CoChat
Sign Up
Cited by 125Adrenal Hormones and DisordersEstrogen and related hormone effectsStress Responses and Cortisol

The DOI matches its Crossref record; 27 of the 29 references it cites were found in a registry or an index.

The effect of oral contraceptives on plasma-free and salivary cortisol and cortisone

Meulenberg, P.M.M., Ross, H.A., Swinkels, L.M.J.W., Benraad, T.J.·1987·Clinica Chimica Acta
DOI 10.1016/0009-8981(87)90183-5
Open this paper in CoChat — free account

Abstract

The effect of a low estrogen oral contraceptive (OC) on glucocorticoid levels in plasma and saliva as well as glucocorticoid binding was studied in 23 healthy women using 30 micrograms ethinyl estradiol (EE2) + 150 micrograms desogestrel (Marvelon) (II). Fifteen healthy females with normal menses served as controls (I). Blood and salivary samples were taken between 9.00 and 9.30 a.m. on the 18th day of menstrual or pill cycle. Assay accuracy had been optimised by applying extraction and chromatographic purification before radioimmunoassay (RIA) of cortisol and cortisone in both plasma and salivary samples. Free steroid assays were performed by applying the same procedure to equilibrium dialysates obtained after dialysing plasma against an equal volume of buffer, instead of measuring tracer distribution. Corticosteroid Binding Globulin (CBG) was measured by a commercial RIA. As expected, CBG as well as plasma total cortisol were elevated in the pill group. Interestingly both plasma free and salivary cortisol were higher than in controls (free cortisol I: 18.0 +/- 7.95 nmol/l; II: 32.3 +/- 9.03 nmol/l; salivary cortisol I: 9.2 +/- 3.88 nmol/l; II: 18.8 +/- 6.92 nmol/l. Salivary cortisol closely parallelled plasma free cortisol both within and between the groups, though at a much lower level (about 50%). Free cortisone was slightly lower in the pill group (I: 10.8 +/- 2.55 nmol/l; II 8.5 +/- 1.86 nmol/l) whereas salivary cortisone was 2.3 (I) and 4.4 (II) times higher than plasma free cortisone and tended to follow the plasma free and salivary cortisol pattern, both within and between the study groups.(ABSTRACT TRUNCATED AT 250 WORDS)

Overview

Integrity signals

Registry

Crossref · 10.1016/0009-8981(87)90183-5

Cites

27 of 27 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Verification

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Citations

Cites

Show all 29 references

Research works printed but not linked: 3

  1. Racadot, 1974, Estimation du cortisol non lié aux proteins au cours de la grossesse et chez les femmes sous oestro-pregestatife, Ann Endocrinol (Paris), 35, 256
  2. Heyns, 1984, Dosage at significance du cortisol libre dans le sang, J Biophys Med Nucl, 8, 239
  3. Katz, 1966, Parotid fluid corticosteroids: a good measure of free cortisol available to the cell, J Clin Invest, 45, 1031

Cited by

Sorted by citations

Items 101–125 of 125

Related

See all

Metadata

Authors
Meulenberg, P. M. M., Ross, H. A., Swinkels, L. M. J. W., & Benraad, T. J.
Affiliations
Radboud University Nijmegen (NL)
Corresponding author
Meulenberg, P.M.M.
Venue
Clinica Chimica Acta
Publisher
Elsevier BV
Published
1987-06
Volume
165
Issue
2-3
Pages
379-385
ISSN
0009-8981 (ISSN-L)
DOI
10.1016/0009-8981(87)90183-5
OpenAlex
W1987525998
Cited by
125
References
29
Citations by year
2026: 3 · 2025: 2 · 2024: 6 · 2023: 6 · 2022: 2 · 2021: 6 · 2020: 4 · 2019: 5 · 2018: 5 · 2017: 5 · 2016: 1 · 2015: 4 · 2014: 5 · 2013: 3 · 2012: 8
FWCI
1.13
Type
journal article
Language
en
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • Clinica Chimica Acta (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adrenal Hormones and Disorders
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Endocrinology › Estrogen and related hormone effects
  • Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
Keywords
oral contraceptives, ethinyl estradiol, desogestrel, Marvelon, free cortisol, salivary cortisol, plasma cortisol, corticosteroid-binding globulin, glucocorticoid binding, hypothalamic-pituitary-adrenal axis, menstrual cycle, women
MeSH terms
Adolescent, Adult, Carrier Proteins, Contraceptives, Oral, Hormonal, Corticosterone, Cortisone, Dialysis, Female, Humans, Hydrocortisone, Middle Aged, Radioimmunoassay, Saliva

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review