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Cited by 125Adrenal Hormones and DisordersEstrogen and related hormone effectsStress Responses and Cortisol

The DOI matches its Crossref record; 27 of the 29 references it cites were found in a registry or an index.

The effect of oral contraceptives on plasma-free and salivary cortisol and cortisone

Meulenberg, P.M.M., Ross, H.A., Swinkels, L.M.J.W., Benraad, T.J.·1987·Clinica Chimica Acta
DOI 10.1016/0009-8981(87)90183-5
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Abstract

The effect of a low estrogen oral contraceptive (OC) on glucocorticoid levels in plasma and saliva as well as glucocorticoid binding was studied in 23 healthy women using 30 micrograms ethinyl estradiol (EE2) + 150 micrograms desogestrel (Marvelon) (II). Fifteen healthy females with normal menses served as controls (I). Blood and salivary samples were taken between 9.00 and 9.30 a.m. on the 18th day of menstrual or pill cycle. Assay accuracy had been optimised by applying extraction and chromatographic purification before radioimmunoassay (RIA) of cortisol and cortisone in both plasma and salivary samples. Free steroid assays were performed by applying the same procedure to equilibrium dialysates obtained after dialysing plasma against an equal volume of buffer, instead of measuring tracer distribution. Corticosteroid Binding Globulin (CBG) was measured by a commercial RIA. As expected, CBG as well as plasma total cortisol were elevated in the pill group. Interestingly both plasma free and salivary cortisol were higher than in controls (free cortisol I: 18.0 +/- 7.95 nmol/l; II: 32.3 +/- 9.03 nmol/l; salivary cortisol I: 9.2 +/- 3.88 nmol/l; II: 18.8 +/- 6.92 nmol/l. Salivary cortisol closely parallelled plasma free cortisol both within and between the groups, though at a much lower level (about 50%). Free cortisone was slightly lower in the pill group (I: 10.8 +/- 2.55 nmol/l; II 8.5 +/- 1.86 nmol/l) whereas salivary cortisone was 2.3 (I) and 4.4 (II) times higher than plasma free cortisone and tended to follow the plasma free and salivary cortisol pattern, both within and between the study groups.(ABSTRACT TRUNCATED AT 250 WORDS)

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Crossref · 10.1016/0009-8981(87)90183-5

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27 of 27 references verified0 citation errors · 0 not checkable

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Research works printed but not linked: 3

  1. Racadot, 1974, Estimation du cortisol non lié aux proteins au cours de la grossesse et chez les femmes sous oestro-pregestatife, Ann Endocrinol (Paris), 35, 256
  2. Heyns, 1984, Dosage at significance du cortisol libre dans le sang, J Biophys Med Nucl, 8, 239
  3. Katz, 1966, Parotid fluid corticosteroids: a good measure of free cortisol available to the cell, J Clin Invest, 45, 1031

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Metadata

Authors
Meulenberg, P. M. M., Ross, H. A., Swinkels, L. M. J. W., & Benraad, T. J.
Affiliations
Radboud University Nijmegen (NL)
Corresponding author
Meulenberg, P.M.M.
Venue
Clinica Chimica Acta
Publisher
Elsevier BV
Published
1987-06
Volume
165
Issue
2-3
Pages
379-385
ISSN
0009-8981 (ISSN-L)
DOI
10.1016/0009-8981(87)90183-5
OpenAlex
W1987525998
Cited by
125
References
29
Citations by year
2026: 3 · 2025: 2 · 2024: 6 · 2023: 6 · 2022: 2 · 2021: 6 · 2020: 4 · 2019: 5 · 2018: 5 · 2017: 5 · 2016: 1 · 2015: 4 · 2014: 5 · 2013: 3 · 2012: 8
FWCI
1.13
Type
journal article
Language
en
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • Clinica Chimica Acta (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adrenal Hormones and Disorders
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Endocrinology › Estrogen and related hormone effects
  • Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
Keywords
oral contraceptives, ethinyl estradiol, desogestrel, Marvelon, free cortisol, salivary cortisol, plasma cortisol, corticosteroid-binding globulin, glucocorticoid binding, hypothalamic-pituitary-adrenal axis, menstrual cycle, women
MeSH terms
Adolescent, Adult, Carrier Proteins, Contraceptives, Oral, Hormonal, Corticosterone, Cortisone, Dialysis, Female, Humans, Hydrocortisone, Middle Aged, Radioimmunoassay, Saliva

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