · Cited by 664 · see citing works

REVIEW: Gastrointestinal Melatonin: Localization, Function, and Clinical Relevance

Bubenik, G. A. (2002) · Digestive Diseases and Sciences · doi:10.1023/a:1020107915919 · Cited by 655 · see citing works

International Union of Basic and Clinical Pharmacology. LXXV. Nomenclature, Classification, and Pharmacology of G Protein-Coupled Melatonin Receptors

Dubocovich, M. L., Delagrange, P., Krause, D. N., Sugden, D., Cardinali, D. P., & Olcese, J. (2010) · Pharmacological Reviews · doi:10.1124/pr.110.002832 · Cited by 636 · see citing works

Melatonin: A Coordinating Signal for Mammalian Reproduction?

Tamarkin, L., Baird, C. J., & Almeida, O. F. X. (1985) · Science · doi:10.1126/science.3881822 · Cited by 630 · see citing works

Melatonin as a chronobiotic

Arendt, J., & Skene, D. J. (2005) · Sleep Medicine Reviews · doi:10.1016/j.smrv.2004.05.002 · Cited by 629 · see citing works

Melatonin as an antioxidant: biochemical mechanisms and pathophysiological implications in humans.

Reiter, R. J., Tan, D., Mayo, J. C., Sainz, R. M., León, J., & Czarnocki, Z. (2003) · Acta Biochimica Polonica · doi:10.18388/abp.2003_3637 · Cited by 623 · see citing works

A variant near MTNR1B is associated with increased fasting plasma glucose levels and type 2 diabetes risk

Bouatia-Naji, N., Bonnefond, A., Cavalcanti-Proença, C., Sparsø, T., Holmkvist, J., Marchand, M., Delplanque, J., Lobbens, S., Rocheleau, G., Durand, E., et al. (2009) · Nature Genetics · doi:10.1038/ng.277 · Cited by 611 · see citing works

Identification of the Melatonin-binding SiteMT 3 as the Quinone Reductase 2

Nosjean, O., Ferro, M., Cogé, F., Beauverger, P., Henlin, J., Lefoulon, F., Fauchère, J., Delagrange, P., Canet, E., & Boutin, J. A. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m005141200 · Cited by 604 · see citing works

Neurobiology of the Sleep-Wake Cycle: Sleep Architecture, Circadian Regulation, and Regulatory Feedback

Fuller, P. M., Gooley, J. J., & Saper, C. B. (2006) · Journal of Biological Rhythms · doi:10.1177/0748730406294627 · Cited by 596 · see citing works

Oxidative stress caused by mitochondrial calcium overload

Peng, T., & Jou, M. (2010) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2010.05634.x · Cited by 569 · see citing works

Free-Running Activity Rhythms in the Rat: Entrainment by Melatonin

Redman, J., Armstrong, S., & Ng, K. T. (1983) · Science · doi:10.1126/science.6823571 · Cited by 551 · see citing works

Melatonin: a hormone, a tissue factor, an autocoid, a paracoid, and an antioxidant vitamin

Tan, D., Manchester, L. C., Hardeland, R., López‐Burillo, S., Mayo, J. C., Sainz, R. M., & Reiter, R. J. (2002) · Journal of Pineal Research · doi:10.1034/j.1600-079x.2003.02111.x · Cited by 541 · see citing works

Association of structural polymorphisms in the human period3 gene with delayed sleep phase syndrome

Ebisawa, T., Uchiyama, M., Kajimura, N., Mishima, K., Kamei, Y., Katoh, M., Watanabe, T., Sekimoto, M., Shibui, K., Kim, K., et al. (2001) · EMBO Reports · doi:10.1093/embo-reports/kve070 · Cited by 517 · see citing works

Melatonin mitigates mitochondrial malfunction

León, J., Acuña-Castroviejo, D., Escames, G., Tan, D. X., & Reiter, R. J. (2004) · Journal of Pineal Research · doi:10.1111/j.1600-079x.2004.00181.x · Cited by 515 · see citing works

Mitochondria—A Nexus for Aging, Calorie Restriction, and Sirtuins?

Guarente, L. (2008) · Cell · doi:10.1016/j.cell.2008.01.007 · Cited by 513 · see citing works

A proposed mechanism to explain the stimulatory effect of melatonin on antioxidative enzymes

Tomás‐Zapico, C., & Coto‐Montes, A. M. (2005) · Journal of Pineal Research · doi:10.1111/j.1600-079x.2005.00248.x · Cited by 504 · see citing works

SCN Outputs and the Hypothalamic Balance of Life

Kalsbeek, A., Palm, I. F., la Fleur, S., Scheer, F., Perreau‐Lenz, S., Ruiter, M., Kreier, F., Cailotto, C., & Buijs, R. (2006) · Journal of Biological Rhythms · doi:10.1177/0748730406293854 · Cited by 492 · see citing works

Melatonin-Immune System Relationships

Guerrero, J. M., & Reiter, R. J. (2002) · Current Topics in Medicinal Chemistry · doi:10.2174/1568026023394335 · Cited by 476 · see citing works

Subcellular localization of Nox4 and regulation in diabetes

Block, K. L., Gorin, Y. C., & Abboud, H. E. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0906805106 · Cited by 476 · see citing works

Kynuramines, metabolites of melatonin and other indoles: the resurrection of an almost forgotten class of biogenic amines

Hardeland, R., Tan, D., & Reiter, R. J. (2009) · Journal of Pineal Research · doi:10.1111/j.1600-079x.2009.00701.x · Cited by 474 · see citing works

Melatonin and the ovary: physiological and pathophysiological implications

Tamura, H., Nakamura, Y., Korkmaz, A., Manchester, L. C., Tan, D., Sugino, N., & Reiter, R. J. (2008) · Fertility and Sterility · doi:10.1016/j.fertnstert.2008.05.016 · Cited by 469 · see citing works

Inflammatory Neurodegeneration Mediated by Nitric Oxide, Glutamate, and Mitochondria

Brown, G. C., & Bal‐Price, A. (2003) · Molecular Neurobiology · doi:10.1385/mn:27:3:325 · Cited by 461 · see citing works

Evidence of melatonin synthesis by human lymphocytes and its physiological significance: possible role as intracrine, autocrine, and/or paracrine substance

Carrillo‐Vico, A., Calvo, J. R., Abreu, P. M., Lardone, P. J., García‐Mauriño, S., Reiter, R. J., & Guerrero, J. M. (2004) · The FASEB Journal · doi:10.1096/fj.03-0694fje · Cited by 457 · see citing works

Mammalian melatonin receptors: molecular biology and signal transduction

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Molecular pharmacology regulation and function of mammalian melatonin receptors

Dubocovich, M. L. (2003) · Frontiers in bioscience · doi:10.2741/1089 · Cited by 453 · see citing works

Spectral Responses of the Human Circadian System Depend on the Irradiance and Duration of Exposure to Light

Gooley, J. J., Rajaratnam, S. M. W., Brainard, G. C., Kronauer, R. E., Czeisler, C. A., & Lockley, S. W. (2010) · Science Translational Medicine · doi:10.1126/scitranslmed.3000741 · Cited by 447 · see citing works

STRUCTURE OF MELATONIN1

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Pineal gland hormone melatonin binds and activates an orphan of the nuclear receptor superfamily.

