Identification of SLURP-1 as an epidermal neuromodulator explains the clinical phenotype of Mal de Meleda
Open accessAbstract
Mal de Meleda is an autosomal recessive inflammatory and keratotic palmoplantar skin disorder due to mutations in the ARS B gene, encoding for SLURP-1 (secreted mammalian Ly-6/uPAR-related protein 1). SLURP-1 belongs to the Ly-6/uPAR superfamily of receptor and secreted proteins, which participate in signal transduction, immune cell activation or cellular adhesion. The high degree of structural similarity between SLURP-1 and the three fingers motif of snake neurotoxins and Lynx1 suggests that this protein interacts with the neuronal acetylcholine receptors. We found that SLURP-1 potentiates the human alpha 7 nicotinic acetylcholine receptors that are present in keratinocytes. These results identify SLURP-1 as a secreted epidermal neuromodulator which is likely to be essential for both epidermal homeostasis and inhibition of TNF-alpha release by macrophages during wound healing. This explains both the hyperproliferative as well as the inflammatory clinical phenotype of Mal de Meleda.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
SLURP-1 is mutated in Mal de Meleda.
“For example, SLURP-1 is mutated in Mal de Meleda (120).”
From Nicotine is a selective pharmacological chaperone of acetylcholine receptor number and stoichiometry. Implications for drug discovery (2009) · cites this paper as [120]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
The neighbor-joining method: a new method for reconstructing phylogenetic trees.
Saitou, N., & Nei, M. (1987) · Molecular Biology and Evolution · doi:10.1093/oxfordjournals.molbev.a040454 · Cited by 59,962 · see citing works
Vagus nerve stimulation attenuates the systemic inflammatory response to endotoxin
Borovikova, L. V., Ivanova, S., Zhang, M., Yang, H., Botchkina, G. I., Watkins, L. R., Wang, H., Abumrad, N., Eaton, J. W., & Tracey, K. J. (2000) · Nature · doi:10.1038/35013070 · Cited by 4,211 · see citing works
Nicotinic acetylcholine receptor α7 subunit is an essential regulator of inflammation
Wang, H., Yu, M., Ochani, M., Amella, C. A., Tanovic, M., Susarla, S., Li, J. H., Wang, H., Yang, H., Ulloa, L., et al. (2003) · Nature · doi:10.1038/nature01339 · Cited by 3,228 · see citing works
Enhanced genome annotation using structural profiles in the program 3D-PSSM 1 1Edited by J. Thornton
Kelley, L. A., MacCallum, R. M., & Sternberg, M. J. E. (2000) · Journal of Molecular Biology · doi:10.1006/jmbi.2000.3741 · Cited by 1,462 · see citing works
uPAR: a versatile signalling orchestrator
Blasi, F., & Carmeliet, P. (2002) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm977 · Cited by 1,224 · see citing works
Jordan, M., Schallhorn, A., & Wurm, F. M. (1996) · Nucleic Acids Research · doi:10.1093/nar/24.4.596 · Cited by 862 · see citing works
Köck, A., Schwarz, T., Kirnbauer, R., Urbanski, A., Perry, P., Ansel, J. C., & Luger, T. A. (1990) · The Journal of Experimental Medicine · doi:10.1084/jem.172.6.1609 · Cited by 712 · see citing works
Prostate stem cell antigen: A cell surface marker overexpressed in prostate cancer
Reiter, R. E., Gu, Z., Watabe, T., THOMAS, G. V., Szigeti, K., Davis, E., Wahl, M. I., Nisitani, S., Yamashiro, J. M., Beau, M. M. L., et al. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.4.1735 · Cited by 675 · see citing works
Menon, G. K., Grayson, S., & Elias, P. M. (1985) · Journal of Investigative Dermatology · doi:10.1111/1523-1747.ep12273485 · Cited by 453 · see citing works
lynx1, an Endogenous Toxin-like Modulator of Nicotinic Acetylcholine Receptors in the Mammalian CNS
Miwa, J. M., Ibáñez-Tallon, I., Crabtree, G. W., Sánchez, R., Šali, A., Role, L. W., & Heintz, N. (1999) · Neuron · doi:10.1016/s0896-6273(00)80757-6 · Cited by 287 · see citing works
Snake venom α‐neurotoxins and other ‘three‐finger’ proteins
Tsetlin, V. I. (1999) · European Journal of Biochemistry · doi:10.1046/j.1432-1327.1999.00623.x · Cited by 281 · see citing works
