The DOI matches its Crossref record; 83 of the 83 references it cites were found in a registry or an index.
Relationship between Secondary Metabolism and Fungal Development
Open accessAbstract
SUMMARY: Filamentous fungi are unique organisms—rivaled only by actinomycetes and plants—in producing a wide range of natural products called secondary metabolites. These compounds are very diverse in structure and perform functions that are not always known. However, most secondary metabolites are produced after the fungus has completed its initial growth phase and is beginning a stage of development represented by the formation of spores. In this review, we describe secondary metabolites produced by fungi that act as sporogenic factors to influence fungal development, are required for spore viability, or are produced at a time in the life cycle that coincides with development. We describe environmental and genetic factors that can influence the production of secondary metabolites. In the case of the filamentous fungus Aspergillus nidulans, we review the only described work that genetically links the sporulation of this fungus to the production of the mycotoxin sterigmatocystin through a shared G-protein signaling pathway.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
The Involvement of Cell-to-Cell Signals in the Development of a Bacterial Biofilm
Davies, D. G., Parsek, M. R., Pearson, J. P., Iglewski, B. H., Costerton, J. W., & Greenberg, E. P. (1998) · Science · doi:10.1126/science.280.5361.295 · Cited by 3,396
The ancient regulatory-protein family of WD-repeat proteins
Neer, E. J., Schmidt, C. J., Nambudripad, R., & Smith, T. F. (1994) · Nature · doi:10.1038/371297a0 · Cited by 1,498
The WD repeat: a common architecture for diverse functions
Smith, T. F., Gaitatzes, C., Saxena, K., & Neer, E. J. (1999) · Trends in Biochemical Sciences · doi:10.1016/s0968-0004(99)01384-5 · Cited by 1,253
Signal Transduction Cascades Regulating Fungal Development and Virulence
Lengeler, K. B., Davidson, R. C., D'souza, C., Harashima, T., Shen, W.-C., Wang, P., Pan, X., Waugh, M., & Heitman, J. (2000) · Microbiology and Molecular Biology Reviews · doi:10.1128/mmbr.64.4.746-785.2000 · Cited by 915
The Natural Functions of Secondary Metabolites
Demain, A. L., & Fang, A. (2000) · Advances in Biochemical Engineering/Biotechnology · doi:10.1007/3-540-44964-7_1 · Cited by 707
Tilburn, J., Sarkar, S., Widdick, D. A., Espeso, E. A., Orejas, M., Mungroo, J., Peñalva, M. A., & Arst, H. N. (1995) · The EMBO Journal · doi:10.1002/j.1460-2075.1995.tb07056.x · Cited by 644
Metabolic Pathway Gene Clusters in Filamentous Fungi
Keller, N. P., & Hohn, T. M. (1997) · Fungal Genetics and Biology · doi:10.1006/fgbi.1997.0970 · Cited by 604
Self-citationTwenty-five coregulated transcripts define a sterigmatocystin gene cluster in Aspergillus nidulans.
Brown, D. W., Yu, J. H., Kelkar, H. S., Fernandes, M., Nesbitt, T. C., Keller, N. P., Adams, T. H., & Leonard, T. J. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.4.1418 · Cited by 507
Self-citationbrlA is necessary and sufficient to direct conidiophore development in aspergillus nidulans
Adams, T. H., Boylan, M. T., & Timberlake, W. E. (1988) · Cell · doi:10.1016/0092-8674(88)90198-5 · Cited by 473
Repression domain of the yeast global repressor Tup1 interacts directly with histones H3 and H4.
Edmondson, D. G., Smith, M. M., & Roth, S. Y. (1996) · Genes & Development · doi:10.1101/gad.10.10.1247 · Cited by 450
Cited by
LaeA, a Regulator of Secondary Metabolism in Aspergillus spp
Bok, J. W., & Keller, N. P. (2004) · Eukaryotic Cell · doi:10.1128/ec.3.2.527-535.2004 · Cited by 902
Self-citationA novel role for Trichoderma secondary metabolites in the interactions with plants
Vinale, F., Sivasithamparam, K., Ghisalberti, E. L., Marra, R., Barbetti, M. J., Li, H., Woo, S. L., & Lorito, M. (2008) · Physiological and Molecular Plant Pathology · doi:10.1016/j.pmpp.2008.05.005 · Cited by 593
Lactic acid bacteria as antifungal and anti-mycotoxigenic agents: A comprehensive review
Sadiq, F. A., Yan, B., Tian, F., Zhao, J., Zhang, H., & Chen, W. (2019) · Comprehensive Reviews in Food Science and Food Safety · doi:10.1111/1541-4337.12481 · Cited by 313
LaeA, a Regulator of Morphogenetic Fungal Virulence Factors
Bok, J. W., Balajee, S. A., Marr, K. A., Andes, D., Nielsen, K. F., Frisvad, J. C., & Keller, N. P. (2005) · Eukaryotic Cell · doi:10.1128/ec.4.9.1574-1582.2005 · Cited by 283
Self-citationFilamentous fungi and mycotoxins in cheese: A review
Hymery, N., Vasseur, V., Coton, M., Mounier, J., Jany, J., Barbier, G., & Coton, E. (2014) · Comprehensive Reviews in Food Science and Food Safety · doi:10.1111/1541-4337.12069 · Cited by 215
Metadata
- Authors
- Calvo, A. M., Wilson, R. A., Bok, J. W., & Keller, N. P.
- Venue
- Microbiology and Molecular Biology Reviews
- Publisher
- American Society for Microbiology
- Published
- 2002-09
- Volume
- 66
- Issue
- 3
- Pages
- 447-459
- ISSN
- 1092-2172 (ISSN-L)
- 1098-5557
- OpenAlex
- W2120117970
- Cited by
- 1,123
- References
- 83
- FWCI
- 1.74
- Type
- journal article
- Language
- en
- Open access
- green
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Relationship between Secondary Metabolism and Fungal Development. https://app.cochat.ai/papers/10.1128/mmbr.66.3.447-459.2002
- The paper
- Calvo, A. M., Wilson, R. A., Bok, J. W., & Keller, N. P. (2002). Relationship between Secondary Metabolism and Fungal Development. Microbiology and Molecular Biology Reviews. https://doi.org/10.1128/mmbr.66.3.447-459.2002
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
