Apoptosis in primary lymphoid organs with aging
Abstract
Age-associated changes in the immune system are responsible for an increased likelihood of infection, autoimmune diseases, and cancer in the elderly. Immunosenescence is characterized by reduced levels of the peripheral naive T cell pool derived from thymus and the loss of immature B lineage cells in the bone marrow. Primary lymphoid organs, i.e., bone marrow and thymus, exhibit a loss of cellularity with age, which is especially dramatic in the thymus. A summary of major changes associated with aging in primary lymphoid organs is described in this article. The participation of apoptosis in cell loss in the immune system, a change associated with age, as well as a description of molecular machinery involved, is presented. Finally, the involvement of different hormonal and non-hormonal agents in counteracting apoptosis in thymus and bone marrow during aging is explained. Here, we underlie the important role of glucocorticoids as immunodepressors and melatonin as an immunostimulatory agent.
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Some cell types are characterized by increased PCD during aging.
“Some cell types are characterized by increased PCD during aging.”
From Programmed cell death in aging (2015) · cites this paper as Sainz et al., 2003
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Research Article Melatonin biosynthesis in the thymus of humans and rats
Naranjo, M. C., Guerrero, J. M., Rubio, A., Lardone, P. J., Carrillo‐Vico, A., Carrascosa-Salmoral, M. P., Jimnez-Jorge, S., Arellano, M. V., Leal-Noval, S. R., Leal, M., et al. (2007)
Role of Apoptosis in Aging: Therapeutic Targets and Strategies
Manna, A., Majumder, C., Halder, S., & Jana, K. (2024) · Springer eBooks · doi:10.1007/978-981-97-7905-5_17
- Authors
- Sainz, R. M., Mayo, J. C., Reiter, R. J., Tan, D. X., & Rodriguez, C.
- Affiliations
- Universidad de Oviedo (ES)
- The University of Texas at San Antonio Health Science Center (US)
- Corresponding author
- Sainz, Rosa M.
- Venue
- Microscopy Research and Technique
- Publisher
- Wiley
- Published
- 2003-11-17
- Volume
- 62
- Issue
- 6
- Pages
- 524-539
- ISSN
- 1059-910X (ISSN-L)
- 1097-0029
- OpenAlex
- W2022114401
- Cited by
- 32
- References
- 176
- Citations by year
- 2026: 1 · 2024: 2 · 2023: 2 · 2022: 1 · 2020: 3 · 2017: 1 · 2016: 1 · 2015: 1 · 2013: 1 · 2012: 6
- FWCI
- 0.17
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Microscopy Research and Technique (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute on Aging (T32AG00165-13, T32AG000165)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Cell death mechanisms and regulation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
- Keywords
- apoptosis, immunosenescence, aging, primary lymphoid organs, thymus, bone marrow, glucocorticoids, melatonin
- MeSH terms
- Aging, Animals, Bone Marrow, Humans, Lymphoid Tissue, Thymus Gland, Apoptosis, Mice, Rats
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