Ploug, M., & Ellis, V. (1994) · FEBS Letters · doi:10.1016/0014-5793(94)00674-1 · Cited by 248 · see citing works
Biological Functions of Keratinocyte Cholinergic Receptors
Grando, S. A. (1997) · Journal of Investigative Dermatology Symposium Proceedings · doi:10.1038/jidsymp.1997.10 · Cited by 243 · see citing works
Mutations in the gene encoding SLURP-1 in Mal de Meleda
Fischer, J. (2001) · Human Molecular Genetics · doi:10.1093/hmg/10.8.875 · Cited by 217 · see citing works
Modulations in Epidermal Calcium Regulate the Expression of Differentiation-Specific Markers
Elias, P. M., Ahn, S. K., Denda, M., Brown, B. E., Crumrine, D. A., Kimutai, L. K., Kömüves, L. G., Lee, S. H., & Feingold, K. R. (2002) · Journal of Investigative Dermatology · doi:10.1046/j.1523-1747.2002.19512.x · Cited by 216 · see citing works
Grando, S. A., Horton, R. M., Pereira, E. F. R., Diethelm-Okita, B. M., George, P. M., Albuquerque, E. X., & Conti‐Fine, B. M. (1995) · Journal of Investigative Dermatology · doi:10.1111/1523-1747.ep12325606 · Cited by 210 · see citing works
Nakayama, T., Fujisawa, R., Yamada, H., Horikawa, T., Kawasaki, H., Hieshima, K., Izawa, D., 藤家, 悟., Tezuka, T., & Yoshie, O. (2001) · International Immunology · doi:10.1093/intimm/13.1.95 · Cited by 193 · see citing works
Nicotine Accelerates Angiogenesis and Wound Healing in Genetically Diabetic Mice
Jacobi, J., Jang, J. J., Sundram, U. N., Dayoub, H., Fajardo, L. F., & Cooke, J. P. (2002) · American Journal Of Pathology · doi:10.1016/s0002-9440(10)64161-2 · Cited by 179 · see citing works
Central role of α7 nicotinic receptor in differentiation of the stratified squamous epithelium
Arredondo, J., Nguyen, V. T., Chernyavsky, A. I., Bercovich, D., Orr‐Urtreger, A., Kummer, W., Lips, K. S., Vetter, D. E., & Grando, S. A. (2002) · The Journal of Cell Biology · doi:10.1083/jcb.200206096 · Cited by 146 · see citing works
Brakenhoff, R. H., Gerretsen, M., Knippels, E. M. C., van Dijk, M., van Essen, H., Weghuis, D. O., Sinke, R. J., Snow, G. B., & van Dongen, G. A. M. S. (1995) · The Journal of Cell Biology · doi:10.1083/jcb.129.6.1677 · Cited by 135 · see citing works
The Cleavage of the Urokinase Receptor Regulates Its Multiple Functions
Montuori, N., Carriero, M. V., Salzano, S., Rossi, G., & Ragno, P. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m207494200 · Cited by 129 · see citing works
Adermann, K., Wattler, F., Wattler, S., Heine, G., Meyer, M., Forssmann, W., & Nehls, M. C. (1999) · Protein Science · doi:10.1110/ps.8.4.810 · Cited by 127 · see citing works
Ploug, M., Kjalke, M., Rønne, E., Weidle, U. H., Høyer‐Hansen, G., & Danø, K. (1993) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)85366-8 · Cited by 125 · see citing works
Zia, S., Ndoye, A., Lee, T. X., Webber, R. J., & Grando, S. A. (2000) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(24)39322-x · Cited by 118 · see citing works
Allosteric mechanisms in normal and pathological nicotinic acetylcholine receptors
Changeux, J., & Edelstein, S. J. (2001) · Current Opinion in Neurobiology · doi:10.1016/s0959-4388(00)00221-x · Cited by 111 · see citing works
Bertrand, D., Cooper, E. A., Valera, S., Rungger, D., & Ballivet, M. (1991) · Methods in neurosciences · doi:10.1016/b978-0-12-185257-3.50017-3 · Cited by 91 · see citing works
Kondo, S., & Sauder, D. N. (1997) · European Journal of Immunology · doi:10.1002/eji.1830270718 · Cited by 87 · see citing works
Tsuji, H., Okamoto, K., Matsuzaka, Y., Iizuka, H., Tamiya, G., & Inoko, H. (2003) · Genomics · doi:10.1016/s0888-7543(02)00025-3 · Cited by 86 · see citing works
The structure of the urokinase-type plasminogen activator receptor gene
Casey, J., Petranka, J., Kottra, J., Fleenor, D. E., & Rosse, W. (1994) · Blood · doi:10.1182/blood.v84.4.1151.1151 · Cited by 79 · see citing works
Eckl, K., Stevens, H. P., Lestringant, G. G., Westenberger-Treumann, M., Traupe, H., Hinz, B., Frossard, P., Stadler, R., Leigh, I. M., Nürnberg, P., et al. (2003) · Human Genetics · doi:10.1007/s00439-002-0838-8 · Cited by 73 · see citing works
