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Primary structure of sheep prostaglandin endoperoxide synthase deduced from cDNA sequence
Abstract
The complete amino acid sequence of prostaglandin endoperoxide synthase from sheep vesicular gland has been deduced by cloning and sequence analysis of DNA complementary to its messenger RNA. The results were confirmed by digestion of the enzyme with carboxypeptidase Y and by automated Edman degradation of the intact enzyme polypeptide and peptide fragments obtained by limited proteolysis of the enzyme with Achromobacter proteinase I. Mature sheep prostaglandin endoperoxide synthase is shown to be composed of 576 amino acids with an M r of 66 175. The precursor peptide is predicted to contain a 24‐residue signal peptide. The serine residue susceptible to acetylation by aspirin is found to be located near the C‐terminus of the enzyme polypeptide.
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Cited by
Vane, J. R., Bakhle, Y. S., & Botting, R. M. (1998) · Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev.pharmtox.38.1.97 · Cited by 2,734
Lee, J. Y., Sohn, K. H., Rhee, S. H., & Hwang, D. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m011695200 · Cited by 1,299
Greenhough, A., Smartt, H. J. M., Moore, A. E., Roberts, H. R., Williams, A. C., Paraskeva, C., & Kaidi, A. (2009) · Carcinogenesis · doi:10.1093/carcin/bgp014 · Cited by 1,220
Langenbach, R., Morham, S. G., Tiano, H. F., Loftin, C. D., Ghanayem, B. I., Chulada, P. C., Mahler, J. F., Lee, C. A., Goulding, E. H., Kluckman, K. D., et al. (1995) · Cell · doi:10.1016/0092-8674(95)90126-4 · Cited by 1,123
Prostaglandin E2 synthesis and secretion: The role of PGE2 synthases
Park, J. Y., Pillinger, M. H., & Abramson, S. B. (2006) · Clinical Immunology · doi:10.1016/j.clim.2006.01.016 · Cited by 793
Metadata
- Authors
- Yokoyama, C., Takai, T., & Tanabe, T.
- Venue
- FEBS Letters
- Publisher
- Wiley
- Published
- 1988-04-25
- Volume
- 231
- Issue
- 2
- Pages
- 347-351
- ISSN
- 0014-5793 (ISSN-L)
- 1873-3468
- OpenAlex
- W1966183396
- Cited by
- 218
- References
- 0
- FWCI
- 13.32
- Type
- journal article
- Language
- en
- Open access
- closed
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- Yokoyama, C., Takai, T., & Tanabe, T. (1988). Primary structure of sheep prostaglandin endoperoxide synthase deduced from cDNA sequence. FEBS Letters. https://doi.org/10.1016/0014-5793(88)80847-0
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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