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Lipid peroxidation in microsomes induced by crocidolite fibres

Gulumian, Mairam, Sardianos, Fay, Kilroe-Smith, Terence, Ockerse, Gerald·1983·Chemico-Biological Interactions

Abstract

When rat liver and lung microsomes were incubated with crocidolite fibres, a substantial increase in lipid peroxidation was observed. Increasing concentrations of this fibre in the incubation mixture, produced a concomitant induction in microsomal lipid peroxidation. This increase was very rapid as the reaction was almost complete within 10 min. The ability of these fibres to induce this process after a short period of incubation seems to be due to their binding to the microsomes. The iron present in the structure of crocidolite is thought to be responsible for catalysing the peroxidation. The formation of free radicals by asbestos and possible pathological sequelae are discussed.

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Research works printed but not linked: 31

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Metadata

Authors
Gulumian, M., Sardianos, F., Kilroe-Smith, T., & Ockerse, G.
Venue
Chemico-Biological Interactions
Publisher
Elsevier BV
Published
1983-04
Volume
44
Issue
1-2
Pages
111-118
ISSN
0009-2797
Cited by
33
References
0
Language
en

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CoChat. (2026). Citation check: Lipid peroxidation in microsomes induced by crocidolite fibres. https://app.cochat.ai/papers/10.1016/0009-2797(83)90133-3
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Gulumian, M., Sardianos, F., Kilroe-Smith, T., & Ockerse, G. (1983). Lipid peroxidation in microsomes induced by crocidolite fibres. Chemico-Biological Interactions. https://doi.org/10.1016/0009-2797(83)90133-3