Genetic linkage of Meleda disease to chromosome 8qter
Fischer, J., Bouadjar, B., Heilig, R., Fizames, C., Prud’homme, J.-F., & Weissenbach, J. (1998) · European Journal of Human Genetics · doi:10.1038/sj.ejhg.5200254 · Cited by 51 · see citing works
Tone, M., Walsh, L. A., & Waldmann, H. (1992) · Journal of Molecular Biology · doi:10.1016/0022-2836(92)90239-g · Cited by 50 · see citing works
Isolation and Characterization of a New Member of the HumanGene Family( )
Horie, M., Okutomi, K., Taniguchi, Y., Ohbuchi, Y., Suzuki, M., & Takahashi, E. (1998) · Genomics · doi:10.1006/geno.1998.5462 · Cited by 40 · see citing works
Schrijvers, A. H. G. J., Gerretsen, M., Fritz, J. M., van Walsum, M., Quak, J. J., Snow, G. B., & van Dongen, G. A. M. S. (1991) · Experimental Cell Research · doi:10.1016/0014-4827(91)90260-2 · Cited by 36 · see citing works
The urokinase-type plasminogen activator receptor is a member of the Ly-6 superfamily
Palfree, R. G. E. (1991) · Immunology Today · doi:10.1016/s0167-5699(05)80051-9 · Cited by 35 · see citing works
Ward, K. M., Celebi, J. T., Dicle, Ö., & Yılmaz, E. (2003) · Journal of Investigative Dermatology · doi:10.1046/j.1523-1747.2003.12020.x · Cited by 34 · see citing works
Shan, X., Bourdeau, A., Rhoton, A., Wells, D. E., Cohen, E. H., Landgraf, B. E., & Palfree, R. G. E. (1998) · The Journal of Immunology · doi:10.4049/jimmunol.160.1.197 · Cited by 25 · see citing works
Ly6d-L, a Cell Surface Ligand for Mouse Ly6d
Apostolopoulos, J. J., McKenzie, I. F. C., & Sandrin, M. S. (2000) · Immunity · doi:10.1016/s1074-7613(00)80175-2 · Cited by 23 · see citing works
Neumann (1898) · Archives of Dermatological Research · doi:10.1007/bf01977221 · Cited by 21 · see citing works
The structure of the urokinase-type plasminogen activator receptor gene
Casey, J., Petranka, J., Kottra, J., et al. (1994) · Blood · doi:10.1182/blood.v84.4.1151.bloodjournal8441151 · Cited by 13 · see citing works
Hopkins, S. J., & Rothwell, N. J. (1991) · Immunology Today · doi:10.1016/s0167-5699(05)80050-7 · Cited by 8 · see citing works
The urokinase-type plasminogen activator receptor is a member of the Ly-6 superfamily
Palfree, R. G. E. (1991) · Immunology Today · doi:10.1016/0167-5699(91)90086-9 · Cited by 2 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Regulation of cell signalling by uPAR
Smith, H. W., & Marshall, C. (2009) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2821 · Cited by 955 · see citing works
Nicotinic acetylcholine receptors: From basic science to therapeutics
Hurst, R. S., Rollema, H., & Bertrand, D. (2012) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2012.08.012 · Cited by 525 · see citing works
Fry, B. G. (2005) · Genome Research · doi:10.1101/gr.3228405 · Cited by 486 · see citing works
Hurst, R. S., Hajós, M., Raggenbass, M., Wall, T. M., Higdon, N. R., Lawson, J. A., Rutherford-Root, K. L., Berkenpas, M. B., Hoffmann, W. E., Piotrowski, D. W., et al. (2005) · Journal of Neuroscience · doi:10.1523/jneurosci.5269-04.2005 · Cited by 447 · see citing works
Cys-loop receptors: new twists and turns
Lester, H. A. (2004) · Trends in Neurosciences · doi:10.1016/j.tins.2004.04.002 · Cited by 431 · see citing works
Expression and Function of the Cholinergic System in Immune Cells
Fujii, T., Mashimo, M., Moriwaki, Y., Misawa, H., Ono, S., Horiguchi, K., & Kawashima, K. (2017) · Frontiers in Immunology · doi:10.3389/fimmu.2017.01085 · Cited by 378 · see citing works
Grando, S. A., Pittelkow, M. R., & Schallreuter, K. U. (2006) · Journal of Investigative Dermatology · doi:10.1038/sj.jid.5700151 · Cited by 291 · see citing works
Diversity of native nicotinic receptor subtypes in mammalian brain
Zoli, M., Pistillo, F., & Gotti, C. (2015) · Neuropharmacology · doi:10.1016/j.neuropharm.2014.11.003 · Cited by 277 · see citing works
Grønlien, J. H., Håkerud, M., Ween, H., Thorin‐Hagene, K., Briggs, C. A., Gopalakrishnan, M., & Malysz, J. (2007) · Molecular Pharmacology · doi:10.1124/mol.107.035410 · Cited by 274 · see citing works
