Evidence that manganese inhibits an early event during stimulation of lymphocytes by mitogens
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High manganese suppresses lymphocyte proliferation.
“However, high manganese also inhibits lymphocyte proliferation (Hart, 1978)”
From The Impact of Dietary Transition Metals on Host-Bacterial Interactions (2018) · cites this paper as Hart, 1978
Cites
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Voltage-gated potassium channels are required for human T lymphocyte activation.
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“However, high manganese also inhibits lymphocyte proliferation (Hart, 1978), exemplifying how balancing metal levels is necessary for optimum immune function.”
BackgroundVoltage-dependent ion channels in T-lymphocytes
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(1985) · Elsevier eBooks · doi:10.1016/b978-0-12-281450-1.50019-2
- Authors
- Hart, D. A.
- Affiliations
- University of Texas Health Science Center at Dallas (US)
- Corresponding author
- Hart, D.A.
- ORCID
- Hart, D.A.
- Venue
- Experimental Cell Research
- Publisher
- Elsevier BV
- Published
- 1978-04
- Volume
- 113
- Issue
- 1
- Pages
- 139-150
- ISSN
- 0014-4827 (ISSN-L)
- OpenAlex
- W1988073771
- Cited by
- 21
- References
- 19
- Citations by year
- 2018: 1 · 2017: 1
- FWCI
- 1.63
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Experimental Cell Research (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › Immunotoxicology and immune responses
- Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
- Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Heavy Metal Exposure and Toxicity
- Keywords
- manganese, mitogen stimulation, lymphocyte proliferation, B cells, T cells, concanavalin A, phytohemagglutinin, calcium, strontium, thymidine incorporation, lymphocyte activation
- MeSH terms
- Calcium, Concanavalin A, Lymphocyte Activation, Lymphocytes, Manganese, Mitogens, Strontium, Time Factors, Lectins
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