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Presence of mast cell precursors in the yolk sac of mice
Abstract
Concentration of mast-cell precursors in hematopoietic tissues of mouse embryos was evaluated by a limiting dilution method. Cells from yolk sacs, livers, and bodies of (WB x C57BL/6)F1 (hereafter called WBB6F1)- +/+ embryos were injected directly into the skin of adult WBB6F1-W/Wv mice which were genetically depleted of tissue mast cells. Concentration of mast-cell precursors was calculated from the proportion of injection sites at which mast cells did not appear. Since the concentration of mast-cell precursors in the yolk sac was about 30 times as great as that of embryonic body at Day 9.5 of the pregnancy, the mast-cell precursors seemed to be generated within the yolk sac. The concentration in the yolk sac reached the maximum level at Day 11, and then dropped markedly at Day 13. In contrast, mast-cell precursors increased from Day 11 to Day 15 in the fetal liver. As a result, the concentration of 11-day yolk sacs was comparable to that of 15-day fetal liver. Although intravenous injection of 15-day fetal liver cells (2 x 10(6)) rescued the general mast-cell depletion of WBB6F1-W/Wv mice, the intravenous injection of the same number of 11-day yolk sac cells did not rescue it. In contrast with fetal livers, yolk sacs scarcely contained hematopoietic stem cells which were measured by spleen colony formation. Therefore, the mast-cell precursors of the yolk sac may not originate from such stem cells.
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“In keeping with this, mast cell potential was identified in the extra‐embryonic yolk sac and fetal liver. 27 , 49 , 51”
From Mast cell ontogeny: From fetal development to life‐long health and disease (2023) · cites this paper as [51]
In the citing paper
“This revealed that between E9.5 and E11.5, the highest mast cell potential is found in the YS, followed by the fetal liver that predominates from E13.5 onwards. 51”
From Mast cell ontogeny: From fetal development to life‐long health and disease (2023) · cites this paper as [51]
In the citing paper
“Indeed, based on transplantation assays, mast cell potential is present in the YS until E13.5, and mast cells are in fact generated more efficiently from the YS than the fetal liver until E11.5. 51”
From Mast cell ontogeny: From fetal development to life‐long health and disease (2023) · cites this paper as [51]
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Cited by
Sorted by citations
Mast cell ontogeny: From fetal development to life‐long health and disease
Chia, S. L., Kapoor, S., Carvalho, C., Bajénoff, M., & Gentek, R. (2023) · Immunological Reviews · doi:10.1111/imr.13191 · Cited by 60
Metadata
- Authors
- Sonoda, T., Hayashi, C., & Kitamura, Y.
- Venue
- Developmental Biology
- Publisher
- Elsevier BV
- Published
- 1983-05
- Volume
- 97
- Issue
- 1
- Pages
- 89-94
- ISSN
- 0012-1606
- Cited by
- 83
- References
- 0
- Language
- en
- Funders
- Ministry of Health, Labour and Welfare
- Mitsubishi Foundation
- Naito Foundation
- Ministry of Education, Culture, Sports, Science and Technology
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