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Circadian clocks: regulators of endocrine and metabolic rhythms

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The significance of the metabolism of the neurohormone melatonin: Antioxidative protection and formation of bioactive substances

Hardeland, R., Reiter, R. J., Pöeggeler, B., & Tan, D. X. (1993) · Neuroscience & Biobehavioral Reviews · doi:10.1016/s0149-7634(05)80016-8 · Cited by 424 · see citing works

Dim light melatonin onset (DLMO): A tool for the analysis of circadian phase in human sleep and chronobiological disorders

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Effect of Melatonin on the Reproductive Systems of Male and Female Syrian Hamsters: A Diurnal Rhythm in Sensitivity to Melatonin12

Tamarkin, L., Westrom, W. K., HAMILL, A. I., & Goldman, B. D. (1976) · Endocrinology · doi:10.1210/endo-99-6-1534 · Cited by 404 · see citing works

Hypothalamic melatonin receptor sites revealed by autoradiography

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Non‐vertebrate melatonin

Hardeland, R., & Pöeggeler, B. (2003) · Journal of Pineal Research · doi:10.1034/j.1600-079x.2003.00040.x · Cited by 400 · see citing works

Free Radical‐Mediated Molecular Damage

Reiter, R. J., Acuña-Castroviejo, D., Tan, D. X., & Burkhardt, S. (2001) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2001.tb03627.x · Cited by 398 · see citing works

Daily Melatonin Administration to Middle-Aged Male Rats Suppresses Body Weight, Intraabdominal Adiposity, and Plasma Leptin and Insulin Independent of Food Intake and Total Body Fat1

Wolden‐Hanson, T., Mitton, D. R., McCants, R. L., Yellon, S. M., Wilkinson, C. W., Matsumoto, A. M., & Rasmussen, D. D. (2000) · Endocrinology · doi:10.1210/endo.141.2.7311 · Cited by 390 · see citing works

Human Melatonin Suppression by Light is Intensity Dependent

Mclntyre, I. M., Norman, T. R., Burrows, G. D., & Armstrong, S. M. (1989) · Journal of Pineal Research · doi:10.1111/j.1600-079x.1989.tb00412.x · Cited by 389 · see citing works

Melatonin and Human Rhythms

Arendt, J. (2006) · Chronobiology International · doi:10.1080/07420520500464361 · Cited by 383 · see citing works

Evidence for melatonin synthesis in mouse and human bone marrow cells

Conti, A., Conconi, S., Hertens, E., Skwarło‐Sońta, K., Markowska, M., & Maestroni, G. J. M. (2000) · Journal of Pineal Research · doi:10.1034/j.1600-079x.2000.280401.x · Cited by 381 · see citing works

Melatonin as a Chronobiotic / Anticancer Agent: Cellular, Biochemical, and Molecular Mechanisms of Action and their Implications for Circadian-Based Cancer Therapy

Blask, D. E., Sauer, L. A., & Dauchy, R. T. (2002) · Current Topics in Medicinal Chemistry · doi:10.2174/1568026023394407 · Cited by 381 · see citing works

Melatonin enhances IL-2, IL-6, and IFN-gamma production by human circulating CD4+ cells: a possible nuclear receptor-mediated mechanism involving T helper type 1 lymphocytes and monocytes

García‐Mauriño, S., González-Haba, M. G., Calvo, J. R., Rafii-El-Idrissi, M., Sánchez‐Margalet, V., Goberna, R., & Guerrero, J. M. (1997) · The Journal of Immunology · doi:10.4049/jimmunol.159.2.574 · Cited by 380 · see citing works

Melatonin, cardiolipin and mitochondrial bioenergetics in health and disease

Paradies, G., Petrosillo, G., Paradies, V., Reiter, R. J., & Ruggiero, F. M. (2010) · Journal of Pineal Research · doi:10.1111/j.1600-079x.2010.00759.x · Cited by 378 · see citing works

Melatonin receptors in humans: biological role and clinical relevance

Ekmekçioğlu, C. (2006) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2006.01.002 · Cited by 371 · see citing works

The changing biological roles of melatonin during evolution: from an antioxidant to signals of darkness, sexual selection and fitness

Tan, D. X., Hardeland, R., Manchester, L. C., Paredes, S. D., Korkmaz, A., Sainz, R. M., Mayo, J. C., Fuentes‐Broto, L., & Reiter, R. J. (2009) · Biological reviews/Biological reviews of the Cambridge Philosophical Society · doi:10.1111/j.1469-185x.2009.00118.x · Cited by 365 · see citing works

Mitochondrial biogenesis and healthy aging

López-Lluch, G., Irusta, P. M., Navas, P., & de Cabo, R. (2008) · Experimental Gerontology · doi:10.1016/j.exger.2008.06.014 · Cited by 364 · see citing works

Melatonin receptors: role on sleep and circadian rhythm regulation

Dubocovich, M. L. (2007) · Sleep Medicine · doi:10.1016/j.sleep.2007.10.007 · Cited by 364 · see citing works

Circadian Rhythms, Oxidative Stress, and Antioxidative Defense Mechanisms

Hardeland, R., Coto‐Montes, A. M., & Pöeggeler, B. (2003) · Chronobiology International · doi:10.1081/cbi-120025245 · Cited by 358 · see citing works

Differential Association of Circadian Genes with Mood Disorders: CRY1 and NPAS2 are Associated with Unipolar Major Depression and CLOCK and VIP with Bipolar Disorder

Soria, V., Martínez‐Amorós, È., Escaramís, G., Valero, J., Pérez‐Egea, R., García, C. B., Gutiérrez‐Zotes, A., Puigdemont, D., Bayés, M., Crespo, J. M., et al. (2010) · Neuropsychopharmacology · doi:10.1038/npp.2009.230 · Cited by 352 · see citing works

Phytomelatonin: a review

Paredes, S. D., Korkmaz, A., Manchester, L. C., Tan, D., & Reiter, R. J. (2008) · Journal of Experimental Botany · doi:10.1093/jxb/ern284 · Cited by 349 · see citing works

Redox signaling (cross-talk) from and to mitochondria involves mitochondrial pores and reactive oxygen species

Daiber, A. (2010) · Biochimica et Biophysica Acta (BBA) - Bioenergetics · doi:10.1016/j.bbabio.2010.01.032 · Cited by 347 · see citing works

Light-at-night, circadian disruption and breast cancer: assessment of existing evidence

Stevens, R. G. (2009) · International Journal of Epidemiology · doi:10.1093/ije/dyp178 · Cited by 345 · see citing works

Significance and application of melatonin in the regulation of brown adipose tissue metabolism: relation to human obesity

Tan, D. ‐., Manchester, L. C., Fuentes‐Broto, L., Paredes, S. D., & Reiter, R. J. (2010) · Obesity Reviews · doi:10.1111/j.1467-789x.2010.00756.x · Cited by 343 · see citing works

Melatonin signaling and cell protection function

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Minireview: Entrainment of the Suprachiasmatic Clockwork in Diurnal and Nocturnal Mammals

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Circadian clock-related polymorphisms in seasonal affective disorder and their relevance to diurnal preference

Johansson, C., Willeit, M., Smedh, C., Ekholm, J., Paunio, T., Kieseppä, T., Lichtermann, D., Praschak-Rieder, N., Neumeister, A., Nilsson, L.-G., et al. (2003) · Neuropsychopharmacology · doi:10.1038/sj.npp.1300121 · Cited by 341 · see citing works

Night Shift Work and the Risk of Endometrial Cancer

Viswanathan, A. N., Hankinson, S. E., & Schernhammer, E. S. (2007) · Cancer Research · doi:10.1158/0008-5472.can-07-2485 · Cited by 338 · see citing works

