Studies on the mechanism of inhibition of hepatic cAMP accumulation by vasopressin
Abstract
Vasopressin elicited a dose‐dependent inhibition of glucagon‐induced cAMP accumulation in isolated hepatocytes. This response was not diminished by incubation of cells with the calmodulin antagonists trifluoperazine or chlorpromazine and was only slightly reduced in Ca 2+‐depleted hepatocytes. Half‐maximal inhibition of cAMP accumulation occurred at 8 × 10‐11 M vasopressin, a dose which does not increase cytosolic Ca 2+ in hepatocytes. Direct activation of adenylate cyclase by forskolin was significantly inhibited by vasopressin in Ca 2+‐depleted cells. It is concluded that inhibition of hormone‐induced cAMP accumulation by vasopressin in liver is not dependent on cellular Ca 2+ mobilisation but may involve direct inhibition of adenylate cyclase.
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In hepatocytes, interactions between the V1a receptor and the glucagon receptor and their signalling pathways have been reported.
“Crosstalk between V1aR and glucagon receptor and their signalling pathways has been described also in hepatocytes [37,38].”
From Vasopressin and hydration play a major role in the development of glucose intolerance and hepatic steatosis in obese rats (2015) · cites this paper as [37]
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Taveau, C., Chollet, C., Waeckel, L., Desposito, D., Bichet, D. G., Arthus, M.-F., Magnan, C., Philippe, E., Paradis, V., Foufelle, F., et al. (2015) · Diabetologia · doi:10.1007/s00125-015-3496-9 · Cited by 86 · see citing works
- Authors
- Morgan, N. G., Shipp, C. C., & Exton, J. H.
- Affiliations
- Howard Hughes Medical Institute (US)
- ORCID
- Morgan, Noel G.
- Venue
- FEBS Letters
- Publisher
- Wiley
- Published
- 1983-11-14
- Volume
- 163
- Issue
- 2
- Pages
- 277-281
- ISSN
- 0014-5793 (ISSN-L)
- 1873-3468
- OpenAlex
- W1967615830
- Cited by
- 26
- References
- 19
- Citations by year
- 2017: 1 · 2015: 1
- FWCI
- 0.79
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- FEBS Letters (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Receptor Mechanisms and Signaling
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Protein Kinase Regulation and GTPase Signaling
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Phosphodiesterase function and regulation
- Keywords
- vasopressin, cAMP accumulation, hepatocytes, glucagon, adenylate cyclase inhibition, calmodulin, calcium depletion, forskolin, liver
- MeSH terms
- Cyclic AMP, Adenylyl Cyclases, Animals, Calcium, Calmodulin, Chlorpromazine, Diterpenes, Dose-Response Relationship, Drug, Enzyme Activation, Colforsin, Glucagon, Liver, Male, Rats, Inbred Strains, Trifluoperazine, Vasopressins, Rats, In Vitro Techniques
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