Cited by 192Psychedelics and Drug StudiesNeurotransmitter Receptor Influence on BehaviorHallucinations in medical conditions

The DOI matches its Crossref record; 20 of the 22 references it cites were found in a registry or an index.

Antagonism of the effects of the hallucinogen dom and the purported 5-HT agonist quipazine by 5-HT2 antagonists

Glennon, Richard A., Young, Richard, Rosecrans, John A.·1983·European Journal of Pharmacology

DOI 10.1016/0014-2999(83)90464-8

Open this paper in CoChat — free account

Abstract

Rats trained to discriminate 1.0 mg/kg of 1-(2,5-dimethoxy-4-methylphenyl)-2-aminopropane (DOM) from saline in a two-lever operant choice task were administered doses of mescaline, LSD, 5-methoxy-N,N-dimethyltryptamine (5-OMe DMT), quipazine, TFMPP and RU-24969. The DOM-stimulus generalized to the three hallucinogenic agents and to quipazine, but not to the purported serotonin agonists TFMPP or RU-24969. Pretreatment of the animals with the 5-HT2 antagonists ketanserin and pirenperone antagonized the effect produced by DOM. Pirenperone also blocked DOM-stimulus generalization to mescaline, LSD, 5-OMe DMT and quipazine. The results of this study suggest that the discriminative stimulus effects of DOM, the three hallucinogenic agents to which DOM-stimulus generalization occurred, and quipazine, may involve those sub-populations of serotonin receptors that are labeled by tritiated ketanserin (i.e. 5-HT2 sites).

Integrity signals

Registry

Crossref · 10.1016/0014-2999(83)90464-8

Cites

20 of 20 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

A SIMPLIFIED METHOD OF EVALUATING DOSE-EFFECT EXPERIMENTS
Litchfield, J. T., & Wilcoxon, F. (1949) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(25)03549-9 · Cited by 7,798
Multiple Serotonin Receptors: Differential Binding of [3H]5-Hydroxytryptamine, [3H]Lysergic Acid Diethylamide and [3H]Spiroperidol
Peroutka, S. J., & Snyder, S. H. (1979) · Molecular Pharmacology · doi:10.1016/s0026-895x(25)13812-1 · Cited by 1,363
[3H]Ketanserin (R 41 468), a selective 3H-ligand for serotonin2 receptor binding sites. Binding properties, brain distribution, and functional role.
Leysen, J. E., Niemegeers, C. J. E., Nueten, J. M. V., & Laduron, P. M. (1982) · Molecular Pharmacology · doi:10.1016/s0026-895x(25)14623-3 · Cited by 1,071
Receptor binding profile of R 41 468, A novel antagonist at 5-HT2 receptors
Leysen, J. E., Awouters, F. H. L., Kennis, L. E. J., Laduron, P. M., Vandenberk, J., & Janssen, P. A. J. (1981) · Life Sciences · doi:10.1016/0024-3205(81)90747-5 · Cited by 843
Two Distinct Central Serotonin Receptors with Different Physiological Functions
Peroutka, S. J., Lebovitz, R. M., & Snyder, S. H. (1981) · Science · doi:10.1126/science.7221567 · Cited by 639
A drug discrimination analysis of lysergic acid diethylamide (LSD): in vivo agonist and antagonist effects of purported 5-hydroxytryptamine antagonists and of pirenperone, a LSD-antagonist.
Colpaert, F. C., Niemegeers, C. J. E., & Janssen, P. A. J. (1982) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(25)33038-7 · Cited by 168
Quipazine: Its effects on rat brain 5-hydroxytryptamine metabolism, monoamine oxidase activity and behaviour
Green, A. R., Youdim, M. B. H., & Smith, A. D. (1976) · Neuropharmacology · doi:10.1016/0028-3908(76)90026-5 · Cited by 120
Drug‐induced discrimination: A description of the paradigm and a review of its specific application to the study of hallucinogenic agents
Glennon, R. A., Rosecrans, J. A., & Young, R. (1983) · Medicinal Research Reviews · doi:10.1002/med.2610030305 · Cited by 89
Self-citation
A BEHAVIOURAL AND BIOCHEMICAL STUDY IN RATS OF 5‐HYDROXYTRYPTAMINE RECEPTOR AGONISTS AND ANTAGONISTS, WITH OBSERVATIONS ON STRUCTURE‐ACTIVITY REQUIREMENTS FOR THE AGONISTS
GREEN, A. R., Hall, J., & Rees, A. R. (1981) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.1981.tb16806.x · Cited by 88
DOM-stimulus generalization to LSD and other hallucinogenic indolealkylamines
Glennon, R. A., Young, R., Jacyno, J. M., Slusher, M., & Rosecrans, J. A. (1983) · European Journal of Pharmacology · doi:10.1016/0014-2999(83)90196-6 · Cited by 67
Self-citation

