CoChat
Sign Up
Cited by 2,802Cellular Mechanics and InteractionsElasticity and Material ModelingNitric Oxide and Endothelin Effects

Flow-mediated endothelial mechanotransduction

Open access
Davies, P. F.·1995·Physiological Reviews
DOI 10.1152/physrev.1995.75.3.519PMC PMC3053532
Open this paper in CoChat — free account

Abstract

Mechanical forces associated with blood flow play important roles in the acute control of vascular tone, the regulation of arterial structure and remodeling, and the localization of atherosclerotic lesions. Major regulation of the blood vessel responses occurs by the action of hemodynamic shear stresses on the endothelium. The transmission of hemodynamic forces throughout the endothelium and the mechanotransduction mechanisms that lead to biophysical, biochemical, and gene regulatory responses of endothelial cells to hemodynamic shear stresses are reviewed.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Integrity signals

Registry

Crossref · 10.1152/physrev.1995.75.3.519

Cites

374 of 374 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Cites

Flagged first, then by citations

Research works printed but not linked: 47

  1. [1]Achard C, Aynaud M. Recherches sur l’impregnation histologique de l’endothelium. Arch. Med. Exp. 1907;19:437–450. [Google Scholar]
  2. [10]Anitschkof N. Experimentelle atherosklerose der aorta bein near schweinchen. Ziegler’s Beitrage. 1922;70:104–145. [Google Scholar]
  3. [13]Aschoff L. Lectures in Pathology. Berlin: Hueber; 1924. [Google Scholar]
  4. [14]Awolesi N, Sessa WC, Sumpio B. Cyclic strain up-regulates the endothelial cell nitric oxide synthase gene (Abstract) FASEB J. 1993;7:4360. [Google Scholar]
  5. [20]Berthiaume F, Frangos JA. Flow effects on endothelial cell signal transduction, function, and mediator release. In: Bevan J, Kaley G, Rubanyi G, editors. Flow-Dependent Regulation of Vascular Function. New York: Oxford Univ. Press; 1994. [Google Scholar]
  6. [34]Burridge K. Substrate adhesions in normal and transformed fibroblasts: organization and regulation of cytoskeletal, membrane, and extracellular matrix components at focal contacts. Cancer Res. 1986;4:18–78. [Google Scholar]
  7. [41]Carrington WA, Fogarty KE, Fay FS. Noninvasive Techniques In Cell Biology. New York: Wiley-Liss; 1990. Three-D fluorescence imaging of single cells using image restoration; pp. 53–72. [Google Scholar]
  8. [59]Darnell JE, Lodish H, Baltimore D. Molecular Cell Biology. New York: Scientific American; 1986. [Google Scholar]
  9. [60]Davies PF. Endothelial cells, hemodynamic forces, and the localization of atherosclerosis. In: Ryan U, editor. Endothelial Cells. vol. II. Boca Raton, FL: CRC; 1986. pp. 123–139. [Google Scholar]
  10. [61]Davies PF. How do vascular endothelial cells respond to flow? News Physiol. Sci. 1989;4:22–26. [Google Scholar]
  11. [63]Davies PF. Flow-mediated signal transduction in endothelial cells. In: Bevan J, Kaley G, Rubanyi G, editors. Flow Dependent Regulation of Vascular Function in Health and Disease. New York: Academic; 1984. pp. 46–61. [Google Scholar]
  12. [64]Davies PF, Barbee KA. Endothelial cell surface imaging: insights into hemodynamic force transmission and transduction. News Physiol. Sci. 1994;9:153–158. [Google Scholar]
  13. [65]Davies PF, Barbee KA, Lal R. Hemodynamics and atherosclerosis: endothelial surface dynamics in flow signal transduction. Ann. NY Acad. Sci. 1995;748:86–104. [PubMed] [Google Scholar]
  14. [74]Demolle D, Lecomte M, Boeynaems JM. Pattern of protein phosphorylation in aortic endothelial cell. J. Biol. Chem. 1988;263:18459–18465. [PubMed] [Google Scholar]
  15. [80]Diamond SL, Sharefkin JB, Dieffenbach CW, Eskin SG, McIntire LV. Regulation of endothelial cell gene expression by hemodynamic forces: implications for intimal hyperplasia and graft patency. In: Yao J, Pearce WH, editors. Technologies in Vascular Surgery. Philadelphia, PA: Saunders; 1992. pp. 12–24. [Google Scholar]
  16. [87]Ezzell C. Just the FAK(s), Ma’am: researchers investigate a new signalling enzyme. J. NIH Res. 1993;5:49–54. [Google Scholar]
  17. [96]Frangos JA, Kuchan MJ. Fluid flow activates G proteins that are coupled to Ca-dependent and -independent EDRF production in cultured endothelial cells (Abstract) FASEB J. 1991;5:A1820. [Google Scholar]
  18. [100]Fry DL. Atherogenesis: initiating factors. Ciba Found. Symp. 1973;12:96–118. [Google Scholar]
  19. [109]Giddens DN, Zarins CK, Glagov S. Response of arteries to near-wall fluid dynamic behavior. Appl. Mech. Rev. 1990;43 Suppl.:S98–S102. [Google Scholar]
  20. [110]Gimbrone MA., Jr. Endothelial dysfunction and the pathogenesis of atherosclerosis. In: Gotto AM, Smith LC, Allen B, editors. Atherosclerosis V. New York: Springer-Verlag; 1980. pp. 415–425. [Google Scholar]
  21. [125]Guyton JR. Mechanical control of smooth muscle growth. In: Seidel CL, Weisbrodt NW, editors. Hypertrophic Response in Smooth Muscle. vol. II. Boca Raton, FL: CRC; 1987. pp. 121–152. [Google Scholar]
