The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Exchange of Conduction Pathways Between Two Related K + Channels
Abstract
The structure of the ion conduction pathway or pore of voltage-gated ion channels is unknown, although the linker between the membrane spanning segments S5 and S6 has been suggested to form part of the pore in potassium channels. To test whether this region controls potassium channel conduction, a 21-amino acid segment of the S5-S6 linker was transplanted from the voltage-activated potassium channel NGK2 to another potassium channel DRK1, which has very different pore properties. In the resulting chimeric channel, the single channel conductance and blockade by external and internal tetraethylammonium (TEA) ion were characteristic of the donor NGK2 channel. Thus, this 21-amino acid segment controls the essential biophysical properties of the pore and may form the conduction pathway of these potassium channels.
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Citations
Cites
Interaction of Tetraethylammonium Ion Derivatives with the Potassium Channels of Giant Axons
Armstrong, C. M. (1971) · The Journal of General Physiology · doi:10.1085/jgp.58.4.413 · Cited by 929
Cited by
Mutations in the K+ channel signature sequence
Heginbotham, L., Lu, Z., Abramson, T., & MacKinnon, R. (1994) · Biophysical Journal · doi:10.1016/s0006-3495(94)80887-2 · Cited by 830
Calcium channel characteristics conferred on the sodium channel by single mutations
Heinemann, S. H., Terlau, H., Stühmer, W., Imoto, K., & Numa, S. (1992) · Nature · doi:10.1038/356441a0 · Cited by 784
Acetylcholine Receptor Channel Structure Probed in Cysteine-Substitution Mutants
Akabas, M. H., Stauffer, D. A., Xu, M., & Karlin, A. (1992) · Science · doi:10.1126/science.1384130 · Cited by 665
A Component of Calcium-activated Potassium Channels Encoded by the Drosophila slo Locus
Atkinson, N. S., Robertson, G. A., & Ganetzky, B. (1991) · Science · doi:10.1126/science.1857984 · Cited by 631
CLONED POTASSIUM CHANNELS FROM EUKARYOTES AND PROKARYOTES
Jan, L. Y., & Jan, Y. N. (1997) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.20.1.91 · Cited by 503
Metadata
- Authors
- Hartmann, H. A., Kirsch, G. E., Drewe, J. A., Taglialatela, M., Joho, R. H., & Brown, A. M.
- Venue
- Science
- Published
- 1991-02-22
- Volume
- 251
- Issue
- 4996
- Pages
- 942-944
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2031017369
- Cited by
- 385
- References
- 1
- FWCI
- 20.55
- Type
- journal article
- Language
- en
- Open access
- closed
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- Hartmann, H. A., Kirsch, G. E., Drewe, J. A., Taglialatela, M., Joho, R. H., & Brown, A. M. (1991). Exchange of Conduction Pathways Between Two Related K + Channels. Science. https://doi.org/10.1126/science.2000495
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
