The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Apoptotic hepatocytes become insoluble in detergents and chaotropic agents as a result of transglutaminase action
Open accessAbstract
Physiological deletion of cells ensues programmed death which involves formation of apoptotic bodies with fragmented DNA. Here we report that apoptotic hepatocytes are insoluble in detergents, urea, guanidine hydrochloride, reducing agents and thereby can be isolated from rat liver following collagenase treatment. They are wrinkled, spherical structures similar to cornified envelopes of epidermis by phase‐contrast microscopy and show irregular, globular morphology by scanning‐electron microscopy. Part of their DNA content is cleaved into nueleosomal and oligonucleosomal fragments. Their insolubility, like that of the cornified envelope, is evoked by ε‐(γ‐glutamyl)lysine and N 1,N 8‐bis(γ‐glutamyl)spermidine protein cross‐linking bonds formed by transglutaminase.
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Citations
Cites
Burton, K. (1956) · Biochemical Journal · doi:10.1042/bj0620315 · Cited by 14,090
Cited by
Mechanisms and Functions of Cell Death
Ellis, R. E., Yuan, J., & Horvitz, H. R. (1991) · Annual Review of Cell Biology · doi:10.1146/annurev.cb.07.110191.003311 · Cited by 2,057
The cornified envelope: a model of cell death in the skin
Candi, E., Schmidt, R., & Melino, G. (2005) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm1619 · Cited by 1,776
Apoptosis: The Biochemistry and Molecular Biology of Programmed Cell Death*
SCHWARTZMAN, R. A., & CIDLOWSKI, J. A. (1993) · Endocrine Reviews · doi:10.1210/edrv-14-2-133 · Cited by 1,040
Apoptosis: Molecular Regulation of Cell Death
Hale, A. J., Smith, C. A., Sutherland, L. C., Stoneman, V. E. A., Longthorne, V. L., Culhane, A. C., & Williams, G. T. (1996) · European Journal of Biochemistry · doi:10.1111/j.1432-1033.1996.00001.x · Cited by 656
The Role of Calcium in the Regulation of Apoptosis
McConkey, D. J., & Orrenius, S. (1997) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1997.7409 · Cited by 462
Metadata
- Authors
- Fesus, L., Thomazy, V., Autuori, F., Ceru, M. P., Tarcsa, E., & Piacentini, M.
- Venue
- FEBS Letters
- Publisher
- Wiley
- Published
- 1989-03-13
- Volume
- 245
- Issue
- 1-2
- Pages
- 150-154
- ISSN
- 0014-5793 (ISSN-L)
- 1873-3468
- OpenAlex
- W2082814018
- Cited by
- 248
- References
- 1
- FWCI
- 4.59
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Fesus, L., Thomazy, V., Autuori, F., Ceru, M. P., Tarcsa, E., & Piacentini, M. (1989). Apoptotic hepatocytes become insoluble in detergents and chaotropic agents as a result of transglutaminase action. FEBS Letters. https://doi.org/10.1016/0014-5793(89)80210-8
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
