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Cited by 133Renin-Angiotensin System StudiesCardiovascular, Neuropeptides, and Oxidative Stress ResearchCardiac electrophysiology and arrhythmias

The DOI matches its Crossref record; 13 of the 13 references it cites were found in a registry or an index.

Positive chronotropic and inotropic effects of angiotension II in the dog heart

Kobayashi, Miyoharu, Furukawa, Yasuyuki, Chiba, Shigetoshi·1978·European Journal of Pharmacology
DOI 10.1016/0014-2999(78)90249-2
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Abstract

The effects of angiotensin II on sinus rate and atrial contractility were investigated in 17 isolated canine atria and 5 isolated paced ventricular preparations perfused with arterial blood conducted from a heparinized donor dog. When angiotensin II was injected into the cannulated sinus node artery, positive chronotropic responses were dose-dependently produced starting from the 0.01 microgram dose although inotropic responses to angiotensin II were not consistently induced. Angiotensin II produced a similar inotropic response pattern in the paced ventricular preparation. Moreover, when angiotensin II was given into the jugular vein of the donor dog, similar positive chronotropic and inotropic responses were also shown in the isolated atrium. Angiotensin II-induced positive chronotropic and slight inotropic effects were not influenced by treatment with the beta-adrenoceptor blocking agents, propranolol and carteolol, but significantly suppressed by saralasin which has been reported to be a competitive antagonist of angiotensin II. From these results, it is suggested that angiotensin II induced a positive chronotropic and slight positive inotropic effect via angiotensin II receptors in the dog heart.

Overview

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Crossref · 10.1016/0014-2999(78)90249-2

Cites

13 of 13 references verified0 citation errors · 0 not checkable

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Citations

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Research works printed but not linked: 1

  1. Farr, 1967, Sympathetically mediated effects of angiotensin on the dog heart and in situ, J. Pharmacol. Exptl. Therap., 156], 528

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Metadata

Authors
Kobayashi, M., Furukawa, Y., & Chiba, S.
Affiliations
Shinshu University (JP)
Corresponding author
Chiba, Shigetoshi
Venue
European Journal of Pharmacology
Publisher
Elsevier BV
Published
1978-07
Volume
50
Issue
1
Pages
17-25
ISSN
0014-2999 (ISSN-L)
DOI
10.1016/0014-2999(78)90249-2
OpenAlex
W1999422984
Cited by
132
References
13
Citations by year
2025: 1 · 2021: 2 · 2020: 1 · 2019: 3 · 2017: 2 · 2013: 2 · 2012: 2
FWCI
1.74
Type
journal article
Language
en
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • European Journal of Pharmacology (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Renin-Angiotensin System Studies
  • Health Sciences › Medicine › Surgery › Cardiovascular, Neuropeptides, and Oxidative Stress Research
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac electrophysiology and arrhythmias
Keywords
angiotensin II, positive chronotropic effect, positive inotropic effect, sinoatrial node, atrial contractility, ventricular contractility, angiotensin II receptor, saralasin, beta-adrenergic blockade, propranolol, carteolol, isolated atria, isolated ventricle, dog heart
MeSH terms
Angiotensin II, Animals, Dogs, Heart Rate, Injections, Intra-Arterial, Injections, Intravenous, Jugular Veins, Myocardial Contraction, Norepinephrine, Propranolol, Saralasin, Stimulation, Chemical, In Vitro Techniques

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CoChat. (2026). Citation check: Positive chronotropic and inotropic effects of angiotension II in the dog heart. https://app.cochat.ai/papers/10.1016/0014-2999(78)90249-2
The paper
Kobayashi, M., Furukawa, Y., & Chiba, S. (1978). Positive chronotropic and inotropic effects of angiotension II in the dog heart. European Journal of Pharmacology. https://doi.org/10.1016/0014-2999(78)90249-2

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.