Cardiovascular diseases: protective effects of melatonin

Tengattini, S., Reiter, R. J., Tan, D., Terrón, M. P., Rodella, L. F., & Rezzani, R. (2007) · Journal of Pineal Research · doi:10.1111/j.1600-079x.2007.00518.x · Cited by 337 · see citing works

The orphan GPR50 receptor specifically inhibits MT1 melatonin receptor function through heterodimerization

Levoye, A., Dam, J., Ayoub, M. A., Guillaume, J., Couturier, C., Delagrange, P., & Jockers, R. (2006) · The EMBO Journal · doi:10.1038/sj.emboj.7601193 · Cited by 335 · see citing works

Melatonin increases survival and inhibits oxidative and amyloid pathology in a transgenic model of Alzheimer's disease

Matsubara, E., Bryant‐Thomas, T., Pacheco Quinto, J., Henry, T. L., Poeggeler, B., Herbert, D., Cruz‐Sanchez, F., Chyan, Y., Smith, M. A., Perry, G., et al. (2003) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2003.01654.x · Cited by 332 · see citing works

Anti-inflammatory actions of melatonin and its metabolites, N1-acetyl-N2-formyl-5-methoxykynuramine (AFMK) and N1-acetyl-5-methoxykynuramine (AMK), in macrophages

Mayo, J. C., Sainz, R. M., Tan, D., Hardeland, R., León, J., Rodrı́guez, C., & Reiter, R. J. (2005) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2005.05.002 · Cited by 332 · see citing works

Monitoring of Ligand-independent Dimerization and Ligand-induced Conformational Changes of Melatonin Receptors in Living Cells by Bioluminescence Resonance Energy Transfer

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Sleep disorders and melatonin rhythms in elderly people

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Antioxidative Effects of Melatonin in Protection Against Cellular Damage Caused by Ionizing Radiation

Karbownik‐Lewińska, M., & Reiter, R. J. (2000) · Proceedings of The Society for Experimental Biology and Medicine · doi:10.1111/j.1525-1373.2000.22502.x · Cited by 313 · see citing works

Direct inhibition of the mitochondrial permeability transition pore: a possible mechanism responsible for anti‐apoptotic effects of melatonin

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Retinoid X receptors: common heterodimerization partners with distinct functions

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Melatonin, endocrine pancreas and diabetes

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Shift work: coping with the biological clock.

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The contribution of extrapineal sites of melatonin synthesis to circulating melatonin levels in higher vertebrates

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Melatonin and cell death: differential actions on apoptosis in normal and cancer cells

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Decreased Melatonin Levels in Postmortem Cerebrospinal Fluid in Relation to Aging, Alzheimer’s Disease, and Apolipoprotein E-ε4/4 Genotype¹

Liu, R.-Y., Zhou, J.-N., van Heerikhuize, J., Hofman, M. A., & Swaab, D. F. (1999) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.84.1.5394 · Cited by 304 · see citing works

Clinical Uses of Melatonin: Evaluation of Human Trials

Sanchez-Barcelo, E. J., Mediavilla, M. D., Tan, D. X., & Reiter, R. J. (2010) · Current Medicinal Chemistry · doi:10.2174/092986710791233689 · Cited by 301 · cited 1× · see citing works

The site of production of superoxide radical in mitochondrial Complex I is not a bound ubisemiquinone but presumably iron–sulfur cluster N2

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Association study of eight circadian genes with bipolar I disorder, schizoaffective disorder and schizophrenia

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Melatonin receptors, heterodimerization, signal transduction and binding sites: what's new?

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Distinct Contributions of Rod, Cone, and Melanopsin Photoreceptors to Encoding Irradiance

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Abnormal mitochondrial dynamics and neurodegenerative diseases

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Inhibition of NADPH Oxidase is Neuroprotective after Ischemia—Reperfusion

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Disrupting Circadian Homeostasis of Sympathetic Signaling Promotes Tumor Development in Mice

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Serotoninergic and melatoninergic systems are fully expressed in human skin

Slominski, A. T., Pisarchik, A. V., Semak, I. V., Sweatman, T. W., Wortsman, J., Szczesniewski, A., Slugocki, G., McNulty, J. A., Kauser, S., Tobin, D. J., et al. (2002) · The FASEB Journal · doi:10.1096/fj.01-0952fje · Cited by 285 · see citing works

Reduced oxidative damage in ALS by high‐dose enteral melatonin treatment

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Melatonin Reduces Body Weight Gain in Sprague Dawley Rats with Diet-Induced Obesity

Prunet‐Marcassus, B., Desbazeille, M., Bros, A., Louche, K., Delagrange, P., Renard, P., Casteilla, L., & Pénicaud, L. (2003) · Endocrinology · doi:10.1210/en.2003-0693 · Cited by 281 · see citing works

Dual Signaling of Human Mel1a Melatonin Receptors via Gi2, Gi3, and Gq/11 Proteins

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SIRT3 interacts with the daf-16 homolog FOXO3a in the Mitochondria, as well as increases FOXO3a Dependent Gene expression

Jacobs, K. M., Pennington, J. D., Bisht, K. S., Aykin‐Burns, N., Kim, H., Mishra, M. V., Sun, L., Nguyen, P., Ahn, B., Leclerc, J., et al. (2008) · International Journal of Biological Sciences · doi:10.7150/ijbs.4.291 · Cited by 281 · see citing works

Melatonin inhibits expression of the inducible NO synthase II in liver and lung and prevents endotoxemia in lipopolysaccharide‐induced multiple organ dysfunction syndrome in rats

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Disturbance and strategies for reactivation of the circadian rhythm system in aging and Alzheimer’s disease

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Melatonin protects the mitochondria from oxidative damage reducing oxygen consumption, membrane potential, and superoxide anion production

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Nox2-Derived Reactive Oxygen Species Mediate Neurovascular Dysregulation in the Aging Mouse Brain

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Peroxynitrite: an endogenous oxidizing and nitrating agent

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Melatonin rhythmicity: effect of age and Alzheimer's disease

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Melatonin secretion rhythm disorders in patients with senile dementia of Alzheimer’s type with disturbed sleep–waking

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On the primary functions of melatonin in evolution: Mediation of photoperiodic signals in a unicell, photooxidation, and scavenging of free radicals*

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Properties, Entrainment, and Physiological Functions of Mammalian Peripheral Oscillators

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Effect of tryptophan administration on circulating melatonin levels in chicks and rats: Evidence for stimulation of melatonin synthesis and release in the gastrointestinal tract

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Melatonin suppresses macrophage cyclooxygenase-2 and inducible nitric oxide synthase expression by inhibiting p52 acetylation and binding

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Activation of MT2melatonin receptors in rat suprachiasmatic nucleus phase advances the circadian clock

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Visualization of the antioxidative effects of melatonin at the mitochondrial level during oxidative stress‐induced apoptosis of rat brain astrocytes

Jou, M., Peng, T., Reiter, R. J., Jou, S., WU, H., & Wen, S. (2004) · Journal of Pineal Research · doi:10.1111/j.1600-079x.2004.00140.x · Cited by 265 · see citing works

The Nuclear Receptor for Melatonin Represses 5-Lipoxygenase Gene Expression in Human B Lymphocytes

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Melatonin Action and Signal Transduction in the Rat Suprachiasmatic Circadian Clock: Activation of Protein Kinase C at Dusk and Dawn

