Cited by 941Redox biology and oxidative stressAntioxidant Activity and Oxidative StressFree Radicals and Antioxidants

The importance of free radicals and catalytic metal ions in human diseases.

Halliwell, Barry, Gutteridge, John M.C.·1985·Molecular Aspects of Medicine

Abstract

The study of free radical reactions is not an isolated and esoteric branch of science. A knowledge of free radical chemistry and biochemistry is relevant to an understanding of all diseases and the mode of action of all toxins, if only because diseased or damaged tissues undergo radical reactions more readily than do normal tissues. However it does not follow that because radical reactions can be demonstrated, they are important in any particular instance. We hope that the careful techniques needed to assess the biological role of free radicals will become more widely used.

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Crossref · 10.1016/0098-2997(85)90001-9

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602 of 602 references verified0 citation errors · 0 not checkable

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Authors
Halliwell, B., & Gutteridge, J. M. C.
Affiliations
University of London (GB)
Venue
Molecular Aspects of Medicine
Publisher
Elsevier BV
Published
1985-01
Volume
8
Issue
2
Pages
89-193
ISSN
0098-2997 (ISSN-L)
OpenAlex
W2069471046
Cited by
941
References
602
Citations by year
2026: 6 · 2025: 7 · 2024: 7 · 2023: 14 · 2022: 19 · 2021: 9 · 2020: 26 · 2019: 18 · 2018: 10 · 2017: 15 · 2016: 16 · 2015: 26 · 2014: 17 · 2013: 28 · 2012: 20
FWCI
5.45
Type
journal article
Language
en
Open access
closed
Locations
  • Molecular Aspects of Medicine (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Redox biology and oxidative stress
  • Health Sciences › Medicine › Biochemistry › Antioxidant Activity and Oxidative Stress
  • Physical Sciences › Chemistry › Organic Chemistry › Free Radicals and Antioxidants
Keywords
free radicals, catalytic metal ions, radical reactions, human disease, toxins, tissue damage, oxidative stress
MeSH terms
Aging, Autoimmune Diseases, Brain Ischemia, Copper, Coronary Disease, Disease, Physical Exertion, Free Radicals, Humans, Intestines, Iron, Ischemia, Joint Diseases, Lipid Peroxides, Malaria, Metals, Neoplasms, Nervous System Diseases, Respiratory Distress Syndrome

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