Defensins: antimicrobial peptides of innate immunity
Abstract
The production of natural antibiotic peptides has emerged as an important mechanism of innate immunity in plants and animals. Defensins are diverse members of a large family of antimicrobial peptides, contributing to the antimicrobial action of granulocytes, mucosal host defence in the small intestine and epithelial host defence in the skin and elsewhere. This review, inspired by a spate of recent studies of defensins in human diseases and animal models, focuses on the biological function of defensins.
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These structurally diverse peptides make multimeric forms during infection and disrupt the membrane of the pathogen.
“These structurally diverse peptides make multimeric forms during infection and disrupt the membrane of the pathogen (Ganz, 2003).”
From Identification of Candidate Signature Genes and Key Regulators Associated With Trypanotolerance in the Sheko Breed (2019) · cites this paper as Ganz, 2003
Many clinical studies have identified positive associations between levels of airway epithelial cell-derived inflammatory mediators and disease severity.
“Many clinical studies have identified positive associations between levels of airway epithelial cell-derived inflammatory mediators and disease severity.”
From The airway epithelium: soldier in the fight against respiratory viruses (2011) · cites this paper as [76]
Dose-related associations were found between several cytokines and chemokines (including IL-8/CXLC8, MIP-1α/CCL3, MCP-1/CCL2, and the IL-6/TNF-α ratio) in respiratory secretions and the severity of RSV bronchiolitis.
“For instance, dose-related associations were found between several cytokines and chemokines (including IL-8/CXLC8, MIP-1α/CCL3, MCP-1/CCL2, and the IL-6/TNF-α ratio) in respiratory secretions and the severity of RSV bronchiolitis (76, 114, 271)”
From The airway epithelium: soldier in the fight against respiratory viruses (2011) · cites this paper as [76]
The associations between inflammatory mediators and RSV bronchiolitis severity suggest a relationship between overly aggressive innate immune responses and disease following infection.
“suggesting a relationship between overly aggressive innate immune responses and disease following infection.”
From The airway epithelium: soldier in the fight against respiratory viruses (2011) · cites this paper as [76]
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- Authors
- Ganz, T.
- Affiliations
- University of California, Los Angeles (US)
- Corresponding author
- Ganz, Tomas
- ORCID
- Ganz, Tomas
- Venue
- Nature Reviews Immunology
- Published
- 2003-09
- Volume
- 3
- Issue
- 9
- Pages
- 710-720
- ISSN
- 1474-1733 (ISSN-L)
- 1474-1741
- OpenAlex
- W2057198053
- Cited by
- 3,066
- References
- 163
- Citations by year
- 2026: 79 · 2025: 97 · 2024: 112 · 2023: 111 · 2022: 138 · 2021: 126 · 2020: 145 · 2019: 147 · 2018: 157 · 2017: 133 · 2016: 139 · 2015: 150 · 2014: 161 · 2013: 170 · 2012: 165
- FWCI
- 12.60
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature reviews. Immunology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health
- Topics
- Life Sciences › Immunology and Microbiology › Microbiology › Antimicrobial Peptides and Activities
- Life Sciences › Immunology and Microbiology › Immunology › Invertebrate Immune Response Mechanisms
- Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
- Keywords
- defensins, antimicrobial peptides, innate immunity, granulocytes, mucosal immunity, small intestine, natural antibiotics, human disease
- MeSH terms
- Amino Acid Sequence, Animals, Humans, Immunity, Innate, Models, Molecular, Molecular Sequence Data, Salmonella, Salmonella Infections, Sequence Alignment, Defensins
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