Cited by 32T-cell and B-cell ImmunologyCell death mechanisms and regulationGenetics, Aging, and Longevity in Model Organisms

Apoptosis in primary lymphoid organs with aging

Sainz, Rosa M., Mayo, Juan C., Reiter, R.J., Tan, D.X., Rodriguez, C.·2003·Microscopy Research and Technique

Abstract

Age-associated changes in the immune system are responsible for an increased likelihood of infection, autoimmune diseases, and cancer in the elderly. Immunosenescence is characterized by reduced levels of the peripheral naive T cell pool derived from thymus and the loss of immature B lineage cells in the bone marrow. Primary lymphoid organs, i.e., bone marrow and thymus, exhibit a loss of cellularity with age, which is especially dramatic in the thymus. A summary of major changes associated with aging in primary lymphoid organs is described in this article. The participation of apoptosis in cell loss in the immune system, a change associated with age, as well as a description of molecular machinery involved, is presented. Finally, the involvement of different hormonal and non-hormonal agents in counteracting apoptosis in thymus and bone marrow during aging is explained. Here, we underlie the important role of glucocorticoids as immunodepressors and melatonin as an immunostimulatory agent.

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Crossref · 10.1002/jemt.10414

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175 of 175 references verified0 citation errors · 0 not checkable

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  • Some cell types are characterized by increased PCD during aging.

    “Some cell types are characterized by increased PCD during aging.”

    From Programmed cell death in aging (2015) · cites this paper as Sainz et al., 2003

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Authors
Sainz, R. M., Mayo, J. C., Reiter, R. J., Tan, D. X., & Rodriguez, C.
Affiliations
  • Universidad de Oviedo (ES)
  • The University of Texas at San Antonio Health Science Center (US)
Corresponding author
Sainz, Rosa M.
Venue
Microscopy Research and Technique
Publisher
Wiley
Published
2003-11-17
Volume
62
Issue
6
Pages
524-539
ISSN
  • 1059-910X (ISSN-L)
  • 1097-0029
OpenAlex
W2022114401
Cited by
32
References
176
Citations by year
2026: 1 · 2024: 2 · 2023: 2 · 2022: 1 · 2020: 3 · 2017: 1 · 2016: 1 · 2015: 1 · 2013: 1 · 2012: 6
FWCI
0.17
Type
journal article
Language
en
Open access
closed
Locations
  • Microscopy Research and Technique (publishedVersion)
  • PubMed (publishedVersion)
Funders
National Institute on Aging (T32AG00165-13, T32AG000165)
Topics
  • Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Cell death mechanisms and regulation
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
Keywords
apoptosis, immunosenescence, aging, primary lymphoid organs, thymus, bone marrow, glucocorticoids, melatonin
MeSH terms
Aging, Animals, Bone Marrow, Humans, Lymphoid Tissue, Thymus Gland, Apoptosis, Mice, Rats

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