The COX-2/PGE2 pathway, key roles in the hallmarks of cancer and adaptation to the tumour microenvironment

The hallmarks of cancer

Hanahan, D., & Weinberg, R. A. (2000) · Cell · doi:10.1016/s0092-8674(00)81683-9 · Cited by 29,219 · see citing works

Apoptosis: A Basic Biological Phenomenon with Wideranging Implications in Tissue Kinetics

Kerr, J. F. R., Wyllie, A. H., & Currie, A. R. (1972) · British Journal of Cancer · doi:10.1038/bjc.1972.33 · Cited by 15,673 · see citing works

A genetic model for colorectal tumorigenesis

Fearon, E. R., & Vogelstein, B. (1990) · Cell · doi:10.1016/0092-8674(90)90186-i · Cited by 12,132 · see citing works

Mutations of the BRAF gene in human cancer

Davies, H., Bignell, G. R., Cox, C., Stephens, P., Edkins, S., Clegg, S., Teague, J., Woffendin, H., Garnett, M. J., Bottomley, W., et al. (2002) · Nature · doi:10.1038/nature00766 · Cited by 10,674 · see citing works

Stem cells, cancer, and cancer stem cells

Reya, T., Morrison, S. J., Clarke, M. F., & Weissman, I. L. (2001) · Nature · doi:10.1038/35102167 · Cited by 9,738 · see citing works

Inhibition of Prostaglandin Synthesis as a Mechanism of Action for Aspirin-like Drugs

VANE, J. R. (1971) · Nature New Biology · doi:10.1038/newbio231232a0 · Cited by 8,605 · see citing works

Patterns and emerging mechanisms of the angiogenic switch during tumorigenesis

Hanahan, D., & Folkman, J. (1996) · Cell · doi:10.1016/s0092-8674(00)80108-7 · Cited by 6,885 · see citing works

Apoptosis in the Pathogenesis and Treatment of Disease

Thompson, C. B. (1995) · Science · doi:10.1126/science.7878464 · Cited by 6,524 · see citing works

The phosphatidylinositol 3-Kinase–AKT pathway in human cancer

Vivanco, I., & Sawyers, C. L. (2002) · Nature reviews. Cancer · doi:10.1038/nrc839 · Cited by 6,041 · see citing works

Akt phosphorylation of BAD couples survival signals to the cell-intrinsic death machinery

Datta, S. R., Dudek, H., Tao, X., Masters, S., Fu, H., Gotoh, Y., & Greenberg, M. E. (1997) · Cell · doi:10.1016/s0092-8674(00)80405-5 · Cited by 5,689 · see citing works

Lessons from hereditary colorectal cancer

Kinzler, K. W., & Vogelstein, B. (1996) · Cell · doi:10.1016/s0092-8674(00)81333-1 · Cited by 4,919 · see citing works

Cell Death

Danial, N. N., & Korsmeyer, S. J. (2004) · Cell · doi:10.1016/s0092-8674(04)00046-7 · Cited by 4,651 · see citing works

Cancer genes and the pathways they control

Vogelstein, B., & Kinzler, K. W. (2004) · Nature Medicine · doi:10.1038/nm1087 · Cited by 4,245 · see citing works

TGFβ in Cancer

Massagué, J. (2008) · Cell · doi:10.1016/j.cell.2008.07.001 · Cited by 3,907 · see citing works

Prostaglandins and Leukotrienes: Advances in Eicosanoid Biology

Funk, C. D. (2001) · Science · doi:10.1126/science.294.5548.1871 · Cited by 3,817 · see citing works

Wnt signalling in stem cells and cancer

Reya, T., & Clevers, H. (2005) · Nature · doi:10.1038/nature03319 · Cited by 3,666 · see citing works

High Frequency of Mutations of the PIK3CA Gene in Human Cancers

Samuels, Y., Wang, Z., Bardelli, A., Silliman, N., Ptak, J., Szabo, S., Yan, H., Gazdar, A. F., Powell, S. M., Riggins, G. J., et al. (2004) · Science · doi:10.1126/science.1096502 · Cited by 3,448 · see citing works

Targeting RAS signalling pathways in cancer therapy

Downward, J. (2003) · Nature reviews. Cancer · doi:10.1038/nrc969 · Cited by 3,262 · see citing works

Cyclooxygenases: Structural, cellular, and molecular biology

Smith, W. L., DeWitt, D. L., & Garavito, R. M. (2000) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.69.1.145 · Cited by 2,925 · see citing works

The Genomic Landscapes of Human Breast and Colorectal Cancers

Wood, L. D., Parsons, D. W., Jones, S., Lin, J., Sjöblom, T., Leary, R. J., Shen, D., Boca, S. M., Barber, T., Ptak, J., et al. (2007) · Science · doi:10.1126/science.1145720 · Cited by 2,833 · see citing works

Met, metastasis, motility and more

Birchmeier, C., Birchmeier, W., Gherardi, E., & Woude, G. V. (2003) · Nature reviews. Molecular cell biology · doi:10.1038/nrm1261 · Cited by 2,667 · see citing works

The Effect of Celecoxib, a Cyclooxygenase-2 Inhibitor, in Familial Adenomatous Polyposis

Steinbach, G., Lynch, P. M., Phillips, R. K. S., Wallace, M. H., Hawk, E. T., Gordon, G., Wakabayashi, N., Saunders, B. P., Shen, Y., Fujimura, T., et al. (2000) · New England Journal of Medicine · doi:10.1056/nejm200006293422603 · Cited by 2,522 · see citing works

Cardiovascular Events Associated with Rofecoxib in a Colorectal Adenoma Chemoprevention Trial

Bresalier, R. S., Sandler, R. S., Quan, H., Bolognese, J. A., Oxenius, B., Horgan, K., Lines, C., Riddell, R., Morton, D., Lanas, A., et al. (2005) · New England Journal of Medicine · doi:10.1056/nejmoa050493 · Cited by 2,519 · see citing works

Up-regulation of cyclooxygenase 2 gene expression in human colorectal adenomas and adenocarcinomas

Eberhart, C. E., Coffey, R. J., Aramandla, R., Giardiello, F. M., Ferrenbach, S., & DuBois, R. N. (1994) · Gastroenterology · doi:10.1016/0016-5085(94)90246-1 · Cited by 2,512 · see citing works

Suppression of Intestinal Polyposis in ApcΔ716 Knockout Mice by Inhibition of Cyclooxygenase 2 (COX-2)

Oshima, M., Dinchuk, J. E., Kargman, S., Oshima, H., Hancock, B. C., Kwong, E. C., Trzăskos, J. M., Evans, J. F., & Taketo, M. M. (1996) · Cell · doi:10.1016/s0092-8674(00)81988-1 · Cited by 2,363 · see citing works