Allosteric modulation of nicotinic acetylcholine receptors
Bertrand, D., & Gopalakrishnan, M. (2007) · Biochemical Pharmacology · doi:10.1016/j.bcp.2007.07.011 · Cited by 256 · see citing works
Williams, D. K., Wang, J., & Papke, R. L. (2011) · Biochemical Pharmacology · doi:10.1016/j.bcp.2011.05.001 · Cited by 247 · see citing works
Timmermann, D. B., Grønlien, J. H., Kohlhaas, K. L., Nielsen, E. Ø., Dam, E., Dyhring, T., Ahring, P. K., Peters, D., Holst, D., Chrsitensen, J. K., et al. (2007) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.107.120436 · Cited by 217 · see citing works
Neural Systems Governed by Nicotinic Acetylcholine Receptors: Emerging Hypotheses
Miwa, J. M., Freedman, R., & Lester, H. A. (2011) · Neuron · doi:10.1016/j.neuron.2011.03.014 · Cited by 205 · see citing works
Physiological functions of the cholinergic system in immune cells
Fujii, T., Mashimo, M., Moriwaki, Y., Misawa, H., Ono, S., Horiguchi, K., & Kawashima, K. (2017) · Journal of Pharmacological Sciences · doi:10.1016/j.jphs.2017.05.002 · Cited by 207 · see citing works
Alpha7 nicotinic receptors as novel therapeutic targets for inflammation-based diseases
Bencherif, M., Lippiello, P., Lucas, R., & Marrero, M. (2010) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-010-0525-1 · Cited by 216 · see citing works
Pawlak, J., Mackessy, S. P., Sixberry, N. M., Stura, E. A., Du, M. L., Ménez, R., Foo, C. S., Ménèz, A., Nirthanan, S., & Kini, R. M. (2008) · The FASEB Journal · doi:10.1096/fj.08-113555 · Cited by 193 · see citing works
Organization, evolution and functions of the human and mouse Ly6/uPAR family genes
Loughner, C. L., Bruford, E. A., McAndrews-Hill, M., Delp, E. E., Swamynathan, S., & Swamynathan, S. K. (2016) · Human Genomics · doi:10.1186/s40246-016-0074-2 · Cited by 192 · see citing works
Modulatory effects of α7 nAChRs on the immune system and its relevance for CNS disorders
Kalkman, H. O., & Feuerbach, D. (2016) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-016-2175-4 · Cited by 182 · see citing works
Judge, M. R., McLean, W. H. I., & Munro, C. S. (2004) · doi:10.1002/9780470750520.ch34 · Cited by 176 · see citing works
Lester, H. A., Xiao, C., Srinivasan, R., Son, C. D., Miwa, J., Pantoja, R., Banghart, M. R., Dougherty, D. A., Goate, A. M., & Wang, J. C. (2009) · The AAPS Journal · doi:10.1208/s12248-009-9090-7 · Cited by 163 · see citing works
Biological Effects of SLURP-1 on Human Keratinocytes
Arredondo, J., Chernyavsky, A. I., Webber, R. J., & Grando, S. A. (2005) · Journal of Investigative Dermatology · doi:10.1111/j.0022-202x.2005.23973.x · Cited by 154 · see citing works
Miwa, J. M., Stevens, T. R., King, S. L., Caldarone, B. J., Ibanez-Tallon, I., Xiao, C., Fitzsimonds, R. M., Pavlides, C., Lester, H. A., Picciotto, M. R., et al. (2006) · Neuron · doi:10.1016/j.neuron.2006.07.025 · Cited by 154 · see citing works
Why do we study animal toxins?
Zhang, Y. (2015) · PubMed Central · doi:10.13918/j.issn.2095-8137.2015.4.183 · Cited by 154 · see citing works
Activated Cholinergic Signaling Provides a Target in Squamous Cell Lung Carcinoma
Song, P., Sekhon, H. S., Fu, X. W., Maier, M., Jia, Y., Duan, J., Proskosil, B. J., Gravett, C., Lindstrom, J., Mark, G. P., et al. (2008) · Cancer Research · doi:10.1158/0008-5472.can-08-0183 · Cited by 141 · see citing works
Araud, T., Graw, S. L., Berger, R., Lee, M., Neveu, E., Bertrand, D., & Leonard, S. S. (2011) · Biochemical Pharmacology · doi:10.1016/j.bcp.2011.06.018 · Cited by 122 · see citing works
Evolution and diversification of the Toxicofera reptile venom system
Fry, B. G., Vidal, N., van der Weerd, L., Kochva, E., & Renjifo, C. (2009) · Journal of Proteomics · doi:10.1016/j.jprot.2009.01.009 · Cited by 118 · see citing works
The Non-Neuronal Cholinergic System in Health and Disease
Beckmann, J., & Lips, K. S. (2013) · Pharmacology · doi:10.1159/000355835 · Cited by 117 · see citing works
A role for LYNX2 in anxiety-related behavior
Tekinay, A. B., Nong, Y., Miwa, J. M., Lieberam, I., Ibáñez-Tallon, I., Greengard, P., & Heintz, N. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0813109106 · Cited by 110 · see citing works