Show all 22 references

Research works printed but not linked: 3

Leysen, 1981, Serotonergic receptors in brain tissue: properties and identification of various [3H]-ligand binding sites in vitro, J. Physiol. (Paris), 77, 351
Leysen, 1982, [3H]-ketanserin (R 41,468), a selective 3H-ligand for serotonin2 receptor binding sites, Mol. Pharmacol., 21, 301
Lucki, 1982, Behavioral effects of indole- and piperazine-type serotonin receptor agonists, Abstr. Soc. Neurosci., 8, 101

Sorted by citations

Psychedelics
Nichols, D. E. (2016) · Pharmacological Reviews · doi:10.1124/pr.115.011478 · Cited by 1,762
Hallucinogens
Nichols, D. E. (2004) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2003.11.002 · Cited by 1,211
Serotonin Receptors
Nichols, D. E., & Nichols, C. D. (2008) · Chemical Reviews · doi:10.1021/cr078224o · Cited by 895
Evidence for 5-HT2 involvement in the mechanism of action of hallucinogenic agents
Glennon, R. A., Titeler, M., & MCKENNEY, J. D. J. (1984) · Life Sciences · doi:10.1016/0024-3205(84)90436-3 · Cited by 635
Self-citation
Differences Between the Mechanism of Action of MDMA, MBDB, and the Classic Hallucinogens. Identification of a New Therapeutic Class: Entactogens
Nichols, D. E. (1986) · Journal of Psychoactive Drugs · doi:10.1080/02791072.1986.10472362 · Cited by 564
Classic psychedelics: An integrative review of epidemiology, therapeutics, mystical experience, and brain network function
Johnson, M. W., Hendricks, P. S., Barrett, F. S., & Griffiths, R. R. (2019) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2018.11.010 · Cited by 506
Multiple receptors contribute to the behavioral effects of indoleamine hallucinogens
Halberstadt, A. L., & Geyer, M. A. (2011) · Neuropharmacology · doi:10.1016/j.neuropharm.2011.01.017 · Cited by 435
Recent advances in the neuropsychopharmacology of serotonergic hallucinogens
Halberstadt, A. L. (2015) · Behavioural Brain Research · doi:10.1016/j.bbr.2014.07.016 · Cited by 312
“…and all legal disclaimers that apply to the journal pertain. anuscript A uthor M anuscript A uthor M anuscript A uthor M anuscript hallucinogens produce similar discriminative stimulus effects (Glennon et al., 1982) and act as agonists of the serotonin-2A (5-HT2A) receptor (Glennon et al., 1983).”
Background
Psychedelics and the Human Receptorome
Ray, T. S. (2010) · PLoS ONE · doi:10.1371/journal.pone.0009019 · Cited by 300
In vitro and in vivo neurochemical effects of methylenedioxymethamphetamine on striatal monoaminergic systems in the rat brain
Schmidt, C. J., Levin, J. A., & Lovenberg, W. M. (1987) · Biochemical Pharmacology · doi:10.1016/0006-2952(87)90729-5 · Cited by 297
The hallucinogenic world of tryptamines: an updated review
Araújo, A. M., Carvalho, F. D., Bastos, M. D. L., de Pinho, P. G., & Carvalho, M. C. (2015) · Archives of Toxicology · doi:10.1007/s00204-015-1513-x · Cited by 292
Correlation between the potency of hallucinogens in the mouse head-twitch response assay and their behavioral and subjective effects in other species
Halberstadt, A. L., Chatha, M., Klein, A. K., Wallach, J., & Brandt, S. D. (2020) · Neuropharmacology · doi:10.1016/j.neuropharm.2019.107933 · Cited by 278
Ritanserin, a 5-HT2 receptor antagonist, activates midbrain dopamine neurons by blocking serotonergic inhibition
Ugedo, L., Grenhoff, J., & Svensson, T. H. (1989) · Psychopharmacology · doi:10.1007/bf00442004 · Cited by 268
The behavioral pharmacology of hallucinogens
Fantegrossi, W. E., Murnane, K. S., & Reissig, C. J. (2007) · Biochemical Pharmacology · doi:10.1016/j.bcp.2007.07.018 · Cited by 238
Serotonergic basis of antipsychotic drug effects in schizophrenia
Lieberman, J. A., Mailman, R. B., Duncan, G., Sikich, L., Chakos, M., Nichols, D. E., & Kraus, J. E. (1998) · Biological Psychiatry · doi:10.1016/s0006-3223(98)00187-5 · Cited by 210
Clinical applications of hallucinogens: a review