Tumor cell metabolism: cancer's Achilles' heel

Kroemer, G., & Pouyssegur, J. (2008) · Cancer Cell · doi:10.1016/j.ccr.2008.05.005 · Cited by 2,337 · see citing works

Alterations in cellular adhesion and apoptosis in epithelial cells overexpressing prostaglandin endoperoxide synthase 2

Tsujii, M., & DuBois, R. N. (1995) · Cell · doi:10.1016/0092-8674(95)90127-2 · Cited by 2,292 · see citing works

Cyclooxygenase regulates angiogenesis induced by colon cancer cells

Tsujii, M., Kawano, S., Tsuji, S., Sawaoka, H., Hori, M., & DuBois, R. N. (1998) · Cell · doi:10.1016/s0092-8674(00)81433-6 · Cited by 2,272 · see citing works

Inactivation of the Type II TGF-β Receptor in Colon Cancer Cells with Microsatellite Instability

Markowitz, S. D., Wang, J., Myeroff, L. L., Parsons, R. E., Sun, L., Lutterbaugh, J., Fan, R. S., Zborowska, E., Kinzler, K. W., Vogelstein, B., et al. (1995) · Science · doi:10.1126/science.7761852 · Cited by 2,267 · see citing works

Immunosuppressive networks in the tumour environment and their therapeutic relevance

Zou, W. (2005) · Nature Reviews Cancer · doi:10.1038/nrc1586 · Cited by 2,057 · see citing works

The β-Catenin/TCF-4 Complex Imposes a Crypt Progenitor Phenotype on Colorectal Cancer Cells

van de Wetering, M., Sancho, E., Verweij, C., de Lau, W., Oving, I., Hurlstone, A., van der Horn, K., Batlle, E., Coudreuse, D., Haramis, A.-P., et al. (2002) · Cell · doi:10.1016/s0092-8674(02)01014-0 · Cited by 2,030 · see citing works

COX-3, a cyclooxygenase-1 variant inhibited by acetaminophen and other analgesic/antipyretic drugs: Cloning, structure, and expression

Chandrasekharan, N. V., Dai, H., Roos, K. L. T., Evanson, N. K., Tomsik, J., Elton, T. S., & Simmons, D. L. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.162468699 · Cited by 1,989 · see citing works

Cell Survival Promoted by the Ras-MAPK Signaling Pathway by Transcription-Dependent and -Independent Mechanisms

Bonni, A., Brunet, A., West, A. E., Datta, S. R., Takasu, M. A., & Greenberg, M. E. (1999) · Science · doi:10.1126/science.286.5443.1358 · Cited by 1,887 · see citing works

Prevalence of ras gene mutations in human colorectal cancers

Bos, J. L., Fearon, E. R., Hamilton, S. R., Vries, M. V., BOOM, J. H. V., van der Eb, A. J., & Vogelstein, B. (1987) · Nature · doi:10.1038/327293a0 · Cited by 1,860 · see citing works

The epigenetic progenitor origin of human cancer

Feinberg, A. P., OHLSSON, R. I., & Henikoff, S. (2005) · Nature Reviews Genetics · doi:10.1038/nrg1748 · Cited by 1,851 · see citing works

TIS10, a phorbol ester tumor promoter-inducible mRNA from Swiss 3T3 cells, encodes a novel prostaglandin synthase/cyclooxygenase homologue

Kujubu, D. A., Fletcher, B. S., Varnum, B. C., Lim, R. W., & Herschman, H. R. (1991) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)98774-0 · Cited by 1,786 · see citing works

The Journal of Laboratory and Clinical Medicine

(2003) · Journal of Laboratory and Clinical Medicine · doi:10.1016/s0022-2143(03)00127-6 · Cited by 1,767 · see citing works

Expression of a mitogen-responsive gene encoding prostaglandin synthase is regulated by mRNA splicing.

Xie, W. L., Chipman, J. G., Robertson, D. L., Erikson, R. L., & Simmons, D. L. (1991) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.88.7.2692 · Cited by 1,707 · see citing works

Aspirin Use and Reduced Risk of Fatal Colon Cancer

Thun, M. J., Namboodiri, M. M., & Heath, C. W. (1991) · New England Journal of Medicine · doi:10.1056/nejm199112053252301 · Cited by 1,682 · see citing works

Cytostatic and apoptotic actions of TGF-β in homeostasis and cancer

Siegel, P. M., & Massagué, J. (2003) · Nature reviews. Cancer · doi:10.1038/nrc1208 · Cited by 1,600 · see citing works

Depletion of epithelial stem-cell compartments in the small intestine of mice lacking Tcf-4

Kořínek, V., Barker, N., Moerer, P., van Donselaar, E. G., Huls, G. A., Peters, P. J., & Clevers, H. C. (1998) · Nature Genetics · doi:10.1038/1270 · Cited by 1,580 · see citing works

Human cyclooxygenase-2 cDNA.

Hla, T., & Neilson, K. (1992) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.89.16.7384 · Cited by 1,465 · see citing works

Cyclooxygenase-2 expression in human colon cancer cells increases metastatic potential

Tsujii, M., Kawano, S., & DuBois, R. N. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.7.3336 · Cited by 1,398 · see citing works

Clinical Cancer Research

Horder, & Harnett, W. L. (1941) · BMJ · doi:10.1136/bmj.1.4186.493 · Cited by 1,319 · see citing works

A transforming mutation in the pleckstrin homology domain of AKT1 in cancer

Carpten, J. D., Faber, A. L., Horn, C. L., Donoho, G. P., Briggs, S., Robbins, C. M., Hostetter, G. H., Boguslawski, S. J., Moses, T. Y., Savage, S., et al. (2007) · Nature · doi:10.1038/nature05933 · Cited by 1,291 · see citing works

A matter of life and death

Green, D. R., & Evan, G. I. (2002) · Cancer Cell · doi:10.1016/s1535-6108(02)00024-7 · Cited by 1,254 · see citing works

Apoptotic Pathways

Green, D. R. (1998) · Cell · doi:10.1016/s0092-8674(00)81728-6 · Cited by 1,193 · see citing works

Prostaglandins as modulators of immunity

Harris, S. G., Padilla, J., Koumas, L., Ray, D. M., & Phipps, R. P. (2002) · Trends in Immunology · doi:10.1016/s1471-4906(01)02154-8 · Cited by 1,168 · see citing works

Expression of cyclooxygenase-1 and -2 in human colorectal cancer.

Sano, H., Kawahito, Y., Wilder, R. L., Hashiramoto, A., Mukai, S., Asai, K., Kimura, S., Kato, H., Kondo, M., & Hla, T. (1995) · PubMed · Cited by 1,126 · see citing works

Modulation of apoptosis and Bcl-2 expression by prostaglandin E2 in human colon cancer cells.

