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Structure—function relationships in the receptor for urokinase‐type plasminogen activator Comparison to other members of the Ly‐6 family and snake venom α‐neurotoxins
Open accessAbstract
Plasminogen activation is regulated by the interaction between urokinase‐type plasminogen activator (uPA) and its specific glycolipid‐anchored cell surface receptor (uPAR). uPAR is composed of three homologous domains and is the only multi‐domain member of the Ly‐6 family of glycolipid‐anchored membrane proteins. Recent evidence has highlighted similarities between the individual domains of uPAR and the large family of secreted, single domain snake venom α‐neurotoxins, suggesting that uPAR may adopt the same gross folding pattern as these structurally well characterized proteins. Structural aspects of the binding between α‐neurotoxins and the acetylcholine receptor may have a major influence on future studies of the interaction between uPA and uPAR.
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Cited by
Regulation of cell signalling by uPAR
Smith, H. W., & Marshall, C. J. (2010) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2821 · Cited by 960
Sidenius, N., & Blasi, F. (2003) · Cancer and Metastasis Reviews · doi:10.1023/a:1023099415940 · Cited by 368
The plasminogen activator system: biology and regulation
Irigoyen, J. P., Muñoz-Cánoves, P., Montero, L., Koziczak, M., & Nagamine, Y. (1999) · Cellular and Molecular Life Sciences · doi:10.1007/pl00000615 · Cited by 368
The urokinase plasminogen activator system: a target for anti-cancer therapy
Ulisse, S., Baldini, E., Sorrenti, S., & D'Armiento, M. (2009) · Current Cancer Drug Targets · doi:10.2174/156800909787314002 · Cited by 312
Chimienti, F. (2003) · Human Molecular Genetics · doi:10.1093/hmg/ddg320 · Cited by 247
Metadata
- Authors
- Ploug, M., & Ellis, V.
- Venue
- FEBS Letters
- Publisher
- Wiley
- Published
- 1994-08
- Volume
- 349
- Issue
- 2
- Pages
- 163-168
- ISSN
- 0014-5793 (ISSN-L)
- 1873-3468
- OpenAlex
- W2131307163
- Cited by
- 246
- References
- 0
- FWCI
- 4.15
- Type
- journal article
- Language
- en
- Open access
- bronze
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- CoChat. (2026). Citation check: Structure—function relationships in the receptor for urokinase‐type plasminogen activator Comparison to other members of the Ly‐6 family and snake venom α‐neurotoxins. https://app.cochat.ai/papers/10.1016/0014-5793(94)00674-1
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- Ploug, M., & Ellis, V. (1994). Structure—function relationships in the receptor for urokinase‐type plasminogen activator Comparison to other members of the Ly‐6 family and snake venom α‐neurotoxins. FEBS Letters. https://doi.org/10.1016/0014-5793(94)00674-1
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