The molecular mechanism by which insulin stimulates glycogen synthesis in mammalian skeletal muscle

A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding

Bradford, M. M. (1976) · Analytical Biochemistry · doi:10.1016/0003-2697(76)90527-3 · Cited by 255,302 · see citing works

THE STRUCTURE AND REGULATION OF PROTEIN PHOSPHATASES

Cohen, P. (1989) · Annual Review of Biochemistry · doi:10.1146/annurev.bi.58.070189.002321 · Cited by 2,547 · see citing works

Phosphorylation-Dephosphorylation of Enzymes

Krebs, E. G., & Beavo, J. A. (1979) · Annual Review of Biochemistry · doi:10.1146/annurev.bi.48.070179.004423 · Cited by 2,219 · see citing works

An Adenosine 3′,5′-Monophosphate-dependant Protein Kinase from Rabbit Skeletal Muscle

Walsh, D. A., Perkins, J. P., & Krebs, E. G. (1968) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)34204-8 · Cited by 1,448 · see citing works

Okadaic acid: a new probe for the study of cellular regulation

Cohen, P., Holmes, C. F. B., & Tsukitani, Y. (1990) · Trends in Biochemical Sciences · doi:10.1016/0968-0004(90)90192-e · Cited by 1,373 · see citing works

Insulin-stimulated MAP-2 kinase phosphorylates and activates ribosomal protein S6 kinase II

Sturgill, T. W., Ray, L. B., ERIKSON, E., & Maller, J. L. (1988) · Nature · doi:10.1038/334715a0 · Cited by 1,017 · see citing works

Glycogen synthase kinase-3 from rabbit skeletal muscle. Separation from cyclic-AMP-dependent protein kinase and phosphorylase kinase.

Embi, N., Rylatt, D. B., & Cohen, P. (1980) · PubMed · Cited by 911 · see citing works

Effects of the tumour promoter okadaic acid on intracellular protein phosphorylation and metabolism

Haystead, T., Sim, A. T. R., Carling, D., Honnor, R. C., Tsukitani, Y., Cohen, P., & Hardie, D. G. (1989) · Nature · doi:10.1038/337078a0 · Cited by 842 · see citing works

Protein Phosphatases: Properties and Role in Cellular Regulation

Ingebritsen, T. S., & Cohen, P. (1983) · Science · doi:10.1126/science.6306765 · Cited by 645 · see citing works

Protein phosphatases come of age

Cohen, P. T. W., & Cohen, P. (1989) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(20)88197-6 · Cited by 604 · see citing works

The Protein Phosphatases Involved in Cellular Regulation. 1. Classification and Substrate Specificities

Ingebritsen, T. S., & Cohen, P. (1983) · European Journal of Biochemistry · doi:10.1111/j.1432-1033.1983.tb07357.x · Cited by 472 · see citing works

An improved procedure for identifying and quantitating protein phosphatases in mammalian tissues

Cohen, P., Klumpp, S., & Schelling, D. L. (1989) · FEBS Letters · doi:10.1016/0014-5793(89)80803-8 · Cited by 471 · see citing works

Casein Kinases—Multipotential Protein Kinases

Hathaway, G. M., & Traugh, J. A. (1982) · Current topics in cellular regulation · doi:10.1016/b978-0-12-152821-8.50009-8 · Cited by 458 · see citing works

Separation and Characterization of Two Phosphorylase Phosphatase Inhibitors from Rabbit Skeletal Muscle

Huang, F. L., & Glinsmann, W. H. (1976) · European Journal of Biochemistry · doi:10.1111/j.1432-1033.1976.tb11032.x · Cited by 442 · see citing works

Glycogen Synthetase Activity in Skeletal Muscle

Danforth, W. H. (1965) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)45214-8 · Cited by 435 · see citing works

[37] Protein phosphatase-1 and protein phosphatase-2A from rabbit skeletal muscle

Cohen, P., Alemany, S., Therese, B. A., Resink, J., Strålfors, P., & Tung, H. Y. L. (1988) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/0076-6879(88)59039-0 · Cited by 411 · see citing works

Inactivation of Glycogen Synthetase and Activation of Phosphorylase Kinase by Muscle Adenosine 3',5'-Monophosphate-dependent Protein Kinases

Soderling, T. R., Hickenbottom, J. P., Reimann, E. M., Hunkeler, F. L., Walsh, D. A., & Krebs, E. G. (1970) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)62612-2 · Cited by 408 · see citing works

The Protein Phosphatases Involved in Cellular Regulation. 6. Measurement of Type-1 and Type-2 Protein Phosphatases in Extracts of Mammalian Tissues; an Assessment of Their Physiological Roles

Ingebritsen, T. S., Stewart, A. A., & Cohen, P. (1983) · European Journal of Biochemistry · doi:10.1111/j.1432-1033.1983.tb07362.x · Cited by 362 · see citing works

The Role of Cyclic-AMP-Dependent Protein Kinase in the Regulation of Glycogen Metabolism in Mammalian Skeletal Muscle

Cohen, P. (1978) · Current topics in cellular regulation · doi:10.1016/b978-0-12-152814-0.50008-3 · Cited by 353 · see citing works

Studies on UDPG-α-Glucan Transglucosylase. III. Interconversion of Two Forms of Muscle UDPG-α-Glucan Transglucosylase by a Phosphorylation-Dephosphorylation Reaction Sequence*

Friedman, D. L., & Larner, J. (1963) · Biochemistry · doi:10.1021/bi00904a009 · Cited by 311 · see citing works

Glycogen Synthase from Rabbit Skeletal Muscle; Effect of Insulin on the State of phosphorylation of the Seven Phosphoserine Residues in vivo

Parker, P. J., Caudwell, F. B., & Cohen, P. (1983) · European Journal of Biochemistry · doi:10.1111/j.1432-1033.1983.tb07140.x · Cited by 298 · see citing works

Glycogen synthase from rabbit skeletal muscle. Amino acid sequence at the sites phosphorylated by glycogen synthase kinase-3, and extension of the N-terminal sequence containing the site phosphorylated by phosphorylase kinase.

Rylatt, D. B., Aitken, A., Bilham, T., Condon, G. D., Embi, N., & Cohen, P. (1980) · PubMed · Cited by 285 · see citing works

Autophosphorylation and protein kinase C phosphorylation of the epidermal growth factor receptor. Effect on tyrosine kinase activity and ligand binding affinity.

Downward, J., Waterfield, M. D., & Parker, P. J. (1985) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)38602-7 · Cited by 282 · see citing works

The protein phosphatases involved in cellular regulation

Strålfors, P., Hiraga, A., & Cohen, P. (1985) · European Journal of Biochemistry · doi:10.1111/j.1432-1033.1985.tb08926.x · Cited by 262 · see citing works

Purification of Glycogen Synthase Kinase 3 from Rabbit Skeletal Muscle.. Copurification with the Activating Factor (FA)of the (Mg-ATP) Dependent Protein Phosphatase.

Hemmings, B. A., Yellowlees, D. C., Kernohan, J. C., & Cohen, P. (1981) · European Journal of Biochemistry · doi:10.1111/j.1432-1033.1981.tb05628.x · Cited by 241 · see citing works

Multisite phosphorylation of glycogen synthase

Woodgett, J. R., & Cohen, P. (1984) · Biochimica et Biophysica Acta (BBA) - Protein Structure and Molecular Enzymology · doi:10.1016/0167-4838(84)90047-5 · Cited by 216 · see citing works

Glycogen Synthase from Rabbit Skeletal Muscle

Rylatt, D. B., Aitken, A., Bilham, T., Condon, G. D., Embi, N., & Cohen, P. (1980) · European Journal of Biochemistry · doi:10.1111/j.1432-1033.1980.tb06060.x · Cited by 212 · see citing works

[6] Catalytic subunit of cAMP-dependent protein kinase

Reimann, E. M., & Beham, R. A. (1983) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/0076-6879(83)99039-0 · Cited by 211 · see citing works

Insulin-mediated effect on the activity of UDPG-glycogen transglucosylase of muscle

VILLAR‐PALASI, C., & Larner, J. (1960) · Biochimica et Biophysica Acta · doi:10.1016/0006-3002(60)90142-6 · Cited by 203 · see citing works

Primary-structure requirements for inhibition by the heat-stable inhibitor of the cAMP-dependent protein kinase.