Sheng, H., Shao, J., Morrow, J. D., Beauchamp, R. D., & Dubois, R. N. (1998) · PubMed · Cited by 1,114 · see citing works

Prostaglandin E2 regulates vertebrate haematopoietic stem cell homeostasis

North, T. E., Goessling, W., Walkley, C. R., Lengerke, C., Kopani, K. R., Lord, A. M., Weber, G. J., Bowman, T. V., Jang, I. H., Großer, T., et al. (2007) · Nature · doi:10.1038/nature05883 · Cited by 1,095 · see citing works

PPARδ Is an APC-Regulated Target of Nonsteroidal Anti-Inflammatory Drugs

He, T., Chan, T. A.-T., Vogelstein, B., & Kinzler, K. W. (1999) · Cell · doi:10.1016/s0092-8674(00)81664-5 · Cited by 1,083 · see citing works

Suppression of apoptosis in mammalian cells by NAIP and a related family of IAP genes

Listen, P., Roy, N., Tamai, K., Lefebvre, C. A., Baird, S. D., Cherton-Horvat, G., Farahani, R., McLean, M., lkeda, J.-E., MacKenzie, A., et al. (1996) · Nature · doi:10.1038/379349a0 · Cited by 1,005 · see citing works

Celecoxib for the Prevention of Colorectal Adenomatous Polyps

Arber, N., Eagle, C. J., Špičák, J., Rácz, I. A., Dítě, P., Hajer, J., Zavoral, M., Lechuga, M. J., Gerletti, P., Tang, J., et al. (2006) · New England Journal of Medicine · doi:10.1056/nejmoa061652 · Cited by 974 · see citing works

Prostaglandin E 2 Promotes Colon Cancer Cell Growth Through a G s -Axin-ß-Catenin Signaling Axis

Castellone, M. D., Teramoto, H., Williams, B. O., Druey, K. M., & Gutkind, J. S. (2005) · Science · doi:10.1126/science.1116221 · Cited by 884 · see citing works

Chemokine receptor CXCR4 downregulated by von Hippel–Lindau tumour suppressor pVHL

Staller, P., Sulitkova, J., Lisztwan, J., Moch, H., Oakeley, E. J., & Krek, W. (2003) · Nature · doi:10.1038/nature01874 · Cited by 870 · see citing works

Prostaglandin E2 transactivates EGF receptor: A novel mechanism for promoting colon cancer growth and gastrointestinal hypertrophy

Pai, R., Soreghan, B. A., Szabó, I., Pavelka, M., Baatar, D., & Tarnawski, A. S. (2002) · Nature Medicine · doi:10.1038/nm0302-289 · Cited by 836 · see citing works

Expression of prostaglandin G/H synthase-1 and -2 protein in human colon cancer.

Kargman, S., O’Neill, G. P., Vickers, P. J., Evans, J. F., Mancini, J. A., & Jothy, S. (1995) · PubMed · Cited by 831 · see citing works

Inhibition of angiogenesis by nonsteroidal anti-inflammatory drugs: Insight into mechanisms and implications for cancer growth and ulcer healing

Jones, M. K., Wang, H., Peskar, B. M., Levin, E. R., Itani, R. M., Sarfeh, I. J., & Tarnawski, A. S. (1999) · Nature Medicine · doi:10.1038/70995 · Cited by 826 · see citing works

Prostaglandin E2 synthesis and secretion: The role of PGE2 synthases

Park, J. Y., Pillinger, M. H., & Abramson, S. B. (2006) · Clinical Immunology · doi:10.1016/j.clim.2006.01.016 · Cited by 793 · see citing works

Ways of dying: multiple pathways to apoptosisPreprint

Adams, J. M. (2003) · Genes & Development · doi:10.1101/gad.1126903 · Cited by 776 · see citing works

Mediators of vascular remodelling co-opted for sequential steps in lung metastasis

Gupta, G. P., Nguyen, D. X., Chiang, A. C., Bos, P. D., Kim, J. Y., Nadal, C., Gomis, R. R., Manova-Todorova, K. O., & Massagué, J. (2007) · Nature · doi:10.1038/nature05760 · Cited by 728 · see citing works

Self-Renewal and Cancer of the Gut: Two Sides of a Coin

Radtke, F., & Clevers, H. (2005) · Science · doi:10.1126/science.1104815 · Cited by 690 · see citing works

Host cyclooxygenase-2 modulates carcinoma growth

Williams, C. S., Tsujii, M., Reese, J., Dey, S. K., & DuBois, R. N. (2000) · Journal of Clinical Investigation · doi:10.1172/jci9621 · Cited by 672 · see citing works

Hypoxia Induces Cyclooxygenase-2 via the NF-κB p65 Transcription Factor in Human Vascular Endothelial Cells

Schmedtje, J. F., Ji, Y.-S., Liu, W. L., DuBois, R. N., & Runge, M. S. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.1.601 · Cited by 668 · see citing works

Prostaglandin E2 Increases Growth and Motility of Colorectal Carcinoma Cells

Sheng, H., Shao, J., Washington, M. K., & DuBois, R. N. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m009689200 · Cited by 654 · see citing works

Cyclooxygenase 2: a molecular target for cancer prevention and treatment

Subbaramaiah, K., & Dannenberg, A. J. (2003) · Trends in Pharmacological Sciences · doi:10.1016/s0165-6147(02)00043-3 · Cited by 650 · see citing works

Suppression of Myc-Induced Apoptosis in β Cells Exposes Multiple Oncogenic Properties of Myc and Triggers Carcinogenic Progression

Pelengaris, S., Khan, M., & Evan, G. I. (2002) · Cell · doi:10.1016/s0092-8674(02)00738-9 · Cited by 623 · see citing works

Prevention of hypoxia-induced cell death by Bcl-2 and Bcl-xL

Shimizu, S., Eguchi, Y., Kosaka, H., Kamiike, W., Matsuda, H., & Tsujimoto, Y. (1995) · Nature · doi:10.1038/374811a0 · Cited by 611 · see citing works

Effects of nonsteroidal anti-inflammatory drugs on proliferation and on induction of apoptosis in colon cancer cells by a prostaglandin-independent pathway

Hanif, R., Pittas, A., Feng, Y., Koutsos, M. I., Qiao, L., Staiano‐Coico, L., Shiff, S. I., & Rigas, B. (1996) · Biochemical Pharmacology · doi:10.1016/0006-2952(96)00181-5 · Cited by 604 · see citing works

Acceleration of intestinal polyposis through prostaglandin receptor EP2 in ApcΔ716 knockout mice

Sonoshita, M., Takaku, K., Sasaki, N., Sugimoto, Y., Ushikubi, F., Narumiya, S., Oshima, M., & Taketo, M. M. (2001) · Nature Medicine · doi:10.1038/nm0901-1048 · Cited by 587 · see citing works

Mechanisms underlying nonsteroidal antiinflammatory drug-mediated apoptosis

Chan, T. A.-T., Morin, P. J., Vogelstein, B., et al. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.2.681 · Cited by 584 · see citing works

Altered eicosanoid levels in human colon cancer.

