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Lipid peroxidation in microsomes induced by crocidolite fibres
Abstract
When rat liver and lung microsomes were incubated with crocidolite fibres, a substantial increase in lipid peroxidation was observed. Increasing concentrations of this fibre in the incubation mixture, produced a concomitant induction in microsomal lipid peroxidation. This increase was very rapid as the reaction was almost complete within 10 min. The ability of these fibres to induce this process after a short period of incubation seems to be due to their binding to the microsomes. The iron present in the structure of crocidolite is thought to be responsible for catalysing the peroxidation. The formation of free radicals by asbestos and possible pathological sequelae are discussed.
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“Moreover, surface reactivity with the generation of free radicals [324–328], and their ability to induce the peroxidation of cellular lipids were also studied [329–334].”
From Particle toxicology and health - where are we? (2019) · cites this paper as [333]
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Research works printed but not linked: 31
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Metadata
- Authors
- Gulumian, M., Sardianos, F., Kilroe-Smith, T., & Ockerse, G.
- Venue
- Chemico-Biological Interactions
- Publisher
- Elsevier BV
- Published
- 1983-04
- Volume
- 44
- Issue
- 1-2
- Pages
- 111-118
- ISSN
- 0009-2797
- Cited by
- 33
- References
- 0
- Language
- en
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- Gulumian, M., Sardianos, F., Kilroe-Smith, T., & Ockerse, G. (1983). Lipid peroxidation in microsomes induced by crocidolite fibres. Chemico-Biological Interactions. https://doi.org/10.1016/0009-2797(83)90133-3