The DOI matches its Crossref record; 20 of the 22 references it cites were found in a registry or an index.
Antagonism of the effects of the hallucinogen dom and the purported 5-HT agonist quipazine by 5-HT2 antagonists
Abstract
Rats trained to discriminate 1.0 mg/kg of 1-(2,5-dimethoxy-4-methylphenyl)-2-aminopropane (DOM) from saline in a two-lever operant choice task were administered doses of mescaline, LSD, 5-methoxy-N,N-dimethyltryptamine (5-OMe DMT), quipazine, TFMPP and RU-24969. The DOM-stimulus generalized to the three hallucinogenic agents and to quipazine, but not to the purported serotonin agonists TFMPP or RU-24969. Pretreatment of the animals with the 5-HT2 antagonists ketanserin and pirenperone antagonized the effect produced by DOM. Pirenperone also blocked DOM-stimulus generalization to mescaline, LSD, 5-OMe DMT and quipazine. The results of this study suggest that the discriminative stimulus effects of DOM, the three hallucinogenic agents to which DOM-stimulus generalization occurred, and quipazine, may involve those sub-populations of serotonin receptors that are labeled by tritiated ketanserin (i.e. 5-HT2 sites).
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“To prevent any potential numerical errors, the term “classic psychedelics'' is used, referring to the category of substances that bind to serotonin receptors in the brain, with 5HT2A receptor selectivity [29].”
From Mindfulness meditation and psychedelics: potential synergies and commonalities (2023) · cites this paper as [29]
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Metadata
- Authors
- Glennon, R. A., Young, R., & Rosecrans, J. A.
- Affiliations
- Virginia Commonwealth University (US)
- Corresponding author
- Glennon, Richard A.
- Venue
- European Journal of Pharmacology
- Publisher
- Elsevier BV
- Published
- 1983-07
- Volume
- 91
- Issue
- 2-3
- Pages
- 189-196
- ISSN
- 0014-2999 (ISSN-L)
- OpenAlex
- W1983135802
- Cited by
- 190
- References
- 22
- Citations by year
- 2026: 5 · 2025: 7 · 2024: 5 · 2023: 7 · 2022: 6 · 2021: 2 · 2020: 7 · 2019: 1 · 2018: 5 · 2017: 1 · 2016: 4 · 2015: 2 · 2014: 3
- FWCI
- 15.17
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- European Journal of Pharmacology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Social Sciences › Psychology › Clinical Psychology › Psychedelics and Drug Studies
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Life Sciences › Neuroscience › Cognitive Neuroscience › Hallucinations in medical conditions
- Keywords
- DOM, 5-HT2 receptor antagonist, quipazine, ketanserin, pirenperone, mescaline, LSD, hallucinogens, TFMPP, RU 24969, serotonin receptor agonists
- MeSH terms
- Amphetamines, Animals, DOM 2,5-Dimethoxy-4-Methylamphetamine, Ketanserin, Male, Piperidines, Quinolines, Quipazine, Rats, Inbred Strains, Serotonin Antagonists, Rats
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