Rigas, B., Goldman, I. S., & Levine, L. (1993) · PubMed · Cited by 569 · see citing works

Sodium butyrate induces apoptosis in human colonic tumour cell lines in a p53‐independent pathway: Implications for the possible role of dietary fibre in the prevention of large‐bowel cancer

Hague, A., Manning, A. M., Hanlon, K. A., Hart, D. A., Paraskeva, C., & Huschtscha, L. I. (1993) · International Journal of Cancer · doi:10.1002/ijc.2910550329 · Cited by 531 · see citing works

COX-2: A Molecular Target for Colorectal Cancer Prevention

Brown, J. R., & DuBois, R. N. (2005) · Journal of Clinical Oncology · doi:10.1200/jco.2005.09.051 · Cited by 529 · see citing works

Hypermethylation of CpG Islands in Primary and Metastatic Human Prostate Cancer

Yegnasubramanian, S., Kowalski, J., Gonzalgo, M. L., ZAHURAK, M. L., Piantadosi, S., Walsh, P. C., Bova, G. S., Marzo, A. M. D., Isaacs, W. B., & Nelson, W. G. (2004) · Cancer Research · doi:10.1158/0008-5472.can-03-3972 · Cited by 527 · see citing works

Interaction between β-catenin and HIF-1 promotes cellular adaptation to hypoxia

Kaidi, A., Williams, A. C., & Paraskeva, C. (2007) · Nature Cell Biology · doi:10.1038/ncb1534 · Cited by 518 · see citing works

Sulindac for polyposis of the colon

Waddell, W. R., & Loughry, R. W. (1983) · Journal of Surgical Oncology · doi:10.1002/jso.2930240119 · Cited by 516 · see citing works

Tumor hypoxia and malignant progression

Vaupel, P., Mayer, A., & Höckel, M. (2004) · Methods in Enzymology · doi:10.1016/s0076-6879(04)81023-1 · Cited by 496 · see citing works

Genetic disruption of Ptgs-1, as well as Ptgs-2, reduces intestinal tumorigenesis in Min mice.

Chulada, P. C., Thompson, M. B., Mahler, J. F., Doyle, C. M., Gaul, B. W., Lee, C., Tiano, H. F., Morham, S. G., Smithies, O., & Langenbach, R. J. (2000) · PubMed · Cited by 496 · see citing works

The cyclooxygenase-2 inhibitor celecoxib is a potent preventive and therapeutic agent in the min mouse model of adenomatous polyposis.

Jacoby, R. F., Seibert, K., Cole, C. E., et al. (2000) · PubMed · Cited by 483 · see citing works

The Relationship Between Cyclooxygenase-2 Expression and Colorectal Cancer

Sheehan, K. M. (1999) · JAMA · doi:10.1001/jama.282.13.1254 · Cited by 471 · see citing works

Specific Inhibition of Cyclooxygenase 2 Restores Antitumor Reactivity by Altering the Balance of IL-10 and IL-12 Synthesis

Stolina, M., Sharma, S. P., Lin, Y., Dohadwala, M., Gardner, B. K., Luo, J., Zhu, L. X., Kronenberg, M., Miller, P. W., Portanova, J. P., et al. (2000) · The Journal of Immunology · doi:10.4049/jimmunol.164.1.361 · Cited by 465 · see citing works

Prostaglandin E2 Regulates Cell Migration via the Intracellular Activation of the Epidermal Growth Factor Receptor

Buchanan, F. G., Wang, D., Bargiacchi, F., & DuBois, R. N. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m302474200 · Cited by 463 · see citing works

The APC gene in colorectal cancer

Fodde, R. (2002) · European Journal of Cancer · doi:10.1016/s0959-8049(02)00040-0 · Cited by 461 · see citing works

Biochimica et biophysica acta. Protein structure and molecular enzymology

ScienceDirect (2002) · Cited by 395 · see citing works

Induction of apoptotic cell death in human colorectal carcinoma cell lines by a cyclooxygenase-2 (COX-2)-selective nonsteroidal anti-inflammatory drug: independence from COX-2 protein expression.

Elder, D. J. E., Halton, D. E., Hague, A., & Paraskeva, C. (1997) · PubMed · Cited by 366 · see citing works

Involvement of prostaglandin E receptor subtype EP(4) in colon carcinogenesis.

Mutoh, M., Watanabe, K., Kitamura, T., Shoji, Y., Takahashi, M., Kawamori, T., Tani, K., Kobayashi, M., Maruyama, T., Kobayashi, K., et al. (2002) · PubMed · Cited by 365 · see citing works

Prostaglandin E2 promotes colorectal adenoma growth via transactivation of the nuclear peroxisome proliferator-activated receptor δ

Wang, D., Wang, H., Shi, Q., Katkuri, S., Walhi, W., Desvergne, B., Das, S. K., Dey, S. K., & DuBois, R. N. (2004) · Cancer Cell · doi:10.1016/j.ccr.2004.08.011 · Cited by 340 · see citing works

CXCL1 induced by prostaglandin E2 promotes angiogenesis in colorectal cancer

Wang, D., Wang, H., Brown, J. R., Daikoku, T., Wei, N., Shi, Q., Richmond, A. J., Strieter, R. M., Dey, S. K., & DuBois, R. N. (2006) · The Journal of Experimental Medicine · doi:10.1084/jem.20052124 · Cited by 337 · see citing works

Host Prostaglandin E2-EP3 Signaling Regulates Tumor-Associated Angiogenesis and Tumor Growth

Amano, H., Hayashi, I., Endo, H., Kitasato, H., Yamashina, S., Maruyama, T., Kobayashi, M., Satoh, K., Narita, M., Sugimoto, Y., et al. (2003) · The Journal of Experimental Medicine · doi:10.1084/jem.20021408 · Cited by 325 · see citing works

Epidermal growth factor receptor activation induces nuclear targeting of cyclooxygenase-2, basolateral release of prostaglandins, and mitogenesis in polarizing colon cancer cells

Coffey, R. J., Hawkey, C. J., Damstrup, L., Graves‐Deal, R., Daniel, V. C., Dempsey, P. J., Chinery, R., Kirkland, S. C., DuBois, R. N., Jetton, T. L., et al. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.2.657 · Cited by 315 · see citing works

The Spinal Phospholipase-Cyclooxygenase-Prostanoid Cascade in Nociceptive Processing

Svensson, C. I., & Yaksh, T. L. (2002) · The Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev.pharmtox.42.092401.143905 · Cited by 302 · see citing works

15-Hydroxyprostaglandin Dehydrogenase Is Down-regulated in Colorectal Cancer

Backlund, M. G., Mann, J. R., Holla, V. R., Buchanan, F. G., Tai, H., Musiek, E. S., Milne, G. L., Katkuri, S., & DuBois, R. N. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m411221200 · Cited by 301 · see citing works

Direct transcriptional up-regulation of cyclooxygenase-2 by hypoxia-inducible factor (HIF)-1 promotes colorectal tumor cell survival and enhances HIF-1 transcriptional activity during hypoxia

Kaidi, A., Qualtrough, D., Williams, A. C., & Paraskeva, C. (2006) · Cancer Research · doi:10.1158/0008-5472.can-06-0425 · Cited by 300 · see citing works

Vascular endothelial growth factor gene expression in colon cancer cells exposed to prostaglandin E2 is mediated by hypoxia-inducible factor 1.