Scott, J. D., Glaccum, M. B., Fischer, E. H., & Krebs, E. G. (1986) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.83.6.1613 · Cited by 199 · see citing works

Insulin receptor signaling. Activation of multiple serine kinases.

Czech, M. P., Klarlund, J. K., Yagaloff, K. A., Bradford, A. P., & Lewis, R. E. (1988) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)37908-0 · Cited by 197 · see citing works

The Purification and Properties of Rabbit Skeletal Muscle Glycogen Synthase

Nimmo, H. G., Proud, C. G., & Cohen, P. (1976) · European Journal of Biochemistry · doi:10.1111/j.1432-1033.1976.tb10761.x · Cited by 196 · see citing works

ATP x Mg-dependent protein phosphatase from rabbit skeletal muscle. II. Purification of the activating factor and its characterization as a bifunctional protein also displaying synthase kinase activity.

Vandenheede, J. R., Yang, S. D., Goris, J., & Merlevede, W. J. (1980) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)70200-2 · Cited by 194 · see citing works

The MgATP-Dependent Protein Phosphatase and Protein Phosphatase 1 Have Identical Substrate Specificities

STEWART, A. A., Hemmings, B. A., Cohen, P., Goris, J., & Merlevede, W. J. (2005) · European Journal of Biochemistry · doi:10.1111/j.1432-1033.1981.tb06217.x · Cited by 190 · see citing works

Reconstitution of a Mg‐ATP‐dependent protein phosphatase and its activation through a phosphorylation mechanism

Hemmings, B. A., Resink, T. J., & Cohen, P. (1982) · FEBS Letters · doi:10.1016/0014-5793(82)80760-6 · Cited by 184 · see citing works

Separation and Characterisation of Glycogen Synthase Kinase 3,Glycogen Synthase Kinase 4 and Glycogen Synthase Kinase 5 from Rabbit Skeletal Muscle

Cohen, P., Yellowlees, D. C., Aitken, A., Donella-Deana, A., Hemmings, B. A., & Parker, P. J. (1982) · European Journal of Biochemistry · doi:10.1111/j.1432-1033.1982.tb05902.x · Cited by 180 · see citing works

Phosphorylation of the Type‐II Regulatory Subunit of Cyclic‐AMP‐Dependent Protein Kinase by Glycogen Synthase Kinase 3 and Glycogen Synthase Kinase 5

Hemmings, B. A., Aitken, A., Cohen, P., RYMOND, M., & Hofmann, F. B. (1982) · European Journal of Biochemistry · doi:10.1111/j.1432-1033.1982.tb06896.x · Cited by 179 · see citing works

Multisite phosphorylation of glycogen synthase from rabbit skeletal muscle

Picton, C., Woodgett, J. R., Hemmings, B. A., & Cohen, P. (1982) · FEBS Letters · doi:10.1016/0014-5793(82)81332-x · Cited by 176 · see citing works

The AMP-activated protein kinase: a multisubstrate regulator of lipid metabolism

Hardie, D. G., Carling, D., & Sim, A. T. R. (1989) · Trends in Biochemical Sciences · doi:10.1016/0968-0004(89)90084-4 · Cited by 175 · see citing works

UDP-glucose: glycogen α-4-glucosyltransferase I kinase activity of purified muscle protein kinase

Schlender, K. K., Wei, S. H., & VILLAR‐PALASI, C. (1969) · Biochimica et Biophysica Acta (BBA) - Enzymology · doi:10.1016/0005-2744(69)90246-0 · Cited by 171 · see citing works

Complete Primary Structure of Protein Phosphatase Inhibitor‐1 from Rabbit Skeletal Muscle

Aitken, A., BILHAM, T., & Cohen, P. (1982) · European Journal of Biochemistry · doi:10.1111/j.1432-1033.1982.tb06771.x · Cited by 163 · see citing works

The catalytic subunits of protein phosphatase‐1 and protein phosphatase 2A are distinct gene products

Tung, H. Y. L., Resink, T. J., Hemmings, B. A., Shenolikar, S., & Cohen, P. (1984) · European Journal of Biochemistry · doi:10.1111/j.1432-1033.1984.tb07962.x · Cited by 160 · see citing works

Independent mechanisms account for the regulation by protein kinase C of the epidermal growth factor receptor affinity and tyrosine-protein kinase activity.

Davis, R. J. (1988) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)76563-6 · Cited by 160 · see citing works

Adenosine 3′:5′-cyclic monophosphate- and guanosine 3′:5′-cyclic monophosphate-dependent protein kinases: Possible homologous proteins

Lincoln, T., & Corbin, J. D. (1977) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.74.8.3239 · Cited by 157 · see citing works

Characterisation of a Reconstituted Mg‐ATP‐Dependent Protein Phosphatase

Resink, T. J., Hemmings, B. A., Tung, H. Y. L., & Cohen, P. (1983) · European Journal of Biochemistry · doi:10.1111/j.1432-1033.1983.tb07485.x · Cited by 154 · see citing works

Glycogen Synthase from Rabbit Skeletal Muscle

Parker, P. J., Embi, N., Caudwell, F. B., & Cohen, P. (1982) · European Journal of Biochemistry · doi:10.1111/j.1432-1033.1982.tb05904.x · Cited by 151 · see citing works

The Regulation of Glycogen Metabolism. Purification and Properties of Protein Phosphatase Inhibitor-2 from Rabbit Skeletal Muscle

Foulkes, J. G., & Cohen, P. (1980) · European Journal of Biochemistry · doi:10.1111/j.1432-1033.1980.tb04489.x · Cited by 150 · see citing works

The calmodulin‐dependent glycogen synthase kinase from rabbit skeletal muscle

Woodgett, J. R., Davison, M. T., & Cohen, P. (1983) · European Journal of Biochemistry · doi:10.1111/j.1432-1033.1983.tb07766.x · Cited by 150 · see citing works

The Proteink Phosphatases Involved in Cellur Regulation. 2. Glycogen Metabolism

INGERBRITSEN, T. S., Foulkes, J. G., & Cohen, P. (1983) · European Journal of Biochemistry · doi:10.1111/j.1432-1033.1983.tb07358.x · Cited by 145 · see citing works

Calmodulin-dependent glycogen synthase kinase.

Payne, M. E., & Soderling, T. R. (1980) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)70605-x · Cited by 138 · see citing works

The Hormonal Control of Glycogen Metabolism

Foulkes, J. G., & Cohen, P. (1979) · European Journal of Biochemistry · doi:10.1111/j.1432-1033.1979.tb13109.x · Cited by 132 · see citing works

A multifunctional calmodulin‐dependent protein kinase

McGuinness, T. L., Lai, Y. Y., Greengard, P., Woodgett, J. R., & Cohen, P. (1983) · FEBS Letters · doi:10.1016/0014-5793(83)80846-1 · Cited by 131 · see citing works

Rabbit skeletal muscle glycogen synthase. I. Relationship between phosphorylation state and kinetic properties.

