The DOI matches its Crossref record; 24 of the 24 references it cites were found in a registry or an index.
New structures in complex formation between DNA and cationic liposomes visualized by freeze—fracture electron microscopy
Open accessAbstract
Structures formed during interaction of cationic liposomes and plasmid DNA were studied by freeze—fracture electron microscopy and their morphology was found to be dependent on incubation time and DNA concentration. These structures were formed with liposomes composed of DC‐Chol and DOPE after 30 min incubation at DNA: lipid concentrations encompassing maximal transfection activity. They resembled liposome complexes (meatballs) and additionally bilayer‐covered DNA tubules (spaghetti), whereby the DNA‐tubules were found to be connected to the liposome complexes as well as occurring free in the suspension. At later times and higher DNA‐to‐liposome ratios the complexes grow larger while their membranes become discontinuous, allowing the self‐encapsulation of the DNA. The relative transfection potency of the various morphologically distinct structures is discussed.
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Cites
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Cited by
Formation and Intracellular Trafficking of Lipoplexes and Polyplexes
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Nonviral gene delivery: What we know and what is next
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Metadata
- Authors
- Sternberg, B., Sorgi, F. L., & Huang, L.
- Venue
- FEBS Letters
- Publisher
- Wiley
- Published
- 1994-12-19
- Volume
- 356
- Issue
- 2-3
- Pages
- 361-366
- ISSN
- 0014-5793 (ISSN-L)
- 1873-3468
- OpenAlex
- W1999598401
- Cited by
- 428
- References
- 24
- FWCI
- 7.23
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Sternberg, B., Sorgi, F. L., & Huang, L. (1994). New structures in complex formation between DNA and cationic liposomes visualized by freeze—fracture electron microscopy. FEBS Letters. https://doi.org/10.1016/0014-5793(94)01315-2
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
