The DOI matches its Crossref record; 16 of the 16 references it cites were found in a registry or an index.
Drosophila acetylcholinesterase: Mechanisms of resistance to organophosphates
Abstract
Quantitative and qualitative changes of acetylcholinesterase can affect the sensitivity of insects to insecticides. First, the amount of acetylcholinesterase in the central nervous system is important in Drosophila melanogaster, flies which overexpress the enzyme are more resistant than wild-type flies. On the contrary, flies which express low levels of acetylcholinesterase are more susceptible. An overproduction of acetylcholinesterase outside the central nervous system also protects against organophosphate poisoning, that is, flies producing a soluble acetylcholinesterase, secreted in the haemolymph, are resistant to organophosphates. Second, resistance can also result from a qualitative modification of acetylcholinesterase. Four mutations have been identified in resistant strains: Phe115 to Ser, Ileu199 to Val, Gly303 to Ala and Phe368 to Tyr. Each of these mutations led to a different pattern of resistance and combinations between these mutations led to highly resistant enzymes.
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“The interactions obtained after molecular docking of the compounds with the amino acid residues TRP83, TYR370, PHE371, and HIS480 of AChE were similar to those reported in the literature [38].”
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Gene Amplification and Insecticide Resistance
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Acetylcholinesterase. Two types of modifications confer resistance to insecticide.
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Self-citationCholinesterase Inhibition in Spider Mites Susceptible and Resistant to Organophosphate
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GENETICS OF ACETYLCHOLINESTERASE IN DROSOPHILA MELANOGASTER
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Cited by
Insecticide Resistance in Insect Vectors of Human Disease
Hemingway, J., & Ranson, H. (2000) · Annual Review of Entomology · doi:10.1146/annurev.ento.45.1.371 · Cited by 1,558
Guidelines on nicotine dose selection for in vivo research
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Invertebrate models of drug abuse
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Metadata
- Authors
- Fournier, D., Mutero, A., Pralavorio, M., & Bride, J.-M.
- Affiliations
- Institut National de Recherche pour l'Agriculture, l'Alimentation et l'Environnement (FR)
- Corresponding author
- Fournier, Didier
- Venue
- Chemico-Biological Interactions
- Publisher
- Elsevier BV
- Published
- 1993-06
- Volume
- 87
- Issue
- 1-3
- Pages
- 233-238
- ISSN
- 0009-2797 (ISSN-L)
- OpenAlex
- W2061182635
- Cited by
- 92
- References
- 16
- Citations by year
- 2026: 1 · 2025: 2 · 2024: 5 · 2023: 4 · 2022: 5 · 2021: 1 · 2019: 3 · 2018: 3 · 2017: 3 · 2016: 2 · 2015: 3 · 2014: 5 · 2013: 2 · 2012: 5
- FWCI
- 0.52
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Chemico-Biological Interactions (publishedVersion)
- PubMed (publishedVersion)
- HAL (submittedVersion)
- Funders
- London School of Hygiene and Tropical Medicine
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Insect Resistance and Genetics
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Toxicology › Pesticide Exposure and Toxicity
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurobiology and Insect Physiology Research
- Keywords
- acetylcholinesterase, organophosphate resistance, Drosophila melanogaster, insecticide resistance, enzyme overexpression, hemolymph, central nervous system, enzyme mutations, insecticide susceptibility
- MeSH terms
- Acetylcholinesterase, Animals, Cholinesterase Inhibitors, Drosophila melanogaster, Insecticide Resistance, Insecticides, Organophosphorus Compounds, Point Mutation
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Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
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- CoChat. (2026). Citation check: Drosophila acetylcholinesterase: Mechanisms of resistance to organophosphates. https://app.cochat.ai/papers/10.1016/0009-2797(93)90047-3
- The paper
- Fournier, D., Mutero, A., Pralavorio, M., & Bride, J.-M. (1993). Drosophila acetylcholinesterase: Mechanisms of resistance to organophosphates. Chemico-Biological Interactions. https://doi.org/10.1016/0009-2797(93)90047-3
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
