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Cited by 160

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Distribution of serotonin 5‐HT1C receptor mRNA in adult rat brain

Open access
Hoffman, Beth J., Mezey, Eva·1989·FEBS Letters
DOI 10.1016/0014-5793(89)81390-0
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Abstract

Based on in situ hybridization histochemistry (ISHH), we describe the anatomical distribution of the serotonin 5‐HT 1C receptor mRNA. In addition to the very high levels in epithelial cells of the choroid plexus, 5‐HT 1C receptor mRNA is found throughout the limbic system, in catecholaminergic cells and in serotonergic neurons. Receptor transcripts are also present in the hypothalamus, numerous motor nuclei and the subthalamus. Our results correlate well with serotonin (5‐HT) innervation and receptor binding. Receptor mRNA is present in many brain structures in addition to regions previously shown to have 5‐HT 1C receptor binding. The distribution of this receptor mRNA suggests that the 5‐HT 1C receptor may mediate a number of the central effects of 5‐HT.

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Metadata

Authors
Hoffman, B. J., & Mezey, E.
Venue
FEBS Letters
Publisher
Wiley
Published
1989-04-24
Volume
247
Issue
2
Pages
453-462
ISSN
  • 0014-5793 (ISSN-L)
  • 1873-3468
DOI
10.1016/0014-5793(89)81390-0
OpenAlex
W2013056388
Cited by
160
References
0
FWCI
3.05
Type
journal article
Language
en
Open access
bronze

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CoChat. (2026). Citation check: Distribution of serotonin 5‐HT1C receptor mRNA in adult rat brain. https://app.cochat.ai/papers/10.1016/0014-5793(89)81390-0
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Hoffman, B. J., & Mezey, E. (1989). Distribution of serotonin 5‐HT1C receptor mRNA in adult rat brain. FEBS Letters. https://doi.org/10.1016/0014-5793(89)81390-0

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

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