Fukuda, R., Kelly, B., & Semenza, G. L. (2003) · PubMed · Cited by 293 · see citing works

Regulation of cyclooxygenase-2 expression by the Wnt and ras pathways.

Araki, Y., Okamura, S., Hussain, S. P., Nagashima, M., He, P., Shiseki, M., Miura, K., & Harris, C. C. (2003) · PubMed · Cited by 288 · see citing works

NSAIDs inhibit αVβ3 integrin-mediated and Cdc42/Rac-dependent endothelial-cell spreading, migration and angiogenesis

Dormond, O., Foletti, A., Paroz, C., & Rüegg, C. (2001) · Nature Medicine · doi:10.1038/nm0901-1041 · Cited by 281 · see citing works

Patients with adenomatous polyps and carcinomas have increased colonic mucosal prostaglandin E2.

Pugh, S., & Thomas, G. A. O. (1994) · Gut · doi:10.1136/gut.35.5.675 · Cited by 266 · see citing works

Positive and Negative Regulation of NF-κB by COX-2

Poligone, B., & Baldwin, A. S. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m106599200 · Cited by 263 · see citing works

15-Hydroxyprostaglandin dehydrogenase is an in vivo suppressor of colon tumorigenesis

Myung, S., Rerko, R. M., Yan, M., Platzer, P., Guda, K., Dotson, A., Lawrence, E., Dannenberg, A. J., Lovgren, A. K., Luo, G., et al. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0603235103 · Cited by 262 · see citing works

15-Hydroxyprostaglandin dehydrogenase, a COX-2 oncogene antagonist, is a TGF-β-induced suppressor of human gastrointestinal cancers

Yan, M., Rerko, R. M., Platzer, P., Dawson, D. M., Willis, J. E., Tong, M., Lawrence, E., Lutterbaugh, J., Lu, S., Willson, J. K. V., et al. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0406142101 · Cited by 243 · see citing works

Primary structure of sheep prostaglandin endoperoxide synthase deduced from cDNA sequence

Yokoyama, C., Takai, T., & Tanabe, T. (1988) · FEBS Letters · doi:10.1016/0014-5793(88)80847-0 · Cited by 218 · see citing works

Loss of the tumor suppressor Vhlh leads to upregulation of Cxcr4 and rapidly progressive glomerulonephritis in mice

Ding, M., Cui, S., Li, C., Jothy, S., Haase, V. H., Steer, B. M., Marsden, P. A., Pippin, J. W., Shankland, S. J., Rastaldi, M. P., et al. (2006) · Nature Medicine · doi:10.1038/nm1460 · Cited by 211 · see citing works

Inducible microsomal prostaglandin E synthase is overexpressed in colorectal adenomas and cancer.

Yoshimatsu, K., Golijanin, D., Paty, P. B., Soslow, R. A., Jakobsson, P. ‐., DeLellis, R. A., Subbaramaiah, K., & Dannenberg, A. J. (2001) · PubMed · Cited by 210 · see citing works

Role of cyclooxygenase-2 in colorectal cancer

Sinicrope, F. A., & Gill, S. (2003) · Cancer and Metastasis Reviews · doi:10.1023/a:1025863029529 · Cited by 197 · see citing works

Inhibition of cyclooxygenase-2 by rofecoxib attenuates the growth and metastatic potential of colorectal carcinoma in mice.

Yao, M., Kargman, S., Lam, E. C., et al. (2003) · PubMed · Cited by 195 · see citing works

Prostaglandin E2 Enhances Intestinal Adenoma Growth via Activation of the Ras-Mitogen-Activated Protein Kinase Cascade

Wang, D., Buchanan, F. G., Wang, H., Dey, S. K., & DuBois, R. N. (2005) · Cancer Research · doi:10.1158/0008-5472.can-04-3671 · Cited by 193 · see citing works

Taming cancer by inducing immunity via dendritic cells

Palucka, A. K., Ueno, H., Fay, J. W., & Banchereau, J. (2007) · Immunological Reviews · doi:10.1111/j.1600-065x.2007.00575.x · Cited by 190 · see citing works

Transcriptional activation of cyclooxygenase-2 in Wnt-1-transformed mouse mammary epithelial cells.

Howe, L. R., Subbaramaiah, K., Chung, W. J., Dannenberg, A. J., & Brown, A. M. C. (1999) · PubMed · Cited by 185 · see citing works

Enhancement of colon carcinogenesis by prostaglandin E2 administration

Kawamori, T. (2003) · Carcinogenesis · doi:10.1093/carcin/bgg033 · Cited by 180 · see citing works

Prostaglandins promote colon cancer cell invasion; signaling by cross‐talk between two distinct growth factor receptors

Pai, R., Nakamura, T., Moon, W. S., & Tarnawski, A. S. (2003) · The FASEB Journal · doi:10.1096/fj.02-1011com · Cited by 177 · see citing works

Angiogenic effects of prostaglandin E2 are mediated by up-regulation of CXCR4 on human microvascular endothelial cells

Salcedo, R., Zhang, X., Young, H. A., Michael, N. L., Wasserman, K., Ma, W.-H., Martins‐Green, M. M., Murphy, W. J., & Oppenheim, J. J. (2003) · Blood · doi:10.1182/blood-2002-11-3400 · Cited by 174 · see citing works

Genetic Deletion of mPGES-1 Suppresses Intestinal Tumorigenesis

Nakanishi, M., Montrose, D. C., Clark, P., et al. (2008) · Cancer Research · doi:10.1158/0008-5472.can-07-6100 · Cited by 168 · see citing works

Prostaglandin E2 reduces radiation-induced epithelial apoptosis through a mechanism involving AKT activation and bax translocation

Tessner, T. G., Muhale, F., Riehl, T. E., Anant, S., & Stenson, W. F. (2004) · Journal of Clinical Investigation · doi:10.1172/jci22218 · Cited by 167 · see citing works

Mechanisms of malignant progression

Weinberg, R. A. (2008) · Carcinogenesis · doi:10.1093/carcin/bgn104 · Cited by 167 · see citing works

Prostaglandin EP receptors: Targets for treatment and prevention of colorectal cancer?