McArthur, A. J., Hunt, A. E., & Gillette, M. U. (1997) · Endocrinology · doi:10.1210/endo.138.2.4925 · Cited by 263 · see citing works

Melatonin increases the activity of the oxidative phosphorylation enzymes and the production of ATP in rat brain and liver mitochondria

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Protection against cognitive deficits and markers of neurodegeneration by long‐term oral administration of melatonin in a transgenic model of Alzheimer disease

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Melatonin protects against common deletion of mitochondrial DNA‐augmented mitochondrial oxidative stress and apoptosis

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Daily Melatonin Administration at Middle Age Suppresses Male Rate Visceral Fat, Plasma Leptin, and Plasma Insulin to Youthful Levels

Rasmussen, D. D., Boldt, B. M., Wilkinson, C. W., Yellon, S. M., & Matsumoto, A. M. (1999) · Endocrinology · doi:10.1210/endo.140.2.6674 · Cited by 250 · see citing works

Transcriptional activation of the nuclear receptor RZRα by the pineal gland hormone melatonin and identification of CGP 52608 as a synthetic ligand

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PERIOD3, circadian phenotypes, and sleep homeostasis

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Circadian rhythm abnormalities of melatonin in Smith-Magenis syndrome

Potocki, L., Glaze, D., Tan, D.-X., Park, S.-S., Kashork, C. D., Shaffer, L. G., Reiter, R. J., & Lupski, J. R. (2000) · Journal of Medical Genetics · doi:10.1136/jmg.37.6.428 · Cited by 244 · see citing works

Both physiological and pharmacological levels of melatonin reduce DNA adduct formation induced by the carcinogen safrole

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Direct Action of Melatonin in Human Granulosa-Luteal Cells

Woo, M. M. M., Tai, C.-J., Kang, S. K., Nathwani, P. S., Pang, S. F., & Leung, P. C. K. (2001) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.86.10.4789 · Cited by 240 · see citing works

Targeted Disruption of the Mouse Mel1b Melatonin Receptor

Jin, X., von Gall, C., Pieschl, R. L., Gribkoff, V. K., Stehle, J. H., Reppert, S. M., & Weaver, D. R. (2003) · Molecular and Cellular Biology · doi:10.1128/mcb.23.3.1054-1060.2003 · Cited by 240 · see citing works

An assessment of the antioxidant and the antiamyloidogenic properties of melatonin: implications for Alzheimer's disease

Pappolla, M. A., Chyan, Y., Pöeggeler, B., Frangione, B., Wilson, G. L., Ghiso, J. A., & Reiter, R. J. (2000) · Journal of Neural Transmission · doi:10.1007/s007020050018 · Cited by 239 · see citing works

Antioxidant properties of the melatonin metabolite N1-acetyl-5-methoxykynuramine (AMK): scavenging of free radicals and prevention of protein destruction

Ressmeyer, A., Mayo, J. C., Zelosko, V., Sainz, R. M., Tan, D., Pöeggeler, B., Antolı́n, I., Zsizsik, B. K., Reiter, R. J., & Hardeland, R. (2003) · Redox Report · doi:10.1179/135100003225002709 · Cited by 238 · see citing works

Antioxidative Effects of Melatonin in Protection Against Cellular Damage Caused by Ionizing Radiation

Karbownik‐Lewińska, M., & Reiter, R. J. (2000) · Proceedings of The Society for Experimental Biology and Medicine · doi:10.1046/j.1525-1373.2000.22502.x · Cited by 238 · see citing works

Sirtuins, melatonin and circadian rhythms: building a bridge between aging and cancer

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High physiological levels of melatonin in the bile of mammals

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The Mitochondrial Production of Reactive Oxygen Species in Relation to Aging and Pathology

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Suppression of Nocturnal Plasma Melatonin and 6-Sulphatoxymelatonin by Bright and Dim Light in Man

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Nature's knockout: the Mel1b receptor is not necessary for reproductive and circadian responses to melatonin in Siberian hamsters

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Role of melatonin in neurodegenerative diseases

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The Antiapoptotic Activity of Melatonin in Neurodegenerative Diseases

Wang, X. (2009) · CNS Neuroscience & Therapeutics · doi:10.1111/j.1755-5949.2009.00105.x · Cited by 232 · see citing works

Melatonin mediates two distinct responses in vascular smooth muscle

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Melatonin: Signaling mechanisms of a pleiotropic agent

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A relationship between heat loss and sleepiness: effects of postural change and melatonin administration

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Melatonin in Alzheimer's disease and other neurodegenerative disorders

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Neurotoxic Activation of Microglia Is Promoted by a Nox1-Dependent NADPH Oxidase

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Daily variation in the concentration of melatonin and 5-methoxytryptophol in the human pineal gland: effect of age and Alzheimer's disease

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Melatonin as a cytoskeletal modulator: implications for cell physiology and disease

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Calmodulin mediates melatonin cytoskeletal effects

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Activation of human monocytes by the pineal hormone melatonin.

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The modulatory role of melatonin on immune responsiveness.

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Specific Binding of Melatonin in Bovine Brain*

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Comparing and Contrasting the Roles of AMPK and SIRT1 in Metabolic Tissues

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Reactive oxygen and nitrogen species and cellular and organismal decline: amelioration with melatonin

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Disruption of retinoid‐related orphan receptor β changes circadian behavior, causes retinal degeneration and leads to vacillans phenotype in mice

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Cardiolipin Switch in Mitochondria:  Shutting off the Reduction of Cytochrome <i>c</i> and Turning on the Peroxidase Activity

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Association of the Length Polymorphism in the Human Per3 Gene with the Delayed Sleep-Phase Syndrome: Does Latitude Have an Influence Upon It?

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Binding of 3H-melatonin to calmodulin

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Melatonin Effects on Behavior: Possible Mediation by the Central GABAergic System

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Decreased MT1 melatonin receptor expression in the suprachiasmatic nucleus in aging and Alzheimer's disease

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Involvement of NOX2 in the Development of Behavioral and Pathologic Alterations in Isolated Rats

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Reduced hippocampal MT2 melatonin receptor expression in Alzheimer's disease

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Melatonin Enters the Cerebrospinal Fluid through the Pineal Recess

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Beneficial pleiotropic actions of melatonin in an experimental model of septic shock in mice: regulation of pro‐/anti‐inflammatory cytokine network, protection against oxidative damage and anti‐apoptotic effects

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Increased brain damage after stroke or excitotoxic seizures in melatonin‐deficient rats

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Clinical Aspects of Melatonin Intervention in Alzheimers Disease Progression

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The role of the thalamus in sleep, pineal melatonin production, and circadian rhythm sleep disorders

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Mitochondrial Complex I: Structural and functional aspects

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Diabetic Goto Kakizaki rats as well as type 2 diabetic patients show a decreased diurnal serum melatonin level and an increased pancreatic melatonin‐receptor status

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Melatonin's unique radical scavenging properties – roles of its functional substituents as revealed by a comparison with its structural analogs

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Visual impairment and circadiam rhythm disorders

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Persistent S-Nitrosation of Complex I and Other Mitochondrial Membrane Proteins by S-Nitrosothiols but Not Nitric Oxide or Peroxynitrite

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Vasopressin and the Output of the Hypothalamic Biological Clock

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Melatonin counteracts lipopolysaccharide‐induced expression and activity of mitochondrial nitric oxide synthase in rats