Roach, P. J., Takeda, Y., & Larner, J. (1976) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)33634-7 · Cited by 130 · see citing works

Regulation of protein phosphatase‐1G from rabbit/skeletal muscle

Hubbard, M. J., & COHEN, P. (1989) · European Journal of Biochemistry · doi:10.1111/j.1432-1033.1989.tb15263.x · Cited by 129 · see citing works

Purification of a Hepatic S6 Kinase from Cycloheximide-treated Rats

Price, D. J., Nemenoff, R. A., & Avruch, J. (1989) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)80075-8 · Cited by 128 · see citing works

Influence Of Epinephrine and Insulin on Uridine Diphosphate Glucose-α-Glucan Transferase and Phosphorylase in Muscle

Craig, J. W., & Larner, J. (1964) · Nature · doi:10.1038/202971a0 · Cited by 127 · see citing works

Subunit structure and activation of inactive phosphorylase phosphatase

Ballou, L. M., Brautigan, D. L., & Fischer, E. H. (1983) · Biochemistry · doi:10.1021/bi00283a014 · Cited by 124 · see citing works

Multisite Phosphorylation of Glycogen Synthase from Rabbit Skeletal Muscle

Picton, C., Aitken, A., BILHAM, T., & Cohen, P. (1982) · European Journal of Biochemistry · doi:10.1111/j.1432-1033.1982.tb05903.x · Cited by 123 · see citing works

Multiple phosphorylation of rabbit skeletal muscle glycogen synthase. Evidence for interactions among phosphorylation sites and the resolution of electrophoretically distinct forms of the subunit.

DePaoli-Roach, A. A., Ahmad, Z., Camici, M., Lawrence, J. C., & Roach, P. J. (1983) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)44513-3 · Cited by 119 · see citing works

S6 kinase in quiescent Swiss mouse 3T3 cells is activated by phosphorylation in response to serum treatment.

Ballou, L. M., Siegmann, M., & Thomas, G. (1988) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.85.19.7154 · Cited by 117 · see citing works

Specificity of a protein phosphatase inhibitor from rabbit skeletal muscle

Cohen, P., Nimmo, G. A., & ANTONIW, J. F. (1977) · Biochemical Journal · doi:10.1042/bj1620435 · Cited by 114 · see citing works

Glycogen synthetase kinase 2 (GSK 2); The identification of a new protein kinase in skeletal muscle

Nimmo, H. G., & Cohen, P. (1974) · FEBS Letters · doi:10.1016/0014-5793(74)80450-3 · Cited by 112 · see citing works

Studies on UDPG-α-glucan Transglucosylase. V. Two Forms of the Enzyme in Dog Skeletal Muscle and Their Interconversion*

Rosell-Pérez, M., & Larner, J. (1964) · Biochemistry · doi:10.1021/bi00889a014 · Cited by 111 · see citing works

Glycogen Synthase Kinase-2 and Phosphorylase Kinase Are the Same Enzyme

Embi, N., Rylatt, D. B., & Cohen, P. (1979) · European Journal of Biochemistry · doi:10.1111/j.1432-1033.1979.tb04176.x · Cited by 109 · see citing works

Molecular characteristics of the totally dependent and independent forms of glycogen synthase of rabbit skeletal muscle

Smith, C., Brown, N. E., & Larner, J. (1971) · Biochimica et Biophysica Acta (BBA) - Enzymology · doi:10.1016/0005-2744(71)90089-1 · Cited by 105 · see citing works

Regulation of protein phosphatase‐1G from rabbit skeletal muscle

Hubbard, M. J., & Cohen, P. (1989) · European Journal of Biochemistry · doi:10.1111/j.1432-1033.1989.tb15264.x · Cited by 105 · see citing works

Glycogen Synthase and Glycogen Synthase Kinases

Roach, P. J. (1981) · Current topics in cellular regulation · doi:10.1016/b978-0-12-152820-1.50006-7 · Cited by 102 · see citing works

Analysis of the in vivo phosphorylation state of rabbit skeletal muscle glycogen synthase by fast‐atom‐bombardment mass spectrometry

Poulter, L., Ang, S.-G., Gibson, B. W., Williams, D. H., Holmes, C. F. B., Caudwell, F. B., Pitcher, J. A., & COHEN, P. (1988) · European Journal of Biochemistry · doi:10.1111/j.1432-1033.1988.tb14222.x · Cited by 102 · see citing works

Characterization of a rabbit skeletal muscle protein kinase (PC0.7) able to phosphorylate glycogen synthase and phosvitin.

DePaoli-Roach, A. A., Ahmad, Z., & Roach, P. J. (1981) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)52492-9 · Cited by 101 · see citing works

Rabbit skeletal muscle phosphorylase kinase. Comparison of glycogen synthase and phosphorylase as substrates.

DePaoli-Roach, A. A., Roach, P. J., & Larner, J. (1979) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)50717-1 · Cited by 93 · see citing works

The Insulin Receptor: Structure and Functio

Zick, Y. (1989) · Critical Reviews in Biochemistry and Molecular Biology · doi:10.3109/10409238909082554 · Cited by 90 · see citing works

Purification and Subunit Structure of a High-Molecular-Weight Phosphoprotein Phosphatase (Phosphatase 11) from Rat Liver

Tamura, S., KIKUCHI, H., Kikuchi, K., Hiraga, A., & Tsuiki, S. (1980) · European Journal of Biochemistry · doi:10.1111/j.1432-1033.1980.tb04435.x · Cited by 87 · see citing works

Regulation of glycogen synthetase. Specificity and stoichiometry of phosphorylation of the skeletal muscle enzyme by cyclic 3':5'-AMP-dependent protein kinase.

Soderling, T. R. (1975) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)41196-4 · Cited by 87 · see citing works

The glycogen‐binding subunit of protein phosphatase‐1g from rabbit skeletal muscle

Hubbard, M. J., & COHEN, P. (1989) · European Journal of Biochemistry · doi:10.1111/j.1432-1033.1989.tb14668.x · Cited by 85 · see citing works

Multiple phosphorylation of rabbit skeletal muscle glycogen synthase. Comparison of the actions of different protein kinases capable of catalyzing phosphorylation in vitro.

DePaoli-Roach, A. A., Roach, P. J., & Larner, J. (1979) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)86428-1 · Cited by 83 · see citing works

Stimulation of protein phosphatase activity by insulin and growth factors in 3T3 cells.

Chan, C. P., McNall, S. J., Krebs, E. G., & Fischer, E. H. (1988) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.85.17.6257 · Cited by 82 · see citing works

A Reinvestigation of the Phosphorylation of Rabbit Skeletal‐Muscle Glycogen Synthase by Cyclic‐AMP‐Dependent Protein Kinase

Embi, N., Parker, P. J., & Cohen, P. (1981) · European Journal of Biochemistry · doi:10.1111/j.1432-1033.1981.tb05252.x · Cited by 82 · see citing works

Hormonal control of glycogen synthase in rat hemidiaphragms. Effects of insulin and epinephrine on the distribution of phosphate between two cyanogen bromide fragments.

Lawrence, J. C., Hiken, J., DePaoli-Roach, A. A., & Roach, P. J. (1983) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)44514-5 · Cited by 79 · see citing works

Purification and properties of cyclic AMP-independent glycogen synthase kinase 1 from rabbit skeletal muscle.

Itarte, E., & Huang, K. (1979) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)50694-3 · Cited by 75 · see citing works

Purification and Physicochemical Properties of ATP Citrate (pro‐3S) Lyase from Lactating Rat Mammary Gland and Studies of Its Reversible Phosphorylation

Guy, P. S., Cohen, P., & Hardie, D. G. (1981) · European Journal of Biochemistry · doi:10.1111/j.1432-1033.1981.tb05160.x · Cited by 73 · see citing works

Phosphorylation and inactivation of glycogen synthase by phosphorylase kinase.

