The DOI matches its Crossref record.
Expression cloning of an epithelial amiloride‐sensitive Na+ channel: A new channel type with homologies to Caenorhabditis elegans degenerins
Abstract
A complementary DNA encoding an amiloride‐sensitive Na+ channel has been cloned and characterized from rat colon. The protein encoded by the cDNA has a sequence of 699 amino acids (79 kDa) containing several putative membrane spanning domains and potential phosphorylation sites. It forms a channel that has the electrophysiological and pharmacological properties characteristic of the epithelial Na+ channel. Homologies (including in transmembrane domains) have been found between a part of the channel sequence and the Mec4 gene product of Caenorhabditis elegans, a protein associated with mutation‐induced neuronal degeneration.
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Citations
Cited by
Dose-ranging study of riluzole in amyotrophic lateral sclerosis
Amyotrophic Lateral Sclerosis/Riluzole Study Group II, Lacomblez, L., Bensimon, G., Meininger, V, Leigh, P. N., & Guillet, P. (1996) · The Lancet · doi:10.1016/s0140-6736(96)91680-3 · Cited by 1,301
Staub, O., Dho, S., Henry, P., Correa, J., Ishikawa, T., McGlade, J., & Rotin, D. (1996) · The EMBO Journal · doi:10.1002/j.1460-2075.1996.tb00593.x · Cited by 851
Regulation of stability and function of the epithelial Na+ channel (ENaC) by ubiquitination
Staub, O., Gautschi, I., Ishikawa, T., Breitschopf, K., Ciechanover, A., Schild, L., & Rotin, D. (1997) · The EMBO Journal · doi:10.1093/emboj/16.21.6325 · Cited by 601
TWIK-1, a ubiquitous human weakly inward rectifying K+ channel with a novel structure.
Lesage, F., Guillemare, E., Fink, M., Duprat, F., Lazdunski, M., Romey, G., & Barhanin, J. (1996) · The EMBO Journal · doi:10.1002/j.1460-2075.1996.tb00437.x · Cited by 560
Self-citationCloning of the amiloride-sensitive FMRFamide peptide-gated sodium channel
Lingueglia, E., Champigny, G., Lazdunski, M., & Barbry, P. (1995) · Nature · doi:10.1038/378730a0 · Cited by 391
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Metadata
- Authors
- Lingueglia, E., Voilley, N., Waldmann, R., Lazdunski, M., & Barbry, P.
- Venue
- FEBS Letters
- Publisher
- Wiley
- Published
- 1993-02-22
- Volume
- 318
- Issue
- 1
- Pages
- 95-99
- ISSN
- 0014-5793 (ISSN-L)
- 1873-3468
- OpenAlex
- W1506512444
- Cited by
- 343
- References
- 0
- FWCI
- 10.87
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Expression cloning of an epithelial amiloride‐sensitive Na+ channel: A new channel type with homologies to Caenorhabditis elegans degenerins. https://app.cochat.ai/papers/10.1016/0014-5793(93)81336-x
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- Lingueglia, E., Voilley, N., Waldmann, R., Lazdunski, M., & Barbry, P. (1993). Expression cloning of an epithelial amiloride‐sensitive Na+ channel: A new channel type with homologies to Caenorhabditis elegans degenerins. FEBS Letters. https://doi.org/10.1016/0014-5793(93)81336-x
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