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Selective early cardiolipin peroxidation after traumatic brain injury: an oxidative lipidomics analysis

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Functional Expression of MT2 (Mel1b) Melatonin Receptors in Human PAZ6 Adipocytes

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The Mel1aMelatonin Receptor Is Coupled to Parallel Signal Transduction Pathways1

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Function and expression of melatonin receptors on human pancreatic islets

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Melatonin Signaling Dysfunction in Adolescent Idiopathic Scoliosis

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Comparative pharmacological studies of melatonin receptors: mt1, mt2 and mt3/qr2. tissue distribution of mt3/qr2 11Abbreviations: MCA-NAT, methoxy-carbonylamino-N-acetyltrypta- mine, 2-[125I]-I-MCA-NAT, 2-[125I]-iodomethoxy-carbonylamino-N-acetyltryptamine; 2-IbMT, 2-iodo-N-butanoyl-5-methoxytryptamine; 4-P-PDOT, 4-phenyl-2-propionamido-tetraline; DH97, N-pentanoyl-2-benzyltryptamine; S20760, 5-methoxy-N-cyclopropanoyl-tryptamine; S24635, N-[2-(5-carbamoylbenzofuran-3-yl)ethyl]-acetamide; S25726, N-methyl-(3-{2-[(cyclopropylcarbonyl)-amino]ethyl}benzo[b]furan-5-yl)carbamate; S26553, N-methyl-{1-[2-(acetylamino)ethyl]-naphthalen-7-yl}carbamate.

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Strong nuclear factor-?B-DNA binding parallels cyclooxygenase-2 gene transcription in aging and in sporadic alzheimer's disease superior temporal lobe neocortex

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Melatonin: A Clock‐Output, A Clock‐Input

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mt1 Melatonin Receptor in the Primate Adrenal Gland: Inhibition of Adrenocorticotropin-Stimulated Cortisol Production by Melatonin

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Interactions of melatonin and its metabolites with the ABTS cation radical: extension of the radical scavenger cascade and formation of a novel class of oxidation products, C2‐substituted 3‐indolinones

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Melatonin: A hormone that modulates pain

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A three pulse phase response curve to three milligrams of melatonin in humans

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The melatonin receptor in the human brain: cloning experiments and distribution studies

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Melatonin: Buffering the Immune System

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Sleep deficiency and chronic pain: potential underlying mechanisms and clinical implications

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Functional roles of melatonin in plants, and perspectives in nutritional and agricultural science

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Endogenous non-enzymatic antioxidants in the human body

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Mitochondria and chloroplasts as the original sites of melatonin synthesis: a hypothesis related to melatonin's primary function and evolution in eukaryotes

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The mitigation effects of exogenous melatonin on salinity‐induced stress in Malus hupehensis

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Long‐term exogenous application of melatonin delays drought‐induced leaf senescence in apple

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Sensing the Environment: Regulation of Local and Global Homeostasis by the Skin's Neuroendocrine System

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Metabolomics activity screening for identifying metabolites that modulate phenotype

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Untitled work

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Melatonin and inflammation-Story of a double-edged blade

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Melatonin, the circadian multioscillator system and health: the need for detailed analyses of peripheral melatonin signaling

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Exogenous Melatonin Confers Salt Stress Tolerance to Watermelon by Improving Photosynthesis and Redox Homeostasis

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Melatonin: Current Status and Future Perspectives in Plant Science

Nawaz, M. A., Huang, Y., Bie, Z., Ahmed, W., Reiter, R. J., Niu, M., & Hameed, S. (2016) · Frontiers in Plant Science · doi:10.3389/fpls.2015.01230 · Cited by 355 · see citing works

Melatonin and its analogs in insomnia and depression

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Apoptosis signaling pathways in osteoarthritis and possible protective role of melatonin

Hosseinzadeh, A., Kamrava, S. K., Joghataei, M. T., Darabi, R., Shakeri‐Zadeh, A., Shahriari, M., Reiter, R. J., Ghaznavi, H., & Mehrzadi, S. (2016) · Journal of Pineal Research · doi:10.1111/jpi.12362 · Cited by 345 · see citing works

The Mulberry (Morus alba L.) Fruit—A Review of Characteristic Components and Health Benefits

Yuan, Q., & Zhao, L. (2017) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.7b03614 · Cited by 340 · see citing works

Aging, melatonin, and the pro- and anti-inflammatory networks

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Phytomelatonin: Assisting Plants to Survive and Thrive

Reiter, R. J., Tan, D., Zhou, Z., Cruz, M., Fuentes‐Broto, L., & Galano, A. (2015) · Molecules · doi:10.3390/molecules20047396 · Cited by 335 · see citing works

Melatonin pretreatment improves vanadium stress tolerance of watermelon seedlings by reducing vanadium concentration in the leaves and regulating melatonin biosynthesis and antioxidant-related gene expression

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Melatonin Antioxidative Defense: Therapeutical Implications for Aging and Neurodegenerative Processes

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Exogenous melatonin improves growth and photosynthetic capacity of cucumber under salinity-induced stress

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Exogenous melatonin improves M alus resistance to M arssonina apple blotch

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Alzheimer’s disease: pathological mechanisms and the beneficial role of melatonin

Rosales‐Corral, S., Acuña-Castroviejo, D., Coto‐Montes, A. M., Boga, J. A., Manchester, L. C., Fuentes‐Broto, L., Korkmaz, A., Ma, S., Tan, D. X., & Reiter, R. J. (2011) · Journal of Pineal Research · doi:10.1111/j.1600-079x.2011.00937.x · Cited by 293 · see citing works

Melatonin: A Cutaneous Perspective on its Production, Metabolism, and Functions

Slominski, A. T., Hardeland, R., Zmijewski, M. A., Slominski, R. M., Reiter, R. J., & Paus, R. (2018) · Journal of Investigative Dermatology · doi:10.1016/j.jid.2017.10.025 · Cited by 293 · see citing works

Cancer metastasis: Mechanisms of inhibition by melatonin

Su, S., Hsieh, M., Yang, W., Chung, W., Reiter, R. J., & Yang, S. (2016) · Journal of Pineal Research · doi:10.1111/jpi.12370 · Cited by 285 · see citing works

Potential Role for the Gut Microbiota in Modulating Host Circadian Rhythms and Metabolic Health

Parkar, S. G., Kalsbeek, A., & Cheeseman, J. F. (2019) · Microorganisms · doi:10.3390/microorganisms7020041 · Cited by 285 · see citing works

Melatonin and the theories of aging: a critical appraisal of melatonin's role in antiaging mechanisms

Hardeland, R. (2013) · Journal of Pineal Research · doi:10.1111/jpi.12090 · Cited by 285 · see citing works

Mode of action of agomelatine: Synergy between melatonergic and 5-HT2Creceptors

Racagni, G., Riva, M. A., Molteni, R., Musazzi, L., Calabrese, F., Popoli, M., & Tardito, D. (2011) · The World Journal of Biological Psychiatry · doi:10.3109/15622975.2011.595823 · Cited by 282 · see citing works

On the significance of an alternate pathway of melatonin synthesis via 5‐methoxytryptamine: comparisons across species

Tan, D. X., Hardeland, R., Back, K., Manchester, L. C., Alatorre-Jiménez, M. A., & Reiter, R. J. (2016) · Journal of Pineal Research · doi:10.1111/jpi.12336 · Cited by 282 · see citing works

