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Identification of MAPKAP kinase 2 as a major enzyme responsible for the phosphorylation of the small mammalian heat shock proteins
Open accessAbstract
MAP kinase‐activated protein kinase‐2 (MAPKAP kinase‐2) phosphorylates the serine residues in murine heat shock protein 25 (hsp25) and human heat shock protein 27 (hsp27) which are phosphorylated in vivo in response to growth factors and heat shock, namely Ser 15 and Ser 40 (hsp25) and Ser 15, Ser 78 and Ser 82 (hsp27). Se 86 of hsp25 and the equivalent residue in hsp27 (Ser 82) are phosphorylated preferentially in vitro. The small heat shock protein is present in rabbit skeletal muscle and hsp25 kinase activity in skeletal muscle extracts co‐purifies with MAPKAP kinase‐2 activity throughout the purification of the latter enzyme. These results suggest that MAPKAP kinase‐2 is the enzyme responsible for the phosphorylation of these small heat shock proteins in mammalian cells.
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Cites
Bradford, M. M. (1976) · Analytical Biochemistry · doi:10.1016/0003-2697(76)90527-3 · Cited by 255,302
The molecular mechanism by which insulin stimulates glycogen synthesis in mammalian skeletal muscle
Dent, P., Lavoinne, A., Nakielny, S., Caudwell, F. B., Watt, P., & Cohen, P. (1990) · Nature · doi:10.1038/348302a0 · Cited by 519
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Kyriakis, J. M., & Avruch, J. (2001) · Physiological Reviews · doi:10.1152/physrev.2001.81.2.807 · Cited by 3,382
Activation and function of the MAPKs and their substrates, the MAPK-activated protein kinases
Cargnello, M., & Roux, P. P. (2011) · Microbiology and Molecular Biology Reviews · doi:10.1128/mmbr.00031-10 · Cited by 3,274
(1995) · FEBS Letters · doi:10.1016/0014-5793(95)00357-f · Cited by 2,086
Angiotensin II cell signaling: physiological and pathological effects in the cardiovascular system
Mehta, P. K., & Griendling, K. K. (2007) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00287.2006 · Cited by 1,924
Signal Transduction through MAP Kinase Cascades
(1998) · Advances in Cancer Research · doi:10.1016/s0065-230x(08)60765-4 · Cited by 1,759
Metadata
- Authors
- Stokoe, D., Engel, K., Campbell, D. G., Cohen, P., & Gaestel, M.
- Venue
- FEBS Letters
- Publisher
- Wiley
- Published
- 1992-11-30
- Volume
- 313
- Issue
- 3
- Pages
- 307-313
- ISSN
- 0014-5793 (ISSN-L)
- 1873-3468
- OpenAlex
- W2133181350
- Cited by
- 571
- References
- 2
- FWCI
- 6.62
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Stokoe, D., Engel, K., Campbell, D. G., Cohen, P., & Gaestel, M. (1992). Identification of MAPKAP kinase 2 as a major enzyme responsible for the phosphorylation of the small mammalian heat shock proteins. FEBS Letters. https://doi.org/10.1016/0014-5793(92)81216-9
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
