The DOI matches its Crossref record; 12 of the 12 references it cites were found in a registry or an index.
Prediction of sequential antigenic regions in proteins
Open accessAbstract
Prediction of antigenic regions in a protein will be helpful for a rational approach to the synthesis of peptides which may elicit antibodies reactive with the intact protein. Earlier methods are based on the assumption that antigenic regions are primarily hydrophilic regions at the surface of the protein molecule. The method presented here is based on the amino acid composition of known antigenic regions in 20 proteins which is compared with that of 314 proteins [(1978) Atlas of Protein Sequence and Structure, vol. 5, suppl. 3, 363‐373]. Antigenicity values were derived from the differences between the two data sets. The method was applied to bovine ribonuclease, the B‐subunit of cholera toxin and herpes simplex virus type 1 glycoprotein D. There was a good correlation between the predicted regions and previously determined antigenic regions.
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Cites
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Cited by
Molecular and Biochemical Characterization of Lecithin Retinol Acyltransferase
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Secretion of islet amyloid polypeptide in response to glucose
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Metadata
- Authors
- Welling, G. W., Weijer, W. J., van der Zee, R., & Welling-Wester, S.
- Venue
- FEBS Letters
- Publisher
- Wiley
- Published
- 1985-09-02
- Volume
- 188
- Issue
- 2
- Pages
- 215-218
- ISSN
- 0014-5793 (ISSN-L)
- 1873-3468
- OpenAlex
- W2068997255
- Cited by
- 353
- References
- 12
- FWCI
- 4.67
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Welling, G. W., Weijer, W. J., van der Zee, R., & Welling-Wester, S. (1985). Prediction of sequential antigenic regions in proteins. FEBS Letters. https://doi.org/10.1016/0014-5793(85)80374-4
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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