Cited by 366Mitochondrial Function and PathologyNanoparticle-Based Drug DeliveryAutophagy in Disease and Therapy

Selective targeting of bioactive compounds to mitochondria

Murphy, Michael P.·1997·Trends in Biotechnology

Abstract

Mitochondrial function can be manipulated selectively by targeting bioactive compounds to mitochondria in living cells. Current targeting mechanisms involve harnessing either the mitochondrial membrane potential or the mitochondrial protein-import machinery to take up molecules linked to lipophilic cations or mitochondrial signal peptides, respectively. Compounds localized like this have been used in studies of mitochondrial metabolism and show potential as anticancer drugs. In addition, because mitochondria play a role in many critical cell processes, mitochondrial targeting has the potential to protect, repair or kill cells selectively, and may become a key tool in the development of gene therapy for mitochondrial DNA diseases.

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Crossref · 10.1016/s0167-7799(97)01068-8

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36 of 36 references verified0 citation errors · 0 not checkable

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Authors
Murphy, M. P.
Affiliations
University of Otago (NZ)
Corresponding author
Murphy, Michael P.
Venue
Trends in Biotechnology
Publisher
Elsevier BV
Published
1997-08
Volume
15
Issue
8
Pages
326-330
ISSN
0167-7799 (ISSN-L)
OpenAlex
W2013970530
Cited by
366
References
36
Citations by year
2026: 7 · 2025: 17 · 2024: 20 · 2023: 16 · 2022: 21 · 2021: 17 · 2020: 19 · 2019: 16 · 2018: 15 · 2017: 19 · 2016: 17 · 2015: 16 · 2014: 8 · 2013: 15 · 2012: 11
FWCI
0.33
Type
journal article
Language
en
Open access
closed
Locations
  • Trends in biotechnology (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mitochondrial Function and Pathology
  • Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
  • Health Sciences › Medicine › Epidemiology › Autophagy in Disease and Therapy
Keywords
mitochondrial targeting, bioactive compounds, mitochondrial membrane potential, mitochondrial protein import, lipophilic cations, mitochondrial metabolism, anticancer agents, mitochondrial DNA disease, gene therapy
MeSH terms
Antineoplastic Agents, Humans, Mitochondria, Protein Sorting Signals

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