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Cited by 82Muscle Physiology and DisordersHormonal and reproductive studiesSexual Differentiation and Disorders

Testosterone-induced development of the rat levator ani muscle

Tobin, Christine, Joubert, Yolaine·1991·Developmental Biology
DOI 10.1016/0012-1606(91)90453-a
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Abstract

The perinatal development of the levator ani (LA) muscle in male and female rats was investigated by measuring the total number of muscle units (MU) (i.e., mononucleate cells, clustered or independent myotubes, and muscle fibers) in transverse semithin sections of the entire muscle and the MU cross-sectional area in 22-day-old fetuses (F22), 1-day-old (D1 = day of birth), 3-day-old (D3), and 6-day-old (D6) newborns. Male muscle contained 350 +/- 64 MU on F22, twice that of the female. The number of MU increased markedly in males from F22, but changed little in females; the number of MU in males was 760% that of females on D6. The MU cross-sectional area was greater in males on F22 (120.8 micron(s)2 +/- 7.5) and D1 (155.2 micron(s)2 +/- 64.8) than in females (F22: 89.2 micron(s) +/- 14.2, D1: 64.1 micron(s)2 +/- 19.7) and dropped to about 30 X micron(s)2 in both sexes on D6. Female rats given a single injection of testosterone propionate (TP) before D7 showed a significant increase in the number of fibers, but no increase in cross-sectional area. TP given after D7 had no effect on the fiber number, but increased the average cross-sectional area. The increase in fiber number induced by postnatal TP treatment was a permanent effect, still quantifiable in 15-month-old females. We conclude that the sexual dimorphism of the rat LA muscle is principally due to a dramatic increase in the MU number in male muscles during the perinatal period, rather than to involution of the fibers in female muscles as it is widely accepted. This increase seems to be, at least partly, under the control of testosterone.

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Crossref · 10.1016/0012-1606(91)90453-a

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  • An increase in testosterone could stimulate muscle growth in peacocks, which could in turn influence seasonal differences in locomotion.

    “An increase in testosterone could stimulate muscle growth in peacocks2829, which could in turn influence seasonal differences in locomotion303132.”

    From The peacock train does not handicap cursorial locomotor performance (2016) · cites this paper as [28]

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Authors
Tobin, C., & Joubert, Y.
Affiliations
Centre National de la Recherche Scientifique (FR)
Venue
Developmental Biology
Publisher
Elsevier BV
Published
1991-07
Volume
146
Issue
1
Pages
131-138
ISSN
0012-1606 (ISSN-L)
DOI
10.1016/0012-1606(91)90453-a
OpenAlex
W1998166805
Cited by
82
References
19
Citations by year
2023: 2 · 2022: 1 · 2021: 1 · 2020: 3 · 2019: 1 · 2018: 1 · 2017: 1 · 2016: 1 · 2015: 1 · 2014: 2 · 2013: 3 · 2012: 3
FWCI
1.85
Type
journal article
Language
en
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • Developmental Biology (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Muscle Physiology and Disorders
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Hormonal and reproductive studies
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Sexual Differentiation and Disorders
Keywords
levator ani muscle, testosterone propionate, sexual dimorphism, myogenesis, muscle fiber number, muscle fiber cross-sectional area, perinatal period, myotubes
MeSH terms
Animals, Cell Differentiation, Drug Administration Schedule, Female, Male, Muscles, Rats, Inbred Strains, Sex Characteristics, Testosterone, Rats

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