The DOI matches its Crossref record; 9 of the 9 references it cites were found in a registry or an index.
Lipid Peroxidation and Mechanisms of Toxicity
Abstract
Aerobic organisms by definition require oxygen, and the importance of iron in aerobic respiration has long been recognized, but despite their beneficial roles, these elements can pose a real threat to the organism. During oxygen reduction, reactive species such as O2-. and H2O2 are formed readily. Iron can combine with these species, or with molecular oxygen itself, to generate free radicals which will attack the polyunsaturated fatty acids of membrane lipids. This oxidative deterioration of membrane lipids is known as lipid peroxidation. To protect itself against this form of attack, the organism possesses several types of defense mechanisms. Under normal conditions, these defenses appear to offer adequate protection for cell membranes, but the possibility exists that certain foreign compounds may interfere with or even overwhelm these defenses, and herein could lie a general mechanism of toxicity. This possible cause of toxicity is discussed in relation to other suggested causes.
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Citations
Cites
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Benedetti, A., Comporti, M., & Esterbauer, H. (1980) · Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism · doi:10.1016/0005-2760(80)90209-x · Cited by 1,085
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Iron-catalyzed hydroxyl radical formation. Stringent requirement for free iron coordination site.
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Glutathione Peroxidase, V. The kinetic mechanism
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Cited by
Transition metals as catalysts of “autoxidation” reactions
Miller, D. (1990) · Free Radical Biology and Medicine · doi:10.1016/0891-5849(90)90148-c · Cited by 739
Chauhan, A., & Chauhan, V. (2006) · Pathophysiology · doi:10.1016/j.pathophys.2006.05.007 · Cited by 656
Red blood cell oxidative stress impairs oxygen delivery and induces red blood cell aging
Mohanty, J. G., Nagababu, E., & Rifkind, J. M. (2014) · Frontiers in Physiology · doi:10.3389/fphys.2014.00084 · Cited by 595
“Keywords: red blood cells, oxidative Stress, deformability, heme degradation, cellular aging”
BackgroundOxidative Stress and Psychological Disorders
Salim, S. (2014) · Current Neuropharmacology · doi:10.2174/1570159x11666131120230309 · Cited by 557
Chauhan, A., Chauhan, V., Brown, W. T., & Cohen, I. (2004) · Life Sciences · doi:10.1016/j.lfs.2004.04.038 · Cited by 424
Metadata
- Authors
- Horton, A. A., Fairhurst, S., & Bus, J. S.
- Venue
- CRC Critical Reviews in Toxicology
- Publisher
- Informa UK Limited
- Published
- 1987-01
- Volume
- 18
- Issue
- 1
- Pages
- 27-79
- ISSN
- 0045-6446 (ISSN-L)
- OpenAlex
- W2126811697
- Cited by
- 339
- References
- 9
- FWCI
- 11.03
- Type
- journal article
- Language
- en
- Open access
- closed
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- Horton, A. A., Fairhurst, S., & Bus, J. S. (1987). Lipid Peroxidation and Mechanisms of Toxicity. CRC Critical Reviews in Toxicology. https://doi.org/10.3109/10408448709089856
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
