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Bradykinin stimulates tumor necrosis factor and interleukin‐1 release from macrophages
Abstract
Bradykinin and related kinins have been implicated in the initiation and maintenance of inflammation. Cytokines appear to be the primary mediators of many inflammatory diseases. The potential ability of bradykinin to stimulate release of tumor necrosis factor and interleukin‐1 from macrophages was examined. Bradykinin stimulated release of both cytokines from P388‐D1 and RAW264.7 murine macrophages. Studies with selective agonists and antagonists suggest that cytokine release is mediated by a B 1 kinin receptor.
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Skidgel, R. A., & Erdös, E. G. (1998) · Immunological Reviews · doi:10.1111/j.1600-065x.1998.tb01577.x · Cited by 155
The role of kinin receptors in cancer and therapeutic opportunities
da Costa, P. L. N., Sirois, P., Tannock, I. F., & Chammas, R. (2014) · Cancer Letters · doi:10.1016/j.canlet.2013.12.009 · Cited by 133
Devani, M., Cugno, M., Vecchi, M., Ferrero, S., Berardino, F., Avesani, E. C., Franchis, R., & Colman, R. W. (2002) · The American Journal of Gastroenterology · doi:10.1111/j.1572-0241.2002.05919.x · Cited by 31
Metadata
- Authors
- Tiffany, C. W., & Burch, R. M.
- Venue
- FEBS Letters
- Publisher
- Wiley
- Published
- 1989-04-24
- Volume
- 247
- Issue
- 2
- Pages
- 189-192
- ISSN
- 0014-5793 (ISSN-L)
- 1873-3468
- OpenAlex
- W2045246923
- Cited by
- 238
- References
- 0
- FWCI
- 4.58
- Type
- journal article
- Language
- en
- Open access
- closed
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- Tiffany, C. W., & Burch, R. M. (1989). Bradykinin stimulates tumor necrosis factor and interleukin‐1 release from macrophages. FEBS Letters. https://doi.org/10.1016/0014-5793(89)81331-6
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
