Cited by 150Protease and Inhibitor MechanismsOsteoarthritis Treatment and MechanismsProteoglycans and glycosaminoglycans research

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Susceptibility of the cartilage collagens types II, IX and XI to degradation by the cysteine proteinases, cathepsins B and L

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Maciewicz, Rose A., Wotton, Sandra F., Etherington, David J., Duance, Victor C.·1990·FEBS Letters

DOI 10.1016/0014-5793(90)81151-d

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Abstract

We have investigated the susceptibility of both the helical and non‐helical regions of isolated rat chondrosarcoma collagens, types II, IX and XI, to degradation by the cysteine proteinases, cathepsins B and L. Both enzymes degrade these collagens at temperatures from 20 to 37°C and pH values from 3.5 to 7.0. Cleavage occurs only within the non‐helical domains unless the helix is destabilized. Cathepsin L is more effective than cathepsin B on a molar basis and they appear to cleave at different sites. Since these cathepsins can degrade cartilage collagens at pH values near neutrality, they may contribute to the destruction of cartilage observed in arthritis.

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Authors: Maciewicz, R. A., Wotton, S. F., Etherington, D. J., & Duance, V. C.
Corresponding author: Maciewicz, Rose A.
ORCID: Maciewicz, Rose A.
Venue: FEBS Letters
Publisher: Wiley
Published: 1990-08-20
Volume: 269
Issue: 1
Pages: 189-193
ISSN: 0014-5793 (ISSN-L)
1873-3468
DOI: 10.1016/0014-5793(90)81151-d
OpenAlex: W2063035603
Cited by: 147
References: 17
Citations by year: 2026: 2 · 2025: 2 · 2024: 1 · 2023: 1 · 2022: 2 · 2021: 2 · 2020: 4 · 2019: 3 · 2018: 5 · 2017: 3 · 2016: 3 · 2015: 6 · 2014: 1 · 2012: 3
FWCI: 3.86
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: onlinelibrary.wiley.com/termsAndConditions#vor (vor, 4109 d)
Locations: FEBS Letters (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Protease and Inhibitor Mechanisms
Health Sciences › Medicine › Rheumatology › Osteoarthritis Treatment and Mechanisms
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Proteoglycans and glycosaminoglycans research
Keywords: cartilage collagen, type II collagen, type IX collagen, type XI collagen, cathepsin B, cathepsin L, cysteine protease, collagen degradation, helix destabilization, arthritis, cartilage destruction
MeSH terms: Cathepsin B, Cathepsins, Collagen, Cysteine Endopeptidases, Humans, Hydrogen-Ion Concentration, Liver, Peptide Mapping, Endopeptidases, Temperature, Cathepsin L, In Vitro Techniques

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Susceptibility of the cartilage collagens types II, IX and XI to degradation by the cysteine proteinases, cathepsins B and L

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