Tsetlin, V. I. (2014) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2014.11.003 · Cited by 107 · see citing works
Non-neuronal cholinergic system in regulation of immune function with a focus on α7 nAChRs
Kawashima, K., Fujii, T., Moriwaki, Y., Misawa, H., & Horiguchi, K. (2015) · International Immunopharmacology · doi:10.1016/j.intimp.2015.04.015 · Cited by 107 · see citing works
Allosteric modulation of nicotinic acetylcholine receptors
Chatzidaki, A., & Millar, N. S. (2015) · Biochemical Pharmacology · doi:10.1016/j.bcp.2015.07.028 · Cited by 104 · see citing works
Grando, S. A. (2008) · Journal of Pharmacological Sciences · doi:10.1254/jphs.fm0070087 · Cited by 99 · see citing works
SLURP1 Is a Late Marker of Epidermal Differentiation and Is Absent in Mal de Meleda
Favre, B., Plantard, L., Aeschbach, L., Brakch, N., Christen‐Zaech, S., de Viragh, P. A., Sergeant, A., Huber, M., & Hohl, D. (2006) · Journal of Investigative Dermatology · doi:10.1038/sj.jid.5700551 · Cited by 99 · see citing works
Molecular function of α7 nicotinic receptors as drug targets
Bouzat, C., Lasala, M., Nielsen, B. E., Corradi, J., & Esandi, M. D. C. (2017) · The Journal of Physiology · doi:10.1113/jp275101 · Cited by 96 · see citing works
ClanTox: a classifier of short animal toxins
Naamati, G., Askenazi, M., & Michal Linial, B. (2009) · Nucleic Acids Research · doi:10.1093/nar/gkp299 · Cited by 94 · see citing works
Fujii, Y. X., Fujigaya, H., Moriwaki, Y., Misawa, H., Kasahara, T., Grando, S. A., & KAWASHIMA, K. (2007) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2007.07.003 · Cited by 94 · see citing works
SLURP‐2: A novel cholinergic signaling peptide in human mucocutaneous epithelium
Arredondo, J., Chernyavsky, A. I., Jolkovsky, D. L., Webber, R. J., & Grando, S. A. (2006) · Journal of Cellular Physiology · doi:10.1002/jcp.20661 · Cited by 93 · see citing works
Peters, E. M. J., Валентиновна, М. А., Kupfer, J. P., Kummer, W., Wiegand, S., Niemeier, V., Потекаев, Н. Н., Lvov, A. N., & Gieler, U. (2014) · PLoS ONE · doi:10.1371/journal.pone.0113552 · Cited by 91 · see citing works
NMR Structure and Action on Nicotinic Acetylcholine Receptors of Water-soluble Domain of Human LYNX1
Lyukmanova, E. N., Shenkarev, Z. O., Shulepko, M. A., Mineev, K. S., D’hoedt, D., Kasheverov, I. E., Filkin, S. Y., Krivolapova, A. P., Janíčková, H., Doležal, V., et al. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.189100 · Cited by 91 · see citing works
Lyukmanova, E. N., Shulepko, M. A., Kudryavtsev, D. S., Bychkov, M. L., Kulbatskii, D. S., Kasheverov, I. E., Astapova, M. V., Feofanov, A. V., Thomsen, M. S., Mikkelsen, J. D., et al. (2016) · PLoS ONE · doi:10.1371/journal.pone.0149733 · Cited by 89 · see citing works
Moriwaki, Y., Yoshikawa, K., Fukuda, H., Fujii, Y. X., Misawa, H., & Kawashima, K. (2007) · Life Sciences · doi:10.1016/j.lfs.2006.12.028 · Cited by 87 · see citing works
Allosteric Modulators of the α7 Nicotinic Acetylcholine Receptor
Faghih, R., Gopalakrishnan, M., & Briggs, C. A. (2008) · Journal of Medicinal Chemistry · doi:10.1021/jm070256g · Cited by 86 · see citing works
Tietje, K. R., Anderson, D. J., Bitner, R. S., Blomme, E. A. G., Brackemeyer, P. J., Briggs, C. A., Browman, K. E., Bury, D., Curzon, P., Drescher, K. U., et al. (2008) · CNS Neuroscience & Therapeutics · doi:10.1111/j.1527-3458.2008.00037.x · Cited by 85 · see citing works
Stroncek, D. F., Caruccio, L., & Bettinotti, M. P. (2004) · Journal of Translational Medicine · doi:10.1186/1479-5876-2-8 · Cited by 83 · see citing works
Collins, T., & Millar, N. S. (2010) · Molecular Pharmacology · doi:10.1124/mol.110.064295 · Cited by 80 · see citing works
Nicotinic acetylcholine receptors: an overview on drug discovery
D’hoedt, D., & Bertrand, D. (2009) · Expert Opinion on Therapeutic Targets · doi:10.1517/14728220902841045 · Cited by 79 · see citing works
Novel aspects in cutaneous biology of acetylcholine synthesis and acetylcholine receptors