Garcia-Romeu, A., Kersgaard, B., & Addy, P. H. (2016) · Experimental and Clinical Psychopharmacology · doi:10.1037/pha0000084 · Cited by 201
Behavioural stimulation is induced by separate dopamine D-1 and D-2 receptor sites in reserpine-pretreated but not in normal rats
Arnt, J. (1985) · European Journal of Pharmacology · doi:10.1016/0014-2999(85)90345-0 · Cited by 200
The promises and perils of psychedelic pharmacology for psychiatry
McClure‐Begley, T. D., & Roth, B. L. (2022) · Nature Reviews Drug Discovery · doi:10.1038/s41573-022-00421-7 · Cited by 202
The serotonergic system in Parkinson's disease
Huot, P., Fox, S. H., & Brotchie, J. M. (2011) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2011.08.004 · Cited by 195
Depression of rat brain tryptophan hydroxylase activity following the acute administration of methylenedioxymethamphetamine
Schmidt, C. J., & Taylor, V. L. (1987) · Biochemical Pharmacology · doi:10.1016/0006-2952(87)90566-1 · Cited by 187
Therapeutic Use of LSD in Psychiatry: A Systematic Review of Randomized-Controlled Clinical Trials
Fuentes, J. J., Fonseca, F., Elices, M., Farré, M., & Torrens, M. (2020) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2019.00943 · Cited by 177
The behavioural response to 5-HT receptor agonists and subtypes of the central 5-HT receptor
Tricklebank, M. D. (1985) · Trends in Pharmacological Sciences · doi:10.1016/0165-6147(85)90191-9 · Cited by 168
Hallucinogenic drug interactions with neurotransmitter receptor binding sites in human cortex
Pierce, P. A., & Peroutka, S. J. (1989) · Psychopharmacology · doi:10.1007/bf00443425 · Cited by 152
Substance-Induced Psychoses: An Updated Literature Review
Fiorentini, A., Cantù, F., Crisanti, C., Cereda, G., Oldani, L., & Brambilla, P. (2021) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2021.694863 · Cited by 135
The Acute Effects of Amphetamine Derivatives on Extracellular Serotonin and Dopamine Levels in Rat Nucleus Accumbens
Kankaanpää, A., Meririnne, E., Lillsunde, P. M., & Seppαlä, T. (1998) · Pharmacology Biochemistry and Behavior · doi:10.1016/s0091-3057(97)00527-3 · Cited by 140
3,4-Methylenedioxymethamphetamine (MDMA, "ecstasy") and its stereoisomers as reinforcers in rhesus monkeys: serotonergic involvement
Fantegrossi, W. E., Ullrich, T., Rice, K. C., Woods, J. H., & Winger, G. D. (2002) · Psychopharmacology · doi:10.1007/s00213-002-1021-6 · Cited by 132
PSD-95 Is Essential for Hallucinogen and Atypical Antipsychotic Drug Actions at Serotonin Receptors
Abbas, A. I., Yadav, P. N., Yao, W.-D., Arbuckle, M. I., Grant, S. G. N., Caron, M. G., & Roth, B. L. (2009) · Journal of Neuroscience · doi:10.1523/jneurosci.1090-09.2009 · Cited by 141
Distinct temporal phases in the behavioral pharmacology of LSD: dopamine D2 receptor-mediated effects in the rat and implications for psychosis
Marona‐Lewicka, D., Thisted, R. A., & Nichols, D. E. (2005) · Psychopharmacology · doi:10.1007/s00213-005-2183-9 · Cited by 134
Central serotonin receptors: effector systems, physiological roles and regulation
Conn, P. J., & Sanders‐Bush, E. (1987) · Psychopharmacology · doi:10.1007/bf00210830 · Cited by 133
Hallucinogenic drug interactions at human brain 5-HT2 receptors: Implications for treating LSD-induced hallucinogenesis
Sadzot, B., Baraban, J. M., Glennon, R. A., Lyon, R. A., Leonhardt, S., Jan, C.-R., & Titeler, M. (1989) · Psychopharmacology · doi:10.1007/bf00441948 · Cited by 132
Self-citation
Serotonin-S2 receptor binding sites and functional correlates
Leysen, J. E. (1984) · Neuropharmacology · doi:10.1016/0028-3908(84)90093-5 · Cited by 132
5-HT1 and 5-HT2 binding properties of derivatives of the hallucinugen 1-(2,5-dimethoxyphenyl)-2-aminopropane (2,5-DMA)
Shannon, M. H., Battaglia, G., Glennon, R. A., & Titeler, M. (1984) · European Journal of Pharmacology · doi:10.1016/0014-2999(84)90333-9 · Cited by 128
Self-citation
Recent developments in 5HT-related pharmacology of animal models of anxiety