The regulatory effect of melatonin on physiological, biochemical and molecular parameters in cold-stressed wheat seedlings

Türk, H., Erdal, S., Geni̇şel, M., Atıcı, Ö., Demir, Y., & Yanmış, D. (2014) · Plant Growth Regulation · doi:10.1007/s10725-014-9905-0 · Cited by 270 · see citing works

Melatonin in Plants – Diversity of Levels and Multiplicity of Functions

Hardeland, R. (2016) · Frontiers in Plant Science · doi:10.3389/fpls.2016.00198 · Cited by 256 · see citing works

Melatonin mediates selenium‐induced tolerance to cadmium stress in tomato plants

Li, M., Hasan, M. K., Li, C., Ahammed, G. J., Xia, X., Shi, K., Zhou, Y., Reiter, R. J., Yu, J., Xu, M., et al. (2016) · Journal of Pineal Research · doi:10.1111/jpi.12346 · Cited by 254 · see citing works

Melatonin Mediates Enhancement of Stress Tolerance in Plants

Debnath, B., Islam, W., Li, M., Sun, Y., Lu, X., Mitra, S., Hussain, M., Liu, S., & Qiu, D. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20051040 · Cited by 250 · see citing works

The Keap1-Nrf2-antioxidant response element pathway: a review of its regulation by melatonin and the proteasome

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Chronopharmacology: New Insights and Therapeutic Implications

Dallmann, R., Brown, S. A., & Gachon, F. (2013) · The Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev-pharmtox-011613-135923 · Cited by 244 · see citing works

Exogenous Melatonin Counteracts NaCl-Induced Damage by Regulating the Antioxidant System, Proline and Carbohydrates Metabolism in Tomato Seedlings

Siddiqui, M. H., Alamri, S. A., Al-Khaishany, M. Y., Khan, M. N., Al-Amri, A., Ali, H. M., Alaraidh, I. A., & Alsahli, A. A. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20020353 · Cited by 244 · see citing works

Melatonin as an anti-inflammatory agent modulating inflammasome activation

Favero, G., Franceschetti, L., Bonomini, F., Rodella, L. F., & Rezzani, R. (2017) · International Journal of Endocrinology · doi:10.1155/2017/1835195 · Cited by 233 · see citing works

Protecting the Melatonin Rhythm through Circadian Healthy Light Exposure

Bonmatí‐Carrión, M., Argüelles-Prieto, R., Martínez-Madrid, M. J., Reiter, R. J., Hardeland, R., Rol, M. A., & Madrid, J. A. (2014) · International Journal of Molecular Sciences · doi:10.3390/ijms151223448 · Cited by 238 · see citing works

Effects of melatonin on seedling growth, mineral nutrition, and nitrogen metabolism in cucumber under nitrate stress

Zhang, R., Sun, Y., Liu, Z., Jin, W., & Sun, Y. (2017) · Journal of Pineal Research · doi:10.1111/jpi.12403 · Cited by 209 · see citing works

Peripheral Reproductive Organ Health and Melatonin: Ready for Prime Time

Reiter, R. J., Rosales‐Corral, S., Manchester, L. C., & Tan, D. (2013) · International Journal of Molecular Sciences · doi:10.3390/ijms14047231 · Cited by 204 · see citing works

Melatonin in aging and disease -multiple consequences of reduced secretion, options and limits of treatment.

Hardeland, R. (2012) · Europe PMC (PubMed Central) · Cited by 202 · see citing works

Melatonin: Clinical Perspectives in Neurodegeneration

Cardinali, D. P. (2019) · Frontiers in Endocrinology · doi:10.3389/fendo.2019.00480 · Cited by 202 · see citing works

Mechanisms of Melatonin in Alleviating Alzheimer’s Disease

Shukla, M., Govitrapong, P., Boontem, P., Reiter, R., & Satayavivad, J. (2017) · Current Neuropharmacology · doi:10.2174/1570159x15666170313123454 · Cited by 173 · see citing works

Molecular mechanisms of the pro-apoptotic actions of melatonin in cancer: a review

Bizzarri, M., Proietti, S., Cucina, A., & Reiter, R. J. (2013) · Expert Opinion on Therapeutic Targets · doi:10.1517/14728222.2013.834890 · Cited by 189 · see citing works

Fundamental issues related to the origin of melatonin and melatonin isomers during evolution: relation to their biological functions.

Tan, D.-X., Zheng, X., Kong, J., Manchester, L., Hardeland, R., Kim, S., Xu, X., & Reiter, R. (2014) · International Journal of Molecular Sciences · doi:10.3390/ijms150915858 · Cited by 188 · see citing works

Melatonin attenuates choroidal neovascularization by regulating macrophage/microglia polarization via inhibition of RhoA/ROCK signaling pathway

Xu, Y., Cui, K., Li, J., Tang, X., Lin, J., Lü, X., Huang, R., Yang, B., Shi, Y., Ye, D., et al. (2020) · Journal of Pineal Research · doi:10.1111/jpi.12660 · Cited by 186 · see citing works

Melatonin and Phytomelatonin: Chemistry, Biosynthesis, Metabolism, Distribution and Bioactivity in Plants and Animals—An Overview

Mannino, G., Pernici, C., Serio, G., Gentile, C., & Bertea, C. M. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22189996 · Cited by 189 · see citing works

Melatonin and brain inflammaging

Hardeland, R., Cardinali, D. P., Brown, G. M., & Pandi-Perumal, S. R. (2015) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2015.02.001 · Cited by 186 · see citing works

Melatonin in macrophage biology: Current understanding and future perspectives

Xia, Y., Chen, S., Zeng, S., Zhao, Y., Zhu, C., Deng, B., Zhu, G., Yin, Y., Wang, W., Hardeland, R., et al. (2018) · Journal of Pineal Research · doi:10.1111/jpi.12547 · Cited by 188 · see citing works

CCNP Award Paper: Unveiling the role of melatonin MT 2 receptors in sleep, anxiety and other neuropsychiatric diseases: a novel target in psychopharmacology

Comai, S., & Gobbi, G. (2014) · Journal of Psychiatry and Neuroscience · doi:10.1503/jpn.130009 · Cited by 180 · see citing works

Melatonin in Medicinal and Food Plants: Occurrence, Bioavailability, and Health Potential for Humans

Salehi, B., Sharopov, F. S., Fokou, P. V. T., Kobylińska, A., de Jonge, L., Tadio, K., Sharifi‐Rad, J., Posmyk, M. M., Martorell, M., Martins, N. A., et al. (2019) · Cells · doi:10.3390/cells8070681 · Cited by 189 · see citing works

Neurobiology, Pathophysiology, and Treatment of Melatonin Deficiency and Dysfunction

Hardeland, R. (2012) · The Scientific World Journal · doi:10.1100/2012/640389 · Cited by 173 · see citing works

From combinations to multitarget-directed ligands: A continuum in Alzheimer’s disease polypharmacology

Albertini, C., Salerno, A., de Sena Murteira Pinheiro, P., & Bolognesi, M. L. (2021) · Medicinal Research Reviews · doi:10.1002/med.21699 · Cited by 179 · see citing works

Melatonin Improved Waterlogging Tolerance in Alfalfa (Medicago sativa) by Reprogramming Polyamine and Ethylene Metabolism

Zhang, Q., Liu, X., Zhang, Z., Liu, N., Li, D., & Hu, L. (2019) · Frontiers in Plant Science · doi:10.3389/fpls.2019.00044 · Cited by 170 · see citing works

Night Shift Work and Risk of Breast Cancer

Hansen, J. (2017) · Current Environmental Health Reports · doi:10.1007/s40572-017-0155-y · Cited by 171 · see citing works

Exogenous melatonin accelerates seed germination in cotton (Gossypium hirsutum L.)