Kurzen, H., & Schallreuter, K. U. (2004) · Experimental Dermatology · doi:10.1111/j.1600-0625.2004.00258.x · Cited by 80 · see citing works
Hijazi, A., Masson, W., Augé, B., Waltzer, L., Haenlin, M., & Roch, F. (2009) · Development · doi:10.1242/dev.033845 · Cited by 79 · see citing works
Nicotinic acetylcholine receptor redux: Discovery of accessories opens therapeutic vistas
Matta, J. A., Gu, S., Davini, W. B., & Bredt, D. S. (2021) · Science · doi:10.1126/science.abg6539 · Cited by 75 · see citing works
Positive and negative modulation of nicotinic receptors
Arias, H. R. (2010) · Advances in protein chemistry and structural biology · doi:10.1016/b978-0-12-381264-3.00005-9 · Cited by 75 · see citing works
Tétreault, M., Yang, Y., Travis, J., Yu, Q., Klein–Szanto, A. J., Tobias, J. W., & Katz, J. P. (2010) · Gastroenterology · doi:10.1053/j.gastro.2010.03.048 · Cited by 75 · see citing works
Lochhead, P. J., Frank, B., Hold, G. L., Rabkin, C. S., Ng, M. T. H., Vaughan, T. L., Risch, H. A., Gammon, M. D., Lissowska, J., Weck, M. N., et al. (2010) · Gastroenterology · doi:10.1053/j.gastro.2010.11.001 · Cited by 72 · see citing works
Alpha7 neuronal nicotinic receptors as a drug target in schizophrenia
Wallace, T. L., & Bertrand, D. (2012) · Expert Opinion on Therapeutic Targets · doi:10.1517/14728222.2013.736498 · Cited by 72 · see citing works
Reconciling neuronally and nonneuronally derived acetylcholine in the regulation of immune function
Kawashima, K., Fujii, T., Moriwaki, Y., Misawa, H., & Horiguchi, K. (2012) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2012.06516.x · Cited by 70 · see citing works
Rat retinal transcriptome: Effects of aging and AMD-like retinopathy
Kozhevnikova, O. S., Korbolina, E. E., Ershov, N., & Kolosova, N. G. (2013) · Cell Cycle · doi:10.4161/cc.24825 · Cited by 71 · see citing works
Chernyavsky, A. I., Arredondo, J., Galitovskiy, V., Qian, J., & Grando, S. A. (2010) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00216.2010 · Cited by 67 · see citing works
SLURP-1 and -2 in normal, immortalized and malignant oral keratinocytes
Arredondo, J., Chernyavsky, A. I., & Grando, S. A. (2007) · Life Sciences · doi:10.1016/j.lfs.2007.01.003 · Cited by 66 · see citing works
Malysz, J., Grønlien, J. H., Anderson, D. J., Håkerud, M., Thorin‐Hagene, K., Ween, H., Wetterstrand, C., Briggs, C. A., Faghih, R., Bunnelle, W. H., et al. (2009) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.109.151886 · Cited by 65 · see citing works
Mashimo, M., Komori, M., Matsui, Y. Y., Murase, M. X., Fujii, T., Takeshima, S., Okuyama, H., Ono, S., Moriwaki, Y., Misawa, H., et al. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.01102 · Cited by 62 · see citing works
Levitin, F., Weiss, M., Hahn, Y., Stern, O., Papke, R. L., Matusik, R. J., Nandana, S., Ziv, R., Pichinuk, E., Salame, S., et al. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m801454200 · Cited by 62 · see citing works
“Nagashima-Type” Keratosis as a Novel Entity in the Palmoplantar Keratoderma Category
Kabashima, K., Sakabe, J., Yamada, Y., & TOKURA, Y. (2008) · Archives of Dermatology · doi:10.1001/archderm.144.3.375 · Cited by 61 · see citing works
Curtis, B. J., & Radek, K. A. (2011) · Journal of Investigative Dermatology · doi:10.1038/jid.2011.264 · Cited by 61 · see citing works
Nichols, W. A., Henderson, B. J., Yu, C., Parker, R. L., Richards, C. I., Lester, H. A., & Miwa, J. M. (2014) · Journal of Biological Chemistry · doi:10.1074/jbc.m114.573667 · Cited by 58 · see citing works
Moriwaki, Y., Watanabe, Y., Shinagawa, T., Kai, M., Miyazawa, M., Okuda, T., Kawashima, K., Yabashi, A., Waguri, S., & Misawa, H. (2009) · Neuroscience Research · doi:10.1016/j.neures.2009.04.014 · Cited by 58 · see citing works
Dessaud, É., Salaün, D., Gayet, O., Chabbert, M., & deLapeyrière, O. (2005) · Molecular and Cellular Neuroscience · doi:10.1016/j.mcn.2005.09.010 · Cited by 58 · see citing works
Discovery and development of α7 nicotinic acetylcholine receptor modulators.