Hull, M. A., Ko, S. C., & Hawcroft, G. (2004) · Molecular Cancer Therapeutics · doi:10.1158/1535-7163.1031.3.8 · Cited by 161 · see citing works

Colon Carcinoma Cell Growth Is Associated with Prostaglandin E2/EP4 Receptor-evoked ERK Activation

Pozzi, A., Yan, X. S., Macias‐Perez, I., Wei, S. D., Hata, A. N., BREYER, R. M., Morrow, J. D., & Capdevila, J. H. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m313989200 · Cited by 154 · see citing works

PTEN mutations are common in sporadic microsatellite stable colorectal cancer

Nassif, N. T., Lobo, G. P., Wu, X., Henderson, C. J., Morrison, C. D., Eng, C., Jalaludin, B. B., & Segelov, E. (2004) · Oncogene · doi:10.1038/sj.onc.1207059 · Cited by 153 · see citing works

Hypoxic activation of nuclear factor-kappa B is mediated by a Ras and Raf signaling pathway and does not involve MAP kinase (ERK1 or ERK2).

Koong, A. C., Chen, E. Y., Mivechi, N. F., Denko, N. C., Stambrook, P. J., & Giaccia, A. J. (1994) · PubMed · Cited by 150 · see citing works

Up-regulation of Apoptosis Inhibitory Protein IAP-2 by Hypoxia

Dong, Z., Venkatachalam, M. A., Wang, J., Patel, Y., Saikumar, P., Semenza, G. L., Force, T. L., & Nishiyama, J. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m011774200 · Cited by 150 · see citing works

The Two-Step Model of Prostaglandin Signal Termination: In Vitro Reconstitution with the Prostaglandin Transporter and Prostaglandin 15 Dehydrogenase

Nomura, T., Lu, R., Pucci, M. L., & Schuster, V. L. (2004) · Molecular Pharmacology · doi:10.1124/mol.65.4.973 · Cited by 150 · see citing works

Mediators of PGE2 synthesis and signalling downstream of COX-2 represent potential targets for the prevention/treatment of colorectal cancer

Chell, S. D., Кади, А., Williams, A. C., & Paraskeva, C. (2006) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2006.05.002 · Cited by 144 · see citing works

Downregulation of prostaglandin E receptor subtype EP 3 during colon cancer development

Shoji, Y., Takahashi, M., Kitamura, T., et al. (2004) · Gut · doi:10.1136/gut.2003.028787 · Cited by 143 · see citing works

Increased EP4 Receptor Expression in Colorectal Cancer Progression Promotes Cell Growth and Anchorage Independence

Chell, S. D., Witherden, I. R., Dobson, R. R., Moorghen, M., Herman, A., Qualtrough, D., Williams, A. C., & Paraskeva, C. (2006) · Cancer Research · doi:10.1158/0008-5472.can-05-3702 · Cited by 141 · see citing works

Targeting Prostaglandin E EP Receptors to Inhibit Metastasis

Fulton, A. M., Ma, X., & Kundu, N. (2006) · Cancer Research · doi:10.1158/0008-5472.can-06-2067 · Cited by 140 · see citing works

15-Hydroxyprostaglandin dehydrogenase

Ensor, M., & Tai, H. (1995) · Journal of Lipid Mediators and Cell Signalling · doi:10.1016/0929-7855(95)00040-w · Cited by 138 · see citing works

PEA3 Is Up-regulated in Response to Wnt1 and Activates the Expression of Cyclooxygenase-2

Howe, L. R., Crawford, H. C., Subbaramaiah, K., Hassell, J. A., Dannenberg, A. J., & Brown, A. M. C. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m010692200 · Cited by 136 · see citing works

Fishing for prostanoids: Deciphering the developmental functions of cyclooxygenase-derived prostaglandins

Cha, Y. I., Solnica‐Krezel, L., & DuBois, R. N. (2005) · Developmental Biology · doi:10.1016/j.ydbio.2005.10.013 · Cited by 133 · see citing works

Size-dependent increase in prostanoid levels in adenomas of patients with familial adenomatous polyposis.

Yang, V. W., Shields, J. M., Hamilton, S. R., Spannhake, E. W., Hubbard, W. C., Hylind, L. M., Robinson, C., & Giardiello, F. M. (1998) · PubMed · Cited by 129 · see citing works

Division of labour

Christofori, G. (2007) · Nature · doi:10.1038/446735a · Cited by 126 · see citing works

Regulation of Cyclooxygenase-2 by Hypoxia and Peroxisome Proliferators in the Corneal Epithelium

Bonazzi, A., Mastyugin, V., Mieyal, P. A., Dunn, M. W., & Schwartzman, M. L. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.275.4.2837 · Cited by 120 · see citing works

Two Opposing Effects of Non-steroidal Anti-inflammatory Drugs on the Expression of the Inducible Cyclooxygenase

Paik, J. H., ju, J. H., Lee, J. Y., Boudreau, M. D., & Hwang, D. H. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m002329200 · Cited by 115 · see citing works

Host and Direct Antitumor Effects and Profound Reduction in Tumor Metastasis with Selective EP4 Receptor Antagonism

Yang, L., Huang, Y., Porta, R., et al. (2006) · Cancer Research · doi:10.1158/0008-5472.can-06-1271 · Cited by 115 · see citing works

The impact of eicosanoids on the crosstalk between innate and adaptive immunity: the key roles of dendritic cells

Harizi, H., & Gualde, N. (2005) · Tissue Antigens · doi:10.1111/j.1399-0039.2005.00394.x · Cited by 115 · see citing works

Cyclooxygenase-2 overexpression in the skin of transgenic mice results in suppression of tumor development.