Xiao, S., Liu, L., Wang, H., Li, D., Bai, Z., Zhang, Y., Sun, H., Zhang, K., & Li, C. (2019) · PLoS ONE · doi:10.1371/journal.pone.0216575 · Cited by 167 · see citing works

Caloric restriction, resveratrol and melatonin: Role of SIRT1 and implications for aging and related-diseases

Ramis, M. R., Esteban, S., Miralles, A., Tan, D., & Reiter, R. J. (2015) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2015.03.008 · Cited by 164 · see citing works

Shift Work, Chronotype, and Melatonin Rhythm in Nurses

Razavi, P., Devore, E. E., Bajaj, A., Lockley, S. W., Figueiro, M. G., Ricchiuti, V., Gauderman, W. J., Hankinson, S. E., Willett, W. C., & Schernhammer, E. S. (2019) · Cancer Epidemiology Biomarkers & Prevention · doi:10.1158/1055-9965.epi-18-1018 · Cited by 168 · see citing works

Melatonin and its metabolites protect human melanocytes against UVB-induced damage: Involvement of NRF2-mediated pathways

Janjetovic, Z., Jarrett, S. G., Lee, E. F., Duprey, C., Reiter, R. J., & Slominski, A. T. (2017) · Scientific Reports · doi:10.1038/s41598-017-01305-2 · Cited by 163 · see citing works

Metabolism of melatonin and biological activity of intermediates of melatoninergic pathway in human skin cells

Kim, T., Kleszczyński, K., Janjetović, Z., Sweatman, T. W., Lin, Z., Li, W., Reiter, R. J., Fischer, T. W., & Slominski, A. T. (2013) · The FASEB Journal · doi:10.1096/fj.12-224691 · Cited by 162 · see citing works

Peripheral and Central Effects of Melatonin on Blood Pressure Regulation

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Benzofuran and Indole: Promising Scaffolds for Drug Development in Alzheimer's Disease

Goyal, D., Kaur, A., & Goyal, B. (2018) · ChemMedChem · doi:10.1002/cmdc.201800156 · Cited by 157 · see citing works

Sleep and circadian rhythm dysregulation in schizophrenia

Monti, J. M., BaHammam, A. S., Pandi-Perumal, S. R., Bromundt, V., Spence, D. W., Cardinali, D. P., & Brown, G. M. (2013) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2012.12.021 · Cited by 157 · see citing works

Melatonin: A review of its potential functions and effects on neurological diseases

Günata, M., Parlakpınar, H., & Acet, A. (2019) · Revue Neurologique · doi:10.1016/j.neurol.2019.07.025 · Cited by 154 · see citing works

Local melatonin application induces cold tolerance in distant organs of Citrullus lanatus L. via long distance transport

Li, H., Chang, J., Zheng, J., Dong, Y., Liu, Q., Yang, X., Wei, C., Zhang, Y., Ma, J., & Zhang, X. (2017) · Scientific Reports · doi:10.1038/srep40858 · Cited by 152 · see citing works

Manipulating the sleep-wake cycle and circadian rhythms to improve clinical management of major depression

Hickie, I. B., Naismith, S. L., Robillard, R., Scott, E. M., & Hermens, D. F. (2013) · BMC Medicine · doi:10.1186/1741-7015-11-79 · Cited by 148 · see citing works

The times they’re a-changing: Effects of circadian desynchronization on physiology and disease

Golombek, D. A., Casiraghi, L. P., Agostino, P. V., Paladino, N., Duhart, J. M., Plano, S. A., & Chiesa, J. J. (2013) · Journal of Physiology-Paris · doi:10.1016/j.jphysparis.2013.03.007 · Cited by 147 · see citing works

The wrinkling of time: Aging, inflammation, oxidative stress, and the circadian clock in neurodegeneration

Lananna, B. V., & Musiek, E. S. (2020) · Neurobiology of Disease · doi:10.1016/j.nbd.2020.104832 · Cited by 145 · see citing works

Melatonin regulates carbohydrate metabolism and defenses against Pseudomonas syringae pv. tomato DC 3000 infection in Arabidopsis thaliana

Zhao, H., Xu, L., Su, T., Jiang, Y., Hu, L., & Ma, F. (2015) · Journal of Pineal Research · doi:10.1111/jpi.12245 · Cited by 141 · see citing works

Associations between Melatonin, Neuroinflammation, and Brain Alterations in Depression

Won, E., Na, K., & Kim, Y. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms23010305 · Cited by 146 · see citing works

ROS and NO Regulation by Melatonin Under Abiotic Stress in Plants

Pardo‐Hernández, M., López-Delacalle, M., & Rivero, R. M. (2020) · Antioxidants · doi:10.3390/antiox9111078 · Cited by 138 · see citing works

Melatonin sensitizes human cervical cancer H e L a cells to cisplatin‐induced cytotoxicity and apoptosis: effects on oxidative stress and DNA fragmentation

Pariente, R., Pariente, J. A., Rodríguez, A. B., & Espino, J. (2015) · Journal of Pineal Research · doi:10.1111/jpi.12288 · Cited by 137 · see citing works

The beneficial effects of exogenous melatonin on tomato fruit properties

Liu, J., Zhang, R., Sun, Y., Liu, Z., Jin, W., & Sun, Y. (2016) · Scientia Horticulturae · doi:10.1016/j.scienta.2016.05.003 · Cited by 134 · see citing works

Melatonin overcomes MCR-mediated colistin resistance in Gram-negative pathogens

Liu, Y., Jia, Y., Yang, K., Tong, Z., Shi, J., Li, R., Xiao, X., Ren, W., Hardeland, R., Reiter, R. J., et al. (2020) · Theranostics · doi:10.7150/thno.45951 · Cited by 129 · see citing works

Inter‐relationships of the chronobiotic, melatonin, with leptin and adiponectin: implications for obesity

Szewczyk‐Golec, K., Woźniak, A., & Reiter, R. J. (2015) · Journal of Pineal Research · doi:10.1111/jpi.12257 · Cited by 153 · see citing works

Inflammaging, Metabolic Syndrome and Melatonin: A Call for Treatment Studies

Cardinali, D. P., & Hardeland, R. (2016) · Neuroendocrinology · doi:10.1159/000446543 · Cited by 131 · see citing works

Melatonin and the electron transport chain

Hardeland, R. (2017) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-017-2615-9 · Cited by 126 · see citing works

Peripheral Circadian Oscillators in Mammals

Brown, S. A., & Azzi, A. (2013) · Handbook of experimental pharmacology · doi:10.1007/978-3-642-25950-0_3 · Cited by 120 · see citing works

Evidence for the Benefits of Melatonin in Cardiovascular Disease

Tobeiha, M., Jafari, A., Fadaei, S., Mirazimi, S. M. A., Dashti, F., Amiri, A., Khan, H. Z., Asemi, Z., Reiter, R. J., Hamblin, M. R., et al. (2022) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2022.888319 · Cited by 126 · see citing works

Exogenous Melatonin Alleviates Alkaline Stress in Malus hupehensis Rehd. by Regulating the Biosynthesis of Polyamines