  22. [133]Helmlinger G. Effect of Pulsatile Flow on the Intracellular Free Calcium Concentration of Cultured Vascular Endothelial Cells (PhD thesis) Atlanta: Georgia Institute of Technology; 1994. [Google Scholar]
  23. [138]Holtz J, Forstermann U, Pohl U, Giesler M, Bassenge E. Flow-dependent, endothelium-mediated dilatation of epicardial arteries in concious dogs: effects of cyclo-oxygenase inhibition. J. Cardiovasc. Pharmacol. 1984;6:1161–1169. [PubMed] [Google Scholar]
  24. [139]Honda HM, Wortham C, Navab M, Demer LL. Disturbed flow induces heat shock protein-70 mRNA in bovine and human aortic endothelial cells (Abstract) Circulation. 1992;86 Suppl. I:I-224. [Google Scholar]
  25. [146]Hsieh HJ, Li NQ, Frangos JA. Pulsatile and steady flows increase proto-oncogenes c-fos and c-myc mRNA levels in human endothelial cells (Abstract) FASEB J. 1991;5:A1820. [Google Scholar]
  26. [158]Ingber DE, Jamieson JD. Cells as tensegrity structures: architectural regulation of histodifferentiation by physical forces transduced over basement membrane. In: Andersson LC, Gahmberg CG, Ekblom P, editors. Gene Expression During Normal and Malignant Differentiation. Orlando, FL: Academic; 1985. pp. 13–32. [Google Scholar]
  27. [164]Johnson PC. Handbook of Physiology. The Cardiovascular System. Vascular Smooth Muscle. Bethesda, MD: Am. Physiol. Soc.; 1981. The myogenic response; pp. 409–442. sect. 2, vol. II, chapt. 15. [Google Scholar]
  28. [212]Maguire MH, Satchell DG. Purinergic receptors in visceral smooth muscle. In: Burnstock G, editor. Purinergic Receptors. London: Clapham and Hall; 1981. [Google Scholar]
  29. [223]Massop DW, Wright JG, Smead WL, Sadoun ET, Cornhill JF. Interleukin 6 secretion and gene expression by human aortic endothelial cells in response to laminar shear stress (Abstract) Circulation. 1990;82:206. [Google Scholar]
  30. [224]Masuda H, Bassiouny HS, Glagov S, Zarins CK. Artery wall restructuring in response to increased flow. Surg. Forum. 1989;40:285–286. [Google Scholar]
  31. [228]McMahon TA. Muscles, Reflexes, and Locomotion. Princeton, NJ: Princeton Univ. Press; 1984. [Google Scholar]
  32. [284]Pennisi E. Thicker than water. Biochemistry blends with fluid dynamics to yield a vascular science. Sci. News. 1991;140:220–223. [Google Scholar]
  33. [285]Perry PB, O’Neill WC. Flow stimulates nitric oxide synthesis in endothelial cells through a calcium-independent mechanism (Abstract) Circulation. 1993;88:1–134. [Google Scholar]
  34. [291]Pourageaud F, Freslon JL. Effects of flow direction and endothelium on reactivity of rat coronary arteries in vitro (Abstract) Circulation. 1993;88 Suppl. I:I-36. [Google Scholar]
  35. [304]Robotewskyj A, McKibben S, Dull RO, Griem ML, Davies PF. Dynamics of focal adhesion site remodeling in living endothelial cells in response to shear stress forces using confocal image analysis (Abstract) FASEB J. 1991;5:A527. [Google Scholar]
  36. [308]Rokitansky C. A Manual of Pathological Anatomy. vol. 4. London: Sydenham Soc.; 1952. The pathological anatomy of the organs of respiration and circulation. translated from the German by G. E. Day. [Google Scholar]
  37. [320]Sakurai A, Nakano A, Yamaguchi T, Masuda M, Fujiwara K. A computational fluid mechanical study of flow over cultured endothelial cells. Adv. Bioeng. 1991;20:299–302. [Google Scholar]
  38. [329]Schretzenmayr A. Uber kreislaufregulatorische vorgange an den grossen arterien bei der muskelarbeit. Pfluegers Arch. 1933;232:743–748. [Google Scholar]
  39. 343a.Shyy J-Y, Chien S. The molecular basis for shear stress regulated gene expression (Abstract); Abstracts of the AHA Scientific Conference on the Functional and Structural Aspects of Vascular Wall Salt Lake City UT 1995. [Google Scholar]
  40. [364]Taylor WR, Hanson DG, Nerem RM, Peterson TE, Alexander RW. Characterization of the release of endothelial-derived nitrogen oxides by shear stress (Abstract) FASEB J. 1991;5:A1727. [Google Scholar]
  41. [366]Thoma R. Uber die intima der arterien. Virchows Arch. A. 1921;230:1–45. [Google Scholar]
  42. [367]Tirrell M, Middleman S. Shear modification of enzyme kinetics. Biotechnol. Bioeng. 1975;17:299–303. [Google Scholar]
  43. [375]Uematsu M, Navas JP, Nishida K, Ohara Y, Murphy TJ, Alexander RW, Nerem RM, Harrison DG. Mechanisms of endothelial cell NO synthase induction by shear stress (Abstract) Circulation. 1993;88 Suppl. I:I-184. [Google Scholar]
  44. [387]Watson S, Arkinstall S. The G-Protein Linked Receptor Facts Book. London: Academic; 1994. [Google Scholar]
  45. [393]Wilson T, Sheppard C. Theory and Practice of Scanning Optical Microscopy. Orlando, FL: Academic; 1984. 1984. [Google Scholar]
  46. [395]Yamaguchi T, Hoshiai K, Okino H, Kakurai A, Hanai S, Masuda M, Fujiwara K. Shear stress distribution over confluently cultured endothelial cells studied by computational fluid mechanics. Adv. Bioeng. 1993;20:167–170. [Google Scholar]
  47. [403]Zarins CK. Adaptive responses of arteries. J. Vasc. Surg. 1989;9:382–389. [Google Scholar]