Bol, D. K., Rowley, R. B., Ho, C., Pilz, B., Dell, J., Swerdel, M. R., Kiguchi, K., Muga, S. J., Klein, R. D., & Fischer, S. M. (2002) · PubMed · Cited by 112 · see citing works

PPARδ status and Apc-mediated tumourigenesis in the mouse intestine

Reed, K. R., Sansom, O. J., Hayes, A. J., Gescher, A. J., Winton, D. J., Peters, J. M., & Clarke, A. R. (2004) · Oncogene · doi:10.1038/sj.onc.1208143 · Cited by 110 · see citing works

Repression of Prostaglandin Dehydrogenase by Epidermal Growth Factor and Snail Increases Prostaglandin E2 and Promotes Cancer Progression

Mann, J. R., Backlund, M. G., Buchanan, F. G., Daikoku, T., Holla, V. R., Rosenberg, D. W., Dey, S. K., & DuBois, R. N. (2006) · Cancer Research · doi:10.1158/0008-5472.can-06-1787 · Cited by 108 · see citing works

Prevention of Both Direct and Cross-Priming of Antitumor CD8+ T-Cell Responses following Overproduction of Prostaglandin E2 by Tumor CellsIn vivo

Ahmadi, M., Emery, D. C., & Morgan, D. J. (2008) · Cancer Research · doi:10.1158/0008-5472.can-08-1060 · Cited by 105 · see citing works

Gastrin Stimulates Cyclooxygenase-2 Expression in Intestinal Epithelial Cells through Multiple Signaling Pathways

Guo, Y.-S., Cheng, J.-Z., Jin, G., Gutkind, J. S., Hellmich, M. R., & Townsend, C. M. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m209016200 · Cited by 97 · see citing works

Thioredoxin-1 Modulates Transcription of Cyclooxygenase-2 via Hypoxia-Inducible Factor-1α in Non–Small Cell Lung Cancer

Csiki, I., Yanagisawa, K., Haruki, N., Nadaf, S., Morrow, J. D., Johnson, D. H., & Carbone, D. P. (2006) · Cancer Research · doi:10.1158/0008-5472.can-05-1357 · Cited by 96 · see citing works

Regulation of Prostaglandin Transporters in Colorectal Neoplasia

Holla, V. R., Backlund, M. G., Yang, P., et al. (2008) · Cancer Prevention Research · doi:10.1158/1940-6207.capr-07-0009 · Cited by 94 · see citing works

PGE2inhibits apoptosis in human adenocarcinoma Caco-2 cell line through Ras-PI3K association and cAMP-dependent kinase A activation

Leone, V., di Palma, A., Ricchi, P., et al. (2007) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00584.2006 · Cited by 92 · see citing works

HGF triggers activation of the COX‐2 gene in rat gastric epithelial cells: action mediated through the ERK2 signaling pathway

Jones, M. K., Sasaki, E., Halter, F., et al. (1999) · The FASEB Journal · doi:10.1096/fasebj.13.15.2186 · Cited by 88 · see citing works

The effect of the selective cyclooxygenase-2 inhibitor rofecoxib on human colorectal cancer liver metastases

Fenwick, S. W., Toogood, G. J., Lodge, J. P. A., & Hull, M. A. (2003) · Gastroenterology · doi:10.1016/s0016-5085(03)01061-8 · Cited by 88 · see citing works

Cloning and Characterization of Cyclooxygenase-1b (Putative Cyclooxygenase-3) in Rat

Snipes, J. A., Kis, B., Shelness, G. S., Hewett, J. A., & Busija, D. W. (2005) · The Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.104.079533 · Cited by 82 · see citing works

Cyclooxygenase-2 Expression by Nonsteroidal Anti-inflammatory Drugs in Human Airway Smooth Muscle Cells: Role of Peroxisome Proliferator-Activated Receptors

Pang, L., Nie, M., Corbett, L. M., & Knox, A. J. (2003) · The Journal of Immunology · doi:10.4049/jimmunol.170.2.1043 · Cited by 81 · see citing works

Prostaglandin E2-EP4 receptor signalling promotes tumorigenic behaviour of HT-29 human colorectal cancer cells

Hawcroft, G., Ko, C. W. S., & Hull, M. A. (2006) · Oncogene · doi:10.1038/sj.onc.1210113 · Cited by 81 · see citing works

Human colorectal adenomas demonstrate a size‐dependent increase in epithelial cyclooxygenase‐2 expression

Elder, D. J. E., Baker, J. A., Banu, N. A., Moorghen, M., & Paraskeva, C. (2002) · The Journal of Pathology · doi:10.1002/path.1232 · Cited by 81 · see citing works

Cyclooxygenase-2-Derived Prostaglandin E2 Protects Mouse Embryonic Stem Cells from Apoptosis

Liou, J., Ellent, D. P., Lee, S. H., Goldsby, J. S., Ko, B., Matijevic, N., Huang, J.-C., & Wu, K. K. (2007) · Stem Cells · doi:10.1634/stemcells.2006-0505 · Cited by 77 · see citing works

Intestinal immune responses in wild-type and Apcmin/+ mouse, a model for colon cancer.

Kettunen, H., Kettunen, A., & Rautonen, N. (2003) · PubMed · Cited by 75 · see citing works

Prostaglandin F2α stimulates motility and invasion in colorectal tumor cells

Qualtrough, D., Kaidi, A., Chell, S. D., Jabbour, H. N., Williams, A. C., & Paraskeva, C. (2007) · International Journal of Cancer · doi:10.1002/ijc.22755 · Cited by 69 · see citing works

COX-2 inhibitors for colorectal cancer

Elder, D. J. E., & Paraskeva, C. (1998) · Nature Medicine · doi:10.1038/nm0498-392 · Cited by 69 · see citing works

Immunohistochemical Localization of Cyclooxygenase-1 and Cyclooxygenase-2 in the Human Fetal and Adult Male Reproductive Tracts1

Kirschenbaum, A. M., Liotta, D. R., Shen, Y., et al. (2000) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.85.9.6780 · Cited by 69 · see citing works

Promoter hypermethylation silences cyclooxygenase-2 (Cox-2) and regulates growth of human hepatocellular carcinoma cells

Murata, H., Tsuji, S., Tsujii, M., Sakaguchi, Y., Fu, H. Y., Kawano, S., & Hori, M. (2004) · Laboratory Investigation · doi:10.1038/labinvest.3700118 · Cited by 64 · see citing works

Cyclooxygenase-2 induction and transforming growth factor beta growth inhibition in rat intestinal epithelial cells.

Sheng, H., Shao, J., Eb, H., et al. (1997) · PubMed · Cited by 61 · see citing works

Repression of 15-Hydroxyprostaglandin Dehydrogenase Involves Histone Deacetylase 2 and Snail in Colorectal Cancer

Backlund, M. G., Mann, J. R., Holla, V. R., Shi, Q., Daikoku, T., Dey, S. K., & DuBois, R. N. (2008) · Cancer Research · doi:10.1158/0008-5472.can-08-2893 · Cited by 54 · see citing works

Corrigendum to “Prostaglandin and leukotriene ω-hydroxylases”

Kikuta, Y., Kusunose, E., & Kusunose, M. (2003) · Prostaglandins & Other Lipid Mediators · doi:10.1016/s0090-6980(02)00135-1 · Cited by 53 · see citing works

Immunohistochemical Expression of Cyclooxygenase-2 in Normal Kidneys

Adegboyega, P. A., & Ololade, O. (2004) · Applied immunohistochemistry & molecular morphology · doi:10.1097/00129039-200403000-00013 · Cited by 52 · see citing works

Prostanoids, ornithine decarboxylase, and polyamines in primary chemoprevention of familial adenomatous polyposis

Giardiello, F. M., Casero, R. A., Hamilton, S. R., et al. (2004) · Gastroenterology · doi:10.1053/j.gastro.2003.11.013 · Cited by 52 · see citing works

Immunohistochemical Localization of Cyclooxygenase-1 and Cyclooxygenase-2 in the Human Fetal and Adult Male Reproductive Tracts

Kirschenbaum, A. M. (2000) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.85.9.3436 · Cited by 50 · see citing works

Effects of hypoxia on monocyte inflammatory mediator production: Dissociation between changes in cyclooxygenase-2 expression and eicosanoid synthesis.