Gong, X., Shi, S., Dou, F., Song, Y. P., & Ma, F. (2017) · Molecules · doi:10.3390/molecules22091542 · Cited by 122 · see citing works

The role of melatonin, a multitasking molecule, in retarding the processes of ageing

Majidinia, M., Reiter, R. J., Shakouri, S. K., & Yousefi, B. (2018) · Ageing Research Reviews · doi:10.1016/j.arr.2018.07.010 · Cited by 123 · see citing works

Melatonin protects against cisplatin-induced ovarian damage in mice via the MT1 receptor and antioxidant activity†

Barberino, R. D. S., Menezes, V. G., Ribeiro, A. E. A. S., Palheta, R. C., Jiang, X., Smitz, J. E. J., & Matos, M. H. T. (2017) · Biology of Reproduction · doi:10.1093/biolre/iox053 · Cited by 121 · see citing works

Insomnia and menopause: a narrative review on mechanisms and treatments

Proserpio, P., Marra, S., Campana, C., Agostoni, E. C., Palagini, L., Nobili, L., & Nappi, R. E. (2020) · Climacteric · doi:10.1080/13697137.2020.1799973 · Cited by 120 · see citing works

Melatonin plus physical exercise are highly neuroprotective in the 3xTg-AD mouse

García‐Mesa, Y., Giménez‐Llort, L., López, L. C., Venegas, C., Cristòfol, R. M., Escames, G., Acuña-Castroviejo, D., & Sanfeliu, C. (2011) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2011.11.016 · Cited by 118 · see citing works

Melatonin and the metabolic syndrome: a tool for effective therapy in obesity‐associated abnormalities?

Nduhirabandi, F., Toit, E. F. D., & Lochner, A. (2012) · Acta Physiologica · doi:10.1111/j.1748-1716.2012.02410.x · Cited by 116 · see citing works

An Overview of Melatonin as an Antioxidant Molecule: A Biochemical Approach

Hacışevki, A., & Baba, B. (2018) · IntechOpen eBooks · doi:10.5772/intechopen.79421 · Cited by 118 · see citing works

Molecular Mechanisms of Melatonin-Mediated Cell Protection and Signaling in Health and Disease

Kopustinskienė, D. M., & Bernatonienė, J. (2021) · Pharmaceutics · doi:10.3390/pharmaceutics13020129 · Cited by 120 · see citing works

Melatonin and its metabolites ameliorate ultraviolet B‐induced damage in human epidermal keratinocytes

Janjetovic, Z., Nahmias, Z. P., Hanna, S., Jarrett, S. G., Kim, T., Reiter, R. J., & Slominski, A. T. (2014) · Journal of Pineal Research · doi:10.1111/jpi.12146 · Cited by 113 · see citing works

Therapeutic potential of melatonin and its analogs in Parkinson’s disease: focus on sleep and neuroprotection

Srinivasan, V., Cardinali, D. P., Srinivasan, U. S., Kaur, C., Brown, G. M., Spence, D. W., Hardeland, R., & Pandi-Perumal, S. R. (2011) · Therapeutic Advances in Neurological Disorders · doi:10.1177/1756285611406166 · Cited by 113 · see citing works

Circadian Rhythm and Alzheimer’s Disease

Homolak, J., Mudrovčić, M., Vukić, B., & Toljan, K. (2018) · Medical Sciences · doi:10.3390/medsci6030052 · Cited by 115 · see citing works

Melatonin improves the germination rate of cotton seeds under drought stress by opening pores in the seed coat

Bai, Y., Xiao, S., Zhang, Z., Zhang, Y., Sun, H., Zhang, K., Wang, X., Bai, Z., Li, C., & Liu, L. (2020) · PeerJ · doi:10.7717/peerj.9450 · Cited by 113 · see citing works

Linalool prevents oxidative stress activated protein kinases in single UVB-exposed human skin cells

Gunaseelan, S., Balupillai, A., Govindasamy, K., Ramasamy, K., Muthusamy, G., Shanmugam, M., Radhiga, T., Robert, B. M., Prasad, N. R., Ponniresan, V. K., et al. (2017) · PLoS ONE · doi:10.1371/journal.pone.0176699 · Cited by 112 · see citing works

Exogenous Melatonin Mitigates Acid Rain Stress to Tomato Plants through Modulation of Leaf Ultrastructure, Photosynthesis and Antioxidant Potential

Debnath, B., Hussain, M., Irshad, M., Mitra, S., Li, M., Liu, S., & Qiu, D. (2018) · Molecules · doi:10.3390/molecules23020388 · Cited by 112 · see citing works

Melatonin and the pathologies of weakened or dysregulated circadian oscillators

Hardeland, R. (2016) · Journal of Pineal Research · doi:10.1111/jpi.12377 · Cited by 111 · see citing works

Sleep and fatigue in pediatric oncology: A review of the literature

Walter, L. M., Nixon, G. M., Davey, M. J., Downie, P., & Horne, R. S. C. (2015) · Sleep Medicine Reviews · doi:10.1016/j.smrv.2015.01.001 · Cited by 110 · see citing works

Melatonin and the Metabolic Syndrome: Physiopathologic and Therapeutical Implications

Cardinali, D. P., Cano, P., Jiménez‐Ortega, V., & Esquifino, A. I. (2011) · Neuroendocrinology · doi:10.1159/000324699 · Cited by 110 · see citing works

Essential actions of melatonin in protecting the ovary from oxidative damage

Cruz, M. H. C., Leal, C. L. V., da Cruz, J. F., Tan, D. X., & Reiter, R. J. (2014) · Theriogenology · doi:10.1016/j.theriogenology.2014.07.011 · Cited by 110 · see citing works

Melatonin Receptor Genes in Vertebrates

Li, D., Smith, D. G., Hardeland, R., Yang, M., Xu, H., Zhang, L., Yin, H., & Zhu, Q. C. (2013) · International Journal of Molecular Sciences · doi:10.3390/ijms140611208 · Cited by 109 · see citing works

Melatonin uses in oncology: breast cancer prevention and reduction of the side effects of chemotherapy and radiation

Sánchez‐Barceló, E. J., Mediavilla, M. D., Alonso‐González, C., & Reiter, R. J. (2012) · Expert Opinion on Investigational Drugs · doi:10.1517/13543784.2012.681045 · Cited by 109 · see citing works

Circadian rhythms and neuroprotective effects of melatonin in the central nervous system

Behosh, N. B., Федонюк, Л., Bakalets, O., & Romanyuk, L. (2026) · Bulletin Of Medical And Biological Research · doi:10.11603/bmbr.2706-6290.2026.2.16375

Melatonin

Hardeland, R., Pandi-Perumal, S. R., & Cardinali, D. P. (2005) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2005.08.020 · Cited by 393 · see citing works

Melatonin Beyond Its Classical Functions

Hardeland, R., & Pöeggeler, B. (2008) · The Open Physiology Journal · doi:10.2174/1874360900801010001 · Cited by 55 · see citing works

Melatonin: A Multitasking Molecule

Reiter, R. J., Tan, D. X., & Fuentes‐Broto, L. (2010) · Progress in brain research · doi:10.1016/s0079-6123(08)81008-4 · Cited by 642 · see citing works

Neuroprotective Role of Melatonin and Its Agonists: Neuroprotective Role of Melatonin against Dexamethasone-Induced Neurotoxicity

Srinivasan, V., Gobbi, G., Shillcutt, S. D., & Suzen, S. (2014) · CRC Press eBooks · doi:10.1201/b17448-42