Gardner, C. R. (1986) · Pharmacology Biochemistry and Behavior · doi:10.1016/0091-3057(86)90215-7 · Cited by 126
Toxicokinetics and Toxicodynamics of Ayahuasca alkaloids N,N-dimethyltryptamine (DMT), Harmine, Harmaline and Tetrahydroharmine: clinical and forensic impact
Brito-da-Costa, A. M., Dias-da-Silva, D., Gomes, N. G. M., Dinis-Oliveira, R. J., & Madureira-Carvalho, Á. (2020) · Pharmaceuticals · doi:10.3390/ph13110334 · Cited by 117
Electrophysiology of the Central Serotonin System: Receptor Subtypes and Transducer Mechanismsa
Aghajanian, G. K., Sprouse, J. S., Sheldon, P. W., & Rasmussen, K. (1990) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1990.tb16875.x · Cited by 117
Serotonergic Hallucinogen-Induced Visual Perceptual Alterations
Kometer, M., & Vollenweider, F. X. (2016) · Current topics in behavioral neurosciences · doi:10.1007/7854_2016_461 · Cited by 121
Effect of Hallucinogens on Unconditioned Behavior
Halberstadt, A. L., & Geyer, M. A. (2016) · Current topics in behavioral neurosciences · doi:10.1007/7854_2016_466 · Cited by 117
Serotonin Receptor Subtypes and Sexual Behaviora
Gorzalka, B. B., Mendelson, S. D., & Watson, N. V. (1990) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1990.tb16900.x · Cited by 107
Drug-induced penile erections in rats: indications of serotonin1B receptor mediation
Berendsen, H. H. G., & Broekkamp, C. L. E. (1987) · European Journal of Pharmacology · doi:10.1016/0014-2999(87)90676-5 · Cited by 105
Serotonin2 agonist administration down-regulates rat brain serotonin2 receptors
Buckholtz, N. S., Zhou, D., & Freedman, D. X. (1988) · Life Sciences · doi:10.1016/0024-3205(88)90342-6 · Cited by 106
5HT-2 mediation of acute behavioral effects of hallucinogens in rats
Wing, L. L., Tapson, G. S., & Geyer, M. A. (1990) · Psychopharmacology · doi:10.1007/bf02244617 · Cited by 97
Effect of hallucinogens on spontaneous and sensory-evoked locus coeruleus unit activity in the rat: reversal by selective 5-HT2antagonists
Rasmussen, K., & Aghajanian, G. K. (1986) · Brain Research · doi:10.1016/0006-8993(86)91090-5 · Cited by 103
Evidence for involvement of 5-HT2 and 5-HT1C receptors in the behavioral effects of the 5-HT agonist 1-(2,5-dimethoxy-4-iodophenyl aminopropane)-2 (DOI)
Pranzatelli, M. R. (1990) · Neuroscience Letters · doi:10.1016/0304-3940(90)90520-j · Cited by 93
“Selective” serotonin 5-HT2A receptor antagonists
Casey, A. B., Cui, M., Booth, R. G., & Canal, C. E. (2022) · Biochemical Pharmacology · doi:10.1016/j.bcp.2022.115028 · Cited by 94
Serotonergic regulation of noradrenergic coerulean neurons: electrophysiological evidence for the involvement of 5-HT2 receptors
Gorea, E., & Adrien, J. (1988) · European Journal of Pharmacology · doi:10.1016/0014-2999(88)90203-8 · Cited by 91
Hallucinations Under Psychedelics and in the Schizophrenia Spectrum: An Interdisciplinary and Multiscale Comparison
Leptourgos, P., Fortier, M., Carhart-Harris, R. L., Corlett, P. R., Dupuis, D., Halberstadt, A. L., Kometer, M., Kozáková, E., Larøi, F., Noorani, T. N., et al. (2020) · Schizophrenia Bulletin · doi:10.1093/schbul/sbaa117 · Cited by 90
Neuropharmacological reassessment of the discriminative stimulus properties ofd-lysergic acid diethylamide (LSD)
Cunningham, K. A., & Appel, J. B. (1987) · Psychopharmacology · doi:10.1007/bf00690929 · Cited by 85
A review and reevaluation of the role of serotonin in the modulation of lordosis behavior in the female rat
Mendelson, S. D. (1992) · Neuroscience & Biobehavioral Reviews · doi:10.1016/s0149-7634(05)80204-0 · Cited by 84
The Paradox of 5-Methoxy-N,N-Dimethyltryptamine
Winter, J. C., Filipink, R. A., Timineri, D. M., Helsley, S., & Rabin, R. A. (2000) · Pharmacology Biochemistry and Behavior · doi:10.1016/s0091-3057(99)00178-1 · Cited by 79
ECSTACY: A Review of MDMA and MDA
Climko, R. P., Roehrich, H., Sweeney, D. R., & Al-Razi, J. (1987) · The International Journal of Psychiatry in Medicine · doi:10.2190/dcrp-u22m-aumd-d84h · Cited by 78