Demasi, M., Cleland, L. G., Cook‐Johnson, R. J., Caughey, G. E., & James, M. J. (2017) · Journal of Biological Chemistry · doi:10.1074/jbc.a117.305944 · Cited by 43 · see citing works

Genetic deletion of mPGES-1 accelerates intestinal tumorigenesis in APCMin/+ mice

Elander, N., Ungerbäck, J., Olsson, H., et al. (2008) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2008.05.026 · Cited by 41 · see citing works

Regulation of stromal cell cyclooxygenase-2 in the Apc Min/+ mouse model of intestinal tumorigenesis

Hull, M. A., Faluyi, O. O., Ko, C. W. S., Holwell, S. E., Scott, D. J., Cuthbert, R. J., Poulsom, R., Goodlad, R. A., Bonifer, C., Markham, A. F., et al. (2005) · Carcinogenesis · doi:10.1093/carcin/bgi236 · Cited by 29 · see citing works

The effect of exogenous prostaglandin administration on tumor size and yield in Min/+ mice.

Wilson, J. W., & Potten, C. S. (2000) · PubMed · Cited by 28 · see citing works

Pathways of Colorectal Carcinogenesis

Nguyen, L. H., Goel, A., & Chung, D. C. (2020) · Gastroenterology · doi:10.1053/j.gastro.2019.08.059 · Cited by 606 · see citing works

IL-18 production downstream of the NLRP3 inflammasome confers protection against colorectal tumor formation

Zaki, M. H., Vogel, P., Body-Malapel, M., Lamkanfi, M., & Kanneganti, T.-D. (2010) · The Journal of Immunology · doi:10.4049/jimmunol.1002046 · Cited by 411 · see citing works

Self-regulation of the inflammatory response by peroxisome proliferator-activated receptors

Korbecki, J., Bobiński, R., & Dutka, M. (2019) · Inflammation Research · doi:10.1007/s00011-019-01231-1 · Cited by 415 · see citing works

A Senescence-Inflammatory Switch from Cancer-Inhibitory to Cancer-Promoting Mechanism

Pribluda, A., Elyada, E., Wiener, Z., Hamza, H., Goldstein, R. E., Biton, M., Burstain, I., Morgenstern, Y., Brachya, G., Billauer, H., et al. (2013) · Cancer Cell · doi:10.1016/j.ccr.2013.06.005 · Cited by 239 · see citing works

Pleiotropic regulation of macrophage polarization and tumorigenesis by formyl peptide receptor-2

Li, Y., Cai, L., Wang, H., Wu, P., Gu, W., Chen, Y., Hao, H., Tang, K., Yi, P., Liu, M., et al. (2011) · Oncogene · doi:10.1038/onc.2011.112 · Cited by 192 · see citing works

The Role of COX-2 and PGE2 in the Regulation of Immunomodulation and Other Functions of Mesenchymal Stromal Cells

Kulesza, A., Paczek, L., & Burdzinska, A. (2023) · Biomedicines · doi:10.3390/biomedicines11020445 · Cited by 163 · see citing works

The Pathogenesis of Adenomyosis vis-à-vis Endometriosis

Guo, S.-W. (2020) · Journal of Clinical Medicine · doi:10.3390/jcm9020485 · Cited by 165 · see citing works

The itinerary of Streptococcus gallolyticus infection in patients with colonic malignant disease

Boleij, A., & Tjalsma, H. (2013) · The Lancet Infectious Diseases · doi:10.1016/s1473-3099(13)70107-5 · Cited by 158 · see citing works

Role of epigenetics in transformation of inflammation into colorectal cancer

Yang, Z.-H., Dang, Y.-Q., & Ji, G. (2019) · World Journal of Gastroenterology · doi:10.3748/wjg.v25.i23.2863 · Cited by 81 · see citing works

Increased inflammatory lipid metabolism and anaplerotic mitochondrial activation follow acquired resistance to vemurafenib in BRAF-mutant melanoma cells

Delgado-Goñi, T., Galobart, T. C., Wantuch, S., Normantaite, D., Leach, M. O., Whittaker, S. R., & Beloueche-Babari, M. (2020) · British Journal of Cancer · doi:10.1038/s41416-019-0628-x · Cited by 39 · see citing works

Effect of the dietary intake of melatonin- and hydroxytyrosol-rich wines by healthy female volunteers on the systemic lipidomic-related oxylipins

Marhuenda, J., Medina, S., Martínez-Hernández, P., Arina, S., Zafrilla, P., Mulero, J., Oger, C., Galano, J.-M., Durand, T., Solana, A., et al. (2017) · Food Funct. · doi:10.1039/c7fo01081h · Cited by 22 · see citing works

Activated Platelets Induce Hypoxia-Inducible Factor-1α Expression Likely through Transforming Growth Factor-β1 in Human Endometrial Stromal Cells

Qi, Q.-M., Guo, S.-W., & Liu, X.-S. (2019) · Reproductive and Developmental Medicine · doi:10.4103/2096-2924.262390 · Cited by 15 · see citing works

Tumorigenesis and cell evolution

Cai, D. (1995) · Medical Hypotheses · doi:10.1016/0306-9877(95)90256-2

Progress of the relationship between aberrant p53 protein and tumorigenesis

Xu, J. (2019) · doi:10.3760/cma.j.issn.1006-9801.2019.09.014

Expression of PTTG and its significance in colorectal cancer

Wei-guang, M. (2008) · Shandong yiyao

Immunometabolism in the tumor microenvironment and its related research progress

Zhang, Z., Hu, Y., Chen, Y., Chen, Z., Zhu, Y., Chen, M., Xia, J., Sun, Y., & Xu, W. (2022) · Frontiers in Oncology · doi:10.3389/fonc.2022.1024789 · Cited by 34 · see citing works

Metastasis suppressors Nm23H1 and Nm23H2 differentially regulate neoplastic transformation and tumorigenesis

Tong, Y., Yung, L. Y., & Wong, Y. H. (2015) · Cancer Letters · doi:10.1016/j.canlet.2015.02.050 · Cited by 20 · see citing works