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Defensin‐6 mRNA in human Paneth cells: implications for antimicrobia peptides in host defense of the human bowel
Open accessAbstract
The epithelial surface of the human small intestine is a barrier between the host and the microbial environment of the lumen. A human small intestine cDNA clone was found to encode a new member of the defensin family of antimicrobial peptides, named human defensin‐6. Tissue expression of this mRNA is specific for the small intestine as determined by Northern blot analysis and polymerase chain reaction analysis. In situ hybridization demonstrated that human defensin‐6 mRNA localizes to Paneth cells in the crypts of Lieberkühn. The finding of an abundant defensin mRNA in human Paneth cells supports the notion that these epithelial cells may play a key role in host defense of the human bowel. The results also strengthen the hypothesis that peptide‐based host defenses are prevalent at mucosal surfaces in mammals.
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Cited by
Defensins: antimicrobial peptides of innate immunity
Ganz, T. (2003) · Nature Reviews Immunology · doi:10.1038/nri1180 · Cited by 3,066
Isolation and Characterization of Human μ-Defensin-3, a Novel Human Inducible Peptide Antibiotic
Harder, J., Bartels, J., Christophers, E., & Schröder, J.-M. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m008557200 · Cited by 1,311
Agerberth, B., Charo, J., Werr, J., Olsson, B., Idali, F., Lindbom, L., Kiessling, R., Jörnvall, H., Wigzell, H., & Gudmundsson, G. H. (2000) · Blood · doi:10.1182/blood.v96.9.3086 · Cited by 758
Dermcidin: A novel human antibiotic peptide secreted by sweat glands
Schittek, B., Hipfel, R., Sauer, B., Bauer, J., Kalbacher, H., Stevanovic, S., Schirle, M., Schroeder, K., Blin, N., Meier, F., et al. (2001) · Nature Immunology · doi:10.1038/ni732 · Cited by 730
Paneth Cells: Maestros of the Small Intestinal Crypts
Clevers, H. C., & Bevins, C. L. (2013) · Annual Review of Physiology · doi:10.1146/annurev-physiol-030212-183744 · Cited by 699
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Metadata
- Authors
- Jones, D. E., & Bevins, C. L.
- Venue
- FEBS Letters
- Publisher
- Wiley
- Published
- 1993-01-04
- Volume
- 315
- Issue
- 2
- Pages
- 187-192
- ISSN
- 0014-5793 (ISSN-L)
- 1873-3468
- OpenAlex
- W2029727629
- Cited by
- 341
- References
- 0
- FWCI
- 14.82
- Type
- journal article
- Language
- en
- Open access
- bronze
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- CoChat. (2026). Citation check: Defensin‐6 mRNA in human Paneth cells: implications for antimicrobia peptides in host defense of the human bowel. https://app.cochat.ai/papers/10.1016/0014-5793(93)81160-2
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- Jones, D. E., & Bevins, C. L. (1993). Defensin‐6 mRNA in human Paneth cells: implications for antimicrobia peptides in host defense of the human bowel. FEBS Letters. https://doi.org/10.1016/0014-5793(93)81160-2
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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