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The WD‐40 repeat
Open accessAbstract
An amino acid sequence motif, called the WD‐40 repeat, has been found as a repeat in a large variety of proteins that do not share any obvious functional properties. At present, the function of the repeated motif is not known for any of these proteins. Interestingly, recent experiments in yeast indicate that several proteins containing the WD‐40 repeat are genetically associated with members of the TPR‐family, a protein family that is characterized by the presence of another repeated motif of unknown function: the tetratricopeptide repeat. It is conceivable that proteins containing the WD‐40 repeat interact physically with members of the TPR‐family via their respective repeated motifs.
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Cited by
The ancient regulatory-protein family of WD-repeat proteins
Neer, E. J., Schmidt, C. J., Nambudripad, R., & Smith, T. F. (1994) · Nature · doi:10.1038/371297a0 · Cited by 1,498
The WD repeat: a common architecture for diverse functions
Smith, T. F., Gaitatzes, C., Saxena, K., & Neer, E. J. (1999) · Trends in Biochemical Sciences · doi:10.1016/s0968-0004(99)01384-5 · Cited by 1,253
Relationship between Secondary Metabolism and Fungal Development
Calvo, A. M., Wilson, R. A., Bok, J. W., & Keller, N. P. (2002) · Microbiology and Molecular Biology Reviews · doi:10.1128/mmbr.66.3.447-459.2002 · Cited by 1,123
Viral Subversion of the Immune System
Tortorella, D., Gewurz, B. E., Furman, M. H., Schust, D. J., & Ploegh, H. L. (2000) · Annual Review of Immunology · doi:10.1146/annurev.immunol.18.1.861 · Cited by 835
Self-citationMiller-Dieker lissencephaly gene encodes a subunit of brain platelet-activating factor
Hattori, M., Adachi, H., Tsujimoto, M., Arai, H., & Inoue, K. (1994) · Nature · doi:10.1038/370216a0 · Cited by 469
Metadata
- Authors
- van der Voorn, L., & Ploegh, H. L.
- Venue
- FEBS Letters
- Publisher
- Wiley
- Published
- 1992-07-28
- Volume
- 307
- Issue
- 2
- Pages
- 131-134
- ISSN
- 0014-5793 (ISSN-L)
- 1873-3468
- OpenAlex
- W2026649211
- Cited by
- 245
- References
- 0
- FWCI
- 7.63
- Type
- journal article
- Language
- en
- Open access
- bronze
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- van der Voorn, L., & Ploegh, H. L. (1992). The WD‐40 repeat. FEBS Letters. https://doi.org/10.1016/0014-5793(92)80751-2
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
