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Cited by 1,117Neural dynamics and brain functionNeuroscience and Neuropharmacology ResearchNeurological disorders and treatments

Neurotransmitter actions in the thalamus and cerebral cortex and their role in neuromodulation of thalamocortical activity

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McCormick, David A.·1992·Progress in Neurobiology
DOI 10.1016/0301-0082(92)90012-4
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  • Effects consistent with a role in arousal of pyramidal cell networks include depolarization of cortical neurons through reduction of membrane K+ currents, modulation of the h-current, and control of synaptic transmission.

    “Effects that are consistent with a role in arousal of pyramidal cell networks include depolarization of cortical neurons through the reduction of a variety of membrane K+ currents (McCormick, 1992), modulation of the h-current (Wang et al., 2007), which controls neuronal and dendritic excitability (Magee, 2000), and control of synaptic transmission, through the modulation of presynaptic terminals”

    From Waking state: rapid variations modulate neural and behavioral responses (2015) · cites this paper as McCormick, 1992

  • The release of norepinephrine or acetylcholine can modulate the state of cortical activity through cell type and subcellular specific effects.

    “The release of either of these neurotransmitters can potentially modulate the state of cortical activity through cell type, and even subcellular, specific effects.”

    From Waking state: rapid variations modulate neural and behavioral responses (2015) · cites this paper as McCormick, 1992

  • Through modulation of ionic currents, release of norepinephrine or acetylcholine can control membrane potential and excitability of cortical neurons and strongly suppress generation of slow oscillations.

    “Through the modulation of ionic currents, the release of norephinephrine or acetylcholine can not only control the membrane potential and excitability of cortical neurons, but also strongly suppress the generation of slow oscillations.”

    From Waking state: rapid variations modulate neural and behavioral responses (2015) · cites this paper as McCormick, 1992

  • Layer 5 pyramidal cells respond to activation of α1 adrenergic and muscarinic cholinergic receptors with depolarization towards firing threshold and increased excitability through reduction of K+ currents.

    “Layer 5 pyramidal cells, in particular, respond to the activation of α1 adrenergic and muscarinic cholinergic receptors with depolarization towards firing threshold, and an increase in excitability through the reduction of K+ currents that function to dampen the generation of repetitive trains of action potentials (McCormick, 1992).”

    From Waking state: rapid variations modulate neural and behavioral responses (2015) · cites this paper as McCormick, 1992

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Research works printed but not linked: 25

  1. BLOOM, F. E. (1988) What is the role of general activating systems in cortical function? In: Neurobiology of NeD- cortex, pp. 407-421.
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  3. CURR6 nOSSl, R., NUNEZ, A. and STERIADE, M. (1991b) Electrophysiology of a slow intrinsic oscillation in thala- mocortical cells of cat in vivo. J. Physiol., Lond., in press.
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  5. Ed. G. M. SHEPHERD. Oxford University Press: New York.
  6. GIUFFRIDA, R. and RUSTIONI, A. (1988) Glutamate and aspartate immunoreactivity in corticothalamic neurons of rats. In: Cellular Thalamic Mechanisms, pp. 311-320.
  7. Eds. M. BENTIVOGLIO and R. SPREAFICO. Elsevier: Amsterdam.
  8. JONES, E. G. (1985) The Thalamus. Plenum Press: New York.
  9. KOCH, C. (1985) Understanding the intrinsic circuitry of the cat's LGN: Electrical properties of the spine-triad ar- rangement. Proc. R. Soc., 225, 365-390.
  10. Eds. E. G. JONES and A. PETERs. Plenum Press: New York.
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  12. Eds. M. AVOLI, T. A. READER, R. W. DYKES and P. GLOOR. Plenum Press: New York.
  13. PETERS, A. and JONES, E. G. (1984) Cerebral Cortex. Vol. I. Cellular Components of the Cerebral Cortex. Plenum Press: New York.
  14. Eds. A. V. DEL- GADO-ESCUETA, A. A. WARD, D. M. WOODnURY and R. J. PORTER. Raven Press: New York.
  15. RUAT, M., TRAIFFORT, E., BOUTHENET, M. L., SCHWARTZ, J. C., HIRSCrmSLD, J., BUSCHAU~R, A. and SCRUNACK, W. (1990) Reversible and irreversible labeling and autoradio- graphic localization of cerebral histamine H 2 receptor using [t25I]iodinated probes. Proc. natn Acad. Sci. U.S.A. 87, 1658-1662.
  16. SHELDON, P. W. (1991) Eiectrophysiological and pharmaco- logical studies of the excitatory actions of serotonin (5-HT) in the rat pyriform cortex in an in vitro slice preparation. Ph.D. Thesis. Yale University Medical School, New Havan, Connecticut.
  17. SHERMAN, S. M. and KOCH, C. (1990) Thalamus. In: Synap- tic Organization of the Brain, 3rd edn, pp. 246-278.
  18. Ed. G. M. SHEPHERD. Oxford University Press: New York.
  19. Eds. E. G. JONES and A. PETERS. Plenum Press: New York.
  20. STERIADE, M. and BUZSAKI, G. (1990) Parallel activation of thalamic and cortical neurons by brainstem and basal forebrain cholinergic systems. In: Brain Cholinergic Sys- tems, pp. 3-53. Eds. M. STERIADE and D. BIESOLD. Oxford University Press: New York.
  21. STEmADE, M., JONES, E. G. and LLIN~,S, R. R. (1990e) Thal- amic Oscillations and Signalling. Wiley: New York.
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  23. Eds. O. PETR£-QUADENS and J. D. SCHLAG. Academic Press: New York.
  24. VON KROSIGK, M. and McCoRMICK, D. A. (1991) Glutamate metabotropic receptor activation modulates thalamic neuronal activity. Soc. Neurosci. Abstr., in press.
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Authors
McCormick, D. A.
Affiliations
Yale University (US)
Corresponding author
McCormick, David A.
ORCID
McCormick, David A.
Venue
Progress in Neurobiology
Publisher
Elsevier BV
Published
1992-10
Volume
39
Issue
4
Pages
337-388
ISSN
0301-0082 (ISSN-L)
DOI
10.1016/0301-0082(92)90012-4
OpenAlex
W2028311911
Cited by
1,117
References
439
Citations by year
2026: 8 · 2025: 18 · 2024: 17 · 2023: 38 · 2022: 19 · 2021: 38 · 2020: 25 · 2019: 26 · 2018: 16 · 2017: 20 · 2016: 27 · 2015: 25 · 2014: 26 · 2013: 33 · 2012: 22
FWCI
8.73
Type
journal article
Language
en
Open access
Licence
Locations
  • Progress in Neurobiology (publishedVersion, cc-by-nc-nd)
  • PubMed (publishedVersion)
Funders
  • Alfred P. Sloan Foundation
  • National Institutes of Health
Topics
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
  • Health Sciences › Medicine › Neurology › Neurological disorders and treatments
Keywords
neurotransmitters, thalamus, cerebral cortex, neuromodulation, thalamocortical activity, thalamocortical circuits
MeSH terms
Animals, Cerebral Cortex, Humans, Thalamus, Neurotransmitter Agents

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