Soderling, T. R., Srivastava, A. K., Bass, M. A., & Khatra, B. S. (1979) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.76.6.2536 · Cited by 73 · see citing works

Total conversion of glycogen synthase from the I- to the D-form by a cyclic AMP-independent protein kinase from rabbit skeletal muscle.

Itarte, E., Robinson, J. C., & Huang, K. (1977) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)40645-4 · Cited by 72 · see citing works

Identification of a calmodulin‐dependent glycogen synthase kinase in rabbit skeletal muscle, distinct from phosphorylase kinase

Woodgett, J. R., Tonks, N. K., & Cohen, P. (1982) · FEBS Letters · doi:10.1016/0014-5793(82)81231-3 · Cited by 72 · see citing works

Multisite phosphorylation of the glycogen‐binding subunit of protein phosphatase‐1G by cyclic AMP‐dependent protein kinase and glycogen synthase kinase‐3

Dent, P., Campbell, D. G., Hubbard, M. J., & Cohen, P. (1989) · FEBS Letters · doi:10.1016/0014-5793(89)80433-8 · Cited by 68 · see citing works

Calcium-dependent phosphorylation of glycogen synthase by phosphorylase kinase.

Walsh, K. X., Millikin, D. M., Schlender, K. K., & Reimann, E. M. (1979) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)50412-9 · Cited by 64 · see citing works

Antagonistic effects of insulin and beta-adrenergic agonists on the activity of protein phosphatase inhibitor-1 in skeletal muscle of the perfused rat hemicorpus.

Foulkes, J. G., Cohen, P., Strada, S. J., Everson, W. V., & Jefferson, L. S. (1982) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)33537-3 · Cited by 64 · see citing works

Phosphorylation of glycogen synthase by cyclic AMP-independent casein kinase-2 from rabbit skeletal muscle.

Huang, K., Itarte, E., Singh, T. J., & Akatsuka, A. (1982) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)81101-8 · Cited by 64 · see citing works

Identification of phosphorylation sites in peptides using a gas-phase sequencer

Wang, Y., Fiol, C. J., DePaoli-Roach, A. A., Bell, A. W., Hermodson, M. A., & Roach, P. J. (1988) · Analytical Biochemistry · doi:10.1016/0003-2697(88)90053-x · Cited by 58 · see citing works

Phosphorylation of glycogen synthase by phosphorylase kinase

Soderling, T. R., Sheorain, V. S., & Ericsson, L. H. (1979) · FEBS Letters · doi:10.1016/0014-5793(79)80723-1 · Cited by 57 · see citing works

Insulin and Glycogen Synthase

Larner, J. (1972) · Diabetes · doi:10.2337/diab.21.2.s428 · Cited by 57 · see citing works

Acute regulation of hepatic protein phosphatases by glucagon, insulin, and glucose.

Tóth, B., Bollen, M., & Stalmans, W. (1988) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)68184-0 · Cited by 55 · see citing works

On the effect of adenosine 3′,5′ cyclophosphate on the kinase of UDPG: α-1,4-glucan α-4 glucosyl transferase

Huijing, F., & Larner, J. (1966) · Biochemical and Biophysical Research Communications · doi:10.1016/0006-291x(66)90538-9 · Cited by 54 · see citing works

The protein phosphatases involved in cellular regulation. Antibody to protein phosphatase-2A as a probe of phosphatase structure and function

Alemany, S., Tung, H. Y. L., Shenolikar, S., Pilkis, S. J., & Cohen, P. (1984) · European Journal of Biochemistry · doi:10.1111/j.1432-1033.1984.tb08520.x · Cited by 54 · see citing works

Muscle glycogen synthase in vivo state:

Roach, P. J., Rosell-Pérez, M., & Larner, J. (1977) · FEBS Letters · doi:10.1016/0014-5793(77)80414-6 · Cited by 53 · see citing works

Further studies on the structure of the glycogen‐bound form of protein phosphatase‐1 from rabbit skeletal muscle

Hiraga, A., Kemp, B. E., & Cohen, P. (1987) · European Journal of Biochemistry · doi:10.1111/j.1432-1033.1987.tb10795.x · Cited by 49 · see citing works

Phosphorylation of glycogen synthase and of the beta subunit of eukaryotic initiation factor two by a common protein kinase.

DePaoli-Roach, A. A., Roach, P. J., Pham, K. D., Kramer, G., & Hardesty, B. (1981) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)52475-9 · Cited by 48 · see citing works

Identification of three in vivo phosphorylation sites on the glycogen‐binding subunit of protein phosphatase 1 from rabbit skeletal muscle, and their response to adrenaline

Dent, P., Campbell, D. G., Caudwell, F. B., & Cohen, P. (1990) · FEBS Letters · doi:10.1016/0014-5793(90)80027-g · Cited by 47 · see citing works

Phosphorylation of the glycogen‐binding subunit of protein phosphatase‐1G in response to adrenalin

MacKintosh, C., Campbell, D. G., Hiraga, A., & Cohen, P. (1988) · FEBS Letters · doi:10.1016/0014-5793(88)81331-0 · Cited by 40 · see citing works

Calcium and Phospholipid Turnover as Transmembrane Signaling for Protein Phosphorylation

Takai, Y., Kishimoto, A., & Nishizuka, Y. (1982) · Elsevier eBooks · doi:10.1016/b978-0-12-171402-4.50020-4 · Cited by 40 · see citing works

Regulation of liver phosphorylase phosphatase

Goris, J., Doperé, F., Vandenheede, J. R., & Merlevede, W. J. (1980) · FEBS Letters · doi:10.1016/0014-5793(80)80925-2 · Cited by 39 · see citing works

Hormonal regulation of the rate of the glycogen/glucose‐1‐phosphate cycle in skeletal muscle

Challiss, R. A. J., Crabtree, B., & Newsholme, E. A. (1987) · European Journal of Biochemistry · doi:10.1111/j.1432-1033.1987.tb10756.x · Cited by 39 · see citing works

[36] Glycogen synthase kinase-3 from rabbit skeletal muscle

Hemmings, B. A., & Cohen, P. (1983) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/0076-6879(83)99069-9 · Cited by 39 · see citing works

Insulin Stimulates Dephosphorylation of Phosphorylase in Rat Epitrochlearis Muscles

Zhang, J. N., Hiken, J., Davis, A. E., & Lawrence, J. C. (1989) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)71523-8 · Cited by 33 · see citing works

Identification of the catalytic subunit of an oligomeric casein kinase (G type). Affinity labeling of the nucleotide site using p-(fluorosulfonyl)benzoyladenosine

Feige, J., Cochet, C., Pirollet, F., & CHAMBAZ, E. M. (1983) · Biochemistry · doi:10.1021/bi00275a020 · Cited by 31 · see citing works

Protein-serine kinase from rat epididymal adipose tissue which phosphorylates and activates acetyl-CoA carboxylase. Possible role in insulin action

Borthwick, A. C., Edgell, N. J., & Denton, R. M. (1990) · Biochemical Journal · doi:10.1042/bj2700795 · Cited by 31 · see citing works

Characterization of purified pp60c‐src protein tyrosine kinase from human platelets

Reuter, C. W., Fındık, D., & Presek, P. (1990) · European Journal of Biochemistry · doi:10.1111/j.1432-1033.1990.tb15581.x · Cited by 30 · see citing works

Phosphorylation and activation of rabbit skeletal muscle phosphorylase kinase by a cyclic nucleotide- and Ca2+-independent protein kinase.