Hallucinogens as discriminative stimuli in animals: LSD, phenethylamines, and tryptamines
Winter, J. C. (2009) · Psychopharmacology · doi:10.1007/s00213-008-1356-8 · Cited by 65
The role of dopamine and serotonin receptors in the mediation of the ethanol interoceptive cue
Signs, S. A., & Schechter, M. (1988) · Pharmacology Biochemistry and Behavior · doi:10.1016/0091-3057(88)90424-8 · Cited by 73
Discriminative stimulus properties of 8-hydroxy-2-(di-n-propylamino)tetralin (8-OHDPAT): implications for understanding the actions of novel anxiolytics
Cunningham, K. A., Callahan, P. M., & Appel, J. B. (1987) · European Journal of Pharmacology · doi:10.1016/0014-2999(87)90333-5 · Cited by 72
The Varieties of the Psychedelic Experience: A Preliminary Study of the Association Between the Reported Subjective Effects and the Binding Affinity Profiles of Substituted Phenethylamines and Tryptamines
Zamberlan, F., Sanz, C., Martínez Vivot, R., Pallavicini, C., Erowid, F., Erowid, E., & Tagliazucchi, E. (2018) · Frontiers in Integrative Neuroscience · doi:10.3389/fnint.2018.00054 · Cited by 71
Discriminative stimulus properties of the serotonergic agent 1-(2, 5-dimethoxy-4-iodophenyl)-2-aminopropane (DOI)
Glennon, R. A. (1986) · Life Sciences · doi:10.1016/0024-3205(86)90461-3 · Cited by 70
Self-citation
Serotonin receptor subtype mediation of the interoceptive discriminative stimuli induced by 5-methoxy-N,N-dimethyltryptamine
Spencer, D. G., Gläser, T., & Traber, J. (1987) · Psychopharmacology · doi:10.1007/bf00179927 · Cited by 69
[3H]DOB: A specific agonist radioligand for 5-HT2 serotonin receptors
Titeler, M., Herrick, K. F., Lyon, R. A., MCKENNEY, J. D. J., & Glennon, R. A. (1985) · European Journal of Pharmacology · doi:10.1016/0014-2999(85)90486-8 · Cited by 68
Self-citation
Evidence that 5‐HT2receptor activation decreases noradrenaline release in rat hippocampusin vivo
Done, C., & Sharp, T. (1992) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.1992.tb14493.x · Cited by 66
Serotonergic Receptor Subtypes and Hallucinogen-Induced Stimulus Control
Winter, J. C., Fiorella, D. J., Timineri, D. M., Filipink, R. A., Helsley, S., & Rabin, R. A. (1999) · Pharmacology Biochemistry and Behavior · doi:10.1016/s0091-3057(99)00063-5 · Cited by 64
Problems in in vitro receptor binding studies and identification and role of serotonin receptor sites
Leysen, J. E. (1984) · Neuropharmacology · doi:10.1016/0028-3908(84)90066-2 · Cited by 63
Screening for and validated quantification of phenethylamine‐type designer drugs and mescaline in human blood plasma by gas chromatography/mass spectrometry
Habrdová, V., Peters, F. T., Theobald, D. S., & Maurer, H. H. (2005) · Journal of Mass Spectrometry · doi:10.1002/jms.853 · Cited by 62
Discriminative stimulus properties of the 5-HT1A agonist 8-hydroxy-2-(di-n-propylamino) tetralin (8-OH DPAT)
Glennon, R. A. (1986) · Pharmacology Biochemistry and Behavior · doi:10.1016/0091-3057(86)90243-1 · Cited by 61
Self-citation
Cardiovascular safety of psychedelic medicine: current status and future directions
Wsół, A. (2023) · Pharmacological Reports · doi:10.1007/s43440-023-00539-4 · Cited by 71
Correction: Psychedelics and the Human Receptorome
Ray, T. S. (2010) · PLoS ONE · doi:10.1371/annotation/e580a864-cf13-40c2-9bd9-b9687a6f0fe4 · Cited by 58
Mianserin treatment of patients with psychosis induced by antiparkinsonian drugs
Ikeguchi, K., & Kuroda, A. (1995) · European Archives of Psychiatry and Clinical Neuroscience · doi:10.1007/bf02190411 · Cited by 57
Use of 5HT Receptor Agonists and Antagonists for the Characterization of Their Respective Receptor Sites
Leysen, J. E. (2003) · Humana Press eBooks · doi:10.1385/0-89603-122-5:299 · Cited by 56
[125I]-2-(2,5-Dimethoxy-4-Iodophenyl) aminoethane ([125I]-2C-I) as a label for the 5-HT2 receptor in rat frontal cortex
Johnson, M. P., Mathis, C. A., Shulgin, A. T., Hoffman, A. J., & Nichols, D. E. (1990) · Pharmacology Biochemistry and Behavior · doi:10.1016/0091-3057(90)90228-a · Cited by 55
