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Endothelin stimulates c‐fos and c‐myc expression and proliferation of vascular smooth muscle cells
Abstract
Recently, a potent vasoconstrictor peptide, endothelin (EDT), was isolated from vascular endothelial cells. We examined its effect on rat vascular smooth muscle cells (VSMCs). EDT induced the elevation of intracellular calcium, which was dependent on extracellular calcium and inhibited by a calcium‐channel antagonist in a competitive manner. EDT caused a rapid and transient increase in the c‐fos and c‐myc mRNA levels and stimulated the DNA synthesis of VSMCs in a dose‐dependent manner. This effect of EDT on the proliferation of VSMCs might be related to the development of atherosclerosis.
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Citations
Cited by
Flow-mediated endothelial mechanotransduction
Davies, P. F. (1995) · Physiological Reviews · doi:10.1152/physrev.1995.75.3.519 · Cited by 2,802
Elevated plasma endothelin in patients with diabetes mellitus
Takahashi, K., Ghatei, M. A., Lam, H. C., O'Halloran, D. J., & Bloom, S. R. (1990) · Diabetologia · doi:10.1007/bf00403325 · Cited by 490
Wedgwood, S., Dettman, R. W., & Black, S. M. (2001) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.2001.281.5.l1058 · Cited by 258
Cloning of the GATA-binding protein that regulates endothelin-1 gene expression in endothelial cells
Lee, M. E., Temizer, D. H., Clifford, J. A., & Quertermous, T. (1991) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)98533-9 · Cited by 242
Goya, K., Sumitani, S., Xu, X., Kitamura, T., Yamamoto, H., Kurebayashi, S., Saito, H., Kouhara, H., Kasayama, S., & Kawase, I. (2004) · Arteriosclerosis, Thrombosis, and Vascular Biology · doi:10.1161/01.atv.0000118682.58708.78 · Cited by 174
Metadata
- Authors
- Komuro, I., Kurihara, H., Sugiyama, T., Takaku, F., & Yazaki, Y.
- Venue
- FEBS Letters
- Publisher
- Wiley
- Published
- 1988-10-10
- Volume
- 238
- Issue
- 2
- Pages
- 249-252
- ISSN
- 0014-5793 (ISSN-L)
- 1873-3468
- OpenAlex
- W1973929461
- Cited by
- 726
- References
- 0
- FWCI
- 38.88
- Type
- journal article
- Language
- en
- Open access
- closed
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- The paper
- Komuro, I., Kurihara, H., Sugiyama, T., Takaku, F., & Yazaki, Y. (1988). Endothelin stimulates c‐fos and c‐myc expression and proliferation of vascular smooth muscle cells. FEBS Letters. https://doi.org/10.1016/0014-5793(88)80489-7
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