Cited by

Sorted by citations

Related

Authors
Davies, P. F.
Affiliations
University of Chicago (US)
Corresponding author
Davies, P. F.
Venue
Physiological Reviews
Publisher
American Physiological Society
Published
1995-07-01
Volume
75
Issue
3
Pages
519-560
ISSN
  • 0031-9333 (ISSN-L)
  • 1522-1210
DOI
10.1152/physrev.1995.75.3.519
PMC
PMC3053532
OpenAlex
W1936770188
Cited by
2,802
References
374
Citations by year
2026: 52 · 2025: 55 · 2024: 65 · 2023: 66 · 2022: 77 · 2021: 91 · 2020: 72 · 2019: 77 · 2018: 75 · 2017: 90 · 2016: 86 · 2015: 88 · 2014: 86 · 2013: 102 · 2012: 86
FWCI
23.68
Type
journal article
Language
en
Open access
Locations
  • Physiological Reviews (publishedVersion)
  • PubMed (publishedVersion)
  • PubMed Central (acceptedVersion)
Funders
  • National Institutes of Health (5p50hl015062-25)
  • National Heart, Lung, and Blood Institute (HL-15062, HL-36049, R37HL036049)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Cellular Mechanics and Interactions
  • Physical Sciences › Engineering › Biomedical Engineering › Elasticity and Material Modeling
  • Health Sciences › Medicine › Physiology › Nitric Oxide and Endothelin Effects
Keywords
endothelial mechanotransduction, hemodynamic shear stress, blood flow, vascular tone, arterial remodeling, atherosclerosis, endothelial cell response, gene expression regulation, vascular architecture
MeSH terms
Animals, Blood Circulation, Endothelium, Vascular, Hemodynamics, Humans, Mechanoreceptors, Signal Transduction

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review