Psychedelics as Transformative Therapeutics
Roth, B. L., & Gumpper, R. H. (2023) · American Journal of Psychiatry · doi:10.1176/appi.ajp.20230172 · Cited by 57
Discriminative Stimulus Effects of 1-(2,5-Dimethoxy-4-methylphenyl)-2-aminopropane in Rhesus Monkeys
Li, J., Rice, K. C., & France, C. P. (2007) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.107.130625 · Cited by 52
Behavioral profile of constituents in ayahuasca, an Amazonian psychoactive plant mixture
Freedland, C. S., & Mansbach, R. S. (1999) · Drug and Alcohol Dependence · doi:10.1016/s0376-8716(98)00154-9 · Cited by 51
MDA: A psychoactive agent with dual stimulus effects
Glennon, R. A., & Young, R. (1984) · Life Sciences · doi:10.1016/0024-3205(84)90627-1 · Cited by 49
Self-citation
TFMPP may produce its stimulus effects via a 5-HT1B mechanism
MCKENNEY, J. D. J., & Glennon, R. A. (1986) · Pharmacology Biochemistry and Behavior · doi:10.1016/0091-3057(86)90042-0 · Cited by 49
Self-citation
Serotonergic Psychedelics: Experimental Approaches for Assessing Mechanisms of Action
Canal, C. E. (2018) · Handbook of experimental pharmacology · doi:10.1007/164_2018_107 · Cited by 50
Discriminative stimulus properties of the serotonin agonist 1-(3-trifluoromethylphenyl) piperazine (TFMPP)
Glennon, R. A., MCKENNEY, J. D. J., & Young, R. (1984) · Life Sciences · doi:10.1016/0024-3205(84)90164-4 · Cited by 47
Self-citation
Mindfulness meditation and psychedelics: potential synergies and commonalities
Holas, P., & Kamińska, J. (2023) · Pharmacological Reports · doi:10.1007/s43440-023-00551-8 · Cited by 43
“Psychedelics, on the other hand, offer a shortcut to such states, but their effects can be temporary and influenced by external factors [29, [58].”
BackgroundMethod
Structure–Activity Relationships of Phenylalkylamines as Agonist Ligands for 5‐HT2A Receptors
Blaazer, A. R., Smid, P., & Kruse, C. G. (2008) · ChemMedChem · doi:10.1002/cmdc.200800133 · Cited by 43
Binding to the serotonin 5-HT2 receptor by the enantiohers of 125I-DOI
Johnson, M. P., Hoffman, A. J., Nichols, D. E., & Mathis, C. A. (1987) · Neuropharmacology · doi:10.1016/0028-3908(87)90138-9 · Cited by 41
Inhibition of SKF 38393- and pergolide-induced circling in rats with unilateral 6-OHDA lesion is correlated to dopamine D-1 and D-2 receptor affinitiesin vitro
Arnt, J., & Hyttel, J. (1986) · Journal of Neural Transmission · doi:10.1007/bf01243350 · Cited by 41
Mechanistic investigation of the stimulus properties of 1-(3-trifluoromethylphenyl) piperazine
Herndon, J. L., Pierson, M. E., & Glennon, R. A. (1992) · Pharmacology Biochemistry and Behavior · doi:10.1016/0091-3057(92)90403-3 · Cited by 40
Self-citation
Mechanistic studies on DOM as a discriminative stimulus
Glennon, R. A., & Hauck, A. E. (1985) · Pharmacology Biochemistry and Behavior · doi:10.1016/0091-3057(85)90096-6 · Cited by 40
Self-citation
Interactions between serotonergic agonists and antagonists in rats trained with LSD as a discriminative stimulus
Winter, J. C., & Rabin, R. A. (1988) · Pharmacology Biochemistry and Behavior · doi:10.1016/0091-3057(88)90074-3 · Cited by 40
Bioactive Alkaloids of Hallucinogenic Mushrooms
Wieczorek, P. P., Witkowska, D., Jasicka-Misiak, І., Poliwoda, A., Oterman, M., & Zielińska, K. (2015) · Studies in natural products chemistry · doi:10.1016/b978-0-444-63462-7.00005-1 · Cited by 44
Complex discriminative stimulus properties of (+)lysergic acid diethylamide (LSD) in C57Bl/6J mice
Benneyworth, M. A., Smith, R. L., Barrett, R. J., & Sanders‐Bush, E. (2005) · Psychopharmacology · doi:10.1007/s00213-004-2108-z · Cited by 38
The head-twitch response in the least shrew (Cryptotis parva) is a 5-HT2− and not a 5-HT1C-mediated phenomenon
Darmani, N. A., Mock, O. B., Towns, L. C., & Gerdes, C. (1994) · Pharmacology Biochemistry and Behavior · doi:10.1016/0091-3057(94)90542-8 · Cited by 38