Singh, T. J., Akatsuka, A., & Huang, K. (1982) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)33459-8 · Cited by 27 · see citing works

Amino acid sequence of a region on the glycogen‐binding subunit of protein phosphatase‐1 phosphorylated by cyclic AMP‐dependent protein kinase

Caudwell, F. B., Hiraga, A., & Cohen, P. (1986) · FEBS Letters · doi:10.1016/0014-5793(86)80056-4 · Cited by 24 · see citing works

Hormonal regulation of glycogen synthase phosphorylation in perfused rat skeletal muscle

Chiasson, J., Aylward, J., Shikama, H., & Exton, J. H. (1981) · FEBS Letters · doi:10.1016/0014-5793(81)80350-x · Cited by 23 · see citing works

Phosphorylation of glycogen synthase in rabbit muscle

Sheorain, V. S., Khatra Balwant, S., & Soderling, T. R. (1981) · FEBS Letters · doi:10.1016/0014-5793(81)80349-3 · Cited by 22 · see citing works

Effects of insulin on the phosphate content and kinetics of glycogen synthase in perfused rat hindlimb muscle

Uhing, R. J., Shikama, H., & Exton, J. H. (1981) · FEBS Letters · doi:10.1016/0014-5793(81)80598-4 · Cited by 22 · see citing works

Phosphorylation of K-casein by glycogen synthase kinase-3 from rabbit skeletal muscle

Donella‐Deana, A., Pinna, L. A., Hemmings, B. A., & Cohen, P. (1983) · Biochimica et Biophysica Acta (BBA) - Protein Structure and Molecular Enzymology · doi:10.1016/0167-4838(83)90043-2 · Cited by 8 · see citing works

Inhibition of glycogen synthase kinase-3 by insulin mediated by protein kinase B

Cross, D. A. E., Alessi, D. R., Cohen, P., Andjelkovich, M., & Hemmings, B. A. (1995) · Nature · doi:10.1038/378785a0 · Cited by 5,244 · see citing works

The mitogen-activated protein kinase signal transduction pathway

Davis, R. J. (1993) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)82362-6 · Cited by 2,112 · see citing works

GSK-3: tricks of the trade for a multi-tasking kinase

Doble, B. W., & Woodgett, J. R. (2003) · Journal of Cell Science · doi:10.1242/jcs.00384 · Cited by 2,084 · see citing works

ERKs: A family of protein-serine/threonine kinases that are activated and tyrosine phosphorylated in response to insulin and NGF

Boulton, T. G., Nye, S. H., Robbins, D. J., Ip, N. Y., Radzlejewska, E., Morgenbesser, S. D., DePinho, R. A., Panayotatos, N., Cobb, M. H., & Yancopoulos, G. D. (1991) · Cell · doi:10.1016/0092-8674(91)90098-j · Cited by 1,876 · see citing works

Signal Transduction through MAP Kinase Cascades

Lewis, T. S., Shapiro, P. S., & Ahn, N. G. (1998) · Advances in cancer research · doi:10.1016/s0065-230x(08)60765-4 · Cited by 1,746 · see citing works

Pathogenesis of type 2 diabetes mellitus

DeFronzo, R. A. (2004) · Medical Clinics of North America · doi:10.1016/j.mcna.2004.04.013 · Cited by 1,342 · see citing works

Raf-1 activates MAP kinase-kinase

Kyriakis, J. M., App, H., Zhang, X., Banerjee, P. T., Brautigan, D. L., Rapp, U. R., & Avruch, J. (1992) · Nature · doi:10.1038/358417a0 · Cited by 1,263 · see citing works

Nuclear Localization and Regulation of erk- and rsk-Encoded Protein Kinases

Chen, R., Sarnecki, C., & Blenis, J. (1992) · Molecular and Cellular Biology · doi:10.1128/mcb.12.3.915 · Cited by 1,081 · see citing works

Protein phosphorylation in regulation of photosynthesis

Allen, J. F. (1992) · Biochimica et Biophysica Acta (BBA) - Bioenergetics · doi:10.1016/s0005-2728(09)91014-3 · Cited by 909 · see citing works

Inactivation of glycogen synthase kinase-3 <i>β</i> by phosphorylation: new kinase connections in insulin and growth-factor signalling

Sutherland, C., Leighton, I. A., & Cohen, P. (1993) · Biochemical Journal · doi:10.1042/bj2960015 · Cited by 903 · see citing works

On target with a new mechanism for the regulation of protein phosphorylation

Hubbard, M. J., & Cohen, P. (1993) · Trends in Biochemical Sciences · doi:10.1016/0968-0004(93)90109-z · Cited by 896 · see citing works

Insulin resistance, lipotoxicity, type 2 diabetes and atherosclerosis: the missing links. The Claude Bernard Lecture 2009

DeFronzo, R. A. (2010) · Diabetologia · doi:10.1007/s00125-010-1684-1 · Cited by 889 · see citing works

Insulin Action and the Insulin Signaling Network*

Cheatham, B., & Kahn, C. R. (1995) · Endocrine Reviews · doi:10.1210/edrv-16-2-117 · Cited by 878 · see citing works

MAP kinase pathways

Cobb, M. H. (1999) · Progress in Biophysics and Molecular Biology · doi:10.1016/s0079-6107(98)00056-x · Cited by 869 · see citing works

THE STRUCTURE AND MECHANISM OF PROTEIN PHOSPHATASES: Insights into Catalysis and Regulation

Barford, D., Das, A. K., & Egloff, M. P. (1998) · Annual Review of Biophysics and Biomolecular Structure · doi:10.1146/annurev.biophys.27.1.133 · Cited by 703 · see citing works

Pathogenesis of insulin resistance in skeletal muscle

Abdul-Ghani, M. A., & DeFronzo, R. A. (2010) · Journal of Biomedicine and Biotechnology · doi:10.1155/2010/476279 · Cited by 670 · see citing works

Serine/threonine protein phosphatases

Wera, S., & Hemmings, B. A. (1995) · Biochemical Journal · doi:10.1042/bj3110017 · Cited by 637 · see citing works

FGF and stress regulate CREB and ATF‐1 via a pathway involving p38 MAP kinase and MAPKAP kinase‐2.

Tan, Y., Rouse, J. W., Zhang, A., Cariati, S., Cohen, P., & Comb, M. J. (1996) · The EMBO Journal · doi:10.1002/j.1460-2075.1996.tb00840.x · Cited by 634 · see citing works

Identification of MAPKAP kinase 2 as a major enzyme responsible for the phosphorylation of the small mammalian heat shock proteins

Stokoe, D., Engel, K., Campbell, D. G., Cohen, P., & Gaestel, M. (1992) · FEBS Letters · doi:10.1016/0014-5793(92)81216-9 · Cited by 569 · see citing works

Insulin Resistance, Obesity and Lipotoxicity

Yazıcı, D., & Sezer, H. (2017) · Advances in experimental medicine and biology · doi:10.1007/978-3-319-48382-5_12 · Cited by 507 · see citing works

The inhibition of glycogen synthase kinase-3 by insulin or insulin-like growth factor 1 in the rat skeletal muscle cell line L6 is blocked by wortmannin, but not by rapamycin: evidence that wortmannin blocks activation of the mitogen-activated protein kinase pathway in L6 cells between Ras and Raf

Cross, D. A. E., Alessi, D. R., Vandenheede, J. R., McDowell, H. E., Hundal, H. S., & Cohen, P. (1994) · Biochemical Journal · doi:10.1042/bj3030021 · Cited by 474 · see citing works

MAPKAP kinase‐2; a novel protein kinase activated by mitogen‐activated protein kinase.