Mazurov, A., Speake, J., & Yohannes, D. (2011) · Journal of Medicinal Chemistry · doi:10.1021/jm2007672 · Cited by 60 · see citing works
Zanetti, S. R., Ziblat, A., Torres, N. I., Zwirner, N. W., & Bouzat, C. (2016) · Journal of Biological Chemistry · doi:10.1074/jbc.m115.710574 · Cited by 57 · see citing works
Mashimo, M., Moriwaki, Y., Misawa, H., Kawashima, K., & Fujii, T. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22136818 · Cited by 58 · see citing works
Positive modulation of a Cys-loop acetylcholine receptor by an auxiliary transmembrane subunit
Boulin, T., Rapti, G., Briseño-Roa, L., Stigloher, C., Richmond, J. E., Paoletti, P., & Bessereau, J. (2012) · Nature Neuroscience · doi:10.1038/nn.3197 · Cited by 55 · see citing works
Hruska, M., Keefe, J., Wert, D., Tekinay, A. B., Hulce, J. J., Ibáñez-Tallon, I., & Nishi, R. (2009) · Journal of Neuroscience · doi:10.1523/jneurosci.2271-09.2009 · Cited by 55 · see citing works
Allosteric modulation of ligand-gated ion channels
Hogg, R. C., Buisson, B., & Bertrand, D. (2005) · Biochemical Pharmacology · doi:10.1016/j.bcp.2005.06.010 · Cited by 55 · see citing works
Microarray Analysis of Gene Expression in Cultured Skin Substitutes Compared with Native Human Skin
Smiley, A. K., Klingenberg, J. M., Aronow, B. J., Boyce, S. T., Kitzmiller, W., & Supp, D. M. (2005) · Journal of Investigative Dermatology · doi:10.1111/j.0022-202x.2005.23971.x · Cited by 54 · see citing works
Palmoplantar keratodermas: clinical and genetic aspects
Has, C., & Technau‐Hafsi, K. (2016) · JDDG Journal der Deutschen Dermatologischen Gesellschaft · doi:10.1111/ddg.12930 · Cited by 54 · see citing works
Mal de Meleda: A Focused Review
Perez, C., & Khachemoune, A. (2015) · American Journal of Clinical Dermatology · doi:10.1007/s40257-015-0157-1 · Cited by 52 · see citing works
Miwa, J. M., Lester, H. A., & Walz, A. (2012) · Physiology · doi:10.1152/physiol.00002.2012 · Cited by 52 · see citing works
SLURP1 mutation-impaired T-cell activation in a family with mal de Meleda
Tjiu, J.-W., Lin, P., Wu, W., Cheng, Y.-P., Chiu, H., Thong, H.-Y., Chiang, B., Yang, W., & Jee, S. (2010) · British Journal of Dermatology · doi:10.1111/j.1365-2133.2010.10059.x · Cited by 49 · see citing works
Swamynathan, S., Buela, K.-A. G., Kinchington, P. R., Lathrop, K. L., Misawa, H., Hendricks, R. L., & Swamynathan, S. K. (2012) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.12-10759 · Cited by 48 · see citing works
Role of the α7 Nicotinic Acetylcholine Receptor in the Pathophysiology of Atherosclerosis
Vieira-Alves, I., Coimbra-Campos, L. M. C., Sancho, M., da Silva, R., Côrtes, S. F., & Lemos, V. S. (2020) · Frontiers in Physiology · doi:10.3389/fphys.2020.621769 · Cited by 48 · see citing works
Novel Families of Toxin-like Peptides in Insects and Mammals: A Computational Approach
Kaplan, N., Morpurgo, N., & Michal Linial, B. (2007) · Journal of Molecular Biology · doi:10.1016/j.jmb.2007.02.106 · Cited by 47 · see citing works
Miwa, J. M., Anderson, K., & Hoffman, K. M. (2019) · Frontiers in Pharmacology · doi:10.3389/fphar.2019.00343 · Cited by 46 · see citing works
Mendelian diseases and conditions in Croatian island populations: historic records and new insights.
Saftić, V., Rudan, D., & Zgaga, L. (2006) · PubMed Central · Cited by 47 · see citing works
The three-fingered protein domain of the human genome
Gałat, A. (2008) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-008-8473-8 · Cited by 45 · see citing works
Cholinergic Targets in Lung Cancer
Spindel, E. R. (2016) · Current Pharmaceutical Design · doi:10.2174/1381612822666160127114237 · Cited by 45 · see citing works
Horiguchi, K., Horiguchi, S., Yamashita, N., Irie, K., Masuda, J., Takano‐Ohmuro, H., Himi, T., Miyazawa, M., Moriwaki, Y., Okuda, T., et al. (2009) · Journal of Neuroscience Research · doi:10.1002/jnr.22102 · Cited by 44 · see citing works
Palmoplantar Keratoderma along with Neuromuscular and Metabolic Phenotypes in Slurp1-Deficient Mice
Adeyo, O., Allan, B. B., Barnes, R. H., Goulbourne, C. N., Tatar, A., Tu, Y., Young, L. C., Weinstein, M. M., Tontonoz, P., Fong, L. G., et al. (2014) · Journal of Investigative Dermatology · doi:10.1038/jid.2014.19 · Cited by 44 · see citing works
Modulation of the Ca2+ conductance of nicotinic acetylcholine receptors by Lypd6
Darvas, M., Morsch, M., Rácz, I., Ahmadi, S., Swandulla, D., & Zimmer, A. (2009) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2009.03.007 · Cited by 44 · see citing works
Cell autonomy, receptor autonomy, and thermodynamics in nicotine receptor up-regulation
