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Distribution and characterization of immunoreactive adrenomedullin in human tissue and plasma
Abstract
A specific and sensitive radioimmunoassay for human adrenomedullin has been developed and distribution and characterization of immunoreactive adrenomedullin in human tissue were investigated. The radioimmunoassay specifically recognizes its carboxyterminal region and half maximal inhibition of binding of radioiodinated adrenomedullin(40–52)NH 2 was observed at 11 . Immunoreactive adrenomedullin was abundant in adrenal medulla (47.7 ± 26.1 , mean ± S.D.) and was ubiquitously found in all tissue examined. The mean plasma concentration of adrenomedullin in three normal individuals was 17.2 ± 6.4 (mean ± S.D.). By analysis with reverse‐phase high‐performance liquid chromatography coupled with the radioimmunoassay, most immunoreactive adrenomedullin in the adrenal medulla, atrium and lung was found to be adrenomedullin(1–52)NH 2.
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Cited by
VAN ROSSUM, D., HANISCH, U.-K., & QUIRION, R. (1997) · Neuroscience & Biobehavioral Reviews · doi:10.1016/s0149-7634(96)00023-1 · Cited by 516
Vascular Abnormalities and Elevated Blood Pressure in Mice Lacking Adrenomedullin Gene
Shindo, T., Kurihara, Y., Nishimatsu, H., Moriyama, N., Kakoki, M., Wang, Y., Imai, Y., Ebihara, A., Kuwaki, T., Ju, K.-H., et al. (2001) · Circulation · doi:10.1161/hc4101.097111 · Cited by 297
Self-citationMid-regional pro-adrenomedullin as a prognostic marker in sepsis: an observational study
Christ-Crain, M., Morgenthaler, N. G., Struck, J., Harbarth, S., Bergmann, A., & Müller, B. (2005) · Critical Care · doi:10.1186/cc3885 · Cited by 281
Distribution and characterization of immunoreactive rat adrenomedullin in tissue and plasma
Sakata, J., Shimokubo, T., Kitamura, K., Nishizono, M., Iehiki, Y., Kangawa, K., Matsuo, H., & Eto, T. (1994) · FEBS Letters · doi:10.1016/0014-5793(94)00928-7 · Cited by 269
Self-citationAdrenomedullin is a potent stimulator of osteoblastic activity in vitro and in vivo
Cornish, J., Callon, K. E., Coy, D. H., Jiang, N.-Y., Xiao, L., Cooper, G. J. S., & Reid, I. R. (1997) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1997.273.6.e1113 · Cited by 96
Metadata
- Authors
- Ichiki, Y., Kitamura, K., Kangawa, K., Kawamoto, M., Matsuo, H., & Eto, T.
- Venue
- FEBS Letters
- Publisher
- Wiley
- Published
- 1994-01-24
- Volume
- 338
- Issue
- 1
- Pages
- 6-10
- ISSN
- 0014-5793 (ISSN-L)
- 1873-3468
- OpenAlex
- W2060000931
- Cited by
- 576
- References
- 0
- FWCI
- 13.59
- Type
- journal article
- Language
- en
- Open access
- closed
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- Ichiki, Y., Kitamura, K., Kangawa, K., Kawamoto, M., Matsuo, H., & Eto, T. (1994). Distribution and characterization of immunoreactive adrenomedullin in human tissue and plasma. FEBS Letters. https://doi.org/10.1016/0014-5793(94)80106-1
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