Stokoe, D., Campbell, D. G., Nakielny, S., Hidaka, H., Leevers, S. J., Marshall, C. J., & Cohen, P. T. W. (1992) · The EMBO Journal · doi:10.1002/j.1460-2075.1992.tb05492.x · Cited by 467 · see citing works

The insulin receptor: structure, function, and signaling

Lee, J., & Pilch, P. F. (1994) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.1994.266.2.c319 · Cited by 446 · see citing works

Recent progress in characterization of protein kinase cascades for phosphorylation of ribosomal protein S6

Sturgill, T. W., & Wu, J. (1991) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/s0167-4889(97)90012-4 · Cited by 430 · see citing works

Glycogen synthase kinase 3: an emerging therapeutic target

Eldar-Finkelman, H. (2002) · Trends in Molecular Medicine · doi:10.1016/s1471-4914(01)02266-3 · Cited by 405 · see citing works

Mutations in the kinase Rsk-2 associated with Coffin-Lowry syndrome

Trivier, E., Cesare, D. D., Jacquot, S., Pannetier, S., Zackai, E. H., Young, I., Mandel, J., Sassone‐Corsi, P., & Hanauer, A. (1996) · Nature · doi:10.1038/384567a0 · Cited by 405 · see citing works

Glycogen synthase kinase-3 is rapidly inactivated in response to insulin and phosphorylates eukaryotic initiation factor eIF-2B

Welsh, G. I., & Proud, C. G. (1993) · Biochemical Journal · doi:10.1042/bj2940625 · Cited by 397 · see citing works

Mitogen-activated Protein Kinase Kinase Inhibition Does Not Block the Stimulation of Glucose Utilization by Insulin

Lazar, D. F., Wiese, R. J., Brady, M. J., Mastick, C. C., Waters, S. B., Yamauchi, K., Pessin, J. E., Cuatrecasas, P., & Saltiel, A. R. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.35.20801 · Cited by 396 · see citing works

Energy metabolism of the heart: From basic concepts to clinical applications applications

Taegtmeyer, H. (1994) · Current Problems in Cardiology · doi:10.1016/0146-2806(94)90008-6 · Cited by 391 · see citing works

Identification of multiple extracellular signal-regulated kinases (ERKs) with antipeptide antibodies.

Boulton, T. G., & Cobb, M. H. (1991) · Cell Regulation · doi:10.1091/mbc.2.5.357 · Cited by 390 · see citing works

Involvement of p21ras in activation of extracellular signal-regulated kinase 2

de Vries-Smits, A. M. M., Burgering, B. M. T., Leevers, S. J., shall, C. J. M., & Bos, J. L. (1992) · Nature · doi:10.1038/357602a0 · Cited by 384 · see citing works

Glycogen synthase kinase-3: functions in oncogenesis and development

Plyte, S. E. (1992) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/0304-419x(92)90012-n · Cited by 377 · see citing works

The control of protein phosphatase‐1 by targetting subunits

Alessi, D. R., MacDougall, L. K., Sola, M. M., IKEBE, M., & Cohen, P. (1992) · European Journal of Biochemistry · doi:10.1111/j.1432-1033.1992.tb17508.x · Cited by 374 · see citing works

Increasing cAMP attenuates activation of mitogen-activated protein kinase.

Sevetson, B. R., Kong, X., & Lawrence, J. C. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.21.10305 · Cited by 366 · see citing works

Insulin signal transduction through protein kinase cascades

Avruch, J. (1998) · Molecular and Cellular Biochemistry · doi:10.1023/a:1006823109415 · Cited by 364 · see citing works

The IRS-Signaling System: A Network of Docking Proteins That Mediate Insulin and Cytokine Action

White, M. F., & Yenush, L. (1998) · Current topics in microbiology and immunology · doi:10.1007/978-3-642-80481-6_8 · Cited by 360 · see citing works

Potential Role of Protein Kinase B in Insulin-induced Glucose Transport, Glycogen Synthesis, and Protein Synthesis

Ueki, K., Yamamoto‐Honda, R., Kaburagi, Y., Yamauchi, T., Tobe, K., Burgering, B. M. T., Coffer, P. J., Komuro, I., Akanuma, Y., Yazaki, Y., et al. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.9.5315 · Cited by 356 · see citing works

The Cellular Fate of Glucose and Its Relevance in Type 2 Diabetes

Bouché, C., Serdy, S., Kahn, C. R., & Goldfine, A. B. (2004) · Endocrine Reviews · doi:10.1210/er.2003-0026 · Cited by 348 · see citing works

Mammalian glucokinase and its gene

Iynedjian, P. B. (1993) · Biochemical Journal · doi:10.1042/bj2930001 · Cited by 337 · see citing works

Hexosamines and Insulin Resistance

McClain, D. A., & Crook, E. D. (1996) · Diabetes · doi:10.2337/diab.45.8.1003 · Cited by 325 · see citing works

MAP kinase by any other name smells just as sweet

Thomas, G. (1992) · Cell · doi:10.1016/0092-8674(92)90199-m · Cited by 320 · see citing works

Signal integration at the level of protein kinases, protein phosphatases and their substrates

Cohen, P. (1992) · Trends in Biochemical Sciences · doi:10.1016/0968-0004(92)90010-7 · Cited by 313 · see citing works

Decreased insulin activation of glycogen synthase in skeletal muscles in young nonobese Caucasian first-degree relatives of patients with non-insulin-dependent diabetes mellitus

Vaag, A., Henriksen, J. E., & Beck-Nielsen, H. (1992) · Journal of Clinical Investigation · doi:10.1172/jci115656 · Cited by 299 · see citing works

The Structure, Role, and Regulation of Type 1 Protein Phosphatases

Bollen, M., & Stalmans, W. (1992) · Critical Reviews in Biochemistry and Molecular Biology · doi:10.3109/10409239209082564 · Cited by 293 · see citing works

PTG, a Protein Phosphatase 1-Binding Protein with a Role in Glycogen Metabolism

Printen, J. A., Brady, M., & Saltiel, A. R. (1997) · Science · doi:10.1126/science.275.5305.1475 · Cited by 291 · see citing works

Yeast has homologs (CNA1 and CNA2 gene products) of mammalian calcineurin, a calmodulin-regulated phosphoprotein phosphatase

Cyert, M. S., Kunisawa, R., Kaim, D., & Thorner, J. (1991) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.88.16.7376 · Cited by 289 · see citing works

Regulation of gene expression by insulin

O’Brien, R. M., & Granner, D. K. (1991) · Biochemical Journal · doi:10.1042/bj2780609 · Cited by 282 · see citing works

Insulin stimulation of glycogen synthesis and glycogen synthase activity is blocked by wortmannin and rapamycin in 3T3-L1 adipocytes: evidence for the involvement of phosphoinositide 3-kinase and p70 ribosomal protein-S6 kinase

Shepherd, P. R., Navé, B. T., & Siddle, K. (1995) · Biochemical Journal · doi:10.1042/bj3050025 · Cited by 277 · see citing works

The IRS‐signalling system during insulin and cytokine action

Yenush, L., & White, M. F. (1997) · BioEssays · doi:10.1002/bies.950190608 · Cited by 272 · see citing works

Effects of Serine/Threonine Protein Phosphatases on Ion Channels in Excitable Membranes

Herzig, S., & Neumann, J. (2000) · Physiological Reviews · doi:10.1152/physrev.2000.80.1.173 · Cited by 270 · see citing works

Characterization of the myosin-binding subunit of smooth muscle myosin phosphatase.

SHIMIZU, H., Ito, M., Miyahara, M., Ichikawa, K., Okubo, S., D, T. K. M., Naka, M., Tanaka, T., Hirano, K., & Hartshorne, D. J. (1994) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)43828-8 · Cited by 262 · see citing works

Invited Review: Intracellular signaling in contracting skeletal muscle

Sakamoto, K., & Goodyear, L. J. (2002) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00167.2002 · Cited by 260 · see citing works

Structure, expression, and regulation of protein kinases involved in the phosphorylation of ribosomal protein S6.

