Selective targeting of bioactive compounds to mitochondria
Abstract
Mitochondrial function can be manipulated selectively by targeting bioactive compounds to mitochondria in living cells. Current targeting mechanisms involve harnessing either the mitochondrial membrane potential or the mitochondrial protein-import machinery to take up molecules linked to lipophilic cations or mitochondrial signal peptides, respectively. Compounds localized like this have been used in studies of mitochondrial metabolism and show potential as anticancer drugs. In addition, because mitochondria play a role in many critical cell processes, mitochondrial targeting has the potential to protect, repair or kill cells selectively, and may become a key tool in the development of gene therapy for mitochondrial DNA diseases.
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Cationic triphenylphosphonium-conjugated molecules accumulate in the mitochondrial matrix by many fold.
“The accumulation in the matrix should be very large, as cationic triphenylphosphonium-conjugated molecules accumulate by many fold (230).”
From Mitochondrial Dysfunction in Diabetes: From Molecular Mechanisms to Functional Significance and Therapeutic Opportunities (2010) · cites this paper as [230]
By virtue of their delocalized positive charge, these agents accumulate several hundredfold in mitochondria.
“By virtue of their delocalized positive charge, these agents accumulate several hundredfold in mitochondria (230).”
From Mitochondrial Dysfunction in Diabetes: From Molecular Mechanisms to Functional Significance and Therapeutic Opportunities (2010) · cites this paper as [230]
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Self-citation
- Authors
- Murphy, M. P.
- Affiliations
- University of Otago (NZ)
- Corresponding author
- Murphy, Michael P.
- ORCID
- Murphy, Michael P.
- Venue
- Trends in Biotechnology
- Publisher
- Elsevier BV
- Published
- 1997-08
- Volume
- 15
- Issue
- 8
- Pages
- 326-330
- ISSN
- 0167-7799 (ISSN-L)
- OpenAlex
- W2013970530
- Cited by
- 366
- References
- 36
- Citations by year
- 2026: 7 · 2025: 17 · 2024: 20 · 2023: 16 · 2022: 21 · 2021: 17 · 2020: 19 · 2019: 16 · 2018: 15 · 2017: 19 · 2016: 17 · 2015: 16 · 2014: 8 · 2013: 15 · 2012: 11
- FWCI
- 0.33
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Trends in biotechnology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mitochondrial Function and Pathology
- Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
- Health Sciences › Medicine › Epidemiology › Autophagy in Disease and Therapy
- Keywords
- mitochondrial targeting, bioactive compounds, mitochondrial membrane potential, mitochondrial protein import, lipophilic cations, mitochondrial metabolism, anticancer agents, mitochondrial DNA disease, gene therapy
- MeSH terms
- Antineoplastic Agents, Humans, Mitochondria, Protein Sorting Signals
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