The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Protection against lipid peroxidation by a microsomal glutathione‐dependent labile factor
Abstract
Glutathione (GSH) protects rat liver microsomes against ascorbic acid (0.2 mM)/ferrous iron (10 μM)‐induced lipid peroxidation for some time. The inhibitory effect of GSH is concentration‐dependent (0.1–1.0 mM). Our data suggest that GSH acts by preventing initial radical formation rather than via radical scavenging or GSH—peroxidase activity. A labile GSH‐dependent factor is involved in the inhibition of microsomal lipid peroxidation by GSH, inasmuch as heating the microsomes abolishes the GSH effect. We found that besides heating, lipid peroxidation also destroys the GSH‐dependent factor. Consequently, continuous radical stress will produce lipid peroxidation, despite the presence of GSH. Moreover, a detrimental effect of in vivo‐induced lipid peroxidation (CCl 4‐treatment) on the GSH‐dependent factor was observed. The implications of the present data for the genesis of and the protection against peroxidative damage are discussed.
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Citations
Cites
Ursini, F., Maiorino, M., Valente, M., Ferri, L., & Gregolin, C. (1982) · Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism · doi:10.1016/0005-2760(82)90150-3 · Cited by 884
Cited by
The selenoenzyme phospholipid hydroperoxide glutathione peroxidase
Ursini, F., Maiorino, M., & Gregolin, C. (1985) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/0304-4165(85)90182-5 · Cited by 990
Lipid Peroxidation: Mechanisms, Analysis, Enzymology and Biological Relevance
KAPPUS, H. (1985) · Oxidative Stress · doi:10.1016/b978-0-12-642760-8.50016-8 · Cited by 527
Wells, W. W., Xu, D. P., Yang, Y. F., & Rocque, P. A. (1990) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)55401-6 · Cited by 450
Lipid Peroxidation and Mechanisms of Toxicity
Horton, A. A., Fairhurst, S., & Bus, J. S. (1987) · CRC Critical Reviews in Toxicology · doi:10.3109/10408448709089856 · Cited by 339
Rezk, B. M., Haenen, G. R. M. M., van der Vijgh, W. J. F., & Bast, A. (2002) · Biochemical and Biophysical Research Communications · doi:10.1016/s0006-291x(02)00618-6 · Cited by 301
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Metadata
- Authors
- Haenen, G. R. M. M., & Bast, A.
- Venue
- FEBS Letters
- Publisher
- Wiley
- Published
- 1983-08-08
- Volume
- 159
- Issue
- 1-2
- Pages
- 24-28
- ISSN
- 0014-5793 (ISSN-L)
- 1873-3468
- OpenAlex
- W2092957609
- Cited by
- 174
- References
- 1
- FWCI
- 5.32
- Type
- journal article
- Language
- en
- Open access
- closed
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- Haenen, G. R. M. M., & Bast, A. (1983). Protection against lipid peroxidation by a microsomal glutathione‐dependent labile factor. FEBS Letters. https://doi.org/10.1016/0014-5793(83)80409-8
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
