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The structure of the voltage‐sensitive sodium channel: Inferences derived from computer‐aided analysis of the Electrophorus electricus channel primary structure
Abstract
A variety of computer‐aided analyses was applied to the recently derived amino acid sequence of the Electrophorus electricus sodium channel protein in order to extract structural information such as hydrophobicity, periodicity, and secondary structure predictors. We propose a schematic model for the arrangement and folding of the polypeptide chain within the bilayer. The model consists of 4 homologous regions, each containing 8 membrane‐spanning (probably α‐helical) structures. Several of these structures are amphipathic with a repeat of 3.5 residues, 4 of which (one from each homologous region) are postulated to form a negatively charged channel lining. Gating currents are proposed to arise from voltage‐dependent separation of multiple ion pairs buried within the hydrophobic, intramembranous protein interior.
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Cites
Needleman, S. B., & Wunsch, C. D. (1970) · Journal of Molecular Biology · doi:10.1016/0022-2836(70)90057-4 · Cited by 11,288
Cited by
Synthetic Amphiphilic Peptide Models for Protein Ion Channels
Lear, J. D., Wasserman, Z. R., & DeGrado, W. F. (1988) · Science · doi:10.1126/science.2453923 · Cited by 607
Exchange of Conduction Pathways Between Two Related K + Channels
Hartmann, H. A., Kirsch, G. E., Drewe, J. A., Taglialatela, M., Joho, R. H., & Brown, A. M. (1991) · Science · doi:10.1126/science.2000495 · Cited by 385
A rat brain na+ channel α subunit with novel gating properties
Auld, V. J., Goldin, A. L., Krafte, D. S., Marshall, J., Dunn, J. M., Catterall, W. A., Lester, H. A., Davidson, N., & Dunn, R. J. (1988) · Neuron · doi:10.1016/0896-6273(88)90176-6 · Cited by 358
Pursuing the structure and function of voltage-gated channels
Robert Guy, H., & Conti, F. (1990) · Trends in Neurosciences · doi:10.1016/0166-2236(90)90160-c · Cited by 320
Cloning of a probable potassium channel gene from mouse brain
Tempel, B. L., Jan, Y. N., & Jan, L. Y. (1988) · Nature · doi:10.1038/332837a0 · Cited by 302
Metadata
- Authors
- Greenblatt, R. E., Blatt, Y., & Montai, M.
- Venue
- FEBS Letters
- Publisher
- Wiley
- Published
- 1985-12-02
- Volume
- 193
- Issue
- 2
- Pages
- 125-134
- ISSN
- 0014-5793 (ISSN-L)
- 1873-3468
- OpenAlex
- W1583298558
- Cited by
- 193
- References
- 1
- FWCI
- 5.40
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: The structure of the voltage‐sensitive sodium channel: Inferences derived from computer‐aided analysis of the Electrophorus electricus channel primary structure. https://app.cochat.ai/papers/10.1016/0014-5793(85)80136-8
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- Greenblatt, R. E., Blatt, Y., & Montai, M. (1985). The structure of the voltage‐sensitive sodium channel: Inferences derived from computer‐aided analysis of the Electrophorus electricus channel primary structure. FEBS Letters. https://doi.org/10.1016/0014-5793(85)80136-8
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
