Major tranquillizers can be distinguished from minor tranquillizers on the basis of effects on marble burying and swim-induced grooming in mice

Broekkamp, Chris L.; Rijk, Huub W.; Joly-Gelouin, Danielle; Lloyd, Kenneth L.

doi:10.1016/0014-2999(86)90051-8

Major tranquillizers can be distinguished from minor tranquillizers on the basis of effects on marble burying and swim-induced grooming in mice

The effects of psychotropic compounds on grooming and burying were compared in mice. Burying behaviour was provoked by glass marbles and grooming was observed after 3 min swimming. Compounds with minor tranquilizing properties, such as diazepam, chlordiazepoxide, flunitrazepam, clonazepam, meprob…