The DOI matches its Crossref record.
The cleavable prepiece of an imported mitochondrial protein is sufficient to direct cytosolic dihydrofolate reductase into the mitochondrial matrix
Open accessAbstract
The cleavable prepiece of the precursor to yeast cytochrome c oxidase subunit IV (an imported mitochondrial protein) was attached to the amino‐terminus of mouse dihydrofolate reductase (a cytosolic protein) by gene fusion. The resulting fusion protein was imported into the matrix of isolated, energized yeast mitochondria and cleaved to a polypeptide whose size was similar to that of authentic dihydrofolate reductase.
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Citations
Cited by
Binding of a specific ligand inhibits import of a purified precursor protein into mitochondria
Eilers, M., & Schatz, G. (1986) · Nature · doi:10.1038/322228a0 · Cited by 720
Self-citationProtein Sorting to Mitochondria: Evolutionary Conservations of Folding and Assembly
Hartl, F.-U., & Neupert, W. (1990) · Science · doi:10.1126/science.2406905 · Cited by 489
Randall, L. L., & Hardy, S. J. S. (1986) · Cell · doi:10.1016/0092-8674(86)90074-7 · Cited by 466
Selective targeting of bioactive compounds to mitochondria
Murphy, M. P. (1997) · Trends in Biotechnology · doi:10.1016/s0167-7799(97)01068-8 · Cited by 366
Hartl, F.-U., Schmidt, B., Wachter, E., Weiss, H., & Neupert, W. (1986) · Cell · doi:10.1016/0092-8674(86)90809-3 · Cited by 334
Metadata
- Authors
- Hurt, E. C., Pesold-Hurt, B., & Schatz, G.
- Venue
- FEBS Letters
- Publisher
- Wiley
- Published
- 1984-12-10
- Volume
- 178
- Issue
- 2
- Pages
- 306-310
- ISSN
- 0014-5793 (ISSN-L)
- 1873-3468
- OpenAlex
- W2002012495
- Cited by
- 196
- References
- 0
- FWCI
- 8.32
- Type
- journal article
- Language
- en
- Open access
- bronze
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- CoChat. (2026). Citation check: The cleavable prepiece of an imported mitochondrial protein is sufficient to direct cytosolic dihydrofolate reductase into the mitochondrial matrix. https://app.cochat.ai/papers/10.1016/0014-5793(84)80622-5
- The paper
- Hurt, E. C., Pesold-Hurt, B., & Schatz, G. (1984). The cleavable prepiece of an imported mitochondrial protein is sufficient to direct cytosolic dihydrofolate reductase into the mitochondrial matrix. FEBS Letters. https://doi.org/10.1016/0014-5793(84)80622-5
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
