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Molecular cloning and tissue distribution of a putative member of the rat opioid receptor gene family that is not a μ, δ or κ opioid receptor type
Open accessAbstract
A novel G protein‐coupled receptor was cloned by PCR and homology screening. Its deduced amino acid sequence is 47% identical overall to the μ, δ and κ opioid receptors and 64% identical in the putative transmembrane domains. When transiently expressed in COS‐7 cells this receptor did not bind any of the typical μ, δ or κ opioid receptor ligands with high affinity. In situ hybridization analysis revealed that LC132 mRNA is highly expressed in several rat brain areas, including the cerebral cortex, thalamus, subfornical organ, habenula, hypothalamus, central gray, dorsal raphe, locus coeruleus and the dorsal horn of the spinal cord. Based on this distribution and its high homology with the μ, δ and κ opioid receptors, it is proposed that LC132 is a new member of the opioid receptor family that is involved in analgesia and the perception of pain.
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Cited by
Waldhoer, M., Bartlett, S. E., & Whistler, J. L. (2004) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.73.011303.073940 · Cited by 740
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Mogil, J. S., Grisel, J. E., Reinscheid, R. K., Civelli, O., Belknap, J. K., & Grandy, D. K. (1996) · Neuroscience · doi:10.1016/0306-4522(96)00338-7 · Cited by 375
Self-citationLutfy, K., Eitan, S., Bryant, C. D., Yang, Y. C., Saliminejad, N., Walwyn, W., Kieffer, B. L., Takeshima, H., Carroll, F. I., Maidment, N. T., et al. (2003) · The Journal of Neuroscience · doi:10.1523/jneurosci.23-32-10331.2003 · Cited by 211
Role of the mu-opioid receptor in opioid modulation of immune function
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Metadata
- Authors
- Bunzow, J. R., Saez, C., Mortrud, M., Bouvier, C., Williams, J. T., Low, M., & Grandy, D. K.
- Venue
- FEBS Letters
- Publisher
- Wiley
- Published
- 1994-06-27
- Volume
- 347
- Issue
- 2-3
- Pages
- 284-288
- ISSN
- 0014-5793 (ISSN-L)
- 1873-3468
- OpenAlex
- W1991377640
- Cited by
- 607
- References
- 0
- FWCI
- 12.10
- Type
- journal article
- Language
- en
- Open access
- bronze
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- CoChat. (2026). Citation check: Molecular cloning and tissue distribution of a putative member of the rat opioid receptor gene family that is not a μ, δ or κ opioid receptor type. https://app.cochat.ai/papers/10.1016/0014-5793(94)00561-3
- The paper
- Bunzow, J. R., Saez, C., Mortrud, M., Bouvier, C., Williams, J. T., Low, M., & Grandy, D. K. (1994). Molecular cloning and tissue distribution of a putative member of the rat opioid receptor gene family that is not a μ, δ or κ opioid receptor type. FEBS Letters. https://doi.org/10.1016/0014-5793(94)00561-3
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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