Characterization of methamphetamine effects on the striatal-nigral dynorphin system
Abstract
Multiple high doses of methamphetamine (METH) induced 200-300% increases in the concentration of striatal and nigral dynorphin-like immunoreactivity (DLI). Increases in striatal and nigral DLI levels also were seen within 6 h following a single administration. The changes in the striatal-nigral dynorphin system had subsided 48 h after either acute or multiple treatments with METH. Selective lesioning of the nigral-striatal dopamine pathway blocked the effects; thus, the METH-induced changes appeared to be mediated by dopamine released from the nigral-striatal dopamine projection. Administration of the METH analog, 3,4-methylenedioxymethamphetamine, appeared to alter striatal and nigral DLI concentrations in a manner similar to that of METH.
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Drugs of abuse cause dynorphin release and up-regulation of dynorphin in the dorsal and ventral striatum, which inhibits dopamine release by acting on KOR receptors and is therefore thought to be compensatory.
“Drugs of abuse cause dynorphin release and up-regulation of dynorphin in the dorsal and ventral striatum, which inhibits DA release by acting on KOR receptors and is therefore thought to be compensatory (Hanson et al 1988; Sivam 1989; Spanagel et al 1990; Hurd et al 1992; Daunais et al 1993; El Daly et al 2000; Isola et al 2009).”
From The behavioral, anatomical and pharmacological parallels between social attachment, love and addiction (2012) · cites this paper as Hanson et al 1988
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“Drugs of abuse cause dynorphin release and upregulation of dynorphin in the dorsal and ventral striatum, which inhibits DA release by acting on KOR and is, therefore, thought to be compensatory (Hanson et al. 1988; Sivam 1989; Spanagel et al. 1990; Hurd et al. 1992; Daunais et al. 1993; El Daly et al. 2000; Isola et a…”
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- Authors
- Hanson, G. R., Merchant, K. M., Letter, A. A., Bush, L., & Gibb, J. W.
- Affiliations
- University of Utah (US)
- Corresponding author
- Hanson, Glen R.
- ORCID
- Merchant, Kalpana M.
- Venue
- European Journal of Pharmacology
- Publisher
- Elsevier BV
- Published
- 1988-10
- Volume
- 155
- Issue
- 1-2
- Pages
- 11-18
- ISSN
- 0014-2999 (ISSN-L)
- OpenAlex
- W2004560227
- Cited by
- 77
- References
- 33
- Citations by year
- 2025: 1 · 2017: 1 · 2015: 1 · 2014: 2 · 2012: 1
- FWCI
- 1.38
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- European Journal of Pharmacology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- U.S. Public Health Service
- National Institute on Drug Abuse (DA 00869, DA 04222)
- National Institute of General Medical Sciences (GM07579)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
- Health Sciences › Medicine › Neurology › Parkinson's Disease Mechanisms and Treatments
- Keywords
- methamphetamine, striatum, substantia nigra, dopamine release, 3,4-methylenedioxymethamphetamine
- MeSH terms
- Animals, Corpus Striatum, Dynorphins, Hydroxydopamines, Male, Methamphetamine, Radioimmunoassay, Rats, Inbred Strains, Substantia Nigra, Sympathectomy, Chemical, 3,4-Methylenedioxyamphetamine, Oxidopamine, N-Methyl-3,4-methylenedioxyamphetamine, Rats
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