Serotonergic modulation of the discriminative-stimulus effects of cocaine in squirrel monkeys
Schama, K. F., Howell, L. L., & Byrd, L. D. (1997) · Psychopharmacology · doi:10.1007/s002130050316 · Cited by 38
Serotonin type 2 antagonists inhibit lordosis behavior in the female rat: Reversal with quipazine
Mendelson, S. D., & Gorzalka, B. B. (1986) · Life Sciences · doi:10.1016/0024-3205(86)90272-9 · Cited by 38
Site-Selective Serotonin Agonists as Discriminative Stimuli
Glennon, R. A. (1988) · Springer eBooks · doi:10.1007/978-3-642-73223-2_2 · Cited by 37
Self-citation
Serotonin antagonist pirenperone inhibits sexual behavior in the male rat: Attenuation by quipazine
Mendelson, S. D., & Gorzalka, B. B. (1985) · Pharmacology Biochemistry and Behavior · doi:10.1016/0091-3057(85)90276-x · Cited by 36
Local Cerebral Glucose Utilisation Following Indoleamine‐ and Piperazine‐Containing 5‐Hydroxytryptamine Agonists
Grome, J. J., & Harper, A. M. (1986) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1986.tb12933.x · Cited by 39
Synthesis and pharmacological evaluation of N-benzyl substituted 4-bromo-2,5-dimethoxyphenethylamines as 5-HT2A/2C partial agonists
Hansen, M., Jacobsen, S. E., Plunkett, S., Liebscher, G., McCorvy, J. D., Bräuner‐Osborne, H., & Kristensen, J. L. (2014) · Bioorganic & Medicinal Chemistry · doi:10.1016/j.bmc.2014.12.011 · Cited by 35
Further studies on N-methyl-1(3, 4-methylenedioxyphenyl)-2-aminopropane as a discriminative stimulus: Antagonism by 5-hydroxytryptamine3 antagonists
Glennon, R. A., Higgs, R., Young, R., & Issa, H. (1992) · Pharmacology Biochemistry and Behavior · doi:10.1016/0091-3057(92)90488-2 · Cited by 35
Self-citation
Involvement of 5-HT receptor subtypes in the discriminative stimulus properties of mescaline
Appel, J. B., & Callahan, P. M. (1989) · European Journal of Pharmacology · doi:10.1016/0014-2999(89)90041-1 · Cited by 34
Behavioral Models of Serotonin Receptor Activation
Glennon, R. A., & Lucki, I. (1988) · Humana Press eBooks · doi:10.1007/978-1-4612-4560-5_9 · Cited by 33
Self-citation
Preclinical perspectives on the mechanisms underlying the therapeutic actions of psilocybin in psychiatric disorders
Wulff, A. B., Nichols, C. D., & Thompson, S. M. (2023) · Neuropharmacology · doi:10.1016/j.neuropharm.2023.109504 · Cited by 35
Behavioral effects of the highly selective serotonin releasing agent 5-methoxy-6-methyl-2-aminoindan
Marona‐Lewicka, D., & Nichols, D. E. (1994) · European Journal of Pharmacology · doi:10.1016/0014-2999(94)90051-5 · Cited by 31
The 5-HT 3 agent N -(3-chlorophenyl)guanidine (MD-354) serves as a discriminative stimulus in rats and displays partial agonist character in a shrew emesis assay
Dukat, M., Young, R., Darmani, N. N., Ahmed, B., & Glennon, R. A. (2000) · Psychopharmacology · doi:10.1007/s002130000410 · Cited by 30
Self-citation
A comparison of N,N-dimethyltryptamine, harmaline, and selected congeners in rats trained with LSD as a discriminative stimulus
Helsley, S., Fiorella, D. J., Rabin, R. A., & Winter, J. C. (1998) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/s0278-5846(98)00031-1 · Cited by 30
Serotonin receptor mechanisms mediate the discriminative stimulus properties of the atypical antipsychotic clozapine in C57BL/6 mice
Philibin, S. D., Prus, A. J., Pehrson, A. L., & Porter, J. H. (2005) · Psychopharmacology · doi:10.1007/s00213-005-2147-0 · Cited by 29
Activation is Hallucinogenic and Antagonism is Therapeutic: Role of 5-HT2A Receptors in Atypical Antipsychotic Drug Actions
Roth, B. L., Willins, D. L., Kristiansen, K., & Kroeze, W. K. (1999) · The Neuroscientist · doi:10.1177/107385849900500414 · Cited by 28
The G protein biased serotonin 5-HT2A receptor agonist lisuride exerts anti-depressant drug-like activities in mice
Pogorelov, V. M., Rodriguiz, R. M., Roth, B. L., & Wetsel, W. C. (2023) · Frontiers in Molecular Biosciences · doi:10.3389/fmolb.2023.1233743 · Cited by 35