Erikson, R. L. (1991) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)38072-4 · Cited by 255 · see citing works

PDK1, one of the missing links in insulin signal transduction?¹

Cohen, P., Alessi, D. R., & Cross, D. A. E. (1997) · FEBS Letters · doi:10.1016/s0014-5793(97)00490-0 · Cited by 246 · see citing works

MAP kinase activator from insulin‐stimulated skeletal muscle is a protein threonine/tyrosine kinase.

Nakielny, S., Cohen, P., Wu, J., & Sturgill, T. W. (1992) · The EMBO Journal · doi:10.1002/j.1460-2075.1992.tb05271.x · Cited by 244 · see citing works

Regulation of Protein Kinase B and Glycogen Synthase Kinase-3 by Insulin and β-Adrenergic Agonists in Rat Epididymal Fat Cells

MOULE, S. K., Welsh, G. I., EDGELL, N. J., Foulstone, E. J., Proud, C. G., & Denton, R. M. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.12.7713 · Cited by 242 · see citing works

Arachidonic acid inhibits myosin light chain phosphatase and sensitizes smooth muscle to calcium.

Gong, M. C., Fuglsang, A. T., Alessi, D. R., Kobayashi, S., Cohen, P., Somlyo, A. V., & Somlyo, A. P. (1992) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)36636-0 · Cited by 236 · see citing works

Purification of a murine protein-tyrosine/threonine kinase that phosphorylates and activates the Erk-1 gene product: relationship to the fission yeast byr1 gene product.

Crews, C. M., & Erikson, R. L. (1992) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.89.17.8205 · Cited by 226 · see citing works

Co-regulation of the mitogen-activated protein kinase, extracellular signal-regulated kinase 1, and the 90-kDa ribosomal S6 kinase in PC12 cells. Distinct effects of the neurotrophic factor, nerve growth factor, and the mitogenic factor, epidermal growth factor

Nguyen, T. T. H., Scimeca, J., Filloux, C., Peraldi, P., Carpentier, J. L., & OBBERGHEN, E. V. (1993) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)98418-8 · Cited by 222 · see citing works

Insulin activates protein kinase B, inhibits glycogen synthase kinase‐3 and activates glycogen synthase by rapamycin‐insensitive pathways in skeletal muscle and adipose tissue

Cross, D. A. E., Watt, P., Shaw, M., KAAY, J. V. D., Downes, C. P., Holder, J. C., & Cohen, P. (1997) · FEBS Letters · doi:10.1016/s0014-5793(97)00240-8 · Cited by 220 · see citing works

Isolation of MEK5 and Differential Expression of Alternatively Spliced Forms

English, J. M., Vanderbilt, C. A., Xu, S., Marcus, S., & Cobb, M. H. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.48.28897 · Cited by 213 · see citing works

Complementation of snf1, a mutation affecting global regulation of carbon metabolism in yeast, by a plant protein kinase cDNA.

Alderson, A. L., Sabelli, P. A., Dickinson, J. R., Cole, D., Richardson, M., Kreis, M. E., Shewry, P. R., & Halford, N. G. (1991) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.88.19.8602 · Cited by 209 · see citing works

Protein Kinases, Protein Phosphorylation, and the Regulation of Insulin Secretion from Pancreatic -Cells.

Jones, P. M., & Persaud, S. J. (1998) · Endocrine Reviews · doi:10.1210/edrv.19.4.0339 · Cited by 209 · see citing works

Effects of exercise and insulin on mitogen-activated protein kinase signaling pathways in rat skeletal muscle

Goodyear, L. J., Chang, P.-Y., Sherwood, D. J., Dufresne, S. D., & Moller, D. E. (1996) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1996.271.2.e403 · Cited by 208 · see citing works

Purification and characterization of the mammalian myosin light chain phosphatase holoenzyme. The differential effects of the holoenzyme and its subunits on smooth muscle.

Shirazi, A. A., Iizuka, K., Fadden, P., Mosse, C. A., Somlyo, A. P., Somlyo, A. V., & Haystead, T. (1994) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)31736-8 · Cited by 206 · see citing works

Caffeine Ingestion Decreases Glucose Disposal During a Hyperinsulinemic-Euglycemic Clamp in Sedentary Humans

Greer, F. A., Hudson, R., Ross, R., & Graham, T. E. (2001) · Diabetes · doi:10.2337/diabetes.50.10.2349 · Cited by 205 · see citing works

Wortmannin inhibits the effects of insulin and serum on the activities of glycogen synthase kinase-3 and mitogen-activated protein kinase

Welsh, G. I., Foulstone, E. J., Young, S. W., Tavaré, J. M., & Proud, C. G. (1994) · Biochemical Journal · doi:10.1042/bj3030015 · Cited by 200 · see citing works

The role of glucose 6‐phosphate in the control of glycogen synthase

Viijlar‐Palasí, C., & Guinovart, J. J. (1997) · The FASEB Journal · doi:10.1096/fasebj.11.7.9212078 · Cited by 196 · see citing works

Regulation of protein phosphatase-1

Aggen, J. B., Nairn, A. C., & Chamberlin, R. (2000) · Chemistry & Biology · doi:10.1016/s1074-5521(00)00069-7 · Cited by 196 · see citing works

Mitogen-activated Protein Kinase Pathway and AP-1 Are Activated during cAMP-induced Melanogenesis in B-16 Melanoma Cells

Englaro, W., Rezzonico, R., Durand‐Clément, M., Lallemand, D., Ortonne, J. P., & Ballotti, R. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.41.24315 · Cited by 196 · see citing works

1996: A vintage year for yeast and Yeast

Goffeau, A. (1996) · Yeast · doi:10.1002/(sici)1097-0061(199612)12:16 · Cited by 2 · see citing works

Nutritional and endocrine modulation of intracellular calcium: Implications in obesity, insulin resistance and hypertension

Zemel, M. B. (1998) · Springer eBooks · doi:10.1007/978-1-4615-5763-0_14 · Cited by 194 · see citing works

The substrate specificity and structure of mitogen-activated protein (MAP) kinase-activated protein kinase-2

Stokoe, D., Caudwell, B., Cohen, P., & Cohen, P. T. W. (1993) · Biochemical Journal · doi:10.1042/bj2960843 · Cited by 190 · see citing works

Organizing glucose disposal: emerging roles of the glycogen targeting subunits of protein phosphatase-1.

Newgard, C. B., Brady, M. J., O'Doherty, R. M., & Saltiel, A. R. (2000) · Diabetes · doi:10.2337/diabetes.49.12.1967 · Cited by 189 · see citing works

Metabolism of ubiquitinated histones.

