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Cited by 269

The DOI matches its Crossref record; 8 of the 8 references it cites were found in a registry or an index.

Distribution and characterization of immunoreactive rat adrenomedullin in tissue and plasma

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Sakata, Junichiro, Shimokubo, Toru, Kitamura, Kazuo, Nishizono, Masatoshi, Iehiki, Yoshinari, Kangawa, Kenji, Matsuo, Hisayuki, Eto, Tanenao·1994·FEBS Letters

Abstract

Adrenomedullin is a new bioactive peptide recently isolated from pheochromocytoma. We report on the rat adrenomedullin distribution and molecular forms in various tissues and plasma. Using a sensitive radioimmunoassay system for rat adrenomedullin, high concentrations of immunoreactive rat adrenomedullin were detected in adrenal gland, lung and cardiac atrium. In lung and atrium, the immunoreactivity concentration in rat was about 6–10 times higher than that in human. The mean plasma concentration of immunoreactive rat adrenomedullin was 3.60 ±0.34 fmol/ml (mean ± S.D.). Analysis in adrenal gland, lung and atrium with reverse‐phase and gel‐filtration high‐performance liquid chromatography showed that most immunoreactive rat adrenomedullin emerged as a single peak at a position exactly identical to that of the authentic rat adrenomedullin peptide, synthesized according to the sequence predicted from the cDNA.

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Metadata

Authors
Sakata, J., Shimokubo, T., Kitamura, K., Nishizono, M., Iehiki, Y., Kangawa, K., Matsuo, H., & Eto, T.
Venue
FEBS Letters
Publisher
Wiley
Published
1994-09-26
Volume
352
Issue
2
Pages
105-108
ISSN
  • 0014-5793 (ISSN-L)
  • 1873-3468
OpenAlex
W1965850532
Cited by
269
References
8
FWCI
5.49
Type
journal article
Language
en
Open access
bronze

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CoChat. (2026). Citation check: Distribution and characterization of immunoreactive rat adrenomedullin in tissue and plasma. https://app.cochat.ai/papers/10.1016/0014-5793(94)00928-7
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Sakata, J., Shimokubo, T., Kitamura, K., Nishizono, M., Iehiki, Y., Kangawa, K., Matsuo, H., & Eto, T. (1994). Distribution and characterization of immunoreactive rat adrenomedullin in tissue and plasma. FEBS Letters. https://doi.org/10.1016/0014-5793(94)00928-7

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