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Cited by 12T-cell and B-cell ImmunologyCytokine Signaling Pathways and InteractionsProteoglycans and glycosaminoglycans research

The DOI matches its Crossref record; 30 of the 30 references it cites were found in a registry or an index.

Synergistic enhancement of T cell responses and interleukin-1 receptor expression by interleukin-1 and heparin or dextran sulfate

Dziarski, Roman·1992·Cellular Immunology
DOI 10.1016/0008-8749(92)90316-h
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Abstract

Heparin markedly enhances generation of cytotoxic T lymphocytes against allogeneic cells and histocompatible tumors. In this study, we demonstrated a marked synergism between heparin and low concentrations of recombinant IL-1-alpha and IL-1-beta in enhancement of cytotoxic T cell responses in mice. Low molecular weight (8000 Da) dextran sulfate also enhanced the T cell responses and synergized with IL-1, whereas, de-N-sulfated heparin was devoid of both of these activities. The synergistic effect was selective for IL-1, because there was no synergism between heparin or dextran sulfate and other cytokines (tumor necrosis factor-alpha, IL-4, and, as shown previously, IL-2). Heparin did not increase the production of IL-1 (and IL-2, as shown before). Heparin did not bind to IL-1, despite significant amino acid homology between IL-1 and heparin-binding endothelial cell growth factors. Heparin enhanced the growth-promoting effect of IL-1 on the IL-1-dependent helper T cell clone, D10.G4.1, and enhanced IL-1 receptor expression on these cells. These data indicate that heparin acts directly on the T cells and enhances their responsiveness to IL-1 by up-regulating IL-1 receptor expression.

Overview

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Crossref · 10.1016/0008-8749(92)90316-h

Cites

30 of 30 references verified0 citation errors · 0 not checkable

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  • Activation of the innate immune system by polysaccharides leads to attraction of macrophages and natural killer cells to the target site and production of tumoricidal cytokines.

    “The main mechanism of action of polysaccharides cytotoxic effect is the activation of the innate immune system [165,166,167,168], leading to attraction of macrophages and natural killer cells to the target site and production of tumoricidal cytokines [166,169,170,171].”

    From Marine Natural Products: A Source of Novel Anticancer Drugs (2019) · cites this paper as [169]

Citations

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Research works printed but not linked: 7

  1. Schreiber, 1985, 82, 6138
  2. Thomas, 1985, 82, 6409
  3. Koide, 1987, 84, 3802
  4. Le, 1987, Lab. Invest, 56, 234
  5. Dinarello, 1989, Adv. Exp. Med. Biol, 254, 45
  6. Jaques, 1980, Pharmacol. Rev, 31, 99
  7. Altman, 1990, CRC Crit. Rev. Immunol, 10, 347

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Metadata

Authors
Dziarski, R.
Affiliations
Indiana University School of Medicine (US)
Corresponding author
Dziarski, Roman
ORCID
Dziarski, Roman
Venue
Cellular Immunology
Publisher
Elsevier BV
Published
1992-11
Volume
145
Issue
1
Pages
100-110
ISSN
0008-8749 (ISSN-L)
DOI
10.1016/0008-8749(92)90316-h
OpenAlex
W2005355632
Cited by
12
References
30
Citations by year
2024: 1 · 2019: 1
FWCI
0.32
Type
journal article
Language
en
Open access
closed
Licence
Locations
  • Cellular Immunology (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
  • Life Sciences › Immunology and Microbiology › Immunology › Cytokine Signaling Pathways and Interactions
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Proteoglycans and glycosaminoglycans research
Keywords
heparin, dextran sulfate, interleukin-1, cytotoxic T lymphocytes, T cell activation, cytokine synergy, low molecular weight heparin, helper T cell clones, allogeneic cytotoxicity, tumor immunology
MeSH terms
Animals, Cell Line, Drug Synergism, Heparin, Interleukin-1, Mice, Inbred CBA, Mice, Inbred C57BL, T-Lymphocytes, Tumor Necrosis Factor-alpha, Interleukin-4, Dextran Sulfate, Receptors, Interleukin-1, Mice

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