Wu, R., Kohn, K. W., & Bonner, W. M. (1981) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)69296-3 · Cited by 189 · see citing works

Inhibitor‐2 functions like a chaperone to fold three expressed isoforms of mammalian protein phosphatase‐1 into a conformation with the specificity and regulatory properties of the native enzyme

Alessi, D. R., Street, A. J., Cohen, P., & Cohen, P. T. W. (1993) · European Journal of Biochemistry · doi:10.1111/j.1432-1033.1993.tb17853.x · Cited by 185 · see citing works

Regulation of fatty acid and cholesterol metabolism by the AMP-activated protein kinase

Hardie, D. G. (1992) · Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism · doi:10.1016/0005-2760(92)90001-c · Cited by 181 · see citing works

Phosphorylation and activation of human tyrosine hydroxylase in vitro by mitogen‐activated protein (MAP) kinase and MAP‐kinase‐activated kinases 1 and 2

Sutherland, C. D., ALTERIO, J., CAMPBELL, D. G., Bourdellès, B. L., Mallet, J. J., Haavik, J., & Cohen, P. (1993) · European Journal of Biochemistry · doi:10.1111/j.1432-1033.1993.tb18297.x · Cited by 177 · see citing works

3pK, a Novel Mitogen-Activated Protein (MAP) Kinase-Activated Protein Kinase, Is Targeted by Three MAP Kinase Pathways

Ludwig, S., Engel, K., Hoffmeyer, A., Sithanandam, G., Neufeld, B., Palm, D., Gaestel, M., & Rapp, U. R. (1996) · Molecular and Cellular Biology · doi:10.1128/mcb.16.12.6687 · Cited by 177 · see citing works

Protein Phosphorylation in Translational Control

Proud, C. G. (1992) · Current topics in cellular regulation · doi:10.1016/b978-0-12-152832-4.50008-2 · Cited by 177 · see citing works

Regulation of Glucose Transport and Glycogen Synthesis in L6 Muscle Cells during Oxidative Stress

Blair, A. S., Hajduch, É., Litherland, G. J., & Hundal, H. S. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.51.36293 · Cited by 170 · see citing works

The γ134.5 Protein of Herpes Simplex Virus 1 Has the Structural and Functional Attributes of a Protein Phosphatase 1 Regulatory Subunit and Is Present in a High Molecular Weight Complex with the Enzyme in Infected Cells

He, B., Gross, M. S., & Roizman, B. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.33.20737 · Cited by 169 · see citing works

Insulin Resistance of Glycogen Synthase Mediated byO-Linked N-Acetylglucosamine

Parker, G. J., Lund, K. C., Taylor, R. P., & McClain, D. A. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m207787200 · Cited by 169 · see citing works

Potential mechanism (S) involved in the regulation of glycogen synthesis by insulin

Srivastava, A. K., & Pandey, S. (1998) · Springer eBooks · doi:10.1007/978-1-4615-5647-3_14 · Cited by 167 · see citing works

Molecular cloning and expression of the regulatory (RG1) subunit of the glycogen-associated protein phosphatase

Tang, P. M., Bondor, J., Swiderek, K. M., & DePaoli-Roach, A. A. (1991) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)98477-2 · Cited by 167 · see citing works

The role of p21ras in receptor tyrosine kinase signaling

Bos, J. L., Burgering, B. M. T., Pronk, G. J., de Vries-Smits, A. M. M., Medema, J. P., Peppelenbosch, M. P., Wolthuis, R. M. F., & van Weeren, P. C. (1995) · Birkhäuser Basel eBooks · doi:10.1007/978-3-0348-9057-1_1 · Cited by 164 · see citing works

Role of phospholamban phosphorylation on Thr17 in cardiac physiological and pathological conditions

MATTIAZZI, A. R., Mundiña‐Weilenmann, C., GUOXIANG, C., Vittone, L., & Kranias, E. G. (2005) · Cardiovascular Research · doi:10.1016/j.cardiores.2005.08.010 · Cited by 163 · see citing works

GSK3β: role in therapeutic landscape and development of modulators

Phukan, S., Babu, V. V., Kannoji, A., Hariharan, R., & Balaji, V. (2010) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.2010.00661.x · Cited by 160 · see citing works

Insulin Control of Glycogen Metabolism in Knockout Mice Lacking the Muscle-Specific Protein Phosphatase PP1G/R GL

Suzuki, Y., Lannér, C., Kim, J., Vilardo, P. G., Zhang, H., Yang, J., Cooper, L. D., Steele, M., Kennedy, A., Bock, C. B., et al. (2001) · Molecular and Cellular Biology · doi:10.1128/mcb.21.8.2683-2694.2001 · Cited by 158 · see citing works

Regulation and Interaction of pp90 Isoforms with Mitogen-activated Protein Kinases

Zhao, Y., Bjørbæk, C., & Moller, D. E. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.47.29773 · Cited by 158 · see citing works

Amino acid sequence and expression of the hepatic glycogen‐binding (GL‐subunit of protein phosphatase‐1

Doherty, M. J., Moorhead, G. B. G., MORRICE, N. A., Cohen, P., & Cohen, P. T. W. (1995) · FEBS Letters · doi:10.1016/0014-5793(95)01184-g · Cited by 157 · see citing works

Nutritional and endocine modulation of intracellular calcium: Implications in obesity, insulin resistance and hypertension

Zemel, M. B. (1998) · Molecular and Cellular Biochemistry · doi:10.1023/a:1006880708475 · Cited by 155 · see citing works

In vivo regulation of muscle glycogen synthase and the control of glycogen synthesis.

Shulman, R. G., Bloch, G., & Rothman, D. L. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.19.8535 · Cited by 152 · see citing works

Regulation of Both Glycogen Synthase and PHAS-I by Insulin in Rat Skeletal Muscle Involves Mitogen-activated Protein Kinase-independent and Rapamycin-sensitive Pathways

Azpiazu, I., Saltiel, A. R., DePaoli-Roach, A. A., & Lawrence, J. C. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.9.5033 · Cited by 152 · see citing works

GAC1 may encode a regulatory subunit for protein phosphatase type 1 in Saccharomyces cerevisiae.

François, J., Thompson-Jaeger, S., Skroch, J., Zellenka, U., Spevak, W., & Tatchell, K. (1992) · The EMBO Journal · doi:10.1002/j.1460-2075.1992.tb05031.x · Cited by 151 · see citing works

Activation of Mitogen-activated Protein Kinase and Phosphatidylinositol 3′-Kinase Is Not Sufficient for the Hormonal Stimulation of Glucose Uptake, Lipogenesis, or Glycogen Synthesis in 3T3-L1 Adipocytes

Wiese, R. J., Mastick, C. C., Lazar, D. F., & Saltiel, A. R. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.7.3442 · Cited by 150 · see citing works

Diverse signaling pathways in the cellular actions of insulin

Saltiel, A. R. (1996) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1996.270.3.e375 · Cited by 142 · see citing works

Identification of insulin‐stimulated protein kinase‐1 as the rabbit equivalent of rskmo‐2

Sutherland, C. D., Campbell, D. G., & Cohen, P. (1993) · European Journal of Biochemistry · doi:10.1111/j.1432-1033.1993.tb17696.x · Cited by 141 · see citing works

RSK3 Encodes a Novel pp90 rsk Isoform with a Unique N-Terminal Sequence: Growth Factor-Stimulated Kinase Function and Nuclear Translocation

Zhao, Y., Bjørbæk, C., Weremowicz, S., Morton, C. C., & Moller, D. E. (1995) · Molecular and Cellular Biology · doi:10.1128/mcb.15.8.4353 · Cited by 141 · see citing works

Protein phosphatase-1 and insulin action

Ragolia, L., & Begum, N. (1998) · Molecular and Cellular Biochemistry · doi:10.1023/a:1006827227162 · Cited by 59 · see citing works

Protein phosphorylation and the control of glycogen metabolism in skeletal muscle

Cohen, P. (1983) · Philosophical transactions of the Royal Society of London. Series B, Biological sciences · doi:10.1098/rstb.1983.0034 · Cited by 68 · see citing works

Insulin-stimulated Phosphorylation of the Protein Phosphatase-1 Striated Muscle Glycogen-targeting Subunit and Activation of Glycogen Synthase

Liu, J., & Brautigan, D. L. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m909303199 · Cited by 29 · see citing works

How does insulin stimulate glycogen synthesis?

Cohen, P., Nimmo, H. G., & Proud, C. G. (1978) · PubMed · Cited by 46 · see citing works

Insulin Stimulates Dephosphorylation of Phosphorylase in Rat Epitrochlearis Muscles

Zhang, J. N., Hiken, J., Davis, A. E., & Lawrence, J. C. (1989) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)71523-8 · Cited by 33 · see citing works