Authors: Glennon, R. A., Young, R., & Rosecrans, J. A.
Affiliations: Virginia Commonwealth University (US)
Corresponding author: Glennon, Richard A.
ORCID: Glennon, Richard A.
Young, Richard
Venue: European Journal of Pharmacology
Publisher: Elsevier BV
Published: 1983-07
Volume: 91
Issue: 2-3
Pages: 189-196
ISSN: 0014-2999 (ISSN-L)
DOI: 10.1016/0014-2999(83)90464-8
OpenAlex: W1983135802
Cited by: 190
References: 22
Citations by year: 2026: 5 · 2025: 7 · 2024: 5 · 2023: 7 · 2022: 6 · 2021: 2 · 2020: 7 · 2019: 1 · 2018: 5 · 2017: 1 · 2016: 4 · 2015: 2 · 2014: 3
FWCI: 15.17
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: European Journal of Pharmacology (publishedVersion)
PubMed (publishedVersion)
Topics: Social Sciences › Psychology › Clinical Psychology › Psychedelics and Drug Studies
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Life Sciences › Neuroscience › Cognitive Neuroscience › Hallucinations in medical conditions
Keywords: DOM, 5-HT2 receptor antagonist, quipazine, ketanserin, pirenperone, mescaline, LSD, hallucinogens, TFMPP, RU 24969, serotonin receptor agonists
MeSH terms: Amphetamines, Animals, DOM 2,5-Dimethoxy-4-Methylamphetamine, Ketanserin, Male, Piperidines, Quinolines, Quipazine, Rats, Inbred Strains, Serotonin Antagonists, Rats

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Antagonism of the effects of the hallucinogen dom and the purported 5-HT agonist quipazine by 5-HT2 antagonists

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks