Role of the mu-opioid receptor in opioid modulation of immune function

Ninković, Jana; Roy, Sabita

doi:10.1007/s00726-011-1163-0

Cited by 196Neuropeptides and Animal PhysiologyPain Mechanisms and TreatmentsOpioid Use Disorder Treatment

Role of the mu-opioid receptor in opioid modulation of immune function

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Ninković, Jana, Roy, Sabita·2013·Amino Acids

DOI 10.1007/s00726-011-1163-0PMC PMC3912755

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Abstract

Endogenous opioids are synthesized in vivo to modulate pain mechanisms and inflammatory pathways. Endogenous and exogenous opioids mediate analgesia in response to painful stimuli by binding to opioid receptors on neuronal cells. However, wide distribution of opioid receptors on tissues and organ systems outside the CNS, such as the cells of the immune system, indicate that opioids are capable of exerting additional effects in the periphery, such as immunomodulation. The increased prevalence of infections in opioid abuser-based epidemiological studies further highlights the immunosuppressive effects of opioids. In spite of their many debilitating side effects, prescription opioids remain a gold standard for treatment of chronic pain. Therefore, given the prevalence of opioid use and abuse, opioid-mediated immune suppression presents a serious concern in our society today. It is imperative to understand the mechanisms by which exogenous opioids modulate immune processes. In this review, we will discuss the role of opioid receptors and their ligands in mediating immune-suppressive functions. We will summarize recent studies on direct and indirect opioid modulation of the cells of the immune system, as well as the role of opioids in exacerbation of certain disease states.

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Authors: Ninković, J., & Roy, S.
Affiliations: University of Minnesota (US)
Corresponding author: Roy, Sabita
ORCID: Roy, Sabita
Venue: Amino Acids
Publisher: Springer Science and Business Media LLC
Published: 2011-12-15
Volume: 45
Issue: 1
Pages: 9-24
ISSN: 0939-4451 (ISSN-L)
1438-2199
DOI: 10.1007/s00726-011-1163-0
PMC: PMC3912755
OpenAlex: W2006027316
Cited by: 196
References: 157
Citations by year: 2026: 12 · 2025: 10 · 2024: 19 · 2023: 19 · 2022: 15 · 2021: 13 · 2020: 27 · 2019: 23 · 2018: 10 · 2017: 15 · 2016: 16 · 2015: 7 · 2014: 2 · 2013: 4 · 2012: 4
FWCI: 0.30
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.springer.com/tdm (tdm)
Locations: Amino Acids (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
Funders: National Institutes of Health
National Institute on Drug Abuse (K05DA033881, P50DA011806, R01DA022935, R01DA031202, T32DA007097, F31DA026264, R01DA012104, K02DA015349)
Topics: Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
Health Sciences › Medicine › Physiology › Pain Mechanisms and Treatments
Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Opioid Use Disorder Treatment
Keywords: mu-opioid receptor, immunomodulation, immunosuppression, endogenous opioids, exogenous opioids, prescription opioids, opioid abuse, chronic pain, opioid receptor ligands, immune cells, inflammation
MeSH terms: Analgesics, Opioid, Animals, Binding Sites, Humans, Immunity, Cellular, Immunity, Innate, Leukocytes, Mononuclear, Morphine, Pain, Signal Transduction, Receptors, Opioid, mu, Opioid Peptides, Immunomodulation

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Role of the mu-opioid receptor in opioid modulation of immune function

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