Nashmi, R., & Lester, H. (2007) · Biochemical Pharmacology · doi:10.1016/j.bcp.2007.06.040 · Cited by 43 · see citing works
Bencherif, M. (2009) · Acta Pharmacologica Sinica · doi:10.1038/aps.2009.37 · Cited by 44 · see citing works
Grando, S. A., Kawashima, K., Kirkpatrick, C. J., Kummer, W., & Wessler, I. K. (2015) · International Immunopharmacology · doi:10.1016/j.intimp.2015.08.023 · Cited by 42 · see citing works
Chao, L., Zhang, K., Li, Z., Wang, J., Yao, C., & Li, Q. (2018) · Journal of Flood Risk Management · doi:10.1111/jfr3.12518 · Cited by 41 · see citing works
Cysteine-Rich Mini-Proteins in Human Biology
Lavergne, V., Taft, R. J., & Alewood, P. F. (2012) · Current Topics in Medicinal Chemistry · doi:10.2174/156802612802652411 · Cited by 41 · see citing works
Jones, A. K., Buckingham, S., & Sattelle, D. (2010) · TIPS - Trends in Pharmacological Sciences · doi:10.1016/j.tips.2010.07.001 · Cited by 51 · see citing works
Throm, V. M., Männle, D., Giese, T., Bauer, A. S., Gaida, M. M., Kopitz, J., Bruckner, T. M., Plaschke, K., Grekova, S. P., Felix, K., et al. (2018) · Oncotarget · doi:10.18632/oncotarget.24312 · Cited by 39 · see citing works
3 α7 Nicotinic Acetylcholine Receptor Agonists and Positive Allosteric Modulators
Lightfoot, A. P., Kew, J. N. C., & Skidmore, J. (2008) · Progress in medicinal chemistry · doi:10.1016/s0079-6468(07)00003-3 · Cited by 39 · see citing works
Diffuse Nonepidermolytic Palmoplantar Keratoderma Caused by a Recurrent Nonsense Mutation in DSG1
Keren, H., Bergman, R., Mizrachi-Koren, M., Kashi, Y., & Sprecher, E. (2005) · Archives of Dermatology · doi:10.1001/archderm.141.5.625 · Cited by 38 · see citing works
Fujii, T., Horiguchi, K., Sunaga, H., Moriwaki, Y., Misawa, H., Kasahara, T., Tsuji, S., & Kawashima, K. (2013) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2013.12.003 · Cited by 38 · see citing works
Arredondo, J., Chernyavsky, A. I., & Grando, S. A. (2007) · Biochemical Pharmacology · doi:10.1016/j.bcp.2007.06.026 · Cited by 38 · see citing works
Roncarati, R., Seredenina, T. S., Jow, B., Jow, F., Papini, S., Kramer, A., Bothmann, H., Dunlop, J., & Terstappen, G. C. (2008) · Assay and Drug Development Technologies · doi:10.1089/adt.2007.120 · Cited by 37 · see citing works
Stegemann, A., & Böhm, M. (2020) · Experimental Dermatology · doi:10.1111/exd.14173 · Cited by 37 · see citing works
Thomsen, M. S., Cinar, B., Jensen, M. M., Lyukmanova, E. N., Shulepko, M. A., Tsetlin, V. I., Klein, A. B., & Mikkelsen, J. D. (2013) · Brain Structure and Function · doi:10.1007/s00429-013-0611-x · Cited by 36 · see citing works
- Authors
- Chimienti, F.
- Affiliations
- Centre Hospitalier Universitaire Vaudois (CH)
- Corresponding author
- Chimienti, F.
- ORCID
- Chimienti, F.
- Venue
- Human Molecular Genetics
- Publisher
- Oxford University Press (OUP)
- Published
- 2003-09-18
- Volume
- 12
- Issue
- 22
- Pages
- 3017-3024
- ISSN
- 0964-6906 (ISSN-L)
- 1460-2083
- OpenAlex
- W2127747996
- Cited by
- 247
- References
- 40
- Citations by year
- 2026: 2 · 2025: 4 · 2024: 3 · 2023: 7 · 2022: 2 · 2021: 8 · 2020: 7 · 2019: 8 · 2018: 9 · 2017: 11 · 2016: 14 · 2015: 16 · 2014: 12 · 2013: 9 · 2012: 18
- FWCI
- 6.05
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Human Molecular Genetics (publishedVersion)
- PubMed (publishedVersion)
- SERVAL (Université de Lausanne) (publishedVersion, other-oa)
- reroDoc Digital Library (submittedVersion)
- IRIS (submittedVersion)
- Research at the University of Copenhagen (University of Copenhagen) (submittedVersion)
- Funders
- National Science Foundation
- Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic and rare skin diseases.
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Skin and Cellular Biology Research
- Health Sciences › Medicine › Dermatology › Dermatology and Skin Diseases
- Keywords
- SLURP-1, Mal de Meleda, alpha7 nicotinic acetylcholine receptor, keratinocytes, keratosis, anti-TNF therapy, macrophages, wound healing, epidermal homeostasis, autosomal recessive inheritance
- MeSH terms
- Acetylcholine, Amino Acid Sequence, Animals, Antigens, Ly, Cell Line, Cell Nucleus, Clone Cells, Dose-Response Relationship, Drug, Epidermis, Female, Genes, Recessive, Humans, Keratoderma, Palmoplantar, Microinjections, Models, Molecular, Moths, Mutation, Oocytes, Peptides, Phenotype, Receptors, Cholinergic, Recombinant Proteins, Urokinase-Type Plasminogen Activator, Xenopus laevis, Protein Structure, Tertiary, DNA, Complementary, Neurotransmitter Agents, Patch-Clamp Techniques
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review