The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
A role for metals and free radicals in the induction of apoptosis in thymocytes
Open accessAbstract
Recent reports have implicated a possible but undefined role for reactive oxygen species in the induction and mediation of apoptosis. In the present study, the role of free radicals and metal ions in apoptosis induced in rat thymocytes by dexamethasone and etoposide was examined. Copper chelators, but not iron specific chelators, inhibited apoptosis induced by both these stimuli. Several antioxidants also possessed potent inhibitory effects. We therefore propose that diverse agents may induce apoptosis in thymocytes by a common mechanism involving a copper mediated Fenton reaction, generating site specific hydroxyl radicals, possibly as a result of activation of the redox sensitive transcription factor NF‐ϰB.
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Cites
Dithiocarbamates as potent inhibitors of nuclear factor kappa B activation in intact cells.
Schreck, R., Meier, B., Männel, D. N., Dröge, W., & Baeuerle, P. A. (1992) · The Journal of experimental medicine · doi:10.1084/jem.175.5.1181 · Cited by 1,508
Cited by
Mitochondria and programmed cell death: back to the future
Petit, P. X., Susin, S.-A., Zamzami, N., Mignotte, B., & Kroemer, G. (1996) · FEBS Letters · doi:10.1016/0014-5793(96)00988-x · Cited by 503
Nagano, T., & Yoshimura, T. (2002) · Chemical Reviews · doi:10.1021/cr010152s · Cited by 414
Ullah, M. F., Khan, H. Y., Zubair, H., Shamim, U., & Hadi, S. M. (2011) · Cancer Chemotherapy and Pharmacology · doi:10.1007/s00280-010-1290-4 · Cited by 70
Yuan, X. M. (1999) · Free Radical Research · doi:10.1080/10715769900300241 · Cited by 59
Apoptosis in primary lymphoid organs with aging
Sainz, R. M., Mayo, J. C., Reiter, R. J., Tan, D. X., & Rodriguez, C. (2003) · Microscopy Research and Technique · doi:10.1002/jemt.10414 · Cited by 32
Metadata
- Authors
- Wolfe, J. T., Ross, D., & Cohen, G. M.
- Venue
- FEBS Letters
- Publisher
- Wiley
- Published
- 1994-09-19
- Volume
- 352
- Issue
- 1
- Pages
- 58-62
- ISSN
- 0014-5793 (ISSN-L)
- 1873-3468
- OpenAlex
- W2031254695
- Cited by
- 177
- References
- 1
- FWCI
- 5.52
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Wolfe, J. T., Ross, D., & Cohen, G. M. (1994). A role for metals and free radicals in the induction of apoptosis in thymocytes. FEBS Letters. https://doi.org/10.1016/